{"entity": "researcher", "timestamp": "2026-10-08T09:44:13.405Z", "family": "Carulla", "given": "Nat\u00e0lia", "initials": "N", "orcid": "0000-0002-3787-978X", "affiliations": ["University of Bordeaux, CBMN (UMR 5248)-CNRS-IPB, Institut Europ\u00e9en de Chimie et Biologie, 2 rue Escarpit, 33600, Pessac, France. natalia.carulla@gmail.com.", "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, 08028, Barcelona, Spain. natalia.carulla@gmail.com."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/a8e44e07561344299d0d29b03011a2ef.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/a8e44e07561344299d0d29b03011a2ef"}}, "publications": [{"entity": "publication", "iuid": "bc5dea45b8d148c38c3f0096804469f7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bc5dea45b8d148c38c3f0096804469f7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bc5dea45b8d148c38c3f0096804469f7"}}, "title": "A\u03b2(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.", "authors": [{"family": "Ciudad", "given": "Sonia", "initials": "S", "orcid": "0000-0002-9030-175X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a5cf9b106604a72a8f873df97dab76e.json"}}, {"family": "Puig", "given": "Eduard", "initials": "E"}, {"family": "Botzanowski", "given": "Thomas", "initials": "T"}, {"family": "Meigooni", "given": "Moeen", "initials": "M"}, {"family": "Arango", "given": "Andres S", "initials": "AS"}, {"family": "Do", "given": "Jimmy", "initials": "J"}, {"family": "Mayzel", "given": "Maxim", "initials": "M", "orcid": "0000-0002-7413-0444", "researcher": {"href": "https://publications.scilifelab.se/researcher/467c29017024478692460a363ed9a945.json"}}, {"family": "Bayoumi", "given": "Mariam", "initials": "M"}, {"family": "Chaignepain", "given": "St\u00e9phane", "initials": "S"}, {"family": "Maglia", "given": "Giovanni", "initials": "G", "orcid": "0000-0003-2784-0811", "researcher": {"href": "https://publications.scilifelab.se/researcher/98d18f36cb0644029036fde5c55dff28.json"}}, {"family": "Cianferani", "given": "Sarah", "initials": "S"}, {"family": "Orekhov", "given": "Vladislav", "initials": "V"}, {"family": "Tajkhorshid", "given": "Emad", "initials": "E", "orcid": "0000-0001-8434-1010", "researcher": {"href": "https://publications.scilifelab.se/researcher/8ca6a74c70b14ccbaaa39b96415114b5.json"}}, {"family": "Bardiaux", "given": "Benjamin", "initials": "B", "orcid": "0000-0003-4014-9195", "researcher": {"href": "https://publications.scilifelab.se/researcher/f23e6431b8254c01bddb4279617d78f3.json"}}, {"family": "Carulla", "given": "Nat\u00e0lia", "initials": "N", "orcid": "0000-0002-3787-978X", "researcher": {"href": "https://publications.scilifelab.se/researcher/a8e44e07561344299d0d29b03011a2ef.json"}}], "type": "journal article", "published": "2020-06-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "11", "issue": "1", "pages": "3014", "issn-l": "2041-1723"}, "abstract": "Formation of amyloid-beta (A\u03b2) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an A\u03b2 oligomer formed in a membrane mimicking environment, namely an A\u03b2(1-42) tetramer, which comprises a six stranded \u03b2-sheet core. The two faces of the \u03b2-sheet core are hydrophobic and surrounded by the membrane-mimicking environment while the edges are hydrophilic and solvent-exposed. By increasing the concentration of A\u03b2(1-42) in the sample, A\u03b2(1-42) octamers are also formed, made by two A\u03b2(1-42) tetramers facing each other forming a \u03b2-sandwich structure. Notably, A\u03b2(1-42) tetramers and octamers inserted into lipid bilayers as well-defined pores. To establish oligomer structure-membrane activity relationships, molecular dynamics simulations were carried out. These studies revealed a mechanism of membrane disruption in which water permeation occurred through lipid-stabilized pores mediated by the hydrophilic residues located on the core \u03b2-sheets edges of the oligomers.", "doi": "10.1038/s41467-020-16566-1", "pmid": "32541820", "labels": {"Swedish NMR Centre": "Collaborative"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-16566-1"}, {"db": "pmc", "key": "PMC7296003"}], "notes": [], "created": "2020-12-11T09:17:34.243Z", "modified": "2025-10-17T13:03:56.893Z"}]}