{"entity": "researcher", "timestamp": "2026-07-11T23:10:41.970Z", "family": "Feeney", "given": "Rachel H", "initials": "RH", "orcid": "0000-0002-7686-6279", "affiliations": ["Department of Molecular Biology, Ume\u00e5 University, Ume\u00e5, Sweden.", "Laboratory for Molecular Infection Medicine Sweden (MIMS) and Ume\u00e5 Center for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/a1e816ac8a604325b1a878b4a33dbc44.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/a1e816ac8a604325b1a878b4a33dbc44"}}, "publications": [{"entity": "publication", "iuid": "fd3d1863ce1e404cbd824f5ec6d4f971", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fd3d1863ce1e404cbd824f5ec6d4f971.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fd3d1863ce1e404cbd824f5ec6d4f971"}}, "title": "The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids.", "authors": [{"family": "Holmberg", "given": "Sandra M", "initials": "SM", "orcid": "0000-0002-6290-2590", "researcher": {"href": "https://publications.scilifelab.se/researcher/7815cc43d5ee43b1b83aea417aaa7734.json"}}, {"family": "Feeney", "given": "Rachel H", "initials": "RH", "orcid": "0000-0002-7686-6279", "researcher": {"href": "https://publications.scilifelab.se/researcher/a1e816ac8a604325b1a878b4a33dbc44.json"}}, {"family": "Prasoodanan P K", "given": "Vishnu", "initials": "V"}, {"family": "Pu\u00e9rtolas-Balint", "given": "Fabiola", "initials": "F", "orcid": "0000-0003-4898-5673", "researcher": {"href": "https://publications.scilifelab.se/researcher/52b9ecd971f64eb89d05334fe9e975bb.json"}}, {"family": "Singh", "given": "Dhirendra K", "initials": "DK"}, {"family": "Wongkuna", "given": "Supapit", "initials": "S", "orcid": "0000-0003-3766-5391", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f1a42a392e642dbaaee6d5dbf6b1ef5.json"}}, {"family": "Zandbergen", "given": "Lotte", "initials": "L"}, {"family": "Hauner", "given": "Hans", "initials": "H"}, {"family": "Brandl", "given": "Beate", "initials": "B"}, {"family": "Nieminen", "given": "Anni I", "initials": "AI", "orcid": "0000-0001-8999-6040", "researcher": {"href": "https://publications.scilifelab.se/researcher/eddac59bcacb4eff9a44249cf2305779.json"}}, {"family": "Skurk", "given": "Thomas", "initials": "T", "orcid": "0000-0002-6875-1658", "researcher": {"href": "https://publications.scilifelab.se/researcher/f312550741dc4fe6b6c3064d2d8b83b7.json"}}, {"family": "Schroeder", "given": "Bjoern O", "initials": "BO", "orcid": "0000-0002-6716-8284", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2c57653fc214cbcbb242cbbc524d517.json"}}], "type": "journal article", "published": "2024-04-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "3502", "issn-l": "2041-1723"}, "abstract": "Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation and ex vivo analysis of colonic mucus function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensal Blautia, and supplementation of Blautia coccoides to mice confirmed its mucus-stimulating capacity. Mechanistically, B. coccoides stimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases.", "doi": "10.1038/s41467-024-47594-w", "pmid": "38664378", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11045866"}, {"db": "pii", "key": "10.1038/s41467-024-47594-w"}], "notes": [], "created": "2024-11-25T10:16:38.017Z", "modified": "2024-11-25T10:16:38.245Z"}]}