{"entity": "researcher", "timestamp": "2026-08-09T06:55:22.303Z", "family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "affiliations": ["Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. benedikt.strunz@ki.se niklas.bjorkstrom@ki.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c"}}, "publications": [{"entity": "publication", "iuid": "ad8544dcfbdf4b14a12286065b365a09", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ad8544dcfbdf4b14a12286065b365a09.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ad8544dcfbdf4b14a12286065b365a09"}}, "title": "Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19.", "authors": [{"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Mehta", "given": "Adi", "initials": "A"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Sun", "given": "Dan", "initials": "D"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Geanon", "given": "Daniel", "initials": "D"}, {"family": "Parke", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Ekwall-Larson", "given": "Anna", "initials": "A"}, {"family": "Rivino", "given": "Laura", "initials": "L"}, {"family": "MacAry", "given": "Paul A", "initials": "PA"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Lund-Johansen", "given": "Fridtjof", "initials": "F"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Karolinska KI/K COVID-19 Study Group\n", "given": "", "initials": ""}], "type": "journal article", "published": "2024-08-16", "journal": {"title": "J. Infect. Dis.", "issn": "1537-6613", "volume": "230", "issue": "2", "pages": "e318-e326", "issn-l": "0022-1899"}, "abstract": "Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).\n\nThis study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.\n\naIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.\n\nOur data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.", "doi": "10.1093/infdis/jiae036", "pmid": "38421006", "labels": {"Autoimmunity and Serology Profiling": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11326830"}, {"db": "pii", "key": "7616238"}], "notes": [], "created": "2024-10-22T09:29:19.468Z", "modified": "2024-10-22T09:29:19.486Z"}, {"entity": "publication", "iuid": "77d5898d6e3a4fa0ae0fcc6e5870b659", "links": {"self": {"href": "https://publications.scilifelab.se/publication/77d5898d6e3a4fa0ae0fcc6e5870b659.json"}, "display": {"href": "https://publications.scilifelab.se/publication/77d5898d6e3a4fa0ae0fcc6e5870b659"}}, "title": "Tissue-specific nonheritable influences drive endometrial immune system variation.", "authors": [{"family": "Bister", "given": "Jonna", "initials": "J", "orcid": "0009-0003-4604-5060", "researcher": {"href": "https://publications.scilifelab.se/researcher/f6bcfb38814c452ab78f1410e79b759e.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Sun", "given": "Dan", "initials": "D", "orcid": "0000-0003-2147-9308", "researcher": {"href": "https://publications.scilifelab.se/researcher/565b38c0fdb0496fa4a687e94fd05d9e.json"}}, {"family": "Crona-Guterstam", "given": "Ylva", "initials": "Y", "orcid": "0000-0003-4998-4904", "researcher": {"href": "https://publications.scilifelab.se/researcher/be2bb2deeaf2411fac4aac4627016cf2.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications.scilifelab.se/researcher/aad5c88284e54bd0af1e3ce4004dd24c.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-1432-8344", "researcher": {"href": "https://publications.scilifelab.se/researcher/752d22e542a04648b1807f91fe225f6e.json"}}, {"family": "Ivarsson", "given": "Martin A", "initials": "MA", "orcid": "0000-0002-7745-1331", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd83443b18774e3d91400e3cedc045d6.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}], "type": "journal article", "published": "2024-04-05", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "9", "issue": "94", "pages": "eadj7168", "issn-l": null}, "abstract": "Although human twin studies have revealed the combined contribution of heritable and environmental factors in shaping immune system variability in blood, the contribution of these factors to immune system variability in tissues remains unexplored. The human uterus undergoes constant regeneration and is exposed to distinct environmental factors. To assess uterine immune system variation, we performed a system-level analysis of endometrial and peripheral blood immune cells in monozygotic twins. Although most immune cell phenotypes in peripheral blood showed high genetic heritability, more variation was found in endometrial immune cells, indicating a stronger influence by environmental factors. Cytomegalovirus infection was identified to influence peripheral blood immune cell variability but had limited effect on endometrial immune cells. Instead, hormonal contraception shaped the local endometrial milieu and immune cell composition with minor influence on the systemic immune system. These results highlight that the magnitude of human immune system variation and factors influencing it can be tissue specific.", "doi": "10.1126/sciimmunol.adj7168", "pmid": "38579017", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-27T22:24:35.577Z", "modified": "2024-11-27T22:24:35.950Z"}, {"entity": "publication", "iuid": "cf1d945512544bdabec3dbb006c0755d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/cf1d945512544bdabec3dbb006c0755d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/cf1d945512544bdabec3dbb006c0755d"}}, "title": "Human resident liver myeloid cells protect against metabolic stress in obesity.", "authors": [{"family": "Barreby", "given": "Emelie", "initials": "E", "orcid": "0000-0002-6467-5280", "researcher": {"href": "https://publications.scilifelab.se/researcher/994aee7303624575a8f634359e50fa31.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Nock", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-5224-0047", "researcher": {"href": "https://publications.scilifelab.se/researcher/4121a5d5457b48e68e634cf638ee0418.json"}}, {"family": "Naudet", "given": "L\u00e9a", "initials": "L"}, {"family": "Shen", "given": "Joanne X", "initials": "JX"}, {"family": "Johansson", "given": "Helene", "initials": "H"}, {"family": "S\u00f6nnerborg", "given": "Isabella", "initials": "I"}, {"family": "Ma", "given": "Junjie", "initials": "J"}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Pallett", "given": "Laura J", "initials": "LJ", "orcid": "0000-0002-4161-9462", "researcher": {"href": "https://publications.scilifelab.se/researcher/60d13c747ab8459ab192b2c02dd12014.json"}}, {"family": "Hu", "given": "Yizhou", "initials": "Y", "orcid": "0000-0002-2635-0258", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b75010a59c243279eaf9ca7af75315b.json"}}, {"family": "Fardellas", "given": "Achilleas", "initials": "A", "orcid": "0000-0003-2797-6962", "researcher": {"href": "https://publications.scilifelab.se/researcher/c562a71c56674a978f60306446fc7cd1.json"}}, {"family": "Azzimato", "given": "Valerio", "initials": "V", "orcid": "0000-0003-4141-961X", "researcher": {"href": "https://publications.scilifelab.se/researcher/469cbad28708470f9998233f0c5fafc6.json"}}, {"family": "Vankova", "given": "Ana", "initials": "A", "orcid": "0000-0003-0955-8097", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a846c1e204b4369aa677cf2867d37b3.json"}}, {"family": "Levi", "given": "Laura", "initials": "L"}, {"family": "Morgantini", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-3142-2508", "researcher": {"href": "https://publications.scilifelab.se/researcher/297e0d58ae7a45a29d5dee1f7e057809.json"}}, {"family": "Maini", "given": "Mala K", "initials": "MK", "orcid": "0000-0001-6384-1462", "researcher": {"href": "https://publications.scilifelab.se/researcher/1fa684c9aaad4849a48510eb85ff93be.json"}}, {"family": "St\u00e5l", "given": "Per", "initials": "P"}, {"family": "Rosshart", "given": "Stephan P", "initials": "SP", "orcid": "0000-0002-6989-8686", "researcher": {"href": "https://publications.scilifelab.se/researcher/daac4d2d5dd54205bf4d07b1066fad97.json"}}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b74959951024d6ea9712b55f115652e.json"}}, {"family": "Nowak", "given": "Greg", "initials": "G", "orcid": "0000-0001-8766-8860", "researcher": {"href": "https://publications.scilifelab.se/researcher/857e73fc97484151ac37526d45c532f6.json"}}, {"family": "N\u00e4slund", "given": "Erik", "initials": "E", "orcid": "0000-0002-0166-6344", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d2603ac3ac34d75b7167ad1b93d344b.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications.scilifelab.se/researcher/29c123916fbf4948a911560c1a259496.json"}}, {"family": "Ellis", "given": "Ewa", "initials": "E", "orcid": "0000-0002-3057-5337", "researcher": {"href": "https://publications.scilifelab.se/researcher/82ef7cf7903140cfbb7ff8d6f4961dde.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Chen", "given": "Ping", "initials": "P", "orcid": "0000-0002-8068-1891", "researcher": {"href": "https://publications.scilifelab.se/researcher/5b2940a8aca44f28b88de7e3598acd53.json"}}, {"family": "Aouadi", "given": "Myriam", "initials": "M", "orcid": "0000-0001-6256-7107", "researcher": {"href": "https://publications.scilifelab.se/researcher/7ea7bb2be61a4e818685466d1005659d.json"}}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "5", "issue": "7", "pages": "1188-1203", "issn-l": "2522-5812"}, "abstract": "Although multiple populations of macrophages have been described in the human liver, their function and turnover in patients with obesity at high risk of developing non-alcoholic fatty liver disease (NAFLD) and cirrhosis are currently unknown. Herein, we identify a specific human population of resident liver myeloid cells that protects against the metabolic impairment associated with obesity. By studying the turnover of liver myeloid cells in individuals undergoing liver transplantation, we find that liver myeloid cell turnover differs between humans and mice. Using single-cell techniques and flow cytometry, we determine that the proportion of the protective resident liver myeloid cells, denoted liver myeloid cells 2 (LM2), decreases during obesity. Functional validation approaches using human 2D and 3D cultures reveal that the presence of LM2 ameliorates the oxidative stress associated with obese conditions. Our study indicates that resident myeloid cells could be a therapeutic target to decrease the oxidative stress associated with NAFLD.", "doi": "10.1038/s42255-023-00834-7", "pmid": "37414931", "labels": {"Spatial Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10365994"}, {"db": "pii", "key": "10.1038/s42255-023-00834-7"}], "notes": [], "created": "2023-11-21T15:12:13.445Z", "modified": "2023-11-21T15:12:13.896Z"}, {"entity": "publication", "iuid": "830695796d464ad989081011c4283e9e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/830695796d464ad989081011c4283e9e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/830695796d464ad989081011c4283e9e"}}, "title": "Distinct T cell subsets in adipose tissue are associated with obesity.", "authors": [{"family": "Haugst\u00f8yl", "given": "Martha E", "initials": "ME"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strand", "given": "Kristina", "initials": "K"}, {"family": "Stiglund", "given": "Natalie", "initials": "N"}, {"family": "Sun", "given": "Dan", "initials": "D", "orcid": "0000-0003-2147-9308", "researcher": {"href": "https://publications.scilifelab.se/researcher/565b38c0fdb0496fa4a687e94fd05d9e.json"}}, {"family": "Lawrence-Archer", "given": "Laurence", "initials": "L"}, {"family": "Hjellestad", "given": "Iren D", "initials": "ID"}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Busch", "given": "Christian", "initials": "C"}, {"family": "Hjelmesaeth", "given": "J\u00f8ran", "initials": "J"}, {"family": "Hertel", "given": "Jens K", "initials": "JK"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Mellgren", "given": "Gunnar", "initials": "G"}, {"family": "Fern\u00f8", "given": "Johan", "initials": "J"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Eur. J. Immunol.", "issn": "1521-4141", "volume": "53", "issue": "2", "pages": "e2249990", "issn-l": "0014-2980"}, "abstract": "Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data on human adipose tissue T cells in obesity are limited, reflected by the lack of phenotypic markers to define tissue-resident T cell subsets. In this study, we performed a deep characterization of T cells in blood and adipose tissue depots using multicolor flow cytometry and RNA sequencing. We identified distinct subsets of T cells associated with obesity expressing the activation markers, CD26 and CCR5, and obesity-specific genes that are potentially engaged in activating pro-inflammatory pathway, including ceramide signaling, autophagy, and IL-6 signaling. These findings increase our knowledge on the heterogeneity of T cells in adipose tissue and on subsets that may play a role in obesity-related pathogenesis.", "doi": "10.1002/eji.202249990", "pmid": "36433684", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10107125"}], "notes": [], "created": "2023-11-27T21:42:16.094Z", "modified": "2024-01-16T13:48:34.041Z"}, {"entity": "publication", "iuid": "5fb5fa2c98ce45d987c2ea90cb96920a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5fb5fa2c98ce45d987c2ea90cb96920a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5fb5fa2c98ce45d987c2ea90cb96920a"}}, "title": "Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.", "authors": [{"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "J\u00f6nsson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-8389-975X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb54cd37d49c401a9b32067fca10ac47.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Crona-Guterstam", "given": "Ylva", "initials": "Y", "orcid": "0000-0003-4998-4904", "researcher": {"href": "https://publications.scilifelab.se/researcher/be2bb2deeaf2411fac4aac4627016cf2.json"}}, {"family": "Kvedaraite", "given": "Egle", "initials": "E", "orcid": "0000-0001-5308-092X", "researcher": {"href": "https://publications.scilifelab.se/researcher/78502177bad3453a8d3ed96d4ad334ac.json"}}, {"family": "Sleiers", "given": "Natalie", "initials": "N", "orcid": "0000-0002-9378-8145", "researcher": {"href": "https://publications.scilifelab.se/researcher/07af0b70210044bdb8ec575101ac49c0.json"}}, {"family": "Dumitrescu", "given": "Bogdan", "initials": "B", "orcid": "0000-0002-9986-3396", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0d9af82119645cd83cbc1aaffe1a967.json"}}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M", "orcid": "0000-0002-6081-9101", "researcher": {"href": "https://publications.scilifelab.se/researcher/3349b0acffde45d3807643f8d6a61e06.json"}}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications.scilifelab.se/researcher/e282901d24c64b16a540eff0d57776f4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb82c502293d424cb266e1c4e405485f.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications.scilifelab.se/researcher/aad5c88284e54bd0af1e3ce4004dd24c.json"}}, {"family": "Willinger", "given": "Tim", "initials": "T"}, {"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Hamilton", "given": "Russell S", "initials": "RS", "orcid": "0000-0002-0598-3793", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f0bb3c84fa244afbf1372666d603479.json"}}, {"family": "Ivarsson", "given": "Martin A", "initials": "MA"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": null, "volume": "6", "issue": "56", "pages": "eabb7800"}, "abstract": "Immune cell differentiation is critical for adequate tissue-specific immune responses to occur. Here, we studied differentiation of human uterine natural killer cells (uNK cells). These cells reside in a tissue undergoing constant regeneration and represent the major leukocyte population at the maternal-fetal interface. However, their physiological response during the menstrual cycle and in pregnancy remains elusive. By surface proteome and transcriptome analysis as well as using humanized mice, we identify a differentiation pathway of uNK cells in vitro and in vivo with sequential acquisition of killer cell immunoglobulin-like receptors and CD39. uNK cell differentiation occurred continuously in response to the endometrial regeneration and was driven by interleukin-15. Differentiated uNK cells displayed reduced proliferative capacity and immunomodulatory function including enhanced angiogenic capacity. By studying human uterus transplantation and monozygotic twins, we found that the uNK cell niche could be replenished from circulation and that it was under genetic control. Together, our study uncovers a continuous differentiation pathway of human NK cells in the uterus that is coupled to profound functional changes in response to local tissue regeneration and pregnancy.", "doi": "10.1126/sciimmunol.abb7800", "pmid": "33617461", "labels": {"Cellular Immunomonitoring": "Service"}, "xrefs": [{"db": "pii", "key": "6/56/eabb7800"}], "notes": [], "created": "2021-02-23T20:18:56.191Z", "modified": "2021-12-09T08:31:54.136Z"}, {"entity": "publication", "iuid": "6aff0432d2a54d15ac7fdb6ffc28707d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6aff0432d2a54d15ac7fdb6ffc28707d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6aff0432d2a54d15ac7fdb6ffc28707d"}}, "title": "Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.", "authors": [{"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b64addfb67f4e8b898bbb1ced5f5e77.json"}}, {"family": "Sinha", "given": "Indranil", "initials": "I", "orcid": "0000-0002-2513-5927", "researcher": {"href": "https://publications.scilifelab.se/researcher/970cda1bb71d4ae1b36cc5628023f7d4.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Hed Myrberg", "given": "Ida", "initials": "I"}, {"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications.scilifelab.se/researcher/64d9a0bc6b5d4039af5bc308a97eaad6.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Chen", "given": "Puran", "initials": "P", "orcid": "0000-0002-2890-0022", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b2580e94a2145d58db680762eec30bf.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications.scilifelab.se/researcher/3f7958a9ee7748cf8806253a7aeef673.json"}}, {"family": "Brighenti", "given": "Susanna", "initials": "S"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A", "orcid": "0000-0001-9372-1795", "researcher": {"href": "https://publications.scilifelab.se/researcher/25c11b43fc984bbca28fcc5bbf211d58.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications.scilifelab.se/researcher/d8a125a916b34de985de977dd8384650.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications.scilifelab.se/researcher/a6ffa1185f4142b7ab7c372c0c139df6.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "H"}, {"family": "Ginhoux", "given": "Florent", "initials": "F"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Henter", "given": "Jan-Inge", "initials": "J"}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e3185cf86534a96983b39dd93df454a.json"}}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": "", "orcid": "0000-0003-2685-2052", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb6d04afbe8141c2b9297854de64dab8.json"}}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "issn-l": "0027-8424", "volume": "118", "issue": "6", "pages": "e2018587118"}, "abstract": "Dendritic cells (DCs) and monocytes are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these cells may contribute to immunopathology. Here, we performed high-dimensional flow cytometry-analysis focusing on mononuclear phagocyte (MNP) lineages in SARS-CoV-2-infected patients with moderate and severe COVID-19. We provide a deep and comprehensive map of the MNP landscape in COVID-19. A redistribution of monocyte subsets toward intermediate monocytes and a general decrease in circulating DCs was observed in response to infection. Severe disease coincided with the appearance of monocytic myeloid-derived suppressor cell-like cells and a higher frequency of pre-DC2. Furthermore, phenotypic alterations in MNPs, and their late precursors, were cell-lineage-specific and associated either with the general response against SARS-CoV-2 or COVID-19 severity. This included an interferon-imprint in DC1s observed in all patients and a decreased expression of the coinhibitory molecule CD200R in pre-DCs, DC2s, and DC3 subsets of severely sick patients. Finally, unsupervised analysis revealed that the MNP profile, alone, pointed to a cluster of COVID-19 nonsurvivors. This study provides a reference for the MNP response to SARS-CoV-2 infection and unravels mononuclear phagocyte dysregulations associated with severe COVID-19.", "doi": "10.1073/pnas.2018587118", "pmid": "33479167", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "2018587118"}, {"db": "pmc", "key": "PMC8017719"}], "notes": [], "created": "2021-10-06T10:58:11.905Z", "modified": "2021-12-09T13:41:42.272Z"}, {"entity": "publication", "iuid": "6e2a1fc431c64a6086d711f8beca0048", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6e2a1fc431c64a6086d711f8beca0048.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6e2a1fc431c64a6086d711f8beca0048"}}, "title": "MAIT cell activation and dynamics associated with COVID-19 disease severity.", "authors": [{"family": "Parrot", "given": "Tiphaine", "initials": "T", "orcid": "0000-0001-9625-6825", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ae2982949a644f59bcfc88d0e3bf9c4.json"}}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB", "orcid": "0000-0003-4605-1375", "researcher": {"href": "https://publications.scilifelab.se/researcher/a623ffbc0a19427aabd47ad6f047e49d.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications.scilifelab.se/researcher/b691252c7d7446788d0a10f0648ef47f.json"}}, {"family": "Kammann", "given": "Tobias", "initials": "T", "orcid": "0000-0002-8433-036X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ead9a21a35e34fd092774ae13a211255.json"}}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0002-5998-5700", "researcher": {"href": "https://publications.scilifelab.se/researcher/fbfe371f142840bc9470b37777ac1f2f.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications.scilifelab.se/researcher/42434c4f0f504dcd82e5830a727d5a04.json"}}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O", "orcid": "0000-0001-6949-4270", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b48f38b946d4fbc9d687da130f2e661.json"}}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications.scilifelab.se/researcher/3f7958a9ee7748cf8806253a7aeef673.json"}}, {"family": "Rooyackers", "given": "Olav", "initials": "O", "orcid": "0000-0002-3391-5448", "researcher": {"href": "https://publications.scilifelab.se/researcher/52f4fd2e5e204e598aa5087ff3f13680.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E", "orcid": "0000-0002-6585-6235", "researcher": {"href": "https://publications.scilifelab.se/researcher/82777b8f48324c58bcad72799d71fd4a.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A", "orcid": "0000-0001-9372-1795", "researcher": {"href": "https://publications.scilifelab.se/researcher/25c11b43fc984bbca28fcc5bbf211d58.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications.scilifelab.se/researcher/a6ffa1185f4142b7ab7c372c0c139df6.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/7468c415a46645a3a4c3d28badcff954.json"}}], "type": "journal article", "published": "2020-09-28", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "5", "issue": "51", "issn-l": null}, "abstract": "Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.", "doi": "10.1126/sciimmunol.abe1670", "pmid": "32989174", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "5/51/eabe1670"}, {"db": "pmc", "key": "PMC7857393"}], "notes": [], "created": "2020-12-10T16:30:01.335Z", "modified": "2021-11-10T12:47:01.812Z"}, {"entity": "publication", "iuid": "8b20bf8ea1c64b27b9926d89b98d064b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8b20bf8ea1c64b27b9926d89b98d064b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8b20bf8ea1c64b27b9926d89b98d064b"}}, "title": "Natural killer cell immunotypes related to COVID-19 disease severity.", "authors": [{"family": "Maucourant", "given": "Christopher", "initials": "C", "orcid": "0000-0003-1033-2992", "researcher": {"href": "https://publications.scilifelab.se/researcher/8221b644c8a841fca76d35e19b7e61e8.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications.scilifelab.se/researcher/aad5c88284e54bd0af1e3ce4004dd24c.json"}}, {"family": "Hertwig", "given": "Laura", "initials": "L", "orcid": "0000-0002-1170-0948", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b64addfb67f4e8b898bbb1ced5f5e77.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications.scilifelab.se/researcher/e282901d24c64b16a540eff0d57776f4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e879a6ef8ff45bea049986707480e99.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4a3a0f566a342db89c54b87a50d5e5b.json"}}, {"family": "Hull", "given": "Ryan M", "initials": "RM", "orcid": "0000-0001-7153-4198", "researcher": {"href": "https://publications.scilifelab.se/researcher/26f05788ac904e9597ca68f3b3fb5486.json"}}, {"family": "Haroun-Izquierdo", "given": "Alvaro", "initials": "A", "orcid": "0000-0003-4557-3606", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca1f59e2b148496ba53a05d1ee4eb8b2.json"}}, {"family": "Schaffer", "given": "Marie", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E", "orcid": "0000-0002-6585-6235", "researcher": {"href": "https://publications.scilifelab.se/researcher/82777b8f48324c58bcad72799d71fd4a.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/7468c415a46645a3a4c3d28badcff954.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Rooyackers", "given": "Olav", "initials": "O", "orcid": "0000-0002-3391-5448", "researcher": {"href": "https://publications.scilifelab.se/researcher/52f4fd2e5e204e598aa5087ff3f13680.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications.scilifelab.se/researcher/b87ccad53d354bdd80af490dc8a0c019.json"}}, {"family": "Hammer", "given": "Quirin", "initials": "Q", "orcid": "0000-0003-2968-6061", "researcher": {"href": "https://publications.scilifelab.se/researcher/3b6b2e5256c8401f83c3f89b5c5bb92f.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications.scilifelab.se/researcher/a6ffa1185f4142b7ab7c372c0c139df6.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}], "type": "journal article", "published": "2020-08-21", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "5", "issue": "50", "pages": "eabd6832", "issn-l": null}, "abstract": "Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets in peripheral blood of COVID-19 patients. This pattern was mirrored in scRNA-seq signatures of NK cells in bronchoalveolar lavage from COVID-19 patients. Unsupervised high-dimensional analysis of peripheral blood NK cells furthermore identified distinct NK cell immunotypes that were linked to disease severity. Hallmarks of these immunotypes were high expression of perforin, NKG2C, and Ksp37, reflecting increased presence of adaptive NK cells in circulation of patients with severe disease. Finally, arming of CD56bright NK cells was observed across COVID-19 disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors. This study provides a detailed map of the NK cell activation landscape in COVID-19 disease.", "doi": "10.1126/sciimmunol.abd6832", "pmid": "32826343", "labels": {"Affinity Proteomics Stockholm": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "5/50/eabd6832"}, {"db": "pmc", "key": "PMC7665314"}], "notes": [], "created": "2020-12-10T16:30:00.149Z", "modified": "2024-01-16T13:48:41.915Z"}]}