{"entity": "researcher", "timestamp": "2026-08-15T07:34:09.986Z", "family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "affiliations": ["Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. benedikt.strunz@ki.se niklas.bjorkstrom@ki.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50"}}, "publications": [{"entity": "publication", "iuid": "ad8544dcfbdf4b14a12286065b365a09", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ad8544dcfbdf4b14a12286065b365a09.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ad8544dcfbdf4b14a12286065b365a09"}}, "title": "Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19.", "authors": [{"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Mehta", "given": "Adi", "initials": "A"}, {"family": "Wan", "given": "Hui", "initials": "H"}, {"family": "Du", "given": "Likun", "initials": "L"}, {"family": "Sun", "given": "Dan", "initials": "D"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Nordlander", "given": "Anna", "initials": "A"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Geanon", "given": "Daniel", "initials": "D"}, {"family": "Parke", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Ekwall-Larson", "given": "Anna", "initials": "A"}, {"family": "Rivino", "given": "Laura", "initials": "L"}, {"family": "MacAry", "given": "Paul A", "initials": "PA"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Pan-Hammarstr\u00f6m", "given": "Qiang", "initials": "Q"}, {"family": "Lund-Johansen", "given": "Fridtjof", "initials": "F"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Karolinska KI/K COVID-19 Study Group\n", "given": "", "initials": ""}], "type": "journal article", "published": "2024-08-16", "journal": {"title": "J. Infect. Dis.", "issn": "1537-6613", "volume": "230", "issue": "2", "pages": "e318-e326", "issn-l": "0022-1899"}, "abstract": "Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).\n\nThis study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.\n\naIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.\n\nOur data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.", "doi": "10.1093/infdis/jiae036", "pmid": "38421006", "labels": {"Autoimmunity and Serology Profiling": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11326830"}, {"db": "pii", "key": "7616238"}], "notes": [], "created": "2024-10-22T09:29:19.468Z", "modified": "2024-10-22T09:29:19.486Z"}, {"entity": "publication", "iuid": "77d5898d6e3a4fa0ae0fcc6e5870b659", "links": {"self": {"href": "https://publications.scilifelab.se/publication/77d5898d6e3a4fa0ae0fcc6e5870b659.json"}, "display": {"href": "https://publications.scilifelab.se/publication/77d5898d6e3a4fa0ae0fcc6e5870b659"}}, "title": "Tissue-specific nonheritable influences drive endometrial immune system variation.", "authors": [{"family": "Bister", "given": "Jonna", "initials": "J", "orcid": "0009-0003-4604-5060", "researcher": {"href": "https://publications.scilifelab.se/researcher/f6bcfb38814c452ab78f1410e79b759e.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Sun", "given": "Dan", "initials": "D", "orcid": "0000-0003-2147-9308", "researcher": {"href": "https://publications.scilifelab.se/researcher/565b38c0fdb0496fa4a687e94fd05d9e.json"}}, {"family": "Crona-Guterstam", "given": "Ylva", "initials": "Y", "orcid": "0000-0003-4998-4904", "researcher": {"href": "https://publications.scilifelab.se/researcher/be2bb2deeaf2411fac4aac4627016cf2.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications.scilifelab.se/researcher/aad5c88284e54bd0af1e3ce4004dd24c.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-1432-8344", "researcher": {"href": "https://publications.scilifelab.se/researcher/752d22e542a04648b1807f91fe225f6e.json"}}, {"family": "Ivarsson", "given": "Martin A", "initials": "MA", "orcid": "0000-0002-7745-1331", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd83443b18774e3d91400e3cedc045d6.json"}}, {"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}], "type": "journal article", "published": "2024-04-05", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "9", "issue": "94", "pages": "eadj7168", "issn-l": null}, "abstract": "Although human twin studies have revealed the combined contribution of heritable and environmental factors in shaping immune system variability in blood, the contribution of these factors to immune system variability in tissues remains unexplored. The human uterus undergoes constant regeneration and is exposed to distinct environmental factors. To assess uterine immune system variation, we performed a system-level analysis of endometrial and peripheral blood immune cells in monozygotic twins. Although most immune cell phenotypes in peripheral blood showed high genetic heritability, more variation was found in endometrial immune cells, indicating a stronger influence by environmental factors. Cytomegalovirus infection was identified to influence peripheral blood immune cell variability but had limited effect on endometrial immune cells. Instead, hormonal contraception shaped the local endometrial milieu and immune cell composition with minor influence on the systemic immune system. These results highlight that the magnitude of human immune system variation and factors influencing it can be tissue specific.", "doi": "10.1126/sciimmunol.adj7168", "pmid": "38579017", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-27T22:24:35.577Z", "modified": "2024-11-27T22:24:35.950Z"}, {"entity": "publication", "iuid": "5fb5fa2c98ce45d987c2ea90cb96920a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5fb5fa2c98ce45d987c2ea90cb96920a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5fb5fa2c98ce45d987c2ea90cb96920a"}}, "title": "Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.", "authors": [{"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "J\u00f6nsson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-8389-975X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb54cd37d49c401a9b32067fca10ac47.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Crona-Guterstam", "given": "Ylva", "initials": "Y", "orcid": "0000-0003-4998-4904", "researcher": {"href": "https://publications.scilifelab.se/researcher/be2bb2deeaf2411fac4aac4627016cf2.json"}}, {"family": "Kvedaraite", "given": "Egle", "initials": "E", "orcid": "0000-0001-5308-092X", "researcher": {"href": "https://publications.scilifelab.se/researcher/78502177bad3453a8d3ed96d4ad334ac.json"}}, {"family": "Sleiers", "given": "Natalie", "initials": "N", "orcid": "0000-0002-9378-8145", "researcher": {"href": "https://publications.scilifelab.se/researcher/07af0b70210044bdb8ec575101ac49c0.json"}}, {"family": "Dumitrescu", "given": "Bogdan", "initials": "B", "orcid": "0000-0002-9986-3396", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0d9af82119645cd83cbc1aaffe1a967.json"}}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M", "orcid": "0000-0002-6081-9101", "researcher": {"href": "https://publications.scilifelab.se/researcher/3349b0acffde45d3807643f8d6a61e06.json"}}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications.scilifelab.se/researcher/e282901d24c64b16a540eff0d57776f4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb82c502293d424cb266e1c4e405485f.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications.scilifelab.se/researcher/aad5c88284e54bd0af1e3ce4004dd24c.json"}}, {"family": "Willinger", "given": "Tim", "initials": "T"}, {"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Hamilton", "given": "Russell S", "initials": "RS", "orcid": "0000-0002-0598-3793", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f0bb3c84fa244afbf1372666d603479.json"}}, {"family": "Ivarsson", "given": "Martin A", "initials": "MA"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": null, "volume": "6", "issue": "56", "pages": "eabb7800"}, "abstract": "Immune cell differentiation is critical for adequate tissue-specific immune responses to occur. Here, we studied differentiation of human uterine natural killer cells (uNK cells). These cells reside in a tissue undergoing constant regeneration and represent the major leukocyte population at the maternal-fetal interface. However, their physiological response during the menstrual cycle and in pregnancy remains elusive. By surface proteome and transcriptome analysis as well as using humanized mice, we identify a differentiation pathway of uNK cells in vitro and in vivo with sequential acquisition of killer cell immunoglobulin-like receptors and CD39. uNK cell differentiation occurred continuously in response to the endometrial regeneration and was driven by interleukin-15. Differentiated uNK cells displayed reduced proliferative capacity and immunomodulatory function including enhanced angiogenic capacity. By studying human uterus transplantation and monozygotic twins, we found that the uNK cell niche could be replenished from circulation and that it was under genetic control. Together, our study uncovers a continuous differentiation pathway of human NK cells in the uterus that is coupled to profound functional changes in response to local tissue regeneration and pregnancy.", "doi": "10.1126/sciimmunol.abb7800", "pmid": "33617461", "labels": {"Cellular Immunomonitoring": "Service"}, "xrefs": [{"db": "pii", "key": "6/56/eabb7800"}], "notes": [], "created": "2021-02-23T20:18:56.191Z", "modified": "2021-12-09T08:31:54.136Z"}]}