{"entity": "researcher", "timestamp": "2026-07-13T02:53:44.794Z", "family": "Pandit", "given": "Abhay", "initials": "A", "orcid": "0000-0002-6292-4933", "affiliations": ["C\u00daRAM SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, Ireland. abhay.pandit@nuigalway.ie mark.dacosta@nuigalway.ie."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/b4611c209a394949bd971c8b12692fac.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/b4611c209a394949bd971c8b12692fac"}}, "publications": [{"entity": "publication", "iuid": "b6538257193e4bda9387d19ec84faaa0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b6538257193e4bda9387d19ec84faaa0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b6538257193e4bda9387d19ec84faaa0"}}, "title": "Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.", "authors": [{"family": "Spelat", "given": "Renza", "initials": "R", "orcid": "0000-0001-5794-8976", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7974e486fb24bbf979eb920f9d49380.json"}}, {"family": "Ferro", "given": "Federico", "initials": "F", "orcid": "0000-0002-6023-8227", "researcher": {"href": "https://publications.scilifelab.se/researcher/27810903638948feb4391fa537a7eda3.json"}}, {"family": "Contessotto", "given": "Paolo", "initials": "P"}, {"family": "Aljaabary", "given": "Amal", "initials": "A", "orcid": "0000-0003-0361-166X", "researcher": {"href": "https://publications.scilifelab.se/researcher/af820e3a3c8f441c9ed519c8849f163d.json"}}, {"family": "Martin-Salda\u00f1a", "given": "Sergio", "initials": "S", "orcid": "0000-0002-9506-8483", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7a4a6088c0a4597b6c18c2a48c74b7a.json"}}, {"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications.scilifelab.se/researcher/458804f3f7274b8a9efe7a90469d0e56.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications.scilifelab.se/researcher/62e0b7440ff1447c9611d938d185fbc7.json"}}, {"family": "Grealy", "given": "Maura", "initials": "M"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM", "orcid": "0000-0001-7782-0830", "researcher": {"href": "https://publications.scilifelab.se/researcher/1de5317c53f34bc89dabfddb0be44983.json"}}, {"family": "Magni", "given": "Fulvio", "initials": "F"}, {"family": "Chinello", "given": "Clizia", "initials": "C"}, {"family": "Kilcoyne", "given": "Michelle", "initials": "M", "orcid": "0000-0002-8870-1308", "researcher": {"href": "https://publications.scilifelab.se/researcher/d1d1606f98e540fbb09f7251adf921a2.json"}}, {"family": "Pandit", "given": "Abhay", "initials": "A", "orcid": "0000-0002-6292-4933", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4611c209a394949bd971c8b12692fac.json"}}], "type": "journal article", "published": "2022-12-13", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "5", "issue": "1", "pages": "1365", "issn-l": "2399-3642"}, "abstract": "The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages. Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question. Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration. Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration. Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.", "doi": "10.1038/s42003-022-04328-2", "pmid": "36509839", "labels": {"In Situ Sequencing": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9744865"}, {"db": "pii", "key": "10.1038/s42003-022-04328-2"}], "notes": [], "created": "2023-05-31T10:56:03.689Z", "modified": "2025-10-17T13:02:17.158Z"}, {"entity": "publication", "iuid": "903f912e2763491b8c61bc2d0cdb703e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/903f912e2763491b8c61bc2d0cdb703e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/903f912e2763491b8c61bc2d0cdb703e"}}, "title": "Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep.", "authors": [{"family": "Contessotto", "given": "Paolo", "initials": "P", "orcid": "0000-0002-6990-9883", "researcher": {"href": "https://publications.scilifelab.se/researcher/cd9eff0e573f4f7097fb575bf6479f8e.json"}}, {"family": "Orbani\u0107", "given": "Doriana", "initials": "D", "orcid": "0000-0002-9723-7279", "researcher": {"href": "https://publications.scilifelab.se/researcher/07e26f981b9d44c88b3c72e5ca9acc68.json"}}, {"family": "Da Costa", "given": "Mark", "initials": "M", "orcid": "0000-0001-7713-2608", "researcher": {"href": "https://publications.scilifelab.se/researcher/a18320fbed7b43299aedc829736f4eb9.json"}}, {"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications.scilifelab.se/researcher/458804f3f7274b8a9efe7a90469d0e56.json"}}, {"family": "Owens", "given": "Peter", "initials": "P", "orcid": "0000-0003-1117-1035", "researcher": {"href": "https://publications.scilifelab.se/researcher/d2c23314e1964d9182b0e292ac0cdb7a.json"}}, {"family": "Chantepie", "given": "Sandrine", "initials": "S", "orcid": "0000-0003-1652-432X", "researcher": {"href": "https://publications.scilifelab.se/researcher/b080f580cda242108279d1eef8580735.json"}}, {"family": "Chinello", "given": "Clizia", "initials": "C", "orcid": "0000-0002-7921-7768", "researcher": {"href": "https://publications.scilifelab.se/researcher/da3a7a0cdecf441ba963745111e322c5.json"}}, {"family": "Newell", "given": "John", "initials": "J", "orcid": "0000-0001-7685-6655", "researcher": {"href": "https://publications.scilifelab.se/researcher/40a38064ac4c40a0b8a221cd906d3861.json"}}, {"family": "Magni", "given": "Fulvio", "initials": "F", "orcid": "0000-0002-8663-0374", "researcher": {"href": "https://publications.scilifelab.se/researcher/3d2bb884997b4437924cc2659b823637.json"}}, {"family": "Papy-Garcia", "given": "Dulce", "initials": "D", "orcid": "0000-0003-2225-9331", "researcher": {"href": "https://publications.scilifelab.se/researcher/697039fd70604a79804beb2e8179d9cf.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG"}, {"family": "Kilcoyne", "given": "Michelle", "initials": "M", "orcid": "0000-0002-8870-1308", "researcher": {"href": "https://publications.scilifelab.se/researcher/d1d1606f98e540fbb09f7251adf921a2.json"}}, {"family": "Dockery", "given": "Peter", "initials": "P", "orcid": "0000-0001-5103-6589", "researcher": {"href": "https://publications.scilifelab.se/researcher/5355752094da43a39ef13af20f42ae4c.json"}}, {"family": "Rodr\u00edguez-Cabello", "given": "Jos\u00e9 C", "initials": "JC", "orcid": "0000-0002-3438-858X", "researcher": {"href": "https://publications.scilifelab.se/researcher/20649ea23f6d4c85ba4b49a49e474d68.json"}}, {"family": "Pandit", "given": "Abhay", "initials": "A", "orcid": "0000-0002-6292-4933", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4611c209a394949bd971c8b12692fac.json"}}], "type": "journal article", "published": "2021-02-17", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "volume": "13", "issue": "581", "issn-l": "1946-6234"}, "abstract": "Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (ECM)-mimicking hydrogel using catalyst-free click chemistry covalent bonding between two elastin-like recombinamers (ELRs). The resulting customized hydrogel included functional domains for cell adhesion and protease cleavage sites, sensitive to cleavage by matrix metalloproteases overexpressed after myocardial infarction (MI). The scaffold permitted stromal cell invasion and endothelial cell sprouting in vitro. The incidence of non-transmural infarcts has increased clinically over the past decade, and there is currently no treatment preventing further functional deterioration in the infarcted areas. Here, we have developed a clinically relevant ovine model of non-transmural infarcts induced by multiple suture ligations. Intramyocardial injections of the degradable ELRs-hydrogel led to complete functional recovery of ejection fraction 21 days after the intervention. We observed less fibrosis and more angiogenesis in the ELRs-hydrogel-treated ischemic core region compared to the untreated animals, as validated by the expression, proteomic, glycomic, and histological analyses. These findings were accompanied by enhanced preservation of GATA4+ cardiomyocytes in the border zone of the infarct. We propose that our customized ECM favors cardiomyocyte preservation in the border zone by modulating the ischemic core and a marked functional recovery. The functional benefits obtained by the timely injection of the ELRs-hydrogel in a clinically relevant MI model support the potential utility of this treatment for further clinical translation.", "doi": "10.1126/scitranslmed.aaz5380", "pmid": "33597263", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pii", "key": "13/581/eaaz5380"}], "notes": [], "created": "2021-12-09T21:53:00.845Z", "modified": "2024-01-16T13:46:30.797Z"}]}