{"entity": "researcher", "timestamp": "2026-06-15T17:29:40.498Z", "family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "affiliations": ["Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/b46eaae026524ee6b9b589f12846b458.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/b46eaae026524ee6b9b589f12846b458"}}, "publications": [{"entity": "publication", "iuid": "1e4e4601890c4a40880fd60cbab92ad8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1e4e4601890c4a40880fd60cbab92ad8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1e4e4601890c4a40880fd60cbab92ad8"}}, "title": "Motor innervation directs the correct development of the mouse sympathetic nervous system.", "authors": [{"family": "Erickson", "given": "Alek G", "initials": "AG", "orcid": "0000-0001-7110-9386", "researcher": {"href": "https://publications.scilifelab.se/researcher/0fcd4f91a2fa4847a1d81bb5be2b1da9.json"}}, {"family": "Motta", "given": "Alessia", "initials": "A", "orcid": "0000-0002-1008-8347", "researcher": {"href": "https://publications.scilifelab.se/researcher/8124ce783ece4d098fcd3675145d1e53.json"}}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME", "orcid": "0000-0002-0563-7399", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e0722d8c5484a13bb37c3a3b084ff8c.json"}}, {"family": "Edwards", "given": "Steven", "initials": "S"}, {"family": "Coulpier", "given": "Fanny", "initials": "F"}, {"family": "Th\u00e9oulle", "given": "Emy", "initials": "E"}, {"family": "Murtazina", "given": "Aliia", "initials": "A", "orcid": "0000-0003-1630-1855", "researcher": {"href": "https://publications.scilifelab.se/researcher/9590b1e2770b4dfa9233ad9bdd906deb.json"}}, {"family": "Poverennaya", "given": "Irina", "initials": "I", "orcid": "0000-0003-2562-5632", "researcher": {"href": "https://publications.scilifelab.se/researcher/ba58765568c846ae8250bfe56eb9d56e.json"}}, {"family": "Wies", "given": "Daniel", "initials": "D"}, {"family": "Ganofsky", "given": "Jeremy", "initials": "J", "orcid": "0000-0002-2361-7869", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ee1d09bb1b34b3c800943512c13749e.json"}}, {"family": "Canu", "given": "Giovanni", "initials": "G", "orcid": "0000-0002-3349-4479", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d8a7a89ab424482a8d816dda085a7aa.json"}}, {"family": "Lallemend", "given": "Francois", "initials": "F", "orcid": "0000-0001-5484-0011", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a9494a8ea444facbf3b564670930ab5.json"}}, {"family": "Topilko", "given": "Piotr", "initials": "P"}, {"family": "Hadjab", "given": "Saida", "initials": "S", "orcid": "0000-0001-7953-8396", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed79ab77088f43859e11b75dcae33d73.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/b46eaae026524ee6b9b589f12846b458.json"}}, {"family": "Ruhrberg", "given": "Christiana", "initials": "C", "orcid": "0000-0002-3212-9381", "researcher": {"href": "https://publications.scilifelab.se/researcher/71f5aeb40eb04defa937360b83f9d73a.json"}}, {"family": "Schwarz", "given": "Quenten", "initials": "Q", "orcid": "0000-0002-5958-4181", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d558c2ad5704db4a70500e1ca9bbbf2.json"}}, {"family": "Castellani", "given": "Valerie", "initials": "V", "orcid": "0000-0001-9623-9312", "researcher": {"href": "https://publications.scilifelab.se/researcher/4164c2013f294c7cb5e0c0aa7693c912.json"}}, {"family": "Bonanomi", "given": "Dario", "initials": "D", "orcid": "0000-0003-4517-1244", "researcher": {"href": "https://publications.scilifelab.se/researcher/23a9b651c23e4cfab7b7b2df4126c328.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}], "type": "journal article", "published": "2024-08-16", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "15", "issue": "1", "pages": "7065"}, "abstract": "The sympathetic nervous system controls bodily functions including vascular tone, cardiac rhythm, and the \"fight-or-flight response\". Sympathetic chain ganglia develop in parallel with preganglionic motor nerves extending from the neural tube, raising the question of whether axon targeting contributes to sympathetic chain formation. Using nerve-selective genetic ablations and lineage tracing in mouse, we reveal that motor nerve-associated Schwann cell precursors (SCPs) contribute sympathetic neurons and satellite glia after the initial seeding of sympathetic ganglia by neural crest. Motor nerve ablation causes mispositioning of SCP-derived sympathoblasts as well as sympathetic chain hypoplasia and fragmentation. Sympathetic neurons in motor-ablated embryos project precociously and abnormally towards dorsal root ganglia, eventually resulting in fusion of sympathetic and sensory ganglia. Cell interaction analysis identifies semaphorins as potential motor nerve-derived signaling molecules regulating sympathoblast positioning and outgrowth. Overall, central innervation functions both as infrastructure and regulatory niche to ensure the integrity of peripheral ganglia morphogenesis.", "doi": "10.1038/s41467-024-51290-0", "pmid": "39152112", "labels": {"Integrated Microscopy Technologies Stockholm": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11329663"}, {"db": "pii", "key": "10.1038/s41467-024-51290-0"}], "notes": [], "created": "2024-08-27T07:41:28.383Z", "modified": "2024-08-27T07:42:00.559Z"}, {"entity": "publication", "iuid": "dd973b0ce8ea40e58c5a41de25f1b570", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dd973b0ce8ea40e58c5a41de25f1b570.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dd973b0ce8ea40e58c5a41de25f1b570"}}, "title": "Directionality of developing skeletal muscles is set by mechanical forces.", "authors": [{"family": "Sunadome", "given": "Kazunori", "initials": "K"}, {"family": "Erickson", "given": "Alek G", "initials": "AG"}, {"family": "Kah", "given": "Delf", "initials": "D", "orcid": "0000-0002-3800-2461", "researcher": {"href": "https://publications.scilifelab.se/researcher/2feb3ab785af4c0991d02ee953a18b8c.json"}}, {"family": "Fabry", "given": "Ben", "initials": "B", "orcid": "0000-0003-1737-0465", "researcher": {"href": "https://publications.scilifelab.se/researcher/2f391e2904d14618830d1f3cb993bf60.json"}}, {"family": "Adori", "given": "Csaba", "initials": "C"}, {"family": "Kameneva", "given": "Polina", "initials": "P"}, {"family": "Faure", "given": "Louis", "initials": "L", "orcid": "0000-0003-4621-586X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbf218e53c854d69a1b474a61480c33f.json"}}, {"family": "Kanatani", "given": "Shigeaki", "initials": "S", "orcid": "0000-0003-2226-4288", "researcher": {"href": "https://publications.scilifelab.se/researcher/355335d5d964416883ccf63a312b69db.json"}}, {"family": "Kaucka", "given": "Marketa", "initials": "M", "orcid": "0000-0002-8781-9769", "researcher": {"href": "https://publications.scilifelab.se/researcher/933187e42ddc4ab6a29c46d5cca411e6.json"}}, {"family": "Dehnisch Ellstr\u00f6m", "given": "Ivar", "initials": "I"}, {"family": "Tesarova", "given": "Marketa", "initials": "M", "orcid": "0000-0002-5200-7365", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad2bf55bfa2240458ad9a4d73fe9baff.json"}}, {"family": "Zikmund", "given": "Tomas", "initials": "T", "orcid": "0000-0003-2948-5198", "researcher": {"href": "https://publications.scilifelab.se/researcher/7648df9d2584437d8388fab4a130d4eb.json"}}, {"family": "Kaiser", "given": "Jozef", "initials": "J", "orcid": "0000-0002-7397-125X", "researcher": {"href": "https://publications.scilifelab.se/researcher/98b611052bed483eb58f6ac51b35e003.json"}}, {"family": "Edwards", "given": "Steven", "initials": "S"}, {"family": "Maki", "given": "Koichiro", "initials": "K"}, {"family": "Adachi", "given": "Taiji", "initials": "T", "orcid": "0000-0001-5280-4156", "researcher": {"href": "https://publications.scilifelab.se/researcher/a13e752761974a339df29fd35873a6f2.json"}}, {"family": "Yamamoto", "given": "Takuya", "initials": "T"}, {"family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/b46eaae026524ee6b9b589f12846b458.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}], "type": "journal article", "published": "2023-05-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "3060", "issn-l": "2041-1723"}, "abstract": "Formation of oriented myofibrils is a key event in musculoskeletal development. However, the mechanisms that drive myocyte orientation and fusion to control muscle directionality in adults remain enigmatic. Here, we demonstrate that the developing skeleton instructs the directional outgrowth of skeletal muscle and other soft tissues during limb and facial morphogenesis in zebrafish and mouse. Time-lapse live imaging reveals that during early craniofacial development, myoblasts condense into round clusters corresponding to future muscle groups. These clusters undergo oriented stretch and alignment during embryonic growth. Genetic perturbation of cartilage patterning or size disrupts the directionality and number of myofibrils in vivo. Laser ablation of musculoskeletal attachment points reveals tension imposed by cartilage expansion on the forming myofibers. Application of continuous tension using artificial attachment points, or stretchable membrane substrates, is sufficient to drive polarization of myocyte populations in vitro. Overall, this work outlines a biomechanical guidance mechanism that is potentially useful for engineering functional skeletal muscle.", "doi": "10.1038/s41467-023-38647-7", "pmid": "37244931", "labels": {"Integrated Microscopy Technologies Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10224984"}, {"db": "pii", "key": "10.1038/s41467-023-38647-7"}], "notes": [], "created": "2023-06-07T08:57:26.323Z", "modified": "2023-06-07T08:57:26.672Z"}, {"entity": "publication", "iuid": "839b07a36e174736838862141b447caa", "links": {"self": {"href": "https://publications.scilifelab.se/publication/839b07a36e174736838862141b447caa.json"}, "display": {"href": "https://publications.scilifelab.se/publication/839b07a36e174736838862141b447caa"}}, "title": "Motor nerves direct the development of the sympathetic nervous system", "authors": [{"family": "Erickson", "given": "Alek", "initials": "A", "orcid": "0000-0001-7110-9386", "researcher": {"href": "https://publications.scilifelab.se/researcher/0fcd4f91a2fa4847a1d81bb5be2b1da9.json"}}, {"family": "Motta", "given": "Alessia", "initials": "A"}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME", "orcid": "0000-0002-0563-7399", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e0722d8c5484a13bb37c3a3b084ff8c.json"}}, {"family": "Edwards", "given": "Steven", "initials": "S"}, {"family": "Lallemend", "given": "Francois", "initials": "F", "orcid": "0000-0001-5484-0011", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a9494a8ea444facbf3b564670930ab5.json"}}, {"family": "Hadjab", "given": "Saida", "initials": "S", "orcid": "0000-0001-7953-8396", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed79ab77088f43859e11b75dcae33d73.json"}}, {"family": "Ruhrberg", "given": "Christiana", "initials": "C", "orcid": "0000-0002-3212-9381", "researcher": {"href": "https://publications.scilifelab.se/researcher/71f5aeb40eb04defa937360b83f9d73a.json"}}, {"family": "Schwarz", "given": "Quenten", "initials": "Q", "orcid": "0000-0002-5958-4181", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d558c2ad5704db4a70500e1ca9bbbf2.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/b46eaae026524ee6b9b589f12846b458.json"}}, {"family": "Bonanomi", "given": "Dario", "initials": "D", "orcid": "0000-0003-4517-1244", "researcher": {"href": "https://publications.scilifelab.se/researcher/23a9b651c23e4cfab7b7b2df4126c328.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}], "type": "posted-content", "published": "2023-03-18", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.03.17.533145", "pmid": null, "labels": {"Integrated Microscopy Technologies Stockholm": "Collaborative"}, "xrefs": [], "notes": [], "created": "2023-03-22T08:38:53.949Z", "modified": "2025-12-18T19:55:00.636Z"}, {"entity": "publication", "iuid": "5772fc9a0bde4a55bcf300028482da2e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5772fc9a0bde4a55bcf300028482da2e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5772fc9a0bde4a55bcf300028482da2e"}}, "title": "Spatiotemporal structure of cell fate decisions in murine neural crest", "authors": [{"family": "Soldatov", "given": "Ruslan", "initials": "R", "orcid": "0000-0002-5670-5881", "researcher": {"href": "https://publications.scilifelab.se/researcher/3800b61f5f7042e89514b439e9532a97.json"}}, {"family": "Kaucka", "given": "Marketa", "initials": "M", "orcid": "0000-0002-8781-9769", "researcher": {"href": "https://publications.scilifelab.se/researcher/933187e42ddc4ab6a29c46d5cca411e6.json"}}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME", "orcid": "0000-0002-0563-7399", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e0722d8c5484a13bb37c3a3b084ff8c.json"}}, {"family": "Petersen", "given": "Julian", "initials": "J", "orcid": "0000-0002-7444-0610", "researcher": {"href": "https://publications.scilifelab.se/researcher/74d20bbfd5a540a58aac82ada8d80b0d.json"}}, {"family": "Chontorotzea", "given": "Tatiana", "initials": "T", "orcid": "0000-0002-6134-1365", "researcher": {"href": "https://publications.scilifelab.se/researcher/7426e1056a94430bb9ab69191e623fd2.json"}}, {"family": "Englmaier", "given": "Lukas", "initials": "L", "orcid": "0000-0002-0082-2616", "researcher": {"href": "https://publications.scilifelab.se/researcher/aba3d0eb3f634ccda4e6562c37bd77f2.json"}}, {"family": "Akkuratova", "given": "Natalia", "initials": "N", "orcid": "0000-0001-6733-8119", "researcher": {"href": "https://publications.scilifelab.se/researcher/68fc565dc99b4e8eb61d39dcef0f3a48.json"}}, {"family": "Yang", "given": "Yunshi", "initials": "Y", "orcid": "0000-0003-0396-5257", "researcher": {"href": "https://publications.scilifelab.se/researcher/4663511b58bd4c0f9c69da8445c7974b.json"}}, {"family": "H\u00e4ring", "given": "Martin", "initials": "M", "orcid": "0000-0003-4949-0533", "researcher": {"href": "https://publications.scilifelab.se/researcher/eafb570acc6d40159228d08f9dcc985f.json"}}, {"family": "Dyachuk", "given": "Viacheslav", "initials": "V", "orcid": "0000-0001-8100-7367", "researcher": {"href": "https://publications.scilifelab.se/researcher/a32abc6aafed40e382beb35f873ae91c.json"}}, {"family": "Bock", "given": "Christoph", "initials": "C", "orcid": "0000-0001-6091-3088", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ab95ee1c8284fa7bf2e5a2ee987c835.json"}}, {"family": "Farlik", "given": "Matthias", "initials": "M", "orcid": "0000-0003-0698-2992", "researcher": {"href": "https://publications.scilifelab.se/researcher/906ad9a447b64e028f9cf41fbeaea108.json"}}, {"family": "Piacentino", "given": "Michael L", "initials": "ML", "orcid": "0000-0003-1773-031X", "researcher": {"href": "https://publications.scilifelab.se/researcher/75e58e24dbcf4b8ba91ce39db1491c69.json"}}, {"family": "Boismoreau", "given": "Franck", "initials": "F"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM", "orcid": "0000-0001-7782-0830", "researcher": {"href": "https://publications.scilifelab.se/researcher/1de5317c53f34bc89dabfddb0be44983.json"}}, {"family": "Yokota", "given": "Chika", "initials": "C"}, {"family": "Qian", "given": "Xiaoyan", "initials": "X", "orcid": "0000-0001-7509-8071", "researcher": {"href": "https://publications.scilifelab.se/researcher/835743f43787492498e3c610184cf9a3.json"}}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications.scilifelab.se/researcher/197cf8ba83ba430f9712b2f4d94dc3e5.json"}}, {"family": "Bronner", "given": "Marianne E", "initials": "ME", "orcid": "0000-0003-4274-1862", "researcher": {"href": "https://publications.scilifelab.se/researcher/56516b93bfb047aeab63c9d2fee21d4a.json"}}, {"family": "Croci", "given": "Laura", "initials": "L", "orcid": "0000-0002-7826-428X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5e08f8646894441297506e2a3eb5fb57.json"}}, {"family": "Hsiao", "given": "Wen Yu", "initials": "WY"}, {"family": "Guertin", "given": "David A", "initials": "DA"}, {"family": "Brunet", "given": "Jean Francois", "initials": "JF", "orcid": "0000-0002-1985-6103", "researcher": {"href": "https://publications.scilifelab.se/researcher/3e7516ee3e5a47ed9b6163b10d5baf9a.json"}}, {"family": "Consalez", "given": "Gian Giacomo", "initials": "GG", "orcid": "0000-0003-4594-6273", "researcher": {"href": "https://publications.scilifelab.se/researcher/1eabaebce3194d9c93e65ce4123f4254.json"}}, {"family": "Ernfors", "given": "Patrik", "initials": "P", "orcid": "0000-0002-1140-3986", "researcher": {"href": "https://publications.scilifelab.se/researcher/c31df7b8976c496c9d3e3199a91f9d22.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/b46eaae026524ee6b9b589f12846b458.json"}}, {"family": "Kharchenko", "given": "Peter V", "initials": "PV"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}], "type": "journal-article", "published": "2019-06-07", "journal": {"volume": "364", "issn": "0036-8075", "issue": "6444", "pages": "eaas9536", "title": "Science", "issn-l": null}, "abstract": "Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.", "doi": "10.1126/science.aas9536", "pmid": "31171666", "labels": {"National Genomics Infrastructure": "Service", "Eukaryotic Single Cell Genomics (ESCG)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "In Situ Sequencing": "Collaborative"}, "xrefs": [{"db": "pii", "key": "364/6444/eaas9536"}], "notes": [], "created": "2019-06-12T08:11:45.162Z", "modified": "2025-10-17T13:02:18.356Z"}]}