{"entity": "researcher", "timestamp": "2026-07-12T08:49:51.036Z", "family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046"}}, "publications": [{"entity": "publication", "iuid": "78b0c63fefe94913bcd52fec8d95d8db", "links": {"self": {"href": "https://publications.scilifelab.se/publication/78b0c63fefe94913bcd52fec8d95d8db.json"}, "display": {"href": "https://publications.scilifelab.se/publication/78b0c63fefe94913bcd52fec8d95d8db"}}, "title": "A randomized controlled cross-over trial of differences in acute effects on serum metabolites from isocaloric meals based on red meat, fatty fish, or soy protein.", "authors": [{"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}, {"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}], "type": "journal article", "published": "2025-05-26", "journal": {"title": "Eur J Nutr", "issn": "1436-6207", "volume": "64", "issue": "5", "pages": "187", "issn-l": null}, "abstract": "Reducing red meat intake in the Western diet is beneficial for health and the environment. However, red meat is nutrient-rich, so understanding the impact of substituting it with other protein sources such as fish or plant-based proteins is essential, especially for vulnerable groups like the elderly and those with chronic diseases. The purpose of this study was to study the postprandial response in serum metabolites in women with Rheumatoid Arthritis (RA) after intake of red meat, fatty fish, and soy protein.\n\nWomen with RA (n = 24) consumed isocaloric meals that included burgers made from either red meat, fatty fish, or soy protein in a crossover design. Blood samples were taken in fasting state before the meal (0 h) and at intervals up to 5 h after eating. Nuclear Magnetic Resonance (NMR) analysis quantified serum metabolites, and multivariate models and univariate statistics were applied to compare postprandial metabolite changes across protein sources.\n\nPostprandial metabolite patterns varied significantly by protein type. The fatty fish meal led to a faster and higher increase in metabolites, including creatinine, isoleucine, valine, and trimethylamine N-oxide, compared to red meat. Unidentified lipids also differed. However, metabolite patterns after soy protein were similar to those after red meat.\n\nThis postprandial crossover trial found that intake of fatty fish lead to a quicker and more pronounced increase in key blood concentrations of metabolites compared to red meat. However, metabolite profiles in serum based on NMR-analysis were similar after intake of soy protein compared to red meat.\n\nThe PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).", "doi": "10.1007/s00394-025-03710-0", "pmid": "40418340", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12106552"}, {"db": "pii", "key": "10.1007/s00394-025-03710-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04247009"}], "notes": [], "created": "2025-11-27T08:05:28.633Z", "modified": "2025-11-27T08:05:28.716Z"}, {"entity": "publication", "iuid": "b41a066fba2b43eebb34302ff802267c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b41a066fba2b43eebb34302ff802267c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b41a066fba2b43eebb34302ff802267c"}}, "title": "Inflammatory and lipemic response to red meat intake in women with and without Rheumatoid Arthritis: a single meal study within a randomized controlled trial", "authors": [{"family": "S\u00e4llstr\u00f6m", "given": "Torsten", "initials": "T", "orcid": "0009-0001-4818-2531", "researcher": {"href": "https://publications.scilifelab.se/researcher/29042005e6f9498f81cef90894434bcf.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}, {"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}], "type": "journal-article", "published": "2025-04-11", "journal": {"title": "BMC Nutr", "issn": "2055-0928", "volume": "11", "issue": "1", "issn-l": null}, "abstract": null, "doi": "10.1186/s40795-025-01055-9", "pmid": null, "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [], "notes": [], "created": "2025-11-27T08:05:15.808Z", "modified": "2025-11-27T08:05:15.982Z"}, {"entity": "publication", "iuid": "fbd027dd45474789badb397607a262ed", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fbd027dd45474789badb397607a262ed.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fbd027dd45474789badb397607a262ed"}}, "title": "A randomized controlled cross-over trial investigating the acute inflammatory and metabolic response after meals based on red meat, fatty fish, or soy protein: the postprandial inflammation in rheumatoid arthritis (PIRA) trial.", "authors": [{"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}], "type": "journal article", "published": "2024-10-00", "journal": {"title": "Eur J Nutr", "issn": "1436-6207", "volume": "63", "issue": "7", "pages": "2631-2642", "issn-l": null}, "abstract": "Rheumatoid Arthritis (RA) has a point prevalence of around 20 million people worldwide. Patients with RA often believe that food intake affects disease activity, and that intake of red meat aggravate symptoms. The main objective of the Postprandial Inflammation in Rheumatoid Arthritis (PIRA) trial was to assess whether postprandial inflammation and serum lipid profile are affected differently by a meal including red meat, fatty fish, or a soy protein (vegan) meal.\n\nUsing a randomized controlled crossover design, 25 patients were assigned to eat isocaloric hamburger meals consisting of red meat (60% beef, 40% pork), fatty fish (salmon), or soy protein for breakfast. Blood samples were taken before meals and at intervals up to 5 h postprandial. The analysis included the inflammation marker interleukin 6 (IL-6) and serum lipids.\n\nNo significant differences in postprandial IL-6 or triglyceride concentrations were found between meals. However, the area under the curve of very low density lipoprotein (VLDL) particle counts, as well as VLDL-4-bound cholesterol, triglycerides, and phospholipids, was higher after the fatty fish compared to both red meat and soy protein.\n\nPostprandial inflammation assessed by IL-6 did not indicate any acute negative effects of red meat intake compared to fatty fish- or soy protein in patients with RA. The fatty fish meal resulted in a higher number of VLDL-particles and more lipids in the form of small VLDL particles compared to the other protein sources.", "doi": "10.1007/s00394-024-03451-6", "pmid": "38935139", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11490451"}, {"db": "pii", "key": "10.1007/s00394-024-03451-6"}], "notes": [], "created": "2024-11-28T14:39:02.189Z", "modified": "2025-10-17T13:03:52.709Z"}, {"entity": "publication", "iuid": "3e14d69f3011432a9f05cd68d3f08da2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e14d69f3011432a9f05cd68d3f08da2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e14d69f3011432a9f05cd68d3f08da2"}}, "title": "Exploring the differences in serum metabolite profiles after intake of red meat in women with rheumatoid arthritis and a matched control group.", "authors": [{"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}], "type": "journal article", "published": "2023-10-09", "journal": {"title": "Eur J Nutr", "issn": "1436-6207", "issn-l": null}, "abstract": "Studies have suggested that women with RA tend to avoid red meat more often than women without RA, based on their perception that it exacerbates their symptoms. Therefore, the aim of this study is to investigate and compare the postprandial metabolic response following the consumption of a red meat meal in patients with RA and a matched control group.\n\nParticipants were challenged with a meal with red meat and blood samples were collected before and at 0.5, 1, 2, 3 and 5 h after the meal. Serum metabolites were quantified by Nuclear Magnetic Resonance (NMR) analysis. Orthogonal Projections to Latent Structures with Discriminant Analysis (OPLS-DA) was used to evaluate separation by metabolites due to diagnosis of RA or not and to identify changes in metabolites related to RA. Incremental area under the curve was calculated for univariate comparisons for 23 metabolites.\n\nThe matched groups, including 22 women with RA and 22 women without RA, did not differ significantly in age, body mass index, diet quality or reported physical activity. OPLS-DA models had a limited quality indicating that there were no differences in metabolite patterns between the groups. However, phenylalanine was significantly higher in concentration in women with RA compared to controls in both fasting and postprandial samples.\n\nTo conclude, this well-controlled postprandial intervention study found a significantly higher concentration of phenylalanine in both fasting and postprandial samples of women with RA compared to matched women without RA. These findings warrant further investigation in larger studies.\n\nThe PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).", "doi": "10.1007/s00394-023-03257-y", "pmid": "37814020", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pii", "key": "10.1007/s00394-023-03257-y"}, {"db": "ClinicalTrials.gov", "key": "NCT04247009"}], "notes": [], "created": "2023-12-04T09:27:52.694Z", "modified": "2025-10-17T13:03:53.471Z"}, {"entity": "publication", "iuid": "9f212f5620fb4344a73fc451f44ef33f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9f212f5620fb4344a73fc451f44ef33f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9f212f5620fb4344a73fc451f44ef33f"}}, "title": "Improvements in Body Composition after a Proposed Anti-Inflammatory Diet Are Modified by Employment Status in Weight-Stable Patients with Rheumatoid Arthritis, a Randomized Controlled Crossover Trial.", "authors": [{"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}, {"family": "Wadell", "given": "Anna Turesson", "initials": "AT"}, {"family": "Gjertsson", "given": "Inger", "initials": "I"}, {"family": "Winkvist", "given": "Anna", "initials": "A"}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L"}], "type": "journal article", "published": "2022-03-02", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "14", "issue": "5", "issn-l": "2072-6643"}, "abstract": "Rheumatoid Arthritis (RA) is an autoimmune disease affecting peripheral joints. Chronic activation of inflammatory pathways results in decreased function and the development of comorbidities, such as loss of lean mass while retaining total body mass. The objective of this report was to assess whether dietary manipulation affects body composition in patients with RA as a secondary outcome. Fifty patients were included in a randomized controlled crossover trial testing a proposed anti-inflammatory Mediterranean-style diet compared to a Western diet. Body composition was measured by bioelectrical impedance spectroscopy in patients without implants (n = 45). Regardless of treatment, fat-free mass increased and fat mass percentage decreased during weight stability, but no differences between intervention and control in the whole group (n = 42, all p > 0.20) were found. Interaction analysis revealed that participants who were non-employed (n = 15) significantly decreased in fat mass (-1.767 kg; 95% CI: -3.060, -0.475, p = 0.012) and fat mass percentage (-1.805%; 95% CI: -3.024, -0.586, p = 0.008) from the intervention compared to the control period. A Mediterranean-style diet improved body composition in non-employed participants (n = 15). The group as a whole improved regardless of dietary allocation, indicating a potential to treat rheumatoid cachexia by dietary manipulation.", "doi": "10.3390/nu14051058", "pmid": "35268033", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pii", "key": "nu14051058"}, {"db": "pmc", "key": "PMC8912542"}], "notes": [], "created": "2022-04-25T12:26:04.612Z", "modified": "2025-10-17T13:03:54.941Z"}, {"entity": "publication", "iuid": "1a5902fc78604fb69f1203b8fde9c25e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1a5902fc78604fb69f1203b8fde9c25e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1a5902fc78604fb69f1203b8fde9c25e"}}, "title": "Diet intervention improves cardiovascular profile in patients with rheumatoid arthritis: results from the randomized controlled cross-over trial ADIRA.", "authors": [{"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L"}, {"family": "Turesson Wadell", "given": "Anna", "initials": "A"}, {"family": "Gjertsson", "given": "Inger", "initials": "I"}, {"family": "Calder", "given": "Philip C", "initials": "PC"}, {"family": "Winkvist", "given": "Anna", "initials": "A"}, {"family": "Lindqvist", "given": "Helen M", "initials": "HM"}], "type": "journal article", "published": "2021-01-23", "journal": {"title": "Nutr J", "issn": "1475-2891", "volume": "20", "issue": "1", "pages": "9", "issn-l": "1475-2891"}, "abstract": "The chronic inflammation in patients with rheumatoid arthritis (RA) increases the risk for cardiovascular diseases (CVD). The contribution of diet as a risk factor for CVD among these patients is however not fully understood. The aim of this study is to investigate if a proposed anti-inflammatory diet improves cardiovascular profile in weight stable patients with RA.\n\nPatients (n = 50) with RA were included in a cross-over trial. They were randomized to either a diet rich in whole grain, fatty fish, nuts, vegetables and fruit and supplemented with probiotics, or a control diet resembling average nutritional intake in Sweden, for ten weeks. After a 4-month washout they switched diet. Participants received food bags and dietary guidelines. Primary outcome was triglyceride (TG) concentration. Secondary outcomes were total-, high density lipoprotein- (HDL) and low density lipoprotein- (LDL) cholesterol, Apolipoprotein-B100 and -A1, lipoprotein composition, plasma phospholipid fatty acids and blood pressure.\n\nForty-seven patients completed at least one period and they remained weight stable. There was a significant between-dietary treatment effect in TG and HDL-cholesterol concentration in favor of intervention (p = 0.007 and p = 0.049, respectively). Likewise, Apolipoprotein-B100/A1 ratio shifted toward a less atherogenic profile in favor of the intervention (p = 0.007). Plasma fatty acids increased in polyunsaturated- and decreased in monounsaturated- and saturated fatty acids between diet periods in favor of the intervention period.\n\nBlood lipid profile improved indicating cardioprotective effects from an anti-inflammatory dietary intervention in patients with RA.\n\nThis trial is registered at ClinicalTrials.gov as NCT02941055 .", "doi": "10.1186/s12937-021-00663-y", "pmid": "33485336", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pii", "key": "10.1186/s12937-021-00663-y"}, {"db": "pmc", "key": "PMC7827982"}, {"db": "ClinicalTrials.gov", "key": "NCT02941055"}], "notes": [], "created": "2021-07-02T14:05:22.690Z", "modified": "2025-10-17T13:03:56.271Z"}]}