{"entity": "researcher", "timestamp": "2026-07-20T01:00:13.285Z", "family": "Bedoya-Reina", "given": "Oscar C", "initials": "OC", "orcid": "0009-0001-1703-2258", "affiliations": ["Department of Women's and Children's Health, Karolinska Institutet, Stockholm SE-171 77, Sweden.", "School of Medical Sciences, \u00d6rebro University, \u00d6rebro SE-703 62, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/94abfc2a001941cb8c33b64271618be9.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/94abfc2a001941cb8c33b64271618be9"}}, "publications": [{"entity": "publication", "iuid": "d0efba99df6248a3aee00ad4fb43df6a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d0efba99df6248a3aee00ad4fb43df6a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d0efba99df6248a3aee00ad4fb43df6a"}}, "title": "EphA2 and phosphoantigen-mediated selective killing of medulloblastoma by \u03b3\u03b4T cells preserves neuronal and stem cell integrity.", "authors": [{"family": "Boutin", "given": "Lola", "initials": "L", "orcid": "0000-0001-7928-6731", "researcher": {"href": "https://publications.scilifelab.se/researcher/371c988cc4be47cf86c2c777922e3557.json"}}, {"family": "Liu", "given": "Mingzhi", "initials": "M", "orcid": "0000-0001-5842-8307", "researcher": {"href": "https://publications.scilifelab.se/researcher/6dc5d2bd77664158976f148e4088ae5c.json"}}, {"family": "D\u00e9chanet Merville", "given": "Julie", "initials": "J", "orcid": "0000-0001-7521-9531", "researcher": {"href": "https://publications.scilifelab.se/researcher/986ece668416414f806bf451c436de31.json"}}, {"family": "Bedoya-Reina", "given": "Oscar", "initials": "O", "orcid": "0009-0001-1703-2258", "researcher": {"href": "https://publications.scilifelab.se/researcher/94abfc2a001941cb8c33b64271618be9.json"}}, {"family": "Wilhelm", "given": "Margareta T", "initials": "MT", "orcid": "0000-0002-0516-9724", "researcher": {"href": "https://publications.scilifelab.se/researcher/fa0ccfc8178142e4954e05e25613d751.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "14", "issue": "1", "pages": "2485535", "issn-l": "2162-4011"}, "abstract": "Medulloblastoma (MB) is a pediatric brain tumor that develops in the cerebellum, representing one of the most common malignant brain cancers in children. Standard treatments include surgery, chemotherapy, and radiation, but despite a 5-y survival rate of approximately 70%, these therapies often lead to significant neurological damage in the developing brain. This underscores the urgent need for less toxic, more effective therapeutic alternatives. Recent advancements in cancer immunotherapy, including immune checkpoint inhibitors and CAR-T cell therapy, have revolutionized cancer treatment. One promising avenue is the use of Gamma Delta (\u03b3\u03b4)T cells, a unique T cell population with potential advantages, such as non-alloreactivity, potent tumor cell lysis, and broad antigen recognition. However, their capacity to recognize and target MB cells remains underexplored. To investigate the therapeutic potential of \u03b3\u03b4T cells against MB, we analyzed the proportion and status of MB-infiltrated \u03b3\u03b4T cells within patient datasets. We next investigated the expression of \u03b3\u03b4T cell ligands on MB cells and identified the EphA2 receptor and the phosphoantigen/Butyrophilin complex as key ligands, activating V\u03b39 V\u03b41 and V\u03b39 V\u03b42 T cells, respectively, leading to significant MB cell lysis in both monolayer and spheroid models. Importantly, preliminary safety data showed that \u03b3\u03b4T cells did not target differentiated neurons or neuroepithelial stem cells derived from induced pluripotent stem cells, underscoring the selectivity and safety of this approach. In conclusion, \u03b3\u03b4T cells trigger an efficient and specific killing of MB and would offer a promising novel therapeutic strategy.", "doi": "10.1080/2162402X.2025.2485535", "pmid": "40190167", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11980450"}], "notes": [], "created": "2025-11-28T10:48:34.549Z", "modified": "2025-11-28T10:48:34.769Z"}, {"entity": "publication", "iuid": "6364cb53a18c436d8ce6315496b97353", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6364cb53a18c436d8ce6315496b97353.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6364cb53a18c436d8ce6315496b97353"}}, "title": "Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment.", "authors": [{"family": "Lia\u00f1o-Pons", "given": "Judit", "initials": "J", "orcid": "0000-0001-8097-4750", "researcher": {"href": "https://publications.scilifelab.se/researcher/8285ad3848b94349b5d603d817f82db6.json"}}, {"family": "Garde-Lapido", "given": "Elisa", "initials": "E", "orcid": "0009-0001-5321-1253", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb52703f9d1944e5bc91922727deb49c.json"}}, {"family": "Fahrig", "given": "Fenja L", "initials": "FL", "orcid": "0009-0008-9040-5752", "researcher": {"href": "https://publications.scilifelab.se/researcher/1de91297944a444a9d866dd451806130.json"}}, {"family": "J\u00e4ckering", "given": "Merle", "initials": "M", "orcid": "0009-0003-9519-2120", "researcher": {"href": "https://publications.scilifelab.se/researcher/5c3ca09ca6cd42aba02538439b46b63c.json"}}, {"family": "Yuan", "given": "Ye", "initials": "Y"}, {"family": "Andersson", "given": "Stina", "initials": "S", "orcid": "0000-0003-3226-4740", "researcher": {"href": "https://publications.scilifelab.se/researcher/13415a4a70654146ac1c56e009ee31c4.json"}}, {"family": "Schort", "given": "Lea", "initials": "L"}, {"family": "Esteve", "given": "Maria", "initials": "M", "orcid": "0000-0003-2299-9153", "researcher": {"href": "https://publications.scilifelab.se/researcher/9ea254453baa4725a3fd36a5491a57cb.json"}}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}, {"family": "Bedoya-Reina", "given": "Oscar C", "initials": "OC", "orcid": "0009-0001-1703-2258", "researcher": {"href": "https://publications.scilifelab.se/researcher/94abfc2a001941cb8c33b64271618be9.json"}}, {"family": "Arsenian-Henriksson", "given": "Marie", "initials": "M", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}], "type": "journal article", "published": "2025-06-24", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "122", "issue": "25", "pages": "e2427211122", "issn-l": "0027-8424"}, "abstract": "Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN levels, induces apoptosis, and promotes neuronal differentiation accompanied by lipid droplet accumulation, essential for the phenotypic reprogramming. Moreover, combined inhibition of PRDX6 and glutathione S-transferase Pi 1 (GSTP1), a key antioxidant enzyme needed for PRDX6 activation, demonstrated synergistic effects both in vitro and in vivo. This strategy results in neuronal maturation as well as activity and initiates downstream pathways distinct from the ones triggered by retinoic acid, the differentiation-inducing agent currently used in clinical practice for NB. Notably, both PRDX6 and GSTP1 are highly expressed in the developing murine adrenal gland, as well as in high-risk, MYCN-amplified NB, correlating with an undifferentiated state and poor prognosis. Together, our results provide insights into the potential of PRDX6 and GSTP1 as therapeutic targets for differentiation induction for children with NB.", "doi": "10.1073/pnas.2427211122", "pmid": "40531876", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12207458"}], "notes": [], "created": "2025-11-28T10:48:18.601Z", "modified": "2025-11-28T10:48:18.946Z"}]}