{"entity": "researcher", "timestamp": "2026-08-15T21:56:57.214Z", "family": "Gaur", "given": "Rahul", "initials": "R", "orcid": "0000-0003-0529-7176", "affiliations": ["Wallenberg Centre for Molecular Medicine, Ume\u00e5 University, Ume\u00e5, Sweden.", "Department of Radiation Sciences, Ume\u00e5 University, Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/9990aa5c88384a5e8a012fb8b009b1de.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/9990aa5c88384a5e8a012fb8b009b1de"}}, "publications": [{"entity": "publication", "iuid": "fae7836eebed4c84bdc531fa2a25e0e9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fae7836eebed4c84bdc531fa2a25e0e9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fae7836eebed4c84bdc531fa2a25e0e9"}}, "title": "Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer.", "authors": [{"family": "Lidstr\u00f6m", "given": "Tommy", "initials": "T", "orcid": "0000-0002-1353-316X", "researcher": {"href": "https://publications.scilifelab.se/researcher/1011864c212648d6b9132d33928c7752.json"}}, {"family": "Cumming", "given": "Joshua", "initials": "J", "orcid": "0000-0003-3661-7443", "researcher": {"href": "https://publications.scilifelab.se/researcher/fd0f3e688ff047ef8e814134c0446774.json"}}, {"family": "Gaur", "given": "Rahul", "initials": "R", "orcid": "0000-0003-0529-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/9990aa5c88384a5e8a012fb8b009b1de.json"}}, {"family": "Fr\u00e4ngsmyr", "given": "Lars", "initials": "L", "orcid": "0000-0002-6523-5156", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d4ef137f0024aa5ae5954247c10eeb3.json"}}, {"family": "Pateras", "given": "Ioannis S", "initials": "IS", "orcid": "0000-0002-6406-9811", "researcher": {"href": "https://publications.scilifelab.se/researcher/c4a203631ae04776b0583407cc1733ca.json"}}, {"family": "Mickert", "given": "Matthias J", "initials": "MJ", "orcid": "0000-0002-1542-5998", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e269d0e706647829da55f108f69f95b.json"}}, {"family": "Franklin", "given": "Oskar", "initials": "O", "orcid": "0000-0002-3777-6887", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ef2966672d941f881f588707c1edd37.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5947732f625a43e8a08055fc214649b6.json"}}, {"family": "Arnberg", "given": "Niklas", "initials": "N", "orcid": "0000-0002-7069-6678", "researcher": {"href": "https://publications.scilifelab.se/researcher/8764d7981e174798ab8411d36e7d0f1b.json"}}, {"family": "Dongre", "given": "Mitesh", "initials": "M", "orcid": "0000-0002-7151-1137", "researcher": {"href": "https://publications.scilifelab.se/researcher/6acd00be909d41399277be66d9600d41.json"}}, {"family": "Patthey", "given": "Cedric", "initials": "C", "orcid": "0000-0002-2627-9578", "researcher": {"href": "https://publications.scilifelab.se/researcher/6b7707e8bd3d4e029fb1e1f43df86ad4.json"}}, {"family": "\u00d6hlund", "given": "Daniel", "initials": "D", "orcid": "0000-0002-5847-2778", "researcher": {"href": "https://publications.scilifelab.se/researcher/42e9e473f68c460098a37e22d0a41369.json"}}], "type": "journal article", "published": "2023-01-03", "journal": {"title": "Cancer Immunol Res", "issn": "2326-6074", "volume": "11", "issue": "1", "pages": "72-92", "issn-l": null}, "abstract": "Pancreatic ductal adenocarcinoma (PDAC) is characterized by rich deposits of extracellular matrix (ECM), affecting the pathophysiology of the disease. Here, we identified galectin 4 (gal 4) as a cancer cell-produced protein that was deposited into the ECM of PDAC tumors and detected high-circulating levels of gal 4 in patients with PDAC. In orthotopic transplantation experiments, we observed increased infiltration of T cells and prolonged survival in immunocompetent mice transplanted with cancer cells with reduced expression of gal 4. Increased survival was not observed in immunodeficient RAG1-/- mice, demonstrating that the effect was mediated by the adaptive immune system. By performing single-cell RNA-sequencing, we found that the myeloid compartment and cancer-associated fibroblast (CAF) subtypes were altered in the transplanted tumors. Reduced gal 4 expression associated with a higher proportion of myofibroblastic CAFs and reduced numbers of inflammatory CAFs. We also found higher proportions of M1 macrophages, T cells, and antigen-presenting dendritic cells in tumors with reduced gal 4 expression. Using a coculture system, we observed that extracellular gal 4 induced apoptosis in T cells by binding N-glycosylation residues on CD3\u03b5/\u03b4. Hence, we show that gal 4 is involved in immune evasion and identify gal 4 as a promising drug target for overcoming immunosuppression in PDAC.", "doi": "10.1158/2326-6066.CIR-21-1088", "pmid": "36478037", "labels": {"Clinical Genomics Ume\u00e5": "Service", "Bioinformatics Support for Computational Resources": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9808371"}, {"db": "pii", "key": "711503"}], "notes": [], "created": "2023-11-29T09:42:40.822Z", "modified": "2024-11-25T10:29:05.262Z"}]}