{"entity": "researcher", "timestamp": "2026-03-17T02:45:32.175Z", "family": "Sundell", "given": "Timothy", "initials": "T", "orcid": "0000-0001-6244-1790", "affiliations": ["Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/b856449e4da74c9b913751835d0fdc50.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/b856449e4da74c9b913751835d0fdc50"}}, "publications": [{"entity": "publication", "iuid": "c387fb518b4a4cbfa7a96172dc66cda2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c387fb518b4a4cbfa7a96172dc66cda2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c387fb518b4a4cbfa7a96172dc66cda2"}}, "title": "Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells.", "authors": [{"family": "Camponeschi", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-6472-2438", "researcher": {"href": "https://publications.scilifelab.se/researcher/ccbaffafd6a24f4abed1e402219fa472.json"}}, {"family": "Kl\u00e4sener", "given": "Kathrin", "initials": "K", "orcid": "0000-0002-5969-2553", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a46292d2b6d4a46897e5b2fdcbaea25.json"}}, {"family": "Sundell", "given": "Timothy", "initials": "T", "orcid": "0000-0001-6244-1790", "researcher": {"href": "https://publications.scilifelab.se/researcher/b856449e4da74c9b913751835d0fdc50.json"}}, {"family": "Lundqvist", "given": "Christina", "initials": "C", "orcid": "0000-0002-2256-4072", "researcher": {"href": "https://publications.scilifelab.se/researcher/10b339e6cc1f48f3a5f736201038ee59.json"}}, {"family": "Manna", "given": "Paul T", "initials": "PT", "orcid": "0000-0002-2260-2075", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad6605820c294d408293b5a3cc6fdcdc.json"}}, {"family": "Ayoubzadeh", "given": "Negar", "initials": "N", "orcid": "0000-0002-9562-1947", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a5abf127036470a8e62917ece7cfc1b.json"}}, {"family": "Sundqvist", "given": "Martina", "initials": "M", "orcid": "0000-0002-0859-0792", "researcher": {"href": "https://publications.scilifelab.se/researcher/24e6273caf214eab9f4c7c4c8f20a186.json"}}, {"family": "Thorarinsdottir", "given": "Katrin", "initials": "K", "orcid": "0000-0003-2708-1990", "researcher": {"href": "https://publications.scilifelab.se/researcher/dcabbfe494e84a948ef32d94b13fd795.json"}}, {"family": "Gatto", "given": "Mariele", "initials": "M", "orcid": "0000-0003-4012-1248", "researcher": {"href": "https://publications.scilifelab.se/researcher/89af57d620344ca58a1e20c889075002.json"}}, {"family": "Visentini", "given": "Marcella", "initials": "M", "orcid": "0000-0002-4053-6091", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5f4c67ea260466f870cce36476ebf0b.json"}}, {"family": "\u00d6nnheim", "given": "Karin", "initials": "K", "orcid": "0000-0001-5415-6842", "researcher": {"href": "https://publications.scilifelab.se/researcher/e91d446634074987a47b6d0451f33010.json"}}, {"family": "Aranburu", "given": "Alaitz", "initials": "A", "orcid": "0000-0002-7024-7733", "researcher": {"href": "https://publications.scilifelab.se/researcher/41cd21f636e340af93fb3bb0544b158b.json"}}, {"family": "Forsman", "given": "Huamei", "initials": "H", "orcid": "0000-0002-8781-284X", "researcher": {"href": "https://publications.scilifelab.se/researcher/d47631a564bc43f8b37f31adc1aaa043.json"}}, {"family": "Ekwall", "given": "Olov", "initials": "O", "orcid": "0000-0002-4506-9955", "researcher": {"href": "https://publications.scilifelab.se/researcher/2d7af11d7d30410d8fe5f3b5fbd0ba1d.json"}}, {"family": "Fogelstrand", "given": "Linda", "initials": "L", "orcid": "0000-0003-3698-8519", "researcher": {"href": "https://publications.scilifelab.se/researcher/f39ff709aa0646b8ad5e520780a0ad49.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Reth", "given": "Michael", "initials": "M", "orcid": "0000-0002-1025-7198", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9c45a119af24ccdb30c04ceff46ceaf.json"}}, {"family": "M\u00e5rtensson", "given": "Inga-Lill", "initials": "IL", "orcid": "0000-0003-3415-0560", "researcher": {"href": "https://publications.scilifelab.se/researcher/c4f5cf8b693a4915b71a58e700768d6f.json"}}], "type": "journal article", "published": "2022-09-05", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "219", "issue": "9", "issn-l": "0022-1007"}, "abstract": "CD38 is a multifunctional protein expressed on the surface of B cells in healthy individuals but also in B cell malignancies. Previous studies have suggested a connection between CD38 and components of the IgM class B cell antigen receptor (IgM-BCR) and its coreceptor complex. Here, we provide evidence that CD38 is closely associated with CD19 in resting B cells and with the IgM-BCR upon engagement. We show that targeting CD38 with an antibody, or removing this molecule with CRISPR/Cas9, inhibits the association of CD19 with the IgM-BCR, impairing BCR signaling in normal and malignant B cells. Together, our data suggest that CD38 is a new member of the BCR coreceptor complex, where it exerts a modulatory effect on B cell activation upon antigen recognition by regulating CD19. Our study also reveals a new mechanism where \u03b1-CD38 antibodies could be a valuable option in therapeutic approaches to B cell malignancies driven by aberrant BCR signaling.", "doi": "10.1084/jem.20220201", "pmid": "35819358", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9280193"}, {"db": "pii", "key": "213348"}], "notes": [], "created": "2023-03-07T14:34:14.812Z", "modified": "2024-01-16T13:46:28.455Z"}]}