{"entity": "researcher", "timestamp": "2026-08-15T07:18:35.287Z", "family": "Tan", "given": "Zeli", "initials": "Z", "orcid": "0000-0001-5958-2584", "affiliations": ["Pacific Northwest National Laboratory, Washington, USA."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/bd87015d70fb4f71a9c5c40a22b84d4e.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/bd87015d70fb4f71a9c5c40a22b84d4e"}}, "publications": [{"entity": "publication", "iuid": "53004388459e465ab3c59b47d352f040", "links": {"self": {"href": "https://publications.scilifelab.se/publication/53004388459e465ab3c59b47d352f040.json"}, "display": {"href": "https://publications.scilifelab.se/publication/53004388459e465ab3c59b47d352f040"}}, "title": "Systems-level immunomonitoring in children with solid tumors to enable precision medicine.", "authors": [{"family": "Chen", "given": "Qi", "initials": "Q", "orcid": "0000-0002-5864-7574", "researcher": {"href": "https://publications.scilifelab.se/researcher/84dde05e01624f07a374810c1086f20a.json"}}, {"family": "Zhao", "given": "Binbin", "initials": "B", "orcid": "0000-0002-5560-6750", "researcher": {"href": "https://publications.scilifelab.se/researcher/22329dc812fc4684acce02c18ae6fa18.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z", "orcid": "0000-0001-5958-2584", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd87015d70fb4f71a9c5c40a22b84d4e.json"}}, {"family": "Hedberg", "given": "Gustav", "initials": "G"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Gonzalez", "given": "Laura", "initials": "L"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Johnsson", "given": "Anette", "initials": "A"}, {"family": "Negrini", "given": "Erika", "initials": "E"}, {"family": "P\u00e1ez", "given": "Laura Pi\u00f1ero", "initials": "LP"}, {"family": "Rodriguez", "given": "Lucie", "initials": "L", "orcid": "0000-0002-3692-9060", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f9c2cfec48e4c4d8e9bc528a02d489b.json"}}, {"family": "James", "given": "Anna", "initials": "A"}, {"family": "Chen", "given": "Yang", "initials": "Y"}, {"family": "Mike\u0161", "given": "Jarom\u00edr", "initials": "J", "orcid": "0000-0002-9941-7855", "researcher": {"href": "https://publications.scilifelab.se/researcher/21c127bffa7c4a01af7fad8ba6bac90b.json"}}, {"family": "Bernhardsson", "given": "Anna Karin", "initials": "AK"}, {"family": "Reitzner", "given": "Stefan Markus", "initials": "SM", "orcid": "0000-0003-0151-2780", "researcher": {"href": "https://publications.scilifelab.se/researcher/a3ca59c30b2e45459eb3638c65b452b3.json"}}, {"family": "von Walden", "given": "Ferdinand", "initials": "F"}, {"family": "O'Neill", "given": "Olivia", "initials": "O"}, {"family": "Barcenilla", "given": "Hugo", "initials": "H", "orcid": "0000-0002-7255-362X", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0f0d6085e774a0fbdc1ad8d6eea3c23.json"}}, {"family": "Wang", "given": "Chunlin", "initials": "C"}, {"family": "Davis", "given": "Mark M", "initials": "MM"}, {"family": "Carlson", "given": "Lena-Maria", "initials": "LM"}, {"family": "Pal", "given": "Niklas", "initials": "N"}, {"family": "Blomgren", "given": "Klas", "initials": "K", "orcid": "0000-0002-0476-7271", "researcher": {"href": "https://publications.scilifelab.se/researcher/2fb3b554177d481ebc9d4aa0f3b1fbc4.json"}}, {"family": "Repsilber", "given": "Dirk", "initials": "D", "orcid": "0000-0002-7173-5579", "researcher": {"href": "https://publications.scilifelab.se/researcher/86ad21e955ed4524b24822ba4c0de43e.json"}}, {"family": "Herold", "given": "Nikolas", "initials": "N", "orcid": "0000-0001-9468-4543", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a2af6f17f76457680908c36693f2de5.json"}}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications.scilifelab.se/researcher/92e81aa6b0cf4ff0a18b14098bf0fcc1.json"}}, {"family": "Kogner", "given": "Per", "initials": "P", "orcid": "0000-0002-2202-9694", "researcher": {"href": "https://publications.scilifelab.se/researcher/e963274b921a4a2c8263f509334d4e22.json"}}, {"family": "Ljungblad", "given": "Linda", "initials": "L"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}], "type": "journal article", "published": "2025-03-06", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "188", "issue": "5", "pages": "1425-1440.e11", "issn-l": "0092-8674"}, "abstract": "Cancer is the leading cause of death from disease in children. Survival depends not only on surgery, cytostatic drugs, and radiation but also on systemic immune responses. Factors influencing these immune responses in children of different ages and tumor types are unknown. Novel immunotherapies can enhance anti-tumor immune responses, but few children have benefited, and markers of effective responses are lacking. Here, we present a systems-level analysis of immune responses in 191 children within a population-based cohort with diverse tumors and reveal that age and tumor type shape immune responses differently. Systemic inflammation and cytotoxic T cell responses correlate with tumor mutation rates and immune cell infiltration. Clonally expanded T cell responses are rarely detected in blood or tumors at diagnosis but are sometimes elicited during treatment. Expanded T cells are similarly regulated in children and adults with more immunogenic cancers. This research aims to facilitate the development of precision immunotherapies for children with cancer.", "doi": "10.1016/j.cell.2024.12.014", "pmid": "39837329", "labels": {"NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "NGI Short read": "Service", "Affinity Proteomics Stockholm": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0092-8674(24)01427-2"}], "notes": [], "created": "2025-01-30T10:50:10.864Z", "modified": "2025-11-28T10:42:05.786Z"}, {"entity": "publication", "iuid": "57298ccceabf42caaff99aaa28def71d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/57298ccceabf42caaff99aaa28def71d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/57298ccceabf42caaff99aaa28def71d"}}, "title": "Phenological shifts in lake stratification under climate change.", "authors": [{"family": "Woolway", "given": "R Iestyn", "initials": "RI", "orcid": "0000-0003-0498-7968", "researcher": {"href": "https://publications.scilifelab.se/researcher/17c3db86f7b145769cf04f5c485eecb1.json"}}, {"family": "Sharma", "given": "Sapna", "initials": "S", "orcid": "0000-0003-4571-2768", "researcher": {"href": "https://publications.scilifelab.se/researcher/7209e01cface421b9fea8ee9b3022454.json"}}, {"family": "Weyhenmeyer", "given": "Gesa A", "initials": "GA", "orcid": "0000-0002-4013-2281", "researcher": {"href": "https://publications.scilifelab.se/researcher/77867fdf5d184f93b2df8e8b7620e9f3.json"}}, {"family": "Debolskiy", "given": "Andrey", "initials": "A"}, {"family": "Golub", "given": "Malgorzata", "initials": "M"}, {"family": "Mercado-Bett\u00edn", "given": "Daniel", "initials": "D", "orcid": "0000-0003-4572-3029", "researcher": {"href": "https://publications.scilifelab.se/researcher/92bafd44336d4620bfc5beb192c3244b.json"}}, {"family": "Perroud", "given": "Marjorie", "initials": "M"}, {"family": "Stepanenko", "given": "Victor", "initials": "V"}, {"family": "Tan", "given": "Zeli", "initials": "Z", "orcid": "0000-0001-5958-2584", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd87015d70fb4f71a9c5c40a22b84d4e.json"}}, {"family": "Grant", "given": "Luke", "initials": "L"}, {"family": "Ladwig", "given": "Robert", "initials": "R", "orcid": "0000-0001-8443-1999", "researcher": {"href": "https://publications.scilifelab.se/researcher/d3f54a6733df4b8d860d559067fbd534.json"}}, {"family": "Mesman", "given": "Jorrit", "initials": "J", "orcid": "0000-0002-4319-260X", "researcher": {"href": "https://publications.scilifelab.se/researcher/d1cac2fbbeb74007b1393b21bb6e5722.json"}}, {"family": "Moore", "given": "Tadhg N", "initials": "TN", "orcid": "0000-0002-3834-8868", "researcher": {"href": "https://publications.scilifelab.se/researcher/37ed154cb4e04b74820d2028e0ce09bb.json"}}, {"family": "Shatwell", "given": "Tom", "initials": "T", "orcid": "0000-0002-4520-7916", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ec771efaebd4d0ea12675bf7d59aa91.json"}}, {"family": "Vanderkelen", "given": "Inne", "initials": "I", "orcid": "0000-0002-8673-1933", "researcher": {"href": "https://publications.scilifelab.se/researcher/6d8b0ee04bdd43ee91c1ed564215dc5e.json"}}, {"family": "Austin", "given": "Jay A", "initials": "JA", "orcid": "0000-0002-3580-1794", "researcher": {"href": "https://publications.scilifelab.se/researcher/aee3634fdbff47a09f08d730cdba5557.json"}}, {"family": "DeGasperi", "given": "Curtis L", "initials": "CL", "orcid": "0000-0002-2520-7046", "researcher": {"href": "https://publications.scilifelab.se/researcher/a757e7e5b3af43d9ab917b505c201a1c.json"}}, {"family": "Dokulil", "given": "Martin", "initials": "M"}, {"family": "La Fuente", "given": "Sofia", "initials": "S", "orcid": "0000-0002-9665-672X", "researcher": {"href": "https://publications.scilifelab.se/researcher/44ff463a12e94ff88b5e5608452a012d.json"}}, {"family": "Mackay", "given": "Eleanor B", "initials": "EB"}, {"family": "Schladow", "given": "S Geoffrey", "initials": "SG"}, {"family": "Watanabe", "given": "Shohei", "initials": "S"}, {"family": "Marc\u00e9", "given": "Rafael", "initials": "R", "orcid": "0000-0002-7416-4652", "researcher": {"href": "https://publications.scilifelab.se/researcher/25a4cebca664467c87a69ead73741cf4.json"}}, {"family": "Pierson", "given": "Don C", "initials": "DC", "orcid": "0000-0001-6230-0146", "researcher": {"href": "https://publications.scilifelab.se/researcher/416bb47c326d446e9ee434dc252d0240.json"}}, {"family": "Thiery", "given": "Wim", "initials": "W", "orcid": "0000-0002-5183-6145", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0e6d334c3844b2a97855edb7161fa0c.json"}}, {"family": "Jennings", "given": "Eleanor", "initials": "E", "orcid": "0000-0002-9344-2056", "researcher": {"href": "https://publications.scilifelab.se/researcher/53462dc861db4486bc465126071dab1f.json"}}], "type": "journal article", "published": "2021-04-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "2318", "issn-l": "2041-1723"}, "abstract": "One of the most important physical characteristics driving lifecycle events in lakes is stratification. Already subtle variations in the timing of stratification onset and break-up (phenology) are known to have major ecological effects, mainly by determining the availability of light, nutrients, carbon and oxygen to organisms. Despite its ecological importance, historic and future global changes in stratification phenology are unknown. Here, we used a lake-climate model ensemble and long-term observational data, to investigate changes in lake stratification phenology across the Northern Hemisphere from 1901 to 2099. Under the high-greenhouse-gas-emission scenario, stratification will begin 22.0 \u00b1 7.0 days earlier and end 11.3 \u00b1 4.7 days later by the end of this century. It is very likely that this 33.3 \u00b1 11.7 day prolongation in stratification will accelerate lake deoxygenation with subsequent effects on nutrient mineralization and phosphorus release from lake sediments. Further misalignment of lifecycle events, with possible irreversible changes for lake ecosystems, is also likely.", "doi": "10.1038/s41467-021-22657-4", "pmid": "33875656", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-22657-4"}, {"db": "pmc", "key": "PMC8055693"}], "notes": [], "created": "2022-11-09T15:58:17.424Z", "modified": "2024-01-16T13:48:40.058Z"}]}