{"entity": "researcher", "timestamp": "2026-07-11T15:27:52.258Z", "family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "affiliations": ["From the, Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31"}}, "publications": [{"entity": "publication", "iuid": "b31162b460c7480c87a7be42d41b600a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b31162b460c7480c87a7be42d41b600a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b31162b460c7480c87a7be42d41b600a"}}, "title": "The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition", "authors": [{"family": "Moksnes", "given": "Marta Riise", "initials": "MR", "orcid": "0000-0002-2690-5153", "researcher": {"href": "https://publications.scilifelab.se/researcher/15fd5ce3d43a4b76a7a7e710e8724a6f.json"}}, {"family": "Coward", "given": "Eivind", "initials": "E", "orcid": "0009-0008-1323-3555", "researcher": {"href": "https://publications.scilifelab.se/researcher/6a4792db14b645b9b5134243f9ca7b60.json"}}, {"family": "Nethander", "given": "Maria", "initials": "M", "orcid": "0000-0003-3688-906X", "researcher": {"href": "https://publications.scilifelab.se/researcher/53d61951f51c4d40bef24672866382cb.json"}}, {"family": "Dekkers", "given": "Koen", "initials": "K", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications.scilifelab.se/researcher/ee8d56ef781e42d5b6f21b551054a3e7.json"}}, {"family": "Grahnemo", "given": "Louise", "initials": "L", "orcid": "0000-0001-5276-6612", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb1ac8fe74954a5db43e8e6538cf8235.json"}}, {"family": "T\u00f6rnqvist", "given": "Anna E", "initials": "AE"}, {"family": "Li", "given": "Lei", "initials": "L"}, {"family": "Lundmark", "given": "Per", "initials": "P", "orcid": "0009-0006-2334-8802", "researcher": {"href": "https://publications.scilifelab.se/researcher/f30b1a2e60d646c4a0cc0be06ffe77dd.json"}}, {"family": "Pertiwi", "given": "Kamalita", "initials": "K", "orcid": "0000-0003-2861-9051", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9cb279b53204e51b202134c82cf680f.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications.scilifelab.se/researcher/577652ffb15442e1a47a9aaffc3b52e7.json"}}, {"family": "Mjelle", "given": "Robin", "initials": "R"}, {"family": "Moll", "given": "Janne Marie", "initials": "JM", "orcid": "0000-0002-3514-4528", "researcher": {"href": "https://publications.scilifelab.se/researcher/52e482fb976e4bb3a212d98b981c9f2f.json"}}, {"family": "Eklund", "given": "Aron Charles", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications.scilifelab.se/researcher/9f1b0f6b48de45f7916e14d6a4defb09.json"}}, {"family": "Nielsen", "given": "Henrik Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1d5f2e0565a46bcbccfc973eec9e838.json"}}, {"family": "Svensson", "given": "Johan", "initials": "J", "orcid": "0000-0002-4487-6405", "researcher": {"href": "https://publications.scilifelab.se/researcher/fdbca5fe77124646b51e9c55dae4d361.json"}}, {"family": "Langhammer", "given": "Arnulf", "initials": "A", "orcid": "0000-0001-5296-6673", "researcher": {"href": "https://publications.scilifelab.se/researcher/755b4b39d8054f2ea3e28476a7b0ae39.json"}}, {"family": "Giske\u00f8deg\u00e5rd", "given": "Guro F", "initials": "GF", "orcid": "0000-0003-2157-8824", "researcher": {"href": "https://publications.scilifelab.se/researcher/57d6962d8112403fb823764ce0a0d6c6.json"}}, {"family": "Brumpton", "given": "Ben", "initials": "B", "orcid": "0000-0002-3058-1059", "researcher": {"href": "https://publications.scilifelab.se/researcher/da9d23aaf1dc4d18a0a13e4847ea9955.json"}}, {"family": "Hjort", "given": "Rebecka", "initials": "R"}, {"family": "Ness-Jensen", "given": "Eivind", "initials": "E", "orcid": "0000-0001-6005-0729", "researcher": {"href": "https://publications.scilifelab.se/researcher/d619713fc5764a5e9b88c7c012cf0cf1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K", "orcid": "0000-0003-2815-1217", "researcher": {"href": "https://publications.scilifelab.se/researcher/eff63868e95240f695d47e871e31947f.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e54fbe6f0fc4eed93108b382e1b2952.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ed3f066719f43b291743a8bdaf3d2a0.json"}}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications.scilifelab.se/researcher/995dac358caa4a169fc889b7a3eef44a.json"}}], "type": "journal-article", "published": "2026-03-00", "journal": {"title": "Nat Genet", "issn": "1061-4036", "volume": "58", "issue": "3", "pages": "530-539", "issn-l": "1061-4036"}, "abstract": "The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Tr\u00f8ndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017-21,976). We identified 12 reproducible SNP-species associations across six genomic loci, including known (LCT, ABO) and novel (HLA-DQB1, MUC12, SLC37A2, FUT2) regions. Additionally, we detected genetic signals associated with gut microbiota functional modules at three loci (LCT, ABO, FUT2). Follow-up analyses suggest that these host-microbiota associations are linked to the pathogenesis of celiac disease and hemorrhoidal disease. Mendelian randomization analyses provided evidence supporting a causal effect of body mass index on gut microbiota composition. These findings highlight the interplay between host genetics and gut microbiota for human health and disease.", "doi": "10.1038/s41588-026-02502-4", "pmid": "41688637", "labels": {"National Genomics Infrastructure": "Service", "NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12987729"}, {"db": "pii", "key": "10.1038/s41588-026-02502-4"}], "notes": [], "created": "2026-03-19T16:36:31.375Z", "modified": "2026-03-24T09:08:07.330Z"}, {"entity": "publication", "iuid": "fbe87ad7cdb14ba598144e9efea8ef01", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fbe87ad7cdb14ba598144e9efea8ef01.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fbe87ad7cdb14ba598144e9efea8ef01"}}, "title": "Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study-differences and similarities.", "authors": [{"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ed3f066719f43b291743a8bdaf3d2a0.json"}}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O", "orcid": "0000-0002-3474-2438", "researcher": {"href": "https://publications.scilifelab.se/researcher/ffefb8f0aa0b4622b2eb80551a9389c5.json"}}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Brandberg", "given": "John", "initials": "J"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Chorell", "given": "Elin", "initials": "E", "orcid": "0000-0002-8057-1684", "researcher": {"href": "https://publications.scilifelab.se/researcher/e3f7dfbecd6d4f80a9015080ec717ccc.json"}}, {"family": "Engvall", "given": "Jan Edvin", "initials": "JE"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ac1bdc52e3241ea9eb5645f603229a3.json"}}, {"family": "Hjelmgren", "given": "Ola", "initials": "O"}, {"family": "Hultdin", "given": "Johan", "initials": "J"}, {"family": "Jernberg", "given": "Tomas", "initials": "T", "orcid": "0000-0003-1695-379X", "researcher": {"href": "https://publications.scilifelab.se/researcher/cbe08775f7a047ffa46bf6e065c776c9.json"}}, {"family": "Kihlberg", "given": "Johan", "initials": "J"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications.scilifelab.se/researcher/4c517dacca7c4ec58a3e03b59ffb4044.json"}}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Fredrik Hans", "initials": "FH"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications.scilifelab.se/researcher/91a40d3c138d43f2b0d38f66be4b71c7.json"}}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}], "type": "journal article", "published": "2025-09-29", "journal": {"title": "Cardiovasc. Res.", "issn": "1755-3245", "volume": "121", "issue": "11", "pages": "1649-1652", "issn-l": "0008-6363"}, "abstract": null, "doi": "10.1093/cvr/cvaf076", "pmid": "40327543", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12477672"}, {"db": "pii", "key": "8125826"}], "notes": [], "created": "2025-11-25T19:22:38.477Z", "modified": "2025-11-25T19:23:39.737Z"}, {"entity": "publication", "iuid": "346db8ab17674ec68f1e0b0051075be5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/346db8ab17674ec68f1e0b0051075be5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/346db8ab17674ec68f1e0b0051075be5"}}, "title": "Proteins associated with preserved ratio impaired spirometry.", "authors": [{"family": "Lindberg", "given": "Eva", "initials": "E", "orcid": "0000-0002-8552-4510", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca522368e5c04156b2cf775b42d1e4b2.json"}}, {"family": "Zhou", "given": "Xingwu", "initials": "X"}, {"family": "Behndig", "given": "Annelie F", "initials": "AF"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Egesten", "given": "Arne", "initials": "A"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Engvall", "given": "Jan E", "initials": "JE", "orcid": "0000-0002-5716-5098", "researcher": {"href": "https://publications.scilifelab.se/researcher/2dc825fc91ea40afa83516f8fd649b97.json"}}, {"family": "Eriksson", "given": "Maria J", "initials": "MJ"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hamrefors", "given": "Viktor", "initials": "V", "orcid": "0000-0002-8475-0866", "researcher": {"href": "https://publications.scilifelab.se/researcher/2ceb9dab3bf841da9cc06a51d53a296f.json"}}, {"family": "Janson", "given": "Christer", "initials": "C", "orcid": "0000-0001-5093-6980", "researcher": {"href": "https://publications.scilifelab.se/researcher/bae457d633714159a73704f9ebe7bfa6.json"}}, {"family": "Johnsson", "given": "\u00c5se", "initials": "\u00c5"}, {"family": "Lindberg", "given": "Anne", "initials": "A", "orcid": "0000-0002-3292-7471", "researcher": {"href": "https://publications.scilifelab.se/researcher/7ae273fae3f74964b42c6cc110951d64.json"}}, {"family": "Mannila", "given": "Maria", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Fredrik H", "initials": "FH"}, {"family": "Olin", "given": "Anna-Carin", "initials": "AC", "orcid": "0000-0001-6674-9020", "researcher": {"href": "https://publications.scilifelab.se/researcher/1142993cab2b44a09a1f1e7e2bf8783a.json"}}, {"family": "Sk\u00f6ld", "given": "C Magnus", "initials": "CM"}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S", "orcid": "0000-0001-9225-1306", "researcher": {"href": "https://publications.scilifelab.se/researcher/b13944767ad9446e885ce32ca88afebd.json"}}, {"family": "Tanash", "given": "Hanan", "initials": "H"}, {"family": "Tor\u00e9n", "given": "Kjell", "initials": "K"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Malinovschi", "given": "Andrei", "initials": "A", "orcid": "0000-0002-4098-7765", "researcher": {"href": "https://publications.scilifelab.se/researcher/7c246a24a09a4e67836f7ca6f1282610.json"}}, {"family": "Blomberg", "given": "Anders", "initials": "A", "orcid": "0000-0002-2452-7347", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c5b4f5240384d718af7db5d501c637d.json"}}], "type": "journal article", "published": "2025-05-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "11", "issue": "3", "issn-l": "2312-0541"}, "abstract": "Preserved ratio impaired spirometry (PRISm) is a spirometry pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied a proteomic approach to gain more insight into the biological mechanisms associated with PRISm.\n\nFrom the population-based Swedish Cardiopulmonary Bioimage Study (SCAPIS), participants in the Main (n=4835) and Pilot (n=1054) studies, were included as discovery and replication cohorts. The lower limit of normal (LLN) of post-bronchodilator forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC was defined as the fifth percentile in healthy, never-smoking SCAPIS participants. Participants were subdivided into five groups: reference: FEV1/FVC\u2265LLN and FEV1\u2265LLN and FVC\u2265LLN (n=4084)); mild chronic airflow limitation (CAL): FEV1/FVC<LLN and FEV1\u2265LLN (n=278); moderate-severe CAL: FEV1/FVC<LLN and FEV1<LLN (n=170); restrictive spirometric pattern (RSP): FEV1/FVC \u2265LLN and FVC<LLN (n=238); and PRISm: FEV1/FVC\u2265LLN and FEV1<LLN (n=238). Proximity extension assays were used to measure 168 proteins. The associations of each standardised protein were assessed with each study group by multiple linear regression models, adjusting for age, sex, body mass index (BMI), smoking, physical activity and study centres, and corrected for multiple testing to control for a false discovery rate of 5%.\n\nEight proteins were associated with PRISm and replicated: tumour necrosis factor receptor superfamily member 10A, interleukin-6, paraoxonase 3 (negative association), renin, urokinase plasminogen activator surface receptor (U-PAR), E-selectin, matrix metalloproteinase 7 and chitinase-3-like protein 1. Interleukin-6 and U-PAR were also associated with moderate-severe CAL and E-selectin with RSP. In addition, five other proteins were associated with moderate-severe CAL and three with RSP.\n\nProtein profile in PRISm differs from other spirometric patterns suggesting specific disease mechanisms.", "doi": "10.1183/23120541.01045-2024", "pmid": "40589910", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12208607"}, {"db": "pii", "key": "01045-2024"}], "notes": [], "created": "2025-11-25T19:23:20.139Z", "modified": "2025-11-25T19:23:20.300Z"}, {"entity": "publication", "iuid": "403ee779ad0242188b01c12a86d2372d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/403ee779ad0242188b01c12a86d2372d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/403ee779ad0242188b01c12a86d2372d"}}, "title": "Intermediate Monocytes and High Levels of Chemokine CCL3 Are Associated With Increased Risk of Atrial Fibrillation in the General Population.", "authors": [{"family": "Sveen", "given": "Kari Anne", "initials": "KA", "orcid": "0000-0002-1034-9965", "researcher": {"href": "https://publications.scilifelab.se/researcher/9bdf179c8dd74091bd071a659de73816.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications.scilifelab.se/researcher/26e50df6bb7f4194a52546dbd5652e84.json"}}, {"family": "Goncalves", "given": "Isabel", "initials": "I", "orcid": "0000-0002-2935-0181", "researcher": {"href": "https://publications.scilifelab.se/researcher/53cb42ac6ae8458ea9aaaa1dec1717d9.json"}}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2691-9192", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4d8310d9d834bd791b791424774b989.json"}}, {"family": "Engelbertsen", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0289-5210", "researcher": {"href": "https://publications.scilifelab.se/researcher/fc4f0e42f9444337adb276360c27c5cc.json"}}, {"family": "Johnson", "given": "Linda S", "initials": "LS", "orcid": "0000-0002-2249-8220", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa7398daec4e4ffaaa4b2b05ef8906a9.json"}}, {"family": "Melander", "given": "Olle", "initials": "O", "orcid": "0000-0002-2581-484X", "researcher": {"href": "https://publications.scilifelab.se/researcher/868a7e41aa054097a85575aa1d9658cc.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Nilsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-9752-7479", "researcher": {"href": "https://publications.scilifelab.se/researcher/8777140448bc47f0a7984db3c15c0e23.json"}}, {"family": "Bj\u00f6rkbacka", "given": "Harry", "initials": "H", "orcid": "0000-0003-3918-0857", "researcher": {"href": "https://publications.scilifelab.se/researcher/9f4c07bc840f491d843f67a9932d5f3a.json"}}, {"family": "Bengtsson", "given": "Eva", "initials": "E", "orcid": "0000-0001-7075-1772", "researcher": {"href": "https://publications.scilifelab.se/researcher/fde391a1fac24b6ea0e58db2fe1ff6d3.json"}}], "type": "letter", "published": "2025-05-00", "journal": {"title": "Circ Arrhythm Electrophysiol", "issn": "1941-3084", "volume": "18", "issue": "5", "pages": "e013621", "issn-l": null}, "abstract": null, "doi": "10.1161/CIRCEP.124.013621", "pmid": "40242861", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12094257"}], "notes": [], "created": "2025-11-25T19:23:13.321Z", "modified": "2025-11-25T19:23:13.511Z"}, {"entity": "publication", "iuid": "823e715bcc0e4ef089479230e12377ae", "links": {"self": {"href": "https://publications.scilifelab.se/publication/823e715bcc0e4ef089479230e12377ae.json"}, "display": {"href": "https://publications.scilifelab.se/publication/823e715bcc0e4ef089479230e12377ae"}}, "title": "Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.", "authors": [{"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Dekkers", "given": "Koen", "initials": "K"}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahlm", "given": "Kristin", "initials": "K"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Brandberg", "given": "John", "initials": "J"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Cederlund", "given": "Kerstin", "initials": "K"}, {"family": "Duvernoy", "given": "Olov", "initials": "O"}, {"family": "Engvall", "given": "Jan E", "initials": "JE"}, {"family": "Eriksson", "given": "Maria J", "initials": "MJ"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hagstr\u00f6m", "given": "Emil", "initials": "E"}, {"family": "Hamrefors", "given": "Viktor", "initials": "V"}, {"family": "Hedner", "given": "Jan", "initials": "J"}, {"family": "Janzon", "given": "Magnus", "initials": "M"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Johnson", "given": "Linda", "initials": "L"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lindberg", "given": "Eva", "initials": "E"}, {"family": "Mannila", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Ulf", "initials": "U"}, {"family": "Persson", "given": "Anders", "initials": "A"}, {"family": "Persson", "given": "Hans Lennart", "initials": "HL"}, {"family": "Persson", "given": "Margaretha", "initials": "M"}, {"family": "Ramnemark", "given": "Anna", "initials": "A"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Schmidt", "given": "Caroline", "initials": "C"}, {"family": "Skoglund Larsson", "given": "Linn", "initials": "L"}, {"family": "Sk\u00f6ld", "given": "C Magnus", "initials": "CM"}, {"family": "Swahn", "given": "Eva", "initials": "E"}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S"}, {"family": "Tor\u00e9n", "given": "Kjell", "initials": "K"}, {"family": "Waldenstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Wollmer", "given": "Per", "initials": "P"}, {"family": "Zaigham", "given": "Suneela", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2024-01-00", "journal": {"title": "Eur. J. Epidemiol.", "issn": "1573-7284", "volume": "39", "issue": "1", "pages": "35-49", "issn-l": "0393-2990"}, "abstract": "Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.", "doi": "10.1007/s10654-023-01088-z", "pmid": "38165527", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10811042"}, {"db": "pii", "key": "10.1007/s10654-023-01088-z"}], "notes": [], "created": "2024-11-25T10:11:04.848Z", "modified": "2024-11-25T10:11:04.867Z"}, {"entity": "publication", "iuid": "4f762ac2da69462cae587f44662a03f9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4f762ac2da69462cae587f44662a03f9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4f762ac2da69462cae587f44662a03f9"}}, "title": "Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort.", "authors": [{"family": "Korduner", "given": "J", "initials": "J", "orcid": "0000-0003-4132-1516", "researcher": {"href": "https://publications.scilifelab.se/researcher/b91b185ec61548c78609197099113ab0.json"}}, {"family": "Nilsson", "given": "P M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications.scilifelab.se/researcher/f23c2a10ac2a4d73a8f62b94855635f1.json"}}, {"family": "Melander", "given": "O", "initials": "O", "orcid": "0000-0002-2581-484X", "researcher": {"href": "https://publications.scilifelab.se/researcher/868a7e41aa054097a85575aa1d9658cc.json"}}, {"family": "Gerl", "given": "M J", "initials": "MJ", "orcid": "0000-0002-8074-7221", "researcher": {"href": "https://publications.scilifelab.se/researcher/e126ba158b6b413d8e234f2b7ddc4720.json"}}, {"family": "Engstr\u00f6m", "given": "G", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Bachus", "given": "E", "initials": "E", "orcid": "0000-0001-8665-6892", "researcher": {"href": "https://publications.scilifelab.se/researcher/f394dc718c604ad68db66e68c21d5385.json"}}, {"family": "Magnusson", "given": "M", "initials": "M", "orcid": "0000-0003-1710-5936", "researcher": {"href": "https://publications.scilifelab.se/researcher/6126a96481bb4c398a6e8ab6fa596b28.json"}}, {"family": "Ottosson", "given": "F", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications.scilifelab.se/researcher/14c6874eea0d4fd59677b024c2ca58bf.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "J Obes", "issn": "2090-0716", "volume": "2021", "pages": "6616983", "issn-l": null}, "abstract": "Associations between different biomarkers (proteomics, lipidomics, and metabolomics) coupled to either MHO or metabolically unhealthy obese (MUO) individuals were analyzed through principal component analysis (PCA). Subjects were identified from a subsample of 416 obese individuals, selected from the Malm\u00f6 Diet and Cancer study-Cardiovascular arm (MDCS-CV, n = 3,443). They were further divided into MHO (n = 143) and MUO (n = 273) defined by a history of hospitalization, or not, at baseline inclusion, and nonobese subjects (NOC, n = 3,027). Two distinctive principle components (PL2, PP5) were discovered with a significant difference and thus further investigated through their main loadings.\n\nMHO individuals had a more metabolically favorable lipid and glucose profile than MUO subjects, that is, lower levels of traditional blood glucose and triglycerides, as well as a trend of lower metabolically unfavorable lipid biomarkers. PL2 (lipidomics, p=0.02) showed stronger associations of triacylglycerides with MUO, whereas phospholipids correlated with MHO. PP5 (proteomics, p=0.01) included interleukin-1 receptor antagonist (IL-1ra) and leptin with positive relations to MUO and galanin that correlated positively to MHO. The group differences in metabolite profiles were to a large extent explained by factors included in the metabolic syndrome.\n\nCompared to MUO individuals, corresponding MHO individuals present with a more favorable lipid metabolic profile, accompanied by a downregulation of potentially harmful proteomic biomarkers. This unique and extensive biomarker profiling presents novel data on potentially differentiating traits between these two obese phenotypes.", "doi": "10.1155/2021/6616983", "pmid": "34659828", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8514926"}], "notes": [], "created": "2021-12-10T10:05:18.577Z", "modified": "2022-12-02T08:54:36.561Z"}, {"entity": "publication", "iuid": "f61c6bdd2de747f392055a5d9c4b6c9a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f61c6bdd2de747f392055a5d9c4b6c9a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f61c6bdd2de747f392055a5d9c4b6c9a"}}, "title": "Hyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events.", "authors": [{"family": "Sun", "given": "Jiangming", "initials": "J", "orcid": "0000-0001-6814-1297", "researcher": {"href": "https://publications.scilifelab.se/researcher/358e5b727c9c40ff94848a9d7a8d5945.json"}}, {"family": "Singh", "given": "Pratibha", "initials": "P"}, {"family": "\u00d6sterlund", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e54fbe6f0fc4eed93108b382e1b2952.json"}}, {"family": "Melander", "given": "Olle", "initials": "O", "orcid": "0000-0002-2581-484X", "researcher": {"href": "https://publications.scilifelab.se/researcher/868a7e41aa054097a85575aa1d9658cc.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2691-9192", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4d8310d9d834bd791b791424774b989.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J. Intern. Med.", "issn": "1365-2796", "volume": "290", "issue": "4", "pages": "855-865", "issn-l": "0954-6820"}, "abstract": "Apoptosis is central in both diabetes and atherosclerosis, linked to pancreatic beta cell death and plaque progression. Circulating Caspase-3 has also been associated with diabetes and coronary calcium score. Here, we explored if soluble Caspase-3 (sCaspase-3) is associated with cardio-metabolic risk factors and predicts incidence of diabetes and coronary artery disease (CAD).\n\nClinical data and plasma from 4637 individuals from the Malm\u00f6 Diet and Cancer cohort were studied. Plasma sCaspase-3 was measured by a Proximity Extension Assay. National registers were used to identify diabetes and CAD events during follow-up. Type 2 diabetes risk variants and expression quantitative trait loci (eQTL) for sCaspase-3 were retrieved from the DIAGRAM consortium and the Genotype-Tissue Expression project.\n\nHbA1c was the factor with the strongest association with sCaspase-3 (r = 0.18, P = 1.3x10-36 ). During follow-up 666 individuals developed diabetes and 648 individuals suffered from CAD. Increasing sCaspase-3 was associated with a higher risk of developing diabetes (hazard ratio (HR) 1.18 per 1unit; P = 7 \u00d7 10-5 ) and CAD (HR 1.2 per 1 unit, P = 1 \u00d7 10-4 ) during follow-up. A genetic variant rs60780116, located upstream of CASP3, showed strong association with type 2 diabetes (OR 1.06, 95%CI 1.04-1.07, P = 8.4 \u00d7 10-11 ). An eQTL was identified between this variant and gene expression of CASP3, where the allele positively correlated with type 2 diabetes was associated with increased CASP3 expression in blood.\n\nThe present study provides evidence for plasma sCaspase-3 as a marker of cardio-metabolic risk factors and as a predictor of future diabetes and CAD in a cohort without cardiovascular disease or diabetes at baseline.", "doi": "10.1111/joim.13327", "pmid": "34309093", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2021-12-10T09:10:01.585Z", "modified": "2021-12-10T09:10:01.790Z"}]}