{"entity": "researcher", "timestamp": "2026-07-20T13:55:43.352Z", "family": "Unnersj\u00f6-Jess", "given": "David", "initials": "D", "orcid": "0000-0002-4162-0973", "affiliations": ["Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.", "Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/9d475fc7a52a46e4abe984191c5b5b5f.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/9d475fc7a52a46e4abe984191c5b5b5f"}}, "publications": [{"entity": "publication", "iuid": "72c0bcbc6ed645e4a14dd4aa365fac7e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/72c0bcbc6ed645e4a14dd4aa365fac7e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/72c0bcbc6ed645e4a14dd4aa365fac7e"}}, "title": "Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.", "authors": [{"family": "Kvedaraite", "given": "Egle", "initials": "E", "orcid": "0000-0001-5308-092X", "researcher": {"href": "https://publications.scilifelab.se/researcher/78502177bad3453a8d3ed96d4ad334ac.json"}}, {"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications.scilifelab.se/researcher/64d9a0bc6b5d4039af5bc308a97eaad6.json"}}, {"family": "Mouratidou", "given": "Natalia", "initials": "N"}, {"family": "D\u00fcking", "given": "Tim", "initials": "T", "orcid": "0000-0002-4347-7648", "researcher": {"href": "https://publications.scilifelab.se/researcher/6acbe8ae50d94479a37dda5f37336422.json"}}, {"family": "Padhi", "given": "Avinash", "initials": "A"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Sinha", "given": "Indranil", "initials": "I", "orcid": "0000-0002-2513-5927", "researcher": {"href": "https://publications.scilifelab.se/researcher/970cda1bb71d4ae1b36cc5628023f7d4.json"}}, {"family": "Xagoraris", "given": "Ioanna", "initials": "I"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Damdimopoulos", "given": "Anastasios", "initials": "A"}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Hartwig", "given": "Olga", "initials": "O", "orcid": "0000-0001-5016-5960", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a50cebd9533432e80d2fd284c9137eb.json"}}, {"family": "Santos", "given": "Telma E", "initials": "TE"}, {"family": "Soini", "given": "Tea", "initials": "T"}, {"family": "Van Acker", "given": "Aline", "initials": "A"}, {"family": "Rahkonen", "given": "Nelly", "initials": "N"}, {"family": "Flodstr\u00f6m Tullberg", "given": "Malin", "initials": "M", "orcid": "0000-0003-2685-2052", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb6d04afbe8141c2b9297854de64dab8.json"}}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Jorns", "given": "Carl", "initials": "C", "orcid": "0000-0001-7727-8113", "researcher": {"href": "https://publications.scilifelab.se/researcher/59d387bd893f45bdb3663a0ef3aae88a.json"}}, {"family": "Lindforss", "given": "Ulrik", "initials": "U"}, {"family": "Nordenvall", "given": "Caroline", "initials": "C"}, {"family": "Stamper", "given": "Christopher T", "initials": "CT"}, {"family": "Unnersj\u00f6-Jess", "given": "David", "initials": "D", "orcid": "0000-0002-4162-0973", "researcher": {"href": "https://publications.scilifelab.se/researcher/9d475fc7a52a46e4abe984191c5b5b5f.json"}}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Nadisauskaite", "given": "Ruta", "initials": "R"}, {"family": "Jansson", "given": "Jessica", "initials": "J"}, {"family": "Vandamme", "given": "Niels", "initials": "N"}, {"family": "Sorini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-6803-8377", "researcher": {"href": "https://publications.scilifelab.se/researcher/975173f37f144f06b236817e224de7f0.json"}}, {"family": "Grundeken", "given": "Marijke Elise", "initials": "ME", "orcid": "0000-0001-6915-0339", "researcher": {"href": "https://publications.scilifelab.se/researcher/b64d9493eccd419d8c8908dea19602df.json"}}, {"family": "Rolandsdotter", "given": "Helena", "initials": "H"}, {"family": "Rassidakis", "given": "George", "initials": "G"}, {"family": "Villablanca", "given": "Eduardo J", "initials": "EJ", "orcid": "0000-0001-9522-9729", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c6a2dde2d8f40ef82dfba0cf1b52c0d.json"}}, {"family": "Idestr\u00f6m", "given": "Maja", "initials": "M"}, {"family": "Eulitz", "given": "Stefan", "initials": "S"}, {"family": "Arnell", "given": "Henrik", "initials": "H"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications.scilifelab.se/researcher/fcca878a7f314944bf1a4290cfd5d71d.json"}}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1a0d663491c4665a32a612e423dff1b.json"}}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e3185cf86534a96983b39dd93df454a.json"}}], "type": "journal article", "published": "2024-02-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "1752", "issn-l": "2041-1723"}, "abstract": "Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142-/low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142-/low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation.", "doi": "10.1038/s41467-024-46076-3", "pmid": "38409190", "labels": {"NGI Short read": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Long-term Support WABI": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10897309"}, {"db": "pii", "key": "10.1038/s41467-024-46076-3"}], "notes": [], "created": "2024-03-14T11:08:33.238Z", "modified": "2024-10-31T10:36:41.256Z"}, {"entity": "publication", "iuid": "3cd5b89edbcd40e18cbfb354d1adf04f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3cd5b89edbcd40e18cbfb354d1adf04f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3cd5b89edbcd40e18cbfb354d1adf04f"}}, "title": "Three-Dimensional Super-Resolved Imaging of Paraffin-Embedded Kidney Samples", "authors": [{"family": "Unnersj\u00f6-Jess", "given": "David", "initials": "D", "orcid": "0000-0002-4162-0973", "researcher": {"href": "https://publications.scilifelab.se/researcher/9d475fc7a52a46e4abe984191c5b5b5f.json"}}, {"family": "Ramdedovic", "given": "Amer", "initials": "A"}, {"family": "H\u00f6hne", "given": "Martin", "initials": "M"}, {"family": "Butt", "given": "Linus", "initials": "L"}, {"family": "Koehler", "given": "Felix C", "initials": "FC"}, {"family": "M\u00fcller", "given": "Roman Ulrich", "initials": "RU"}, {"family": "Hoyer", "given": "Peter F", "initials": "PF", "orcid": "0000-0002-9132-0282", "researcher": {"href": "https://publications.scilifelab.se/researcher/b12d4092ef9347c1ba1e982e535b9819.json"}}, {"family": "Blom", "given": "Hans", "initials": "H", "orcid": "0000-0002-5584-9170", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ce356a74dc84e0ea6af85397f11d869.json"}}, {"family": "Schermer", "given": "Bernhard", "initials": "B"}, {"family": "Benzing", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0512-1066", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c18d7e8857e426b9e6f38b06cca6992.json"}}], "type": "journal-article", "published": "2021-12-03", "journal": {"title": "Kidney360", "issn": "2641-7650", "pages": "10.34067/KID.0005882021", "issn-l": null}, "abstract": null, "doi": "10.34067/kid.0005882021", "pmid": null, "labels": {"Integrated Microscopy Technologies Stockholm": "Technology development"}, "xrefs": [], "notes": [], "created": "2021-12-09T11:27:08.208Z", "modified": "2022-01-03T10:02:53.596Z"}, {"entity": "publication", "iuid": "ccaa6b6173b94902bf80b8a831521a1a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ccaa6b6173b94902bf80b8a831521a1a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ccaa6b6173b94902bf80b8a831521a1a"}}, "title": "A molecular mechanism explaining albuminuria in kidney disease.", "authors": [{"family": "Butt", "given": "Linus", "initials": "L"}, {"family": "Unnersj\u00f6-Jess", "given": "David", "initials": "D", "orcid": "0000-0002-4162-0973", "researcher": {"href": "https://publications.scilifelab.se/researcher/9d475fc7a52a46e4abe984191c5b5b5f.json"}}, {"family": "H\u00f6hne", "given": "Martin", "initials": "M", "orcid": "0000-0001-8698-5389", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d3ddd0be3164d0d9f483d9c0755c499.json"}}, {"family": "Edwards", "given": "Aurelie", "initials": "A"}, {"family": "Binz-Lotter", "given": "Julia", "initials": "J", "orcid": "0000-0003-4678-0703", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a5b26232abe4fd6b4df6c1cadc56f1f.json"}}, {"family": "Reilly", "given": "Dervla", "initials": "D"}, {"family": "Hahnfeldt", "given": "Robert", "initials": "R", "orcid": "0000-0001-7997-3216", "researcher": {"href": "https://publications.scilifelab.se/researcher/e54b718629e742cf966ea885a9120ef5.json"}}, {"family": "Ziegler", "given": "Vera", "initials": "V"}, {"family": "Fremter", "given": "Katharina", "initials": "K"}, {"family": "Rinschen", "given": "Markus M", "initials": "MM", "orcid": "0000-0002-9252-1342", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b6fcd4a72d346cf865aed8b10f49a2d.json"}}, {"family": "Helmst\u00e4dter", "given": "Martin", "initials": "M"}, {"family": "Ebert", "given": "Lena K", "initials": "LK"}, {"family": "Castrop", "given": "Hayo", "initials": "H"}, {"family": "Hackl", "given": "Matthias J", "initials": "MJ"}, {"family": "Walz", "given": "Gerd", "initials": "G", "orcid": "0000-0002-4950-9946", "researcher": {"href": "https://publications.scilifelab.se/researcher/fd9545e1cff9413e9c2b76920aa53b3e.json"}}, {"family": "Brinkkoetter", "given": "Paul T", "initials": "PT"}, {"family": "Liebau", "given": "Max C", "initials": "MC", "orcid": "0000-0003-0494-9080", "researcher": {"href": "https://publications.scilifelab.se/researcher/678310bc460e4921bb67c6c6670f24d0.json"}}, {"family": "Tory", "given": "K\u00e1lm\u00e1n", "initials": "K", "orcid": "0000-0002-0316-6212", "researcher": {"href": "https://publications.scilifelab.se/researcher/774101da128248578efdccb22b38475b.json"}}, {"family": "Hoyer", "given": "Peter F", "initials": "PF", "orcid": "0000-0002-9132-0282", "researcher": {"href": "https://publications.scilifelab.se/researcher/b12d4092ef9347c1ba1e982e535b9819.json"}}, {"family": "Beck", "given": "Bodo B", "initials": "BB"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H", "orcid": "0000-0003-0578-4003", "researcher": {"href": "https://publications.scilifelab.se/researcher/1ec23336e2ef4e298f340876f1136dce.json"}}, {"family": "Blom", "given": "Hans", "initials": "H", "orcid": "0000-0002-5584-9170", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ce356a74dc84e0ea6af85397f11d869.json"}}, {"family": "Schermer", "given": "Bernhard", "initials": "B", "orcid": "0000-0002-5194-9000", "researcher": {"href": "https://publications.scilifelab.se/researcher/e6ccc28a64e9402fa608fb657d874080.json"}}, {"family": "Benzing", "given": "Thomas", "initials": "T", "orcid": "0000-0003-0512-1066", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c18d7e8857e426b9e6f38b06cca6992.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "2", "issue": "5", "pages": "461-474", "issn-l": "2522-5812"}, "abstract": "Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal filtration barrier results in loss of albumin into urine (albuminuria) across the wall of small renal capillaries, and is a leading cause of chronic kidney disease. However, exactly how the renal filter works and why its permeability is altered in kidney diseases is poorly understood. Here we show that the permeability of the renal filter is modulated through compression of the capillary wall. We collect morphometric data prior to and after onset of albuminuria in a mouse model equivalent to a human genetic disease affecting the renal filtration barrier. Combining quantitative analyses with mathematical modelling, we demonstrate that morphological alterations of the glomerular filtration barrier lead to reduced compressive forces that counteract filtration pressure, thereby resulting in capillary dilatation, and ultimately albuminuria. Our results reveal distinct functions of the different layers of the filtration barrier and expand the molecular understanding of defective renal filtration in chronic kidney disease.", "doi": "10.1038/s42255-020-0204-y", "pmid": "32694662", "labels": {"Integrated Microscopy Technologies Stockholm": "Collaborative"}, "xrefs": [{"db": "pii", "key": "10.1038/s42255-020-0204-y"}], "notes": [], "created": "2020-05-26T07:14:25.600Z", "modified": "2021-11-10T12:51:42.052Z"}]}