{"entity": "researcher", "timestamp": "2026-07-20T22:53:46.920Z", "family": "Karlsson", "given": "Ida K", "initials": "IK", "orcid": "0000-0003-3605-7829", "affiliations": ["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. ida.karlsson@ki.se.", "Institute of Gerontology and Aging Research Network - J\u00f6nk\u00f6ping (ARN-J), School of Health and Welfare, J\u00f6nk\u00f6ping University, J\u00f6nk\u00f6ping, Sweden. ida.karlsson@ki.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/b2c87ada82ae43df9753a891305ddb40.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/b2c87ada82ae43df9753a891305ddb40"}}, "publications": [{"entity": "publication", "iuid": "7e532fb85545426880d8fb6fec942f51", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7e532fb85545426880d8fb6fec942f51.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7e532fb85545426880d8fb6fec942f51"}}, "title": "Epigenome-wide analysis of frailty: Results from two European twin cohorts.", "authors": [{"family": "Mak", "given": "Jonathan K L", "initials": "JKL", "orcid": "0000-0003-4454-8580", "researcher": {"href": "https://publications.scilifelab.se/researcher/4994e82ef4784f06aff8017a9cf9ad1c.json"}}, {"family": "Skovgaard", "given": "Asmus Cosmos", "initials": "AC"}, {"family": "Nygaard", "given": "Marianne", "initials": "M"}, {"family": "Kananen", "given": "Laura", "initials": "L", "orcid": "0000-0003-3742-8927", "researcher": {"href": "https://publications.scilifelab.se/researcher/b95c9eeb27214482bbbca978d69d79c7.json"}}, {"family": "Reynolds", "given": "Chandra A", "initials": "CA"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "Kuja-Halkola", "given": "Ralf", "initials": "R"}, {"family": "Karlsson", "given": "Ida K", "initials": "IK", "orcid": "0000-0003-3605-7829", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2c87ada82ae43df9753a891305ddb40.json"}}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S", "orcid": "0000-0002-2452-1500", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1d010dfe5d84a33b6a6c7ec815ca3dc.json"}}, {"family": "Soerensen", "given": "Mette", "initials": "M"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}], "type": "journal article", "published": "2024-02-27", "journal": {"title": "Aging Cell", "issn": "1474-9726", "pages": "e14135", "issn-l": "1474-9718"}, "abstract": "Epigenetics plays an important role in the aging process, but it is unclear whether epigenetic factors also influence frailty, an age-related state of physiological decline. In this study, we performed a meta-analysis of epigenome-wide association studies in four samples drawn from the Swedish Adoption/Twin Study of Aging (SATSA) and the Longitudinal Study of Aging Danish Twins (LSADT) to explore the association between DNA methylation and frailty. Frailty was defined using the frailty index (FI), and DNA methylation levels were measured in whole blood using Illumina's Infinium HumanMethylation450K and MethylationEPIC arrays. In the meta-analysis consisting of a total of 829 participants, we identified 589 CpG sites that were statistically significantly associated with either the continuous or categorical FI (false discovery rate <0.05). Many of these CpGs have previously been associated with age and age-related diseases. The identified sites were also largely directionally consistent in a longitudinal analysis using mixed-effects models in SATSA, where the participants were followed up to a maximum of 20 years. Moreover, we identified three differentially methylated regions within the MGRN1, MIR596, and TAPBP genes that have been linked to neuronal aging, tumor growth, and immune functions. Furthermore, our meta-analysis results replicated 34 of the 77 previously reported frailty-associated CpGs at p < 0.05. In conclusion, our findings demonstrate robust associations between frailty and DNA methylation levels in 589 novel CpGs, previously unidentified for frailty, and strengthen the role of neuronal/brain pathways in frailty.", "doi": "10.1111/acel.14135", "pmid": "38414347", "labels": {"NGI Short read": "Service", "NGI SNP genotyping": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [], "notes": [], "created": "2024-03-21T08:58:19.904Z", "modified": "2024-03-21T08:58:20.068Z"}, {"entity": "publication", "iuid": "044cd2cc0a644d81948691614fa8c89b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/044cd2cc0a644d81948691614fa8c89b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/044cd2cc0a644d81948691614fa8c89b"}}, "title": "Leukocyte DNA methylation in Alzheimer\u00b4s disease associated genes: replication of findings from neuronal cells.", "authors": [{"family": "Karlsson", "given": "Ida K", "initials": "IK", "orcid": "0000-0003-3605-7829", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2c87ada82ae43df9753a891305ddb40.json"}}, {"family": "Ploner", "given": "Alexander", "initials": "A"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "Gatz", "given": "Margaret", "initials": "M"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}], "type": "journal article", "published": "2022-12-26", "journal": {"title": "Epigenetics", "issn": "1559-2308", "pages": "1-5", "issn-l": "1559-2294"}, "abstract": "Differences in gene-wide DNA methylation of the Alzheimer's disease (AD)-associated genes BIN1, HLA-DRB5, SORL1, SLC24A4, and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations could be found in leukocytes collected pre-mortem. Using cohort data of 544 Swedish twins (204 dementia diagnoses), we replicated the findings in HLA-DRB5 and SLC24A4 at P < 0.05. However, co-twin control analyses indicated that the associations were partly explained by familial confounding. Thus, DNA methylation differences in HLA-DRB5 and SLC24A4 are present in both neuronal cells and leukocytes, and not fully explained familial factors.", "doi": "10.1080/15592294.2022.2158285", "pmid": "36573011", "labels": {"NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [], "notes": [], "created": "2023-01-07T19:43:44.639Z", "modified": "2023-01-19T07:58:14.561Z"}, {"entity": "publication", "iuid": "a4bc69e0882f4272ad5f75cd97457b73", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a4bc69e0882f4272ad5f75cd97457b73.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a4bc69e0882f4272ad5f75cd97457b73"}}, "title": "Epigenome-wide association study of level and change in cognitive abilities from midlife through late life.", "authors": [{"family": "Karlsson", "given": "Ida K", "initials": "IK", "orcid": "0000-0003-3605-7829", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2c87ada82ae43df9753a891305ddb40.json"}}, {"family": "Ericsson", "given": "Malin", "initials": "M"}, {"family": "Wang", "given": "Yunzhang", "initials": "Y"}, {"family": "Jylh\u00e4v\u00e4", "given": "Juulia", "initials": "J"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Dahl Aslan", "given": "Anna K", "initials": "AK"}, {"family": "Reynolds", "given": "Chandra A", "initials": "CA"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}], "type": "journal article", "published": "2021-04-21", "journal": {"title": "Clin Epigenetics", "issn": "1868-7083", "issn-l": "1868-7075", "volume": "13", "issue": "1", "pages": "85"}, "abstract": "Epigenetic mechanisms are important in aging and may be involved in late-life changes in cognitive abilities. We conducted an epigenome-wide association study of leukocyte DNA methylation in relation to level and change in cognitive abilities, from midlife through late life in 535 Swedish twins.\n\nMethylation levels were measured with the Infinium Human Methylation 450 K or Infinium MethylationEPIC array, and all sites passing quality control on both arrays were selected for analysis (n = 250,816). Empirical Bayes estimates of individual intercept (age 65), linear, and quadratic change were obtained from latent growth curve models of cognitive traits and used as outcomes in linear regression models. Significant sites (p < 2.4 \u00d7 10-7) were followed up in between-within twin pair models adjusting for familial confounding and full-growth modeling. We identified six significant associations between DNA methylation and level of cognitive abilities at age 65: cg18064256 (PPP1R13L) with processing speed and spatial ability; cg04549090 (NRXN3) with spatial ability; cg09988380 (POGZ), cg25651129 (-), and cg08011941 (ENTPD8) with working memory. The genes are involved in neuroinflammation, neuropsychiatric disorders, and ATP metabolism. Within-pair associations were approximately half that of between-pair associations across all sites. In full-growth curve models, associations between DNA methylation and cognitive level at age 65 were of small effect sizes, and associations between DNA methylation and longitudinal change in cognitive abilities of very small effect sizes.\n\nLeukocyte DNA methylation was associated with level, but not change in cognitive abilities. The associations were substantially attenuated in within-pair analyses, indicating they are influenced in part by genetic factors.", "doi": "10.1186/s13148-021-01075-9", "pmid": "33883019", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1186/s13148-021-01075-9"}, {"db": "pmc", "key": "PMC8061224"}], "notes": [], "created": "2021-04-28T15:32:47.179Z", "modified": "2024-01-16T13:48:40.037Z"}]}