{"entity": "researcher", "timestamp": "2026-07-20T22:59:03.574Z", "family": "H\u00f6\u00f6k", "given": "Lars", "initials": "L", "orcid": "0000-0003-0104-4796", "affiliations": ["Evolutionary Biology Program, Department of Ecology and Genetics, Uppsala University, Norbyv\u00e4gen 18D, Uppsala, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/a45738fda5954b73a28e47430c4b1f20.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/a45738fda5954b73a28e47430c4b1f20"}}, "publications": [{"entity": "publication", "iuid": "1b9b1f7cd2e24ef1a1ec01582e63e588", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1b9b1f7cd2e24ef1a1ec01582e63e588.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1b9b1f7cd2e24ef1a1ec01582e63e588"}}, "title": "Temporal dynamics of faster neo-Z evolution in butterflies.", "authors": [{"family": "H\u00f6\u00f6k", "given": "Lars", "initials": "L", "orcid": "0000-0003-0104-4796", "researcher": {"href": "https://publications.scilifelab.se/researcher/a45738fda5954b73a28e47430c4b1f20.json"}}, {"family": "Vila", "given": "Roger", "initials": "R", "orcid": "0000-0002-2447-4388", "researcher": {"href": "https://publications.scilifelab.se/researcher/12f9f7ce050d463bb9a67d6970b9428a.json"}}, {"family": "Wiklund", "given": "Christer", "initials": "C"}, {"family": "Backstr\u00f6m", "given": "Niclas", "initials": "N"}], "type": "journal article", "published": "2024-09-03", "journal": {"title": "Evolution", "issn": "1558-5646", "volume": "78", "issue": "9", "pages": "1554-1567", "issn-l": "0014-3820"}, "abstract": "The faster-Z/X hypothesis predicts that sex-linked genes should diverge faster than autosomal genes. However, studies across different lineages have shown mixed support for this effect. So far, most analyses have focused on old and well-differentiated sex chromosomes, but less is known about the divergence of more recently acquired neo-sex chromosomes. In Lepidoptera (moths and butterflies), Z-autosome fusions are frequent, but the evolutionary dynamics of neo-Z chromosomes have not been explored in detail. Here, we analyzed the faster-Z effect in Leptidea sinapis, a butterfly with three Z chromosomes. We show that the neo-Z chromosomes have been acquired stepwise, resulting in strata of differentiation and masculinization. While all Z chromosomes showed evidence of the faster-Z effect, selection for genes on the youngest neo-Z chromosome (Z3) appears to have been hampered by a largely intact, homologous neo-W chromosome. However, the intermediately aged neo-Z chromosome (Z2), which lacks W gametologs, showed fewer evolutionary constraints, resulting in particularly fast evolution. Our results therefore support that neo-sex chromosomes can constitute temporary hot-spots of adaptation and divergence. The underlying dynamics are likely causally linked to shifts in selective constraints, evolution of gene expression, and degeneration of W-linked gametologs which gradually expose Z-linked genes to selection.", "doi": "10.1093/evolut/qpae082", "pmid": "38813673", "labels": {"NGI Short read": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "7685102"}], "notes": [], "created": "2024-08-15T12:10:17.669Z", "modified": "2025-02-28T14:17:36.747Z"}, {"entity": "publication", "iuid": "21acaa69979c4e2cbe8dd6a3a61c1fb1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/21acaa69979c4e2cbe8dd6a3a61c1fb1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/21acaa69979c4e2cbe8dd6a3a61c1fb1"}}, "title": "Nascent evolution of recombination rate differences as a consequence of chromosomal rearrangements.", "authors": [{"family": "N\u00e4svall", "given": "Karin", "initials": "K", "orcid": "0000-0002-2970-4189", "researcher": {"href": "https://publications.scilifelab.se/researcher/9173164aadbe47b0b4132d2c6e654cf3.json"}}, {"family": "Boman", "given": "Jesper", "initials": "J", "orcid": "0000-0002-0537-8219", "researcher": {"href": "https://publications.scilifelab.se/researcher/669c974e6e284e94bfb6009f49ffc06d.json"}}, {"family": "H\u00f6\u00f6k", "given": "Lars", "initials": "L", "orcid": "0000-0003-0104-4796", "researcher": {"href": "https://publications.scilifelab.se/researcher/a45738fda5954b73a28e47430c4b1f20.json"}}, {"family": "Vila", "given": "Roger", "initials": "R"}, {"family": "Wiklund", "given": "Christer", "initials": "C"}, {"family": "Backstr\u00f6m", "given": "Niclas", "initials": "N"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "PLoS Genet.", "issn": "1553-7404", "volume": "19", "issue": "8", "pages": "e1010717", "issn-l": "1553-7390"}, "abstract": "Reshuffling of genetic variation occurs both by independent assortment of chromosomes and by homologous recombination. Such reshuffling can generate novel allele combinations and break linkage between advantageous and deleterious variants which increases both the potential and the efficacy of natural selection. Here we used high-density linkage maps to characterize global and regional recombination rate variation in two populations of the wood white butterfly (Leptidea sinapis) that differ considerably in their karyotype as a consequence of at least 27 chromosome fissions and fusions. The recombination data were compared to estimates of genetic diversity and measures of selection to assess the relationship between chromosomal rearrangements, crossing over, maintenance of genetic diversity and adaptation. Our data show that the recombination rate is influenced by both chromosome size and number, but that the difference in the number of crossovers between karyotypes is reduced as a consequence of a higher frequency of double crossovers in larger chromosomes. As expected from effects of selection on linked sites, we observed an overall positive association between recombination rate and genetic diversity in both populations. Our results also revealed a significant effect of chromosomal rearrangements on the rate of intergenic diversity change between populations, but limited effects on polymorphisms in coding sequence. We conclude that chromosomal rearrangements can have considerable effects on the recombination landscape and consequently influence both maintenance of genetic diversity and efficiency of selection in natural populations.", "doi": "10.1371/journal.pgen.1010717", "pmid": "37549188", "labels": {"NGI Short read": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10434929"}, {"db": "pii", "key": "PGENETICS-D-23-00339"}], "notes": [], "created": "2023-10-11T09:12:41.322Z", "modified": "2024-01-16T13:48:32.739Z"}]}