{"entity": "researcher", "timestamp": "2026-08-11T14:18:51.653Z", "family": "Nordin", "given": "Elise", "initials": "E", "orcid": "0000-0001-5317-3261", "affiliations": ["Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/acf803706d2f4cfca45c1517cd30a983.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/acf803706d2f4cfca45c1517cd30a983"}}, "publications": [{"entity": "publication", "iuid": "8a4b91fa3af3478a97d729479aec1526", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8a4b91fa3af3478a97d729479aec1526.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8a4b91fa3af3478a97d729479aec1526"}}, "title": "Exploration of differential responses to FODMAPs and gluten in people with irritable bowel syndrome- a double-blind randomized cross-over challenge study.", "authors": [{"family": "Nordin", "given": "Elise", "initials": "E", "orcid": "0000-0001-5317-3261", "researcher": {"href": "https://publications.scilifelab.se/researcher/acf803706d2f4cfca45c1517cd30a983.json"}}, {"family": "Landberg", "given": "Rikard", "initials": "R", "orcid": "0000-0002-6399-7608", "researcher": {"href": "https://publications.scilifelab.se/researcher/4472ec17986146d1a095acdb202815e6.json"}}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM", "orcid": "0000-0001-9803-7271", "researcher": {"href": "https://publications.scilifelab.se/researcher/3658a8a5e7b94b58aa3814af45d09b65.json"}}, {"family": "Brunius", "given": "Carl", "initials": "C", "orcid": "0000-0003-3957-870X", "researcher": {"href": "https://publications.scilifelab.se/researcher/560a5d14ee83421680058b00df2ac9e2.json"}}], "type": "randomized controlled trial", "published": "2024-02-12", "journal": {"title": "Metabolomics", "issn": "1573-3890", "volume": "20", "issue": "2", "pages": "21", "issn-l": "1573-3882"}, "abstract": "There is large variation in response to diet in irritable bowel syndrome (IBS) and determinants for differential response are poorly understood.\n\nOur aim was to investigate differential clinical and molecular responses to provocation with fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) and gluten in individuals with IBS.\n\nData were used from a crossover study with week-long interventions with either FODMAPs, gluten or placebo. The study also included a rapid provocation test. Molecular data consisted of fecal microbiota, short chain fatty acids, and untargeted plasma metabolomics. IBS symptoms were evaluated with the IBS severity scoring system. IBS symptoms were modelled against molecular and baseline questionnaire data, using Random Forest (RF; regression and clustering), Parallel Factor Analysis (PARAFAC), and univariate methods.\n\nRegression and classification RF models were in general of low predictive power (Q2 \u2264 0.22, classification rate < 0.73). Out of 864 clustering models, only 2 had significant associations to clusters (0.69 < CR < 0.73, p < 0.05), but with no associations to baseline clinical measures. Similarly, PARAFAC revealed no clear association between metabolome data and IBS symptoms.\n\nDifferential IBS responses to FODMAPs or gluten exposures could not be explained from clinical and molecular data despite extensive exploration with different data analytical approaches. The trial is registered at www.\n\ngov as NCT03653689 31/08/2018.", "doi": "10.1007/s11306-023-02083-x", "pmid": "38347192", "labels": {"Chalmers Mass Spectrometry Infrastructure": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10861383"}, {"db": "pii", "key": "10.1007/s11306-023-02083-x"}, {"db": "ClinicalTrials.gov", "key": "NCT03653689"}], "notes": [], "created": "2024-11-27T15:34:31.555Z", "modified": "2024-11-27T15:34:31.646Z"}, {"entity": "publication", "iuid": "21211fe7f6634cc882fae52a46af7b0a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/21211fe7f6634cc882fae52a46af7b0a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/21211fe7f6634cc882fae52a46af7b0a"}}, "title": "IBS randomized study: FODMAPs alter bile acids, phenolic- and tryptophan metabolites, while gluten modifies lipids.", "authors": [{"family": "Nordin", "given": "Elise", "initials": "E", "orcid": "0000-0001-5317-3261", "researcher": {"href": "https://publications.scilifelab.se/researcher/acf803706d2f4cfca45c1517cd30a983.json"}}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM", "orcid": "0000-0001-8428-0772", "researcher": {"href": "https://publications.scilifelab.se/researcher/e85863b505f34d7e95a23ac127b9d6dc.json"}}, {"family": "Vuong", "given": "Eddie", "initials": "E"}, {"family": "Ribbenstedt", "given": "Anton", "initials": "A"}, {"family": "Brunius", "given": "Carl", "initials": "C"}, {"family": "Landberg", "given": "Rikard", "initials": "R"}], "type": "randomized controlled trial", "published": "2023-09-01", "journal": {"title": "Am. J. Physiol. Regul. Integr. Comp. Physiol.", "issn": "1522-1490", "volume": "325", "issue": "3", "pages": "R248-R259", "issn-l": "0363-6119"}, "abstract": "Diet is considered a culprit for symptoms in irritable bowel syndrome (IBS), although the mechanistic understanding of underlying causes is lacking. Metabolomics, i.e., the analysis of metabolites in biological samples may offer a diet-responsive fingerprint for IBS. Our aim was to explore alterations in the plasma metabolome after interventions with fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) or gluten versus control in IBS, and to relate such alterations to symptoms. People with IBS (n = 110) were included in a double-blind, randomized, crossover study with 1-wk provocations of FODMAPs, gluten, or placebo. Symptoms were evaluated with the IBS severity scoring system (IBS-SSS). Untargeted metabolomics was performed on plasma samples using LC-qTOF-MS. Discovery of metabolite alterations by treatment was performed using random forest followed by linear mixed modeling. Associations were studied using Spearman correlation. The metabolome was affected by FODMAP [classification rate (CR) 0.88, P < 0.0001], but less by gluten intake CR 0.72, P = 0.01). FODMAP lowered bile acids, whereas phenolic-derived metabolites and 3-indolepropionic acid (IPA) were higher compared with placebo. IPA and some unidentified metabolites correlated weakly to abdominal pain and quality of life. Gluten affected lipid metabolism weakly, but with no interpretable relationship to IBS. FODMAP affected gut microbial-derived metabolites relating to positive health outcomes. IPA and unknown metabolites correlated weakly to IBS severity. Minor symptom worsening by FODMAP intake must be weighed against general positive health aspects of FODMAP. The gluten intervention affected lipid metabolism weakly with no interpretable association to IBS severity. Registration: www.clinicaltrials.gov as NCT03653689.NEW & NOTEWORTHY In irritable bowel syndrome (IBS), fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) affected microbial-derived metabolites relating to positive health outcomes such as reduced risk of colon cancer, inflammation, and type 2 diabetes, as shown in previous studies. The minor IBS symptom induction by FODMAP intake must be weighed against the positive health aspects of FODMAP consumption. Gluten affected lipids weakly with no association to IBS severity.", "doi": "10.1152/ajpregu.00016.2023", "pmid": "37399002", "labels": {"Chalmers Mass Spectrometry Infrastructure": "Collaborative", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT03653689"}, {"db": "figshare", "key": "10.6084/m9.figshare.23542068.v1"}], "notes": [], "created": "2023-11-27T21:57:58.810Z", "modified": "2024-01-16T13:48:32.340Z"}, {"entity": "publication", "iuid": "fb3479e7f94345bbbe7bc61d04efe8d2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fb3479e7f94345bbbe7bc61d04efe8d2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fb3479e7f94345bbbe7bc61d04efe8d2"}}, "title": "Effects of FODMAPs and Gluten on Gut Microbiota and Their Association with the Metabolome in Irritable Bowel Syndrome: A Double-Blind, Randomized, Cross-Over Intervention Study.", "authors": [{"family": "Nordin", "given": "Elise", "initials": "E", "orcid": "0000-0001-5317-3261", "researcher": {"href": "https://publications.scilifelab.se/researcher/acf803706d2f4cfca45c1517cd30a983.json"}}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM", "orcid": "0000-0001-8428-0772", "researcher": {"href": "https://publications.scilifelab.se/researcher/e85863b505f34d7e95a23ac127b9d6dc.json"}}, {"family": "Dicksved", "given": "Johan", "initials": "J"}, {"family": "Pelve", "given": "Erik", "initials": "E"}, {"family": "Landberg", "given": "Rikard", "initials": "R"}, {"family": "Brunius", "given": "Carl", "initials": "C"}], "type": "randomized controlled trial", "published": "2023-07-05", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "15", "issue": "13", "issn-l": "2072-6643"}, "abstract": "A mechanistic understanding of the effects of dietary treatment in irritable bowel syndrome (IBS) is lacking. Our aim was therefore to investigate how fermentable oligo- di-, monosaccharides, and polyols (FODMAPs) and gluten affected gut microbiota and circulating metabolite profiles, as well as to investigate potential links between gut microbiota, metabolites, and IBS symptoms.\n\nWe used data from a double-blind, randomized, crossover study with week-long provocations of FODMAPs, gluten, and placebo in participants with IBS. To study the effects of the provocations on fecal microbiota, fecal and plasma short-chain fatty acids, the untargeted plasma metabolome, and IBS symptoms, we used Random Forest, linear mixed model and Spearman correlation analysis.\n\nFODMAPs increased fecal saccharolytic bacteria, plasma phenolic-derived metabolites, 3-indolepropionate, and decreased isobutyrate and bile acids. Gluten decreased fecal isovalerate and altered carnitine derivatives, CoA, and fatty acids in plasma. For FODMAPs, modest correlations were observed between microbiota and phenolic-derived metabolites and 3-indolepropionate, previously associated with improved metabolic health, and reduced inflammation. Correlations between molecular data and IBS symptoms were weak.\n\nFODMAPs, but not gluten, altered microbiota composition and correlated with phenolic-derived metabolites and 3-indolepropionate, with only weak associations with IBS symptoms. Thus, the minor effect of FODMAPs on IBS symptoms must be weighed against the effect on microbiota and metabolites related to positive health factors.", "doi": "10.3390/nu15133045", "pmid": "37447371", "labels": {"Chalmers Mass Spectrometry Infrastructure": "Collaborative", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10346910"}, {"db": "pii", "key": "nu15133045"}], "notes": [], "created": "2023-11-27T22:02:27.949Z", "modified": "2024-01-16T13:48:32.990Z"}, {"entity": "publication", "iuid": "be17ea5f8a81491f9914bfd2714db81a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/be17ea5f8a81491f9914bfd2714db81a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/be17ea5f8a81491f9914bfd2714db81a"}}, "title": "Fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs), but not gluten, elicit modest symptoms of irritable bowel syndrome: a double-blind, placebo-controlled, randomized three-way crossover trial.", "authors": [{"family": "Nordin", "given": "Elise", "initials": "E", "orcid": "0000-0001-5317-3261", "researcher": {"href": "https://publications.scilifelab.se/researcher/acf803706d2f4cfca45c1517cd30a983.json"}}, {"family": "Brunius", "given": "Carl", "initials": "C", "orcid": "0000-0003-3957-870X", "researcher": {"href": "https://publications.scilifelab.se/researcher/560a5d14ee83421680058b00df2ac9e2.json"}}, {"family": "Landberg", "given": "Rikard", "initials": "R", "orcid": "0000-0002-6399-7608", "researcher": {"href": "https://publications.scilifelab.se/researcher/4472ec17986146d1a095acdb202815e6.json"}}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM", "orcid": "0000-0001-8428-0772", "researcher": {"href": "https://publications.scilifelab.se/researcher/e85863b505f34d7e95a23ac127b9d6dc.json"}}], "type": "journal article", "published": "2022-02-09", "journal": {"title": "Am. J. Clin. Nutr.", "issn": "1938-3207", "volume": "115", "issue": "2", "pages": "344-352", "issn-l": "0002-9165"}, "abstract": "Irritable bowel syndrome (IBS) has been associated with diets rich in fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs), and gluten. Most previous studies have been single-blind and have focused on the elimination of FODMAPs or provocation with single FODMAPs. The effect of gluten is unclear, large trials isolating the effect of gluten from that of FODMAPs are needed.\n\nThe aims of this study were to ensure high intakes of a wide range of FODMAPs, gluten, or placebo, and to evaluate the effects on IBS symptoms using the IBS-severity scoring system (IBS-SSS).\n\nThe study was carried out with a double-blind, placebo-controlled, randomized 3-way crossover design in a clinical facility in Uppsala from September 2018 to June 2019. In all, 110 participants fulfilling the IBS Rome IV criteria, with moderate to severe IBS, were randomly assigned; 103 (90 female, 13 male) completed the trial. Throughout, IBS participants maintained a diet with minimal FODMAP content and no gluten. Participants were block-randomly assigned to 1-wk interventions with FODMAPs (50 g/d), gluten (17.3 g/d), or placebo, separated by 1-wk washout. All participants who completed \u22651 intervention were included in the intention-to-treat analysis.\n\nIn participants with IBS (n = 103), FODMAPs caused higher IBS-SSS scores (mean 240 [95% CI: 222, 257]) than placebo (198 [180, 215]; P = 0.00056) or gluten (208 [190, 226]; P = 0.013); no differences were found between the placebo and gluten groups (P = 1.0). There were large interindividual differences in IBS-SSS scores associated with treatment. No adverse events were reported.\n\nIn participants with IBS, FODMAPs had a modest effect on typical IBS symptoms, whereas gluten had no effect. The large interindividual differences in responses to the interventions warrant further detailed studies to identify possible underlying causes and enable individual prediction of responses. This trial was registered at www.clinicaltrials.gov as NCT03653689.", "doi": "10.1093/ajcn/nqab337", "pmid": "34617561", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8827068"}, {"db": "pii", "key": "S0002-9165(22)00144-7"}, {"db": "ClinicalTrials.gov", "key": "NCT03653689"}], "notes": [], "created": "2023-11-27T21:51:50.572Z", "modified": "2024-01-16T13:48:37.518Z"}]}