{"entity": "researcher", "timestamp": "2026-06-15T17:51:56.794Z", "family": "Hagstr\u00f6m-Andersson", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-2904-1311", "affiliations": ["Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. Anna.Hagstrom@med.lu.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89"}}, "publications": [{"entity": "publication", "iuid": "6d6faf7279134df68f3e4160a4981f61", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6d6faf7279134df68f3e4160a4981f61.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6d6faf7279134df68f3e4160a4981f61"}}, "title": "The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia.", "authors": [{"family": "Ahlgren", "given": "Louise", "initials": "L"}, {"family": "Pilheden", "given": "Mattias", "initials": "M"}, {"family": "Sturesson", "given": "Helena", "initials": "H"}, {"family": "Song", "given": "Guangchun", "initials": "G", "orcid": "0000-0002-0190-8315", "researcher": {"href": "https://publications.scilifelab.se/researcher/f133bb6165494dfaba8173b0e8191765.json"}}, {"family": "Walsh", "given": "Michael P", "initials": "MP"}, {"family": "Yang", "given": "Minjun", "initials": "M", "orcid": "0000-0002-3324-1498", "researcher": {"href": "https://publications.scilifelab.se/researcher/62822d0b9c6c4a01a53829b9b05443ba.json"}}, {"family": "Maillard", "given": "Maud", "initials": "M"}, {"family": "Zhao", "given": "Huanbin", "initials": "H", "orcid": "0009-0001-4418-6770", "researcher": {"href": "https://publications.scilifelab.se/researcher/02a78b74f32d4670b628a8e3fb78ea0a.json"}}, {"family": "Cheng", "given": "Zhongshan", "initials": "Z"}, {"family": "Singh", "given": "Varsha", "initials": "V"}, {"family": "Castor", "given": "Anders", "initials": "A", "orcid": "0009-0007-4634-0704", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed2d2dab933049f5b69cdf0ff1e1d8a1.json"}}, {"family": "Pronk", "given": "Cornelis Jan", "initials": "CJ", "orcid": "0000-0002-0073-9660", "researcher": {"href": "https://publications.scilifelab.se/researcher/76e42ba48d824aa0b42e871e9f11b00a.json"}}, {"family": "Marquart", "given": "Hanne Vibeke", "initials": "HV", "orcid": "0000-0001-9740-6522", "researcher": {"href": "https://publications.scilifelab.se/researcher/c9476b7116154ea9990d7c61c675c794.json"}}, {"family": "Lausen", "given": "Birgitte", "initials": "B", "orcid": "0000-0002-5306-0774", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc5eadc48e354c4cb70d68d420bfa6fe.json"}}, {"family": "Schneider", "given": "Pauline", "initials": "P", "orcid": "0000-0003-0162-9436", "researcher": {"href": "https://publications.scilifelab.se/researcher/39a9fea74e284217b80716966bca995b.json"}}, {"family": "Barbany", "given": "Gisela", "initials": "G", "orcid": "0000-0003-3185-2962", "researcher": {"href": "https://publications.scilifelab.se/researcher/13fda0d702d543f981898ebd53849817.json"}}, {"family": "Pokrovskaja Tamm", "given": "Katja", "initials": "K", "orcid": "0000-0001-6359-1256", "researcher": {"href": "https://publications.scilifelab.se/researcher/09ec3ee706764024bd748c7a77443845.json"}}, {"family": "Abrahamsson", "given": "Jonas", "initials": "J", "orcid": "0000-0002-9240-3522", "researcher": {"href": "https://publications.scilifelab.se/researcher/0f3199957bd147ec91bbdc04413f1dba.json"}}, {"family": "Lohi", "given": "Olli", "initials": "O", "orcid": "0000-0001-9195-0797", "researcher": {"href": "https://publications.scilifelab.se/researcher/e11a59310dfc40e6a111367914fdba9e.json"}}, {"family": "Fogelstrand", "given": "Linda", "initials": "L", "orcid": "0000-0003-3698-8519", "researcher": {"href": "https://publications.scilifelab.se/researcher/f39ff709aa0646b8ad5e520780a0ad49.json"}}, {"family": "Menendez", "given": "Pablo", "initials": "P"}, {"family": "Pieters", "given": "Rob", "initials": "R", "orcid": "0000-0003-2997-3570", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb567d1e17e0428c843c07682decb31c.json"}}, {"family": "Zhang", "given": "Jinghui", "initials": "J", "orcid": "0000-0003-3350-9682", "researcher": {"href": "https://publications.scilifelab.se/researcher/38fe8464634149a39bc8accf6077bac4.json"}}, {"family": "Lindkvist-Petersson", "given": "Karin", "initials": "K", "orcid": "0000-0002-5209-3160", "researcher": {"href": "https://publications.scilifelab.se/researcher/efe1ac8c58f640ba98b97c6a5e52b9d5.json"}}, {"family": "Yang", "given": "Jun J", "initials": "JJ", "orcid": "0000-0002-0770-9659", "researcher": {"href": "https://publications.scilifelab.se/researcher/023457113ddc4e3a8309d0b4936c097e.json"}}, {"family": "Gruber", "given": "Tanja A", "initials": "TA", "orcid": "0000-0003-1072-7257", "researcher": {"href": "https://publications.scilifelab.se/researcher/c16c5b66f56f40fd93a9f398b0487a64.json"}}, {"family": "Stam", "given": "Ronald W", "initials": "RW", "orcid": "0000-0003-4986-1656", "researcher": {"href": "https://publications.scilifelab.se/researcher/f528aaa6b3ba479f85619e1496e3f395.json"}}, {"family": "Ma", "given": "Jing", "initials": "J"}, {"family": "Hagstr\u00f6m-Andersson", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-2904-1311", "researcher": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89.json"}}], "type": "journal article", "published": "2025-10-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8964", "issn-l": "2041-1723"}, "abstract": "To study the mechanisms of relapse in KMT2A-rearranged (KMT2A-r) acute lymphoblastic (ALL) and acute myeloid leukemia (AML), we performed whole-genome and exome sequencing of infants and children with relapsed ALL/AML (n = 36), and longitudinal deep-sequencing of 257 samples in 30 patients. Somatic alterations in drug-response genes, most commonly in TP53 and IKZF1 (64%), were highly enriched in early relapse ALL (79%, 9-36 months after diagnosis), but rare in very early relapse ALL (<9 months, 9%). A marked chemotherapy-exposure signature was detected for mutations in early relapse ALL but not in very early ALL or AML relapse, in line with different mechanisms of relapse. Longitudinal analyses could track residual leukemia cells, clonal drug responses, and the upcoming relapse. These results highlight that KMT2A-r ALL and AML evade therapy differently and provide insights into the mechanisms of relapse in this highly lethal form of pediatric acute leukemia.", "doi": "10.1038/s41467-025-64190-8", "pmid": "41062506", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service", "National Genomics Infrastructure": "Service", "NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12508131"}, {"db": "pii", "key": "10.1038/s41467-025-64190-8"}], "notes": [], "created": "2025-10-28T09:43:15.594Z", "modified": "2025-11-07T07:22:38.375Z"}, {"entity": "publication", "iuid": "0d182c82543e4dbaa9df359980262f0b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0d182c82543e4dbaa9df359980262f0b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0d182c82543e4dbaa9df359980262f0b"}}, "title": "The 3D genome of pediatric B-cell precursor acute lymphoblastic leukemia", "authors": [{"family": "Moura-Castro", "given": "Larissa H", "initials": "LH", "orcid": "0000-0001-9063-5592", "researcher": {"href": "https://publications.scilifelab.se/researcher/d326f608c7744622a92cc73768f23afb.json"}}, {"family": "Ayd\u0131n", "given": "Efe", "initials": "E"}, {"family": "Telliam Dushime", "given": "Gladys", "initials": "G"}, {"family": "Woodward", "given": "Eleanor L", "initials": "EL"}, {"family": "Castor", "given": "Anders", "initials": "A", "orcid": "0009-0007-4634-0704", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed2d2dab933049f5b69cdf0ff1e1d8a1.json"}}, {"family": "Gunnarsson", "given": "Rebeqa", "initials": "R", "orcid": "0000-0002-2283-786X", "researcher": {"href": "https://publications.scilifelab.se/researcher/12601745d2c74562bf83d22879f212eb.json"}}, {"family": "Lilljebj\u00f6rn", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8703-1173", "researcher": {"href": "https://publications.scilifelab.se/researcher/b3a75300e8c346858ce8dd8f64ecae85.json"}}, {"family": "Olsson-Arvidsson", "given": "Linda", "initials": "L"}, {"family": "Fioretos", "given": "Thoas", "initials": "T", "orcid": "0000-0002-3235-6154", "researcher": {"href": "https://publications.scilifelab.se/researcher/35a5c1b6023345c6b1317c590bf80680.json"}}, {"family": "Johansson", "given": "Bertil", "initials": "B", "orcid": "0000-0001-8829-4813", "researcher": {"href": "https://publications.scilifelab.se/researcher/fed657adae7f49f2b8d052cff36eac07.json"}}, {"family": "J\u00e4r\u00e5s", "given": "Marcus", "initials": "M", "orcid": "0000-0003-4080-7055", "researcher": {"href": "https://publications.scilifelab.se/researcher/65cacd8558004a8689985676a798ae90.json"}}, {"family": "Hagstr\u00f6m-Andersson", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-2904-1311", "researcher": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89.json"}}, {"family": "Yang", "given": "Minjun", "initials": "M"}, {"family": "Paulsson", "given": "Kajsa", "initials": "K", "orcid": "0000-0001-7950-222X", "researcher": {"href": "https://publications.scilifelab.se/researcher/2033b23811f1432c90ad860dd993e7a8.json"}}], "type": "posted-content", "published": "2025-07-25", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2025.07.22.666073", "pmid": null, "labels": {"Clinical Genomics Lund": "Service"}, "xrefs": [], "notes": [], "created": "2025-11-06T09:11:41.063Z", "modified": "2025-12-18T19:11:22.125Z"}, {"entity": "publication", "iuid": "57c0d4d466524d61b08f72dc7b92965d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/57c0d4d466524d61b08f72dc7b92965d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/57c0d4d466524d61b08f72dc7b92965d"}}, "title": "Activating mutations remodel the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A-rearranged acute leukemia.", "authors": [{"family": "Zhang", "given": "Qirui", "initials": "Q"}, {"family": "Falqu\u00e9s-Costa", "given": "Ton", "initials": "T", "orcid": "0000-0002-5341-4472", "researcher": {"href": "https://publications.scilifelab.se/researcher/a75e19f3905e45059507c43f4722da39.json"}}, {"family": "Pilheden", "given": "Mattias", "initials": "M"}, {"family": "Sturesson", "given": "Helena", "initials": "H"}, {"family": "Ovlund", "given": "Tina", "initials": "T"}, {"family": "Rissler", "given": "Vendela", "initials": "V"}, {"family": "Castor", "given": "Anders", "initials": "A"}, {"family": "Marquart", "given": "Hanne V H", "initials": "HVH"}, {"family": "Lausen", "given": "Birgitte", "initials": "B", "orcid": "0000-0002-5306-0774", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc5eadc48e354c4cb70d68d420bfa6fe.json"}}, {"family": "Fioretos", "given": "Thoas", "initials": "T"}, {"family": "Hyrenius-Wittsten", "given": "Axel", "initials": "A", "orcid": "0000-0002-1239-4954", "researcher": {"href": "https://publications.scilifelab.se/researcher/26ee89834c8f409a9445c5b16d8f691e.json"}}, {"family": "Hagstr\u00f6m-Andersson", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-2904-1311", "researcher": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89.json"}}], "type": "journal article", "published": "2024-09-00", "journal": {"title": "Hemasphere", "issn": "2572-9241", "volume": "8", "issue": "9", "pages": "e70006", "issn-l": null}, "abstract": "Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A-gene rearrangements (KMT2A-r). However, how these mutations cooperate with the KMT2A-r to remodel the epigenetic landscape is unknown. Using a retroviral acute myeloid leukemia (AML) mouse model driven by KMT2A::MLLT3, we show that FLT3 , ITDFLT3 , and N676KNRAS remodeled the chromatin accessibility landscape and associated transcriptional networks. Although the activating mutations shared a common core of chromatin changes, each mutation exhibits unique profiles with most opened peaks associating with enhancers in intronic or intergenic regions. Specifically, G12DFLT3 and N676KNRAS rewired similar chromatin and transcriptional networks, distinct from those mediated by G12DFLT3 . Motif analysis uncovered a role for the AP-1 family of transcription factors in ITDKMT2A::MLLT3 leukemia with FLT3 and N676KNRAS , whereas Runx1 and Stat5a/Stat5b were active in the presence of G12DFLT3 . Furthermore, transcriptional programs linked to immune cell regulation were activated in ITDKMT2A-r AML expressing NRAS or G12DFLT3 , and the expression of NKG2D-ligands on N676KKMT2A-r cells rendered them sensitive to CAR T cell-mediated killing. Human KMT2A-r AML cells could be pharmacologically sensitized to NKG2D-CAR T cells by treatment with the histone deacetylase inhibitor LBH589 (panobinostat) which caused upregulation of NKG2D-ligand levels. Co-treatment with LBH589 and NKG2D-CAR T cells enabled robust AML cell killing, and the strongest effect was observed for cells expressing NRAS . Finally, the results were validated and extended to acute leukemia in infancy. Combined, activating mutations induced mutation-specific changes in the epigenetic landscape, leading to changes in transcriptional programs orchestrated by specific transcription factor networks.G12D", "doi": "10.1002/hem3.70006", "pmid": "39329074", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11426354"}, {"db": "pii", "key": "HEM370006"}], "notes": [], "created": "2024-11-18T12:56:06.452Z", "modified": "2024-11-18T12:56:07.232Z"}, {"entity": "publication", "iuid": "cd65cb61a4fb4e6f89ead24f6c0d243c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/cd65cb61a4fb4e6f89ead24f6c0d243c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/cd65cb61a4fb4e6f89ead24f6c0d243c"}}, "title": "Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity.", "authors": [{"family": "Rodriguez-Zabala", "given": "Maria", "initials": "M"}, {"family": "Ramakrishnan", "given": "Ramprasad", "initials": "R"}, {"family": "Reinbach", "given": "Katrin", "initials": "K"}, {"family": "Ghosh", "given": "Somadri", "initials": "S"}, {"family": "Oburoglu", "given": "Leal", "initials": "L", "orcid": "0000-0003-0130-6602", "researcher": {"href": "https://publications.scilifelab.se/researcher/cac8186ea00246e6a07f421e492041e6.json"}}, {"family": "Falqu\u00e9s-Costa", "given": "Antoni", "initials": "A", "orcid": "0000-0002-5341-4472", "researcher": {"href": "https://publications.scilifelab.se/researcher/a75e19f3905e45059507c43f4722da39.json"}}, {"family": "Bellamkonda", "given": "Kishan", "initials": "K"}, {"family": "Ehinger", "given": "Mats", "initials": "M"}, {"family": "Pe\u00f1a-Mart\u00ednez", "given": "Pablo", "initials": "P", "orcid": "0000-0002-0789-6431", "researcher": {"href": "https://publications.scilifelab.se/researcher/6d675e892dfc4334bb12051e004a7711.json"}}, {"family": "Puente-Moncada", "given": "Noelia", "initials": "N", "orcid": "0000-0002-5996-2349", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d4ac0bd551b4463a22e3f60470c2b6d.json"}}, {"family": "Lilljebj\u00f6rn", "given": "Henrik", "initials": "H"}, {"family": "Cammenga", "given": "J\u00f6rg", "initials": "J"}, {"family": "Pronk", "given": "Cornelis Jan", "initials": "CJ", "orcid": "0000-0002-0073-9660", "researcher": {"href": "https://publications.scilifelab.se/researcher/76e42ba48d824aa0b42e871e9f11b00a.json"}}, {"family": "Lazarevic", "given": "Vladimir", "initials": "V"}, {"family": "Fioretos", "given": "Thoas", "initials": "T"}, {"family": "Hagstr\u00f6m-Andersson", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-2904-1311", "researcher": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89.json"}}, {"family": "Woods", "given": "Niels-Bjarne", "initials": "NB", "orcid": "0000-0001-6052-922X", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c539424e21f41d1b006196a3b4b48bf.json"}}, {"family": "J\u00e4r\u00e5s", "given": "Marcus", "initials": "M", "orcid": "0000-0003-4080-7055", "researcher": {"href": "https://publications.scilifelab.se/researcher/65cacd8558004a8689985676a798ae90.json"}}], "type": "journal article", "published": "2023-09-26", "journal": {"title": "Blood Adv", "issn": "2473-9537", "volume": "7", "issue": "18", "pages": "5382-5395", "issn-l": "2473-9529"}, "abstract": "Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of LSCs. The facilitated glucose transporter type 1 (GLUT1) emerged as a critical in vivo metabolic dependency for LSCs in a murine MLL::AF9-driven model of AML. GLUT1 disruption by genetic ablation or pharmacological inhibition led to suppression of leukemia progression and improved survival of mice that received transplantation with LSCs. Metabolic profiling revealed that Glut1 inhibition suppressed glycolysis, decreased levels of tricarboxylic acid cycle intermediates and increased the levels of amino acids. This metabolic reprogramming was accompanied by an increase in autophagic activity and apoptosis. Moreover, Glut1 disruption caused transcriptional, morphological, and immunophenotypic changes, consistent with differentiation of AML cells. Notably, dual inhibition of GLUT1 and oxidative phosphorylation (OXPHOS) exhibited synergistic antileukemic effects in the majority of tested primary AML patient samples through restraining of their metabolic plasticity. In particular, RUNX1-mutated primary leukemia cells displayed striking sensitivity to the combination treatment compared with normal CD34+ bone marrow and cord blood cells. Collectively, our study reveals a GLUT1 dependency of murine LSCs in the bone marrow microenvironment and demonstrates that dual inhibition of GLUT1 and OXPHOS is a promising therapeutic approach for AML.", "doi": "10.1182/bloodadvances.2023009967", "pmid": "37505194", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service", "Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10509671"}, {"db": "pii", "key": "497184"}], "notes": [], "created": "2023-08-30T07:04:12.928Z", "modified": "2025-10-17T13:03:13.479Z"}, {"entity": "publication", "iuid": "7d8c3416d791408eb80e36578f0510e8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7d8c3416d791408eb80e36578f0510e8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7d8c3416d791408eb80e36578f0510e8"}}, "title": "FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis.", "authors": [{"family": "Hyrenius-Wittsten", "given": "Axel", "initials": "A", "orcid": "0000-0002-1239-4954", "researcher": {"href": "https://publications.scilifelab.se/researcher/26ee89834c8f409a9445c5b16d8f691e.json"}}, {"family": "Pilheden", "given": "Mattias", "initials": "M"}, {"family": "Falqu\u00e9s-Costa", "given": "Antoni", "initials": "A"}, {"family": "Eriksson", "given": "Mia", "initials": "M"}, {"family": "Sturesson", "given": "Helena", "initials": "H"}, {"family": "Schneider", "given": "Pauline", "initials": "P"}, {"family": "Wander", "given": "Priscilla", "initials": "P"}, {"family": "Garcia-Ruiz", "given": "Cristian", "initials": "C", "orcid": "0000-0003-2914-7914", "researcher": {"href": "https://publications.scilifelab.se/researcher/07826d677ce449e2811d69e273becfb4.json"}}, {"family": "Liu", "given": "Jian", "initials": "J"}, {"family": "\u00c5gerstam", "given": "Helena", "initials": "H"}, {"family": "Hultquist", "given": "Anne", "initials": "A"}, {"family": "Lilljebj\u00f6rn", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8703-1173", "researcher": {"href": "https://publications.scilifelab.se/researcher/b3a75300e8c346858ce8dd8f64ecae85.json"}}, {"family": "Stam", "given": "Ronald W", "initials": "RW"}, {"family": "J\u00e4r\u00e5s", "given": "Marcus", "initials": "M"}, {"family": "Hagstr\u00f6m-Andersson", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-2904-1311", "researcher": {"href": "https://publications.scilifelab.se/researcher/bc93a87c663d471ba64fc3be63212a89.json"}}], "type": "letter", "published": "2019-09-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "33", "issue": "9", "pages": "2310-2314", "issn-l": "0887-6924"}, "abstract": null, "doi": "10.1038/s41375-019-0465-1", "pmid": "30953031", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41375-019-0465-1"}, {"db": "pmc", "key": "PMC6756218"}], "notes": [], "created": "2019-12-18T13:04:07.051Z", "modified": "2021-11-23T14:16:07.433Z"}]}