{"entity": "researcher", "timestamp": "2026-10-05T20:18:13.529Z", "family": "Vanlandewijck", "given": "Michael", "initials": "M", "orcid": "0000-0002-0709-7808", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/aa2148fbafb44d59bd110e36bd77769c.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/aa2148fbafb44d59bd110e36bd77769c"}}, "publications": [{"entity": "publication", "iuid": "4371a4380e6d4e3294f5c4116411dd13", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4371a4380e6d4e3294f5c4116411dd13.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4371a4380e6d4e3294f5c4116411dd13"}}, "title": "Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation.", "authors": [{"family": "Petkova", "given": "Milena", "initials": "M", "orcid": "0000-0002-7186-7256", "researcher": {"href": "https://publications.scilifelab.se/researcher/458b9dbc408c4118b97be343da8b3b49.json"}}, {"family": "Kraft", "given": "Marle", "initials": "M", "orcid": "0000-0002-3523-7003", "researcher": {"href": "https://publications.scilifelab.se/researcher/6bac6d144f4143b7ad9ad0a9058d95a0.json"}}, {"family": "Stritt", "given": "Simon", "initials": "S", "orcid": "0000-0002-4299-4934", "researcher": {"href": "https://publications.scilifelab.se/researcher/b561f8d6fb1a46d0ae76c66e440956a1.json"}}, {"family": "Martinez-Corral", "given": "Ines", "initials": "I", "orcid": "0000-0001-9194-2412", "researcher": {"href": "https://publications.scilifelab.se/researcher/0f961131890c4422b8ce5a5d2d1f1dc9.json"}}, {"family": "Orts\u00e4ter", "given": "Henrik", "initials": "H", "orcid": "0000-0002-4046-4702", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f597cc7c8104728ae168db36a8ee9e7.json"}}, {"family": "Vanlandewijck", "given": "Michael", "initials": "M", "orcid": "0000-0002-0709-7808", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa2148fbafb44d59bd110e36bd77769c.json"}}, {"family": "Jakic", "given": "Bojana", "initials": "B", "orcid": "0000-0002-2339-5928", "researcher": {"href": "https://publications.scilifelab.se/researcher/31f0bb6137144060a45a40650aacadc7.json"}}, {"family": "Baselga", "given": "Eul\u00e0lia", "initials": "E", "orcid": "0000-0003-1086-8439", "researcher": {"href": "https://publications.scilifelab.se/researcher/12b835a79f01492e82d1280c8050e01b.json"}}, {"family": "Castillo", "given": "Sandra D", "initials": "SD", "orcid": "0000-0002-7007-3155", "researcher": {"href": "https://publications.scilifelab.se/researcher/de3d0367a9d8474197f66365c1b5c040.json"}}, {"family": "Graupera", "given": "Mariona", "initials": "M", "orcid": "0000-0003-4608-4185", "researcher": {"href": "https://publications.scilifelab.se/researcher/76ead57229884f90bff307099a9a70ea.json"}}, {"family": "Betsholtz", "given": "Christer", "initials": "C", "orcid": "0000-0002-8494-971X", "researcher": {"href": "https://publications.scilifelab.se/researcher/a00cfe9d521047f280978d84d7dcf1b3.json"}}, {"family": "M\u00e4kinen", "given": "Taija", "initials": "T", "orcid": "0000-0002-9338-1257", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf99a0589d1f4532b532bfc575edaada.json"}}], "type": "journal article", "published": "2023-04-03", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "220", "issue": "4", "issn-l": "0022-1007"}, "abstract": "Oncogenic mutations in PIK3CA, encoding p110\u03b1-PI3K, are a common cause of venous and lymphatic malformations. Vessel type-specific disease pathogenesis is poorly understood, hampering development of efficient therapies. Here, we reveal a new immune-interacting subtype of Ptx3-positive dermal lymphatic capillary endothelial cells (iLECs) that recruit pro-lymphangiogenic macrophages to promote progressive lymphatic overgrowth. Mouse model of Pik3caH1047R-driven vascular malformations showed that proliferation was induced in both venous and lymphatic ECs but sustained selectively in LECs of advanced lesions. Single-cell transcriptomics identified the iLEC population, residing at lymphatic capillary terminals of normal vasculature, that was expanded in Pik3caH1047R mice. Expression of pro-inflammatory genes, including monocyte/macrophage chemokine Ccl2, in Pik3caH1047R-iLECs was associated with recruitment of VEGF-C-producing macrophages. Macrophage depletion, CCL2 blockade, or anti-inflammatory COX-2 inhibition limited Pik3caH1047R-driven lymphangiogenesis. Thus, targeting the paracrine crosstalk involving iLECs and macrophages provides a new therapeutic opportunity for lymphatic malformations. Identification of iLECs further indicates that peripheral lymphatic vessels not only respond to but also actively orchestrate inflammatory processes.", "doi": "10.1084/jem.20220741", "pmid": "36688917", "labels": {"Bioinformatics Support and Infrastructure": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9884640"}, {"db": "pii", "key": "213817"}], "notes": [], "created": "2023-11-16T12:40:26.995Z", "modified": "2024-01-16T13:48:33.714Z"}, {"entity": "publication", "iuid": "9b592e44470a4ba18b57b727b2011b71", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9b592e44470a4ba18b57b727b2011b71.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9b592e44470a4ba18b57b727b2011b71"}}, "title": "Integrative discovery of treatments for high-risk neuroblastoma.", "authors": [{"family": "Almstedt", "given": "Elin", "initials": "E", "orcid": "0000-0002-1946-9138", "researcher": {"href": "https://publications.scilifelab.se/researcher/c4414ac7f9284bf9bf0b52530ec19ee3.json"}}, {"family": "Elgendy", "given": "Ramy", "initials": "R", "orcid": "0000-0002-2592-3448", "researcher": {"href": "https://publications.scilifelab.se/researcher/0a5ce4db4317446bb1ef113f7c6e8eb5.json"}}, {"family": "Hekmati", "given": "Neda", "initials": "N"}, {"family": "Ros\u00e9n", "given": "Emil", "initials": "E", "orcid": "0000-0002-1664-2257", "researcher": {"href": "https://publications.scilifelab.se/researcher/db0751a3a95e488bb849059c09c4fc7d.json"}}, {"family": "W\u00e4rn", "given": "Caroline", "initials": "C"}, {"family": "Olsen", "given": "Thale Kristin", "initials": "TK"}, {"family": "Dyberg", "given": "Cecilia", "initials": "C"}, {"family": "Doroszko", "given": "Milena", "initials": "M"}, {"family": "Larsson", "given": "Ida", "initials": "I", "orcid": "0000-0001-5422-4243", "researcher": {"href": "https://publications.scilifelab.se/researcher/1ac604ca793048e9b6ddaa3459b4e97a.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Arsenian Henriksson", "given": "Marie", "initials": "M"}, {"family": "P\u00e5hlman", "given": "Sven", "initials": "S"}, {"family": "Bexell", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9426-9550", "researcher": {"href": "https://publications.scilifelab.se/researcher/dda650768a264d93a80f40da6cb8d7e1.json"}}, {"family": "Vanlandewijck", "given": "Michael", "initials": "M", "orcid": "0000-0002-0709-7808", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa2148fbafb44d59bd110e36bd77769c.json"}}, {"family": "Kogner", "given": "Per", "initials": "P", "orcid": "0000-0002-2202-9694", "researcher": {"href": "https://publications.scilifelab.se/researcher/e963274b921a4a2c8263f509334d4e22.json"}}, {"family": "J\u00f6rnsten", "given": "Rebecka", "initials": "R"}, {"family": "Krona", "given": "Cecilia", "initials": "C"}, {"family": "Nelander", "given": "Sven", "initials": "S"}], "type": "journal article", "published": "2020-01-03", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "71"}, "abstract": "Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with experimental evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumour biobanks, pharmacological databases, and cellular networks to predict how targeted interventions affect mRNA signatures associated with high patient risk or disease processes. We find more than 80 targets to be associated with neuroblastoma risk and differentiation signatures. Selected targets are evaluated in cell lines derived from high-risk patients to demonstrate reversal of risk signatures and malignant phenotypes. Using neuroblastoma xenograft models, we establish CNR2 and MAPK8 as promising candidates for the treatment of high-risk neuroblastoma. We expect that our method, available as a public tool (targettranslator.org), will enhance and expedite the discovery of risk-associated targets for paediatric and adult cancers.", "doi": "10.1038/s41467-019-13817-8", "pmid": "31900415", "labels": {"Genome Engineering Zebrafish": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-019-13817-8"}, {"db": "pmc", "key": "PMC6941971"}], "notes": [], "created": "2020-01-08T11:24:16.666Z", "modified": "2021-12-09T14:05:49.139Z"}]}