{"entity": "researcher", "timestamp": "2026-06-17T04:22:02.255Z", "family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "affiliations": ["Department of Medical Biochemistry, University of Gothenburg, SE-405 30 Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b"}}, "publications": [{"entity": "publication", "iuid": "b31162b460c7480c87a7be42d41b600a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b31162b460c7480c87a7be42d41b600a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b31162b460c7480c87a7be42d41b600a"}}, "title": "The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition", "authors": [{"family": "Moksnes", "given": "Marta Riise", "initials": "MR", "orcid": "0000-0002-2690-5153", "researcher": {"href": "https://publications.scilifelab.se/researcher/15fd5ce3d43a4b76a7a7e710e8724a6f.json"}}, {"family": "Coward", "given": "Eivind", "initials": "E", "orcid": "0009-0008-1323-3555", "researcher": {"href": "https://publications.scilifelab.se/researcher/6a4792db14b645b9b5134243f9ca7b60.json"}}, {"family": "Nethander", "given": "Maria", "initials": "M", "orcid": "0000-0003-3688-906X", "researcher": {"href": "https://publications.scilifelab.se/researcher/53d61951f51c4d40bef24672866382cb.json"}}, {"family": "Dekkers", "given": "Koen", "initials": "K", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications.scilifelab.se/researcher/ee8d56ef781e42d5b6f21b551054a3e7.json"}}, {"family": "Grahnemo", "given": "Louise", "initials": "L", "orcid": "0000-0001-5276-6612", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb1ac8fe74954a5db43e8e6538cf8235.json"}}, {"family": "T\u00f6rnqvist", "given": "Anna E", "initials": "AE"}, {"family": "Li", "given": "Lei", "initials": "L"}, {"family": "Lundmark", "given": "Per", "initials": "P", "orcid": "0009-0006-2334-8802", "researcher": {"href": "https://publications.scilifelab.se/researcher/f30b1a2e60d646c4a0cc0be06ffe77dd.json"}}, {"family": "Pertiwi", "given": "Kamalita", "initials": "K", "orcid": "0000-0003-2861-9051", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9cb279b53204e51b202134c82cf680f.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications.scilifelab.se/researcher/577652ffb15442e1a47a9aaffc3b52e7.json"}}, {"family": "Mjelle", "given": "Robin", "initials": "R"}, {"family": "Moll", "given": "Janne Marie", "initials": "JM", "orcid": "0000-0002-3514-4528", "researcher": {"href": "https://publications.scilifelab.se/researcher/52e482fb976e4bb3a212d98b981c9f2f.json"}}, {"family": "Eklund", "given": "Aron Charles", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications.scilifelab.se/researcher/9f1b0f6b48de45f7916e14d6a4defb09.json"}}, {"family": "Nielsen", "given": "Henrik Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1d5f2e0565a46bcbccfc973eec9e838.json"}}, {"family": "Svensson", "given": "Johan", "initials": "J", "orcid": "0000-0002-4487-6405", "researcher": {"href": "https://publications.scilifelab.se/researcher/fdbca5fe77124646b51e9c55dae4d361.json"}}, {"family": "Langhammer", "given": "Arnulf", "initials": "A", "orcid": "0000-0001-5296-6673", "researcher": {"href": "https://publications.scilifelab.se/researcher/755b4b39d8054f2ea3e28476a7b0ae39.json"}}, {"family": "Giske\u00f8deg\u00e5rd", "given": "Guro F", "initials": "GF", "orcid": "0000-0003-2157-8824", "researcher": {"href": "https://publications.scilifelab.se/researcher/57d6962d8112403fb823764ce0a0d6c6.json"}}, {"family": "Brumpton", "given": "Ben", "initials": "B", "orcid": "0000-0002-3058-1059", "researcher": {"href": "https://publications.scilifelab.se/researcher/da9d23aaf1dc4d18a0a13e4847ea9955.json"}}, {"family": "Hjort", "given": "Rebecka", "initials": "R"}, {"family": "Ness-Jensen", "given": "Eivind", "initials": "E", "orcid": "0000-0001-6005-0729", "researcher": {"href": "https://publications.scilifelab.se/researcher/d619713fc5764a5e9b88c7c012cf0cf1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K", "orcid": "0000-0003-2815-1217", "researcher": {"href": "https://publications.scilifelab.se/researcher/eff63868e95240f695d47e871e31947f.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e54fbe6f0fc4eed93108b382e1b2952.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ed3f066719f43b291743a8bdaf3d2a0.json"}}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications.scilifelab.se/researcher/995dac358caa4a169fc889b7a3eef44a.json"}}], "type": "journal-article", "published": "2026-03-00", "journal": {"title": "Nat Genet", "issn": "1061-4036", "volume": "58", "issue": "3", "pages": "530-539", "issn-l": "1061-4036"}, "abstract": "The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Tr\u00f8ndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017-21,976). We identified 12 reproducible SNP-species associations across six genomic loci, including known (LCT, ABO) and novel (HLA-DQB1, MUC12, SLC37A2, FUT2) regions. Additionally, we detected genetic signals associated with gut microbiota functional modules at three loci (LCT, ABO, FUT2). Follow-up analyses suggest that these host-microbiota associations are linked to the pathogenesis of celiac disease and hemorrhoidal disease. Mendelian randomization analyses provided evidence supporting a causal effect of body mass index on gut microbiota composition. These findings highlight the interplay between host genetics and gut microbiota for human health and disease.", "doi": "10.1038/s41588-026-02502-4", "pmid": "41688637", "labels": {"National Genomics Infrastructure": "Service", "NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12987729"}, {"db": "pii", "key": "10.1038/s41588-026-02502-4"}], "notes": [], "created": "2026-03-19T16:36:31.375Z", "modified": "2026-03-24T09:08:07.330Z"}, {"entity": "publication", "iuid": "fa1f2b26ed3949e2bdbd3c28dd0edf08", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fa1f2b26ed3949e2bdbd3c28dd0edf08.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fa1f2b26ed3949e2bdbd3c28dd0edf08"}}, "title": "Cryo-EM structure of CLCA1 identifies CLCA1 as a founding member of a novel metzincin family", "authors": [{"family": "Nystr\u00f6m", "given": "Elisabeth", "initials": "E", "orcid": "0000-0002-6970-7894", "researcher": {"href": "https://publications.scilifelab.se/researcher/09bd302f8a1341f6a1a5aaf3bfe94a94.json"}}, {"family": "van der Post", "given": "Sjoerd", "initials": "S", "orcid": "0000-0002-7965-5311", "researcher": {"href": "https://publications.scilifelab.se/researcher/26adc68875cb4cb08bcf969868b42890.json"}}, {"family": "Barrett", "given": "Doireann Bradley", "initials": "DB"}, {"family": "Raba", "given": "Grete", "initials": "G", "orcid": "0000-0002-7764-3878", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9c5c71873aa4992bec09f9f6aabba5c.json"}}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}, {"family": "Oltean", "given": "Mihai", "initials": "M", "orcid": "0000-0003-3783-5207", "researcher": {"href": "https://publications.scilifelab.se/researcher/60a46e232d2644afbe9a4f3d89316a7a.json"}}, {"family": "Luis", "given": "Ana S", "initials": "AS", "orcid": "0000-0002-5086-7353", "researcher": {"href": "https://publications.scilifelab.se/researcher/06abcf6fc3584357afbd80d6537fdd48.json"}}, {"family": "Trillo-Muyo", "given": "Sergio", "initials": "S", "orcid": "0000-0002-3135-9134", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e6b6b830e9145a2ae3e6c10895acbee.json"}}], "type": "posted-content", "published": "2025-10-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.10.18.683246", "pmid": null, "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [], "notes": [], "created": "2026-01-12T10:07:24.335Z", "modified": "2026-01-12T10:07:24.558Z"}, {"entity": "publication", "iuid": "313987203417421e9c853c7e0a9afc12", "links": {"self": {"href": "https://publications.scilifelab.se/publication/313987203417421e9c853c7e0a9afc12.json"}, "display": {"href": "https://publications.scilifelab.se/publication/313987203417421e9c853c7e0a9afc12"}}, "title": "MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn's disease.", "authors": [{"family": "Layunta", "given": "Elena", "initials": "E"}, {"family": "J\u00e4verfelt", "given": "Sofia", "initials": "S"}, {"family": "van de Koolwijk", "given": "Fleur C", "initials": "FC"}, {"family": "Sivertsson", "given": "Molly", "initials": "M"}, {"family": "Dolan", "given": "Brendan", "initials": "B", "orcid": "0000-0001-9062-3882", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ff7d8f515ef4707ab6bca8da108f115.json"}}, {"family": "Arike", "given": "Liisa", "initials": "L", "orcid": "0000-0002-2184-0960", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a6ecb751dca49a598e3d13cc92ee5cf.json"}}, {"family": "Thulin", "given": "Sara Im", "initials": "SI"}, {"family": "Vallance", "given": "Bruce A", "initials": "BA"}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}], "type": "journal article", "published": "2024-12-19", "journal": {"title": "JCI Insight", "issn": "2379-3708", "volume": "10", "issue": "3", "issn-l": "2379-3708"}, "abstract": "Crohn's disease (CD) is the chronic inflammation of the terminal ileum and colon triggered by a dysregulated immune response to bacteria, but insights into specific molecular perturbations at the critical bacteria-epithelium interface are limited. Here, we report that the membrane mucin MUC17 protected small intestinal enterocytes against commensal and pathogenic bacteria. In noninflamed CD ileum, reduced MUC17 levels and a compromised glycocalyx barrier allowed recurrent bacterial contact with enterocytes. Muc17 deletion in mice rendered the small intestine particularly prone to atypical bacterial infection while maintaining resistance to colitis. The loss of Muc17 resulted in spontaneous deterioration of epithelial homeostasis and in the extraintestinal translocation of bacteria. Finally, Muc17-deficient mice harbored specific small intestinal bacterial taxa observed in patients with CD. Our findings highlight MUC17 as an essential region-specific line of defense in the small intestine with relevance for early epithelial defects in CD.", "doi": "10.1172/jci.insight.181481", "pmid": "39699961", "labels": {"Bioinformatics Support for Computational Resources": "Service", "Glycoproteomics and MS Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11948581"}, {"db": "pii", "key": "181481"}], "notes": [], "created": "2025-02-28T14:21:40.060Z", "modified": "2025-11-28T10:52:24.618Z"}, {"entity": "publication", "iuid": "40fe795e4a6b41dc96ed06c6d7accad8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/40fe795e4a6b41dc96ed06c6d7accad8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/40fe795e4a6b41dc96ed06c6d7accad8"}}, "title": "BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection.", "authors": [{"family": "Rajan", "given": "Anandi", "initials": "A", "orcid": "0000-0002-4873-8528", "researcher": {"href": "https://publications.scilifelab.se/researcher/261182551e72486895b04cebcaa22d69.json"}}, {"family": "Gallego", "given": "Pablo", "initials": "P"}, {"family": "Dolan", "given": "Brendan", "initials": "B", "orcid": "0000-0001-9062-3882", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ff7d8f515ef4707ab6bca8da108f115.json"}}, {"family": "Patel", "given": "Piyush", "initials": "P"}, {"family": "Dwibedi", "given": "Chinmay", "initials": "C", "orcid": "0000-0001-6416-4440", "researcher": {"href": "https://publications.scilifelab.se/researcher/a0b0dbf807be449da1856c0c018f13a3.json"}}, {"family": "Luis", "given": "Ana S", "initials": "AS", "orcid": "0000-0002-5086-7353", "researcher": {"href": "https://publications.scilifelab.se/researcher/06abcf6fc3584357afbd80d6537fdd48.json"}}, {"family": "Trillo-Muyo", "given": "Sergio", "initials": "S", "orcid": "0000-0002-3135-9134", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e6b6b830e9145a2ae3e6c10895acbee.json"}}, {"family": "Arike", "given": "Liisa", "initials": "L", "orcid": "0000-0002-2184-0960", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a6ecb751dca49a598e3d13cc92ee5cf.json"}}, {"family": "van der Post", "given": "Sjoerd", "initials": "S", "orcid": "0000-0002-7965-5311", "researcher": {"href": "https://publications.scilifelab.se/researcher/26adc68875cb4cb08bcf969868b42890.json"}}, {"family": "Simr\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0003-1931-4926", "researcher": {"href": "https://publications.scilifelab.se/researcher/bef16e586fb144c4897df021225f3843.json"}}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}], "type": "journal article", "published": "2024-09-30", "journal": {"title": "Gut Microbes", "issn": "1949-0984", "volume": "16", "issue": "1", "pages": "2409247", "issn-l": null}, "abstract": "The anaerobic spirochete Brachyspira causes intestinal spirochetosis, characterized by the intimate attachment of bacterial cells to the colonic mucosa, potentially leading to symptoms such as diarrhea, abdominal pain, and weight loss. Despite the clinical significance of Brachyspira infections, the mechanism of the interaction between Brachyspira and the colon epithelium is not known. We characterized the molecular mechanism of the B. pilosicoli-epithelium interaction and its impact on the epithelial barrier during infection. Through a proteomics approach, we identified BPP43_05035 as a candidate B. pilosicoli surface protein that mediates bacterial attachment to cultured human colonic epithelial cells. The crystal structure of BPP43_05035 revealed a globular lipoprotein with a six-bladed beta-propeller domain. Blocking the native BPP43_05035 on B. pilosicoli, either with a specific antibody or via competitive inhibition, abrogated its binding to epithelial cells, which required cell surface-exposed N-glycans. Proximity labeling and interaction assays revealed that BPP43_05035 bound to tight junctions, thereby increasing the permeability of the epithelial monolayer. Extending our investigation to humans, we discovered a downregulation of tight junction and brush border genes in B. pilosicoli-infected patients carrying detectable levels of epithelium-bound BPP43_05035. Collectively, our findings identify BPP43_05035 as a B. pilosicoli adhesin that weakens the colonic epithelial barrier during infection.", "doi": "10.1080/19490976.2024.2409247", "pmid": "39349383", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11444514"}], "notes": [], "created": "2024-11-27T15:36:03.615Z", "modified": "2024-11-27T15:36:03.880Z"}, {"entity": "publication", "iuid": "8041e0533b634b6bb40ff425aec24668", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8041e0533b634b6bb40ff425aec24668.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8041e0533b634b6bb40ff425aec24668"}}, "title": "Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface againstSalmonellaAttack", "authors": [{"family": "van Rijn", "given": "Jorik M", "initials": "JM", "orcid": "0000-0003-2865-4455", "researcher": {"href": "https://publications.scilifelab.se/researcher/8f2defce179d4632a4e7d60666417ab2.json"}}, {"family": "Lopes", "given": "Ana C C", "initials": "ACC"}, {"family": "Ceylan", "given": "Merve", "initials": "M"}, {"family": "Eriksson", "given": "Jens", "initials": "J"}, {"family": "Bergholtz", "given": "Alexandra", "initials": "A"}, {"family": "Ntokaki", "given": "Angelika", "initials": "A"}, {"family": "Hammar", "given": "Rebekkah", "initials": "R", "orcid": "0000-0001-5740-0353", "researcher": {"href": "https://publications.scilifelab.se/researcher/6d8e872219e74a5d90adc8047b1e476e.json"}}, {"family": "Sundbom", "given": "Magnus", "initials": "M", "orcid": "0000-0002-6243-2859", "researcher": {"href": "https://publications.scilifelab.se/researcher/a54316faa45947bd92615d27a38c2b87.json"}}, {"family": "Skogar", "given": "Martin", "initials": "M"}, {"family": "Graf", "given": "Wilhelm", "initials": "W"}, {"family": "Webb", "given": "Dominic Luc", "initials": "DL", "orcid": "0000-0002-6979-9194", "researcher": {"href": "https://publications.scilifelab.se/researcher/868fca24b48f440eb2417acdb04e73d3.json"}}, {"family": "Hellstr\u00f6m", "given": "Per M", "initials": "PM"}, {"family": "Artursson", "given": "Per", "initials": "P", "orcid": "0000-0002-3708-7395", "researcher": {"href": "https://publications.scilifelab.se/researcher/31575936c2714e1eb2f35c12df9a65a8.json"}}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}, {"family": "Di Martino", "given": "Maria Letizia", "initials": "ML", "orcid": "0000-0002-9491-4000", "researcher": {"href": "https://publications.scilifelab.se/researcher/708eae058cb3494f8407574a666a16f0.json"}}, {"family": "Sellin", "given": "Mikael E", "initials": "ME", "orcid": "0000-0002-8355-0803", "researcher": {"href": "https://publications.scilifelab.se/researcher/f797357bcd3d4447bff96c20873dd500.json"}}], "type": "posted-content", "published": "2024-07-13", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2024.07.11.603014", "pmid": null, "labels": {"Integrated Microscopy Technologies Ume\u00e5": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-07T14:56:11.381Z", "modified": "2025-12-18T19:26:59.426Z"}, {"entity": "publication", "iuid": "e35d48e8ac824c1998c799a407674a4b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e35d48e8ac824c1998c799a407674a4b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e35d48e8ac824c1998c799a407674a4b"}}, "title": "The human transmembrane mucin MUC17 responds to TNF\u03b1 by increased presentation at the plasma membrane.", "authors": [{"family": "Schneider", "given": "Hannah", "initials": "H"}, {"family": "Berger", "given": "Evelin", "initials": "E"}, {"family": "Dolan", "given": "Brendan", "initials": "B"}, {"family": "Martinez-Abad", "given": "Beatriz", "initials": "B"}, {"family": "Arike", "given": "Liisa", "initials": "L"}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T", "orcid": "0000-0002-6434-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc0aa3d9762420caa7efaaa19c1174b.json"}}, {"family": "Hansson", "given": "Gunnar C", "initials": "GC", "orcid": "0000-0002-1900-1869", "researcher": {"href": "https://publications.scilifelab.se/researcher/44b3815603154322a6dac16f2fc1c1e9.json"}}], "type": "journal article", "published": "2019-08-22", "journal": {"title": "Biochem. J.", "issn": "1470-8728", "volume": "476", "issue": "16", "pages": "2281-2295", "issn-l": "0264-6021"}, "abstract": "Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O-glycosylated mucin domain to the intestinal lumen. Here, we identified two unknown phosphorylated serine residues, S4428 and S4492, in the cytoplasmic tail of human MUC17. We have previously demonstrated that MUC17 is anchored to the apical membrane domain via an interaction with the scaffolding protein PDZK1. S4492, localized in the C-terminal PDZ binding motif of MUC17, was mutated to generate phosphomimetic and phosphodeficient variants of MUC17. Using Caco-2 cells as a model system, we found that induction of an inflammatory state by long-term stimulation with the proinflammatory cytokine TNF\u03b1 resulted in an increase of MUC17 protein levels and enhanced insertion of MUC17 and its two phospho-variants into apical membranes. Up-regulation and apical insertion of MUC17 was followed by shedding of MUC17-containing vesicles. Transmembrane mucins have previously been shown to play a role in the prevention of bacterial colonization by acting as sheddable decoys for encroaching bacteria. Overexpression and increased presentation at the plasma membrane of wild-type MUC17 and its phosphodeficient variant MUC17 S-4492A protected Caco-2 cells against adhesion of enteropathogenic Escherichia coli, indicating that C-terminal phosphorylation of MUC17 may play a functional role in epithelial cell protection. We propose a new function for MUC17 in inflammation, where MUC17 acts as a second line of defense by preventing attachment of bacteria to the epithelial cell glycocalyx in the small intestine.", "doi": "10.1042/BCJ20190180", "pmid": "31387973", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "BCJ20190180"}, {"db": "pmc", "key": "PMC6705488"}], "notes": [], "created": "2020-01-23T16:13:08.991Z", "modified": "2021-06-18T14:11:11.815Z"}]}