{"entity": "researcher", "timestamp": "2026-10-05T20:52:39.649Z", "family": "Eils", "given": "Roland", "initials": "R", "orcid": "0000-0002-0034-4036", "affiliations": ["Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Digital Health Center, Charit\u00e9platz 1, 10117 Berlin, Germany.", "Intelligent Medicine Institute, Fudan University, Shanghai, China."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/a9ad57aa98c5431189bbd69aadc541d2.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/a9ad57aa98c5431189bbd69aadc541d2"}}, "publications": [{"entity": "publication", "iuid": "f93fd2e8247d4dc182bf9c14fadcfee5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f93fd2e8247d4dc182bf9c14fadcfee5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f93fd2e8247d4dc182bf9c14fadcfee5"}}, "title": "A single-cell multi-omic atlas of the human pancreas reveals potential for cellular plasticity across development, health, and disease", "authors": [{"family": "Mereu", "given": "Elisabetta", "initials": "E", "orcid": "0000-0001-6101-8472", "researcher": {"href": "https://publications.scilifelab.se/researcher/d263fd3d305145959169d1e1f3e76c75.json"}}, {"family": "Balboa", "given": "Diego", "initials": "D", "orcid": "0000-0002-4784-5452", "researcher": {"href": "https://publications.scilifelab.se/researcher/647a7c312e2a4307aa43a10c7d142545.json"}}, {"family": "Liebig", "given": "Johannes", "initials": "J", "orcid": "0000-0002-9188-036X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ce625220e3f645eeab019e87e73b5470.json"}}, {"family": "Gonzalez-Herrero", "given": "Aitor", "initials": "A", "orcid": "0000-0002-2644-8028", "researcher": {"href": "https://publications.scilifelab.se/researcher/8e96783efb9b45ad90ed8c1c0fa6dd11.json"}}, {"family": "Casals", "given": "Anna Martinez", "initials": "AM", "orcid": "0000-0003-2722-1965", 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"orcid": "0000-0002-2172-2198", "researcher": {"href": "https://publications.scilifelab.se/researcher/5e94e84fe1d445bcac01adae0e9800c4.json"}}, {"family": "Steiger", "given": "Katja", "initials": "K"}, {"family": "van Oudenaarden", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9442-3551", "researcher": {"href": "https://publications.scilifelab.se/researcher/86e54078e6ea45949e7468b2653601d9.json"}}, {"family": "Weichert", "given": "Wilko", "initials": "W"}, {"family": "Conrad", "given": "Christian", "initials": "C", "orcid": "0000-0001-7036-342X", "researcher": {"href": "https://publications.scilifelab.se/researcher/64b5e1b25f354b879fb0ce43e0aba260.json"}}, {"family": "Eils", "given": "Roland", "initials": "R", "orcid": "0000-0002-0034-4036", "researcher": {"href": "https://publications.scilifelab.se/researcher/a9ad57aa98c5431189bbd69aadc541d2.json"}}], "type": "journal-article", "published": "2026-08-00", "journal": {"title": "Cell Metabolism", "issn": "1550-4131", "issn-l": "1550-4131"}, "abstract": "The pancreas plays a central role in major human diseases, yet our understanding of its cellular diversity and plasticity remains incomplete. Here, we present a single-cell multiomics atlas of the human pancreas, profiling over four million cells and nuclei from 57 donors across fetal development, adult homeostasis, and type 2 diabetes (T2D). Integrating single-cell RNA sequencing (scRNA-seq)/single-nucleus RNA sequencing (snRNA-seq), snATAC-seq, VASA-seq, spatial transcriptomics (Xenium), and multiplexed proteomics (CODEX), we resolve gene expression, chromatin accessibility, and spatial organization at high resolution. We identify transcriptionally plastic centroacinar-like cells (pCACs) in adults with fetal-like features, delineate endocrine and exocrine lineage trajectories during development, and define HNF1A-defined beta cell epigenetic states. In T2D, we observe shifts in beta cell subtypes and altered regulatory programs. Glucose perturbation of healthy islets reveals cell-type-specific adaptation and stress responses. This atlas provides a foundational framework to understand pancreas biology and the role of cellular plasticity in regeneration and disease.", "doi": "10.1016/j.cmet.2026.07.023", "pmid": "42586061", "labels": {"Spatial Proteomics": "Service"}, "xrefs": [{"db": "pii", "key": "S1550-4131(26)00296-2"}], "notes": [], "created": "2026-08-13T07:03:22.299Z", "modified": "2026-08-17T13:29:42.033Z"}, {"entity": "publication", "iuid": "4ae85c467a6b4088b7f92151b66e932d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4ae85c467a6b4088b7f92151b66e932d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4ae85c467a6b4088b7f92151b66e932d"}}, "title": "Latent plasticity of the human pancreas across development, health, and disease.", "authors": [{"family": "Mereu", "given": "Elisabetta", "initials": "E", "orcid": "0000-0001-6101-8472", "researcher": {"href": "https://publications.scilifelab.se/researcher/d263fd3d305145959169d1e1f3e76c75.json"}}, {"family": "Balboa", "given": "Diego", "initials": "D", "orcid": "0000-0002-4784-5452", "researcher": {"href": "https://publications.scilifelab.se/researcher/647a7c312e2a4307aa43a10c7d142545.json"}}, {"family": "Liebig", "given": "Johannes", "initials": "J", "orcid": "0000-0002-9188-036X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ce625220e3f645eeab019e87e73b5470.json"}}, {"family": "Gonzalez-Herrero", "given": "Aitor", "initials": "A", "orcid": "0000-0002-2644-8028", "researcher": {"href": "https://publications.scilifelab.se/researcher/8e96783efb9b45ad90ed8c1c0fa6dd11.json"}}, {"family": "Martinez-Casals", "given": "Anna", "initials": "A", "orcid": "0000-0003-2722-1965", "researcher": {"href": "https://publications.scilifelab.se/researcher/0fa27c4c76374453ba3ffe7eafff4b9a.json"}}, {"family": "Mardamshina", "given": "Mariya", "initials": "M"}, {"family": "Mollandin", "given": "Fanny", "initials": "F"}, {"family": "Schicktanz", "given": "Felix", "initials": "F"}, {"family": "Tosti", "given": "Luca", "initials": "L"}, {"family": "Vandenbempt", "given": "Valerie", "initials": "V"}, {"family": "Avrahami", "given": "Dana", "initials": "D"}, {"family": "Bernardo", "given": "Edgar", "initials": "E"}, {"family": "Bj\u00f6rklund", "given": "Frida", "initials": "F"}, {"family": "Chua", "given": "Robert Lorenz", "initials": "RL"}, {"family": "Engelse", "given": "Marten", "initials": "M"}, {"family": "Garc\u00eda-Hurtado", "given": "Javier", "initials": "J"}, {"family": "Groen", "given": "Nathalie", "initials": "N"}, {"family": "Hanegraaf", "given": "Maaike", "initials": "M"}, {"family": "Ia\u00f1ez", "given": "Pablo", "initials": "P"}, {"family": "Jechow", "given": "Katharina", "initials": "K"}, {"family": "Konukiewitz", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lawerenz", "given": "Christian", "initials": "C"}, {"family": "Marchese", "given": "Domenica", "initials": "D"}, {"family": "Muraro", "given": "Mauro J", "initials": "MJ"}, {"family": "Pellegrini", "given": "Silvia", "initials": "S"}, {"family": "Sordi", "given": "Valeria", "initials": "V"}, {"family": "Sudy", "given": "Alexander", "initials": "A"}, {"family": "Taron", "given": "Ulrike", "initials": "U"}, {"family": "Ten", "given": "Foo Wei", "initials": "FW"}, {"family": "Trefzer", "given": "Timo", "initials": "T"}, {"family": "Twardziok", "given": "Sven", "initials": "S"}, {"family": "van Agen", "given": "Maarten", "initials": "M"}, {"family": "Carlotti", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "de Koning", "given": "Eelco", "initials": "E"}, {"family": "Ferrer", "given": "Jorge", "initials": "J"}, {"family": "Glaser", "given": "Benjamin", "initials": "B"}, {"family": "Heyn", "given": "Holger", "initials": "H"}, {"family": "Lundberg", "given": "Emma", "initials": "E"}, {"family": "Piemonti", "given": "Lorenzo", "initials": "L"}, {"family": "Steiger", "given": "Katja", "initials": "K"}, {"family": "van Oudenaarden", "given": "Alexander", "initials": "A"}, {"family": "Weichert", "given": "Wilko", "initials": "W"}, {"family": "Conrad", "given": "Christian", "initials": "C", "orcid": "0000-0001-7036-342X", "researcher": {"href": "https://publications.scilifelab.se/researcher/64b5e1b25f354b879fb0ce43e0aba260.json"}}, {"family": "Eils", "given": "Roland", "initials": "R", "orcid": "0000-0002-0034-4036", "researcher": {"href": "https://publications.scilifelab.se/researcher/a9ad57aa98c5431189bbd69aadc541d2.json"}}], "type": "journal article", "published": "2025-10-03", "journal": {"title": "bioRxiv", "issn": "2692-8205", "issn-l": null}, "abstract": "The pancreas plays a central role in major human diseases, yet our understanding of its cellular diversity and plasticity remains incomplete. Here, we present a single-cell multiomics atlas of the human pancreas, profiling over four million cells and nuclei from 57 donors across fetal development, adult homeostasis, and type 2 diabetes (T2D). Integrating sc/snRNA-seq, snATAC-seq, VASA-seq, spatial transcriptomics (Xenium), and multiplexed proteomics (CODEX), we resolve gene expression, chromatin accessibility, and spatial organization at high resolution. We identify transcriptionally plastic centroacinar-like cells (pCACs) in adults with fetal-like features, delineate endocrine and exocrine lineage trajectories during development, and uncover HNF1A-defined beta cell epigenetic states. In T2D, we observe shifts in beta cell subtypes and altered regulatory programs. Glucose perturbation of healthy islets reveals cell-type-specific adaptation and stress responses. This atlas provides a foundational framework to understand pancreas biology and the role of cellular plasticity in regeneration and disease.", "doi": "10.1101/2025.10.01.679230", "pmid": "41256699", "labels": {"Spatial Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12622017"}, {"db": "pii", "key": "2025.10.01.679230"}], "notes": [], "created": "2025-12-02T13:50:54.585Z", "modified": "2025-12-02T13:50:55.922Z"}]}