{"entity": "researcher", "timestamp": "2026-07-11T23:42:11.886Z", "family": "Lantero Rodriguez", "given": "Marta", "initials": "M", "orcid": "0000-0002-9912-6716", "affiliations": ["Wallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/bee7c52fd83149fbbb01ced1cf5fa79d.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/bee7c52fd83149fbbb01ced1cf5fa79d"}}, "publications": [{"entity": "publication", "iuid": "85067a3ac4764a808733b9d4d4adc266", "links": {"self": {"href": "https://publications.scilifelab.se/publication/85067a3ac4764a808733b9d4d4adc266.json"}, "display": {"href": "https://publications.scilifelab.se/publication/85067a3ac4764a808733b9d4d4adc266"}}, "title": "Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow.", "authors": [{"family": "Svedlund Eriksson", "given": "Elin", "initials": "E", "orcid": "0009-0006-0169-6929", "researcher": {"href": "https://publications.scilifelab.se/researcher/afb8b198881944a28e575e8ca8a2cc1d.json"}}, {"family": "Lantero Rodriguez", "given": "Marta", "initials": "M", "orcid": "0000-0002-9912-6716", "researcher": {"href": "https://publications.scilifelab.se/researcher/bee7c52fd83149fbbb01ced1cf5fa79d.json"}}, {"family": "Halvorsen", "given": "Bente", "initials": "B", "orcid": "0000-0002-6529-6485", "researcher": {"href": "https://publications.scilifelab.se/researcher/83218278a90c41609ea44fcd6315d395.json"}}, {"family": "Johansson", "given": "Inger", "initials": "I", "orcid": "0009-0008-3579-9031", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbc07dcc5a824676a0f788ebe060ca02.json"}}, {"family": "M\u00e5rtensson", "given": "Anna K F", "initials": "AKF", "orcid": "0000-0002-8786-4965", "researcher": {"href": "https://publications.scilifelab.se/researcher/13ca4b04916d4318b8e00f1f5f4ca6d3.json"}}, {"family": "Wilhelmson", "given": "Anna S", "initials": "AS", "orcid": "0000-0003-0640-0251", "researcher": {"href": "https://publications.scilifelab.se/researcher/73ed1ad8dfa2406081cef9eb005b3ad6.json"}}, {"family": "Huse", "given": "Camilla", "initials": "C", "orcid": "0000-0002-7694-5196", "researcher": {"href": "https://publications.scilifelab.se/researcher/1025010995224e44bae6f9c15813de38.json"}}, {"family": "Ueland", "given": "Thor", "initials": "T"}, {"family": "Aukrust", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0003-0919-836X", "researcher": {"href": "https://publications.scilifelab.se/researcher/b52ec6832f0742b4be1f6dd2e455a1ed.json"}}, {"family": "Broch", "given": "Kaspar", "initials": "K", "orcid": "0000-0003-4316-805X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c4d9562e7294f849d3ff4508d353bf9.json"}}, {"family": "Gullestad", "given": "Lars", "initials": "L"}, {"family": "Amundsen", "given": "Brage H\u00f8yem", "initials": "BH", "orcid": "0000-0001-7914-7395", "researcher": {"href": "https://publications.scilifelab.se/researcher/b7ee62e8f93047258965bcf42bb4a475.json"}}, {"family": "Andersen", "given": "Geir \u00d8ystein", "initials": "G\u00d8", "orcid": "0000-0003-1578-6440", "researcher": {"href": "https://publications.scilifelab.se/researcher/a498990cfa894f74bd3a273a1bbaee58.json"}}, {"family": "Karlsson", "given": "Mikael C I", "initials": "MCI", "orcid": "0000-0001-5582-614X", "researcher": {"href": "https://publications.scilifelab.se/researcher/9b7a0612c55f4ab8865b6e5f59347271.json"}}, {"family": "Hagberg Thulin", "given": "Malin", "initials": "M", "orcid": "0000-0002-8673-1247", "researcher": {"href": "https://publications.scilifelab.se/researcher/fbf6e0d2d6f748e39f32a70e1e4d597f.json"}}, {"family": "Camponeschi", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-6472-2438", "researcher": {"href": "https://publications.scilifelab.se/researcher/ccbaffafd6a24f4abed1e402219fa472.json"}}, {"family": "Trompet", "given": "Dana", "initials": "D", "orcid": "0000-0001-9472-6184", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ef4d02ec2e1427088522df2a759bf3a.json"}}, {"family": "Hammarsten", "given": "Ola", "initials": "O"}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Omerovic", "given": "Elmir", "initials": "E"}, {"family": "Levin", "given": "Malin C", "initials": "MC"}, {"family": "Chagin", "given": "Andrei S", "initials": "AS", "orcid": "0000-0002-2696-5850", "researcher": {"href": "https://publications.scilifelab.se/researcher/909bca2fc68645e980a93b99dc150e4c.json"}}, {"family": "Dahl", "given": "Tuva B", "initials": "TB", "orcid": "0000-0001-7818-9411", "researcher": {"href": "https://publications.scilifelab.se/researcher/ff93848d0aac4a9fbf8ec2bbedebadea.json"}}, {"family": "Tivesten", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-8318-0486", "researcher": {"href": "https://publications.scilifelab.se/researcher/55ade4099dfd4859970a6fe21af50870.json"}}], "type": "journal article", "published": "2025-02-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "1142", "issn-l": "2041-1723"}, "abstract": "Men develop larger infarct sizes than women after a myocardial infarction (MI), but the mechanism underlying this sex difference is unknown. Here, we demonstrated that blood neutrophil counts post-MI were higher in male than female mice. Castration-induced testosterone deficiency reduced blood neutrophil counts to the level in females and increased survival post-MI. These effects were mimicked by Osterix-directed ablation of the androgen receptor in bone marrow (BM). Mechanistically, androgens downregulated the leukocyte retention factor CXCL12 in BM stromal cells. Post-hoc analysis of clinical trial data showed that neutrophilia was greater in men than women after reperfusion of first-time ST-elevation MI, and tocilizumab, an interleukin-6 receptor inhibitor, reduced blood neutrophil counts and infarct size to a greater extent in men than women. Our work reveals a previously unknown mechanism connecting testosterone with neutrophilia and MI injury via BM and identifies the importance of considering sex when developing anti-inflammatory strategies to treat MI.", "doi": "10.1038/s41467-025-56217-x", "pmid": "39910039", "labels": {"Clinical Genomics": "Service", "Clinical Genomics Gothenburg": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11799197"}, {"db": "pii", "key": "10.1038/s41467-025-56217-x"}], "notes": [], "created": "2025-07-08T13:56:49.778Z", "modified": "2025-11-04T11:38:37.313Z"}]}