{"entity": "researcher", "timestamp": "2026-07-20T01:26:12.263Z", "family": "Svensson", "given": "J Peter", "initials": "JP", "orcid": "0000-0002-5863-6250", "affiliations": ["Department of Biosciences and Nutrition, Neo, Karolinska Institutet, Stockholm, Sweden"], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/8c226ba652024fdabbbf9203e1edb5d1.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/8c226ba652024fdabbbf9203e1edb5d1"}}, "publications": [{"entity": "publication", "iuid": "c70668b3d6344353b5fea94523f88e89", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c70668b3d6344353b5fea94523f88e89.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c70668b3d6344353b5fea94523f88e89"}}, "title": "Peripheral blood CD4+CCR6+ compartment differentiates HIV-1 infected or seropositive elite controllers from long-term successfully treated individuals.", "authors": [{"family": "Svensson Akusj\u00e4rvi", "given": "Sara", "initials": "S", "orcid": "0000-0002-1086-5409", "researcher": {"href": "https://publications.scilifelab.se/researcher/bc3e88a57db14fe0b99dd7b6286f0b81.json"}}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "J\u00fctte", "given": "Bianca B", "initials": "BB"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Gupta", "given": "Soham", "initials": "S", "orcid": "0000-0003-1136-3010", "researcher": {"href": "https://publications.scilifelab.se/researcher/3bbd430437164ba38676d7b94e2189ab.json"}}, {"family": "Rodriguez", "given": "Jimmy Esneider", "initials": "JE", "orcid": "0000-0002-6735-3332", "researcher": {"href": "https://publications.scilifelab.se/researcher/48d26949ce194599889ee9fb2a819f2d.json"}}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-1287-0906", "researcher": {"href": "https://publications.scilifelab.se/researcher/74be6e7c877e4f0da6c7ed3747f3ef9d.json"}}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Svensson", "given": "J Peter", "initials": "JP", "orcid": "0000-0002-5863-6250", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c226ba652024fdabbbf9203e1edb5d1.json"}}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications.scilifelab.se/researcher/2f8094017c2a4d0a94d72813cab526f7.json"}}], "type": "journal article", "published": "2022-04-13", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "5", "issue": "1", "pages": "357", "issn-l": "2399-3642"}, "abstract": "HIV-1 infection induces a chronic inflammatory environment not restored by suppressive antiretroviral therapy (ART). As of today, the effect of viral suppression and immune reconstitution in people living with HIV-1 (PLWH) has been well described but not completely understood. Herein, we show how PLWH who naturally control the virus (PLWHEC) have a reduced proportion of CD4+CCR6+ and CD8+CCR6+ cells compared to PLWH on suppressive ART (PLWHART) and HIV-1 negative controls (HC). Expression of CCR2 was reduced on both CD4+, CD8+ and classical monocytes in PLWHEC compared to PLWHART and HC. Longer suppressive therapy, measured in the same patients, decreased number of cells expressing CCR2 on all monocytic cell populations while expression on CD8+ T cells increased. Furthermore, the CD4+CCR6+/CCR6- cells exhibited a unique proteomic profile with a modulated energy metabolism in PLWHEC compared to PLWHART independent of CCR6 status. The CD4+CCR6+ cells also showed an enrichment in proteins involved in apoptosis and p53 signalling in PLWHEC compared to PLWHART, indicative of increased sensitivity towards cell death mechanisms. Collectively, this data shows how PLWHEC have a unique chemokine receptor profile that may aid in facilitating natural control of HIV-1 infection.", "doi": "10.1038/s42003-022-03315-x", "pmid": "35418589", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9008025"}, {"db": "pii", "key": "10.1038/s42003-022-03315-x"}], "notes": [], "created": "2022-12-02T08:49:45.869Z", "modified": "2022-12-02T08:49:45.999Z"}, {"entity": "publication", "iuid": "be5bf1b1f6ab471bbecf5c58227c4a16", "links": {"self": {"href": "https://publications.scilifelab.se/publication/be5bf1b1f6ab471bbecf5c58227c4a16.json"}, "display": {"href": "https://publications.scilifelab.se/publication/be5bf1b1f6ab471bbecf5c58227c4a16"}}, "title": "A regulatory role for CHD2 in myelopoiesis.", "authors": [{"family": "Shahin Varnoosfaderani", "given": "Farzaneh", "initials": "F"}, {"family": "Palau", "given": "Anna", "initials": "A"}, {"family": "Dong", "given": "Wenbo", "initials": "W", "orcid": "0000-0002-5209-4884", "researcher": {"href": "https://publications.scilifelab.se/researcher/81bd1bba109e48ab9e3c19d3c947bf82.json"}}, {"family": "Persson", "given": "Jenna", "initials": "J"}, {"family": "Durand-Dubief", "given": "Micka\u00ebl", "initials": "M", "orcid": "0000-0002-8556-4459", "researcher": {"href": "https://publications.scilifelab.se/researcher/85c11d5d8d94488aad3e77a84b89ff8d.json"}}, {"family": "Svensson", "given": "J Peter", "initials": "JP", "orcid": "0000-0002-5863-6250", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c226ba652024fdabbbf9203e1edb5d1.json"}}, {"family": "Lennartsson", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2020-01-10", "journal": {"title": "Epigenetics", "issn": "1559-2308", "volume": "15", "issue": "6-7", "pages": "702-714", "issn-l": "1559-2294"}, "abstract": "The transcriptional program that dictates haematopoietic cell fate and differentiation requires an epigenetic regulatory and memory function, provided by a network of epigenetic factors that regulate DNA methylation, post-translational histone modifications and chromatin structure. Disturbed epigenetic regulation causes perturbations in the blood cell differentiation program that results in various types of haematopoietic disorders. Thus, accurate epigenetic regulation is essential for functional haematopoiesis. In this study, we used a CRISPR-Cas9 screening approach to identify new epigenetic regulators in myeloid differentiation. We designed a Chromatin-UMI CRISPR guide library targeting 1092 epigenetic regulators. Phorbol 12-myristate 13-acetate (PMA) treatment of the chronic myeloid leukaemia cell line K-562 was used as a megakaryocytic myeloid differentiation model. Both previously described developmental epigenetic regulators and novel factors were identified in our screen. In this study, we validated and characterized a role for the chromatin remodeller CHD2 in myeloid proliferation and megakaryocytic differentiation.", "doi": "10.1080/15592294.2019.1710913", "pmid": "31900031", "labels": {"NGI Stockholm (Genomics Production)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "National Genomics Infrastructure": "Service", "CRISPR Functional Genomics": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC7574388"}], "notes": [], "created": "2020-01-20T10:22:28.949Z", "modified": "2024-01-16T13:48:43.086Z"}]}