{"entity": "researcher", "timestamp": "2026-10-12T15:13:38.014Z", "family": "Mugal", "given": "Carina F", "initials": "CF", "orcid": "0000-0003-4220-4928", "affiliations": ["Department of Ecology and Genetics, Uppsala University, 752 36 Uppsala, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/8b82f77594994c37b37c72b653e20c28.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/8b82f77594994c37b37c72b653e20c28"}}, "publications": [{"entity": "publication", "iuid": "aedc87381ee04660b9bf4f87238dc4fc", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aedc87381ee04660b9bf4f87238dc4fc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aedc87381ee04660b9bf4f87238dc4fc"}}, "title": "The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome\u2020.", "authors": [{"family": "Chase", "given": "Madeline A", "initials": "MA", "orcid": "0000-0002-7916-3560", "researcher": {"href": "https://publications.scilifelab.se/researcher/3053121df4b64418bc1dcc2d7e50d87c.json"}}, {"family": "Vilcot", "given": "Maurine", "initials": "M", "orcid": "0000-0001-8765-1364", "researcher": {"href": "https://publications.scilifelab.se/researcher/c189cd3e23ad42fbb85859404c2846fc.json"}}, {"family": "Mugal", "given": "Carina F", "initials": "CF", "orcid": "0000-0003-4220-4928", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b82f77594994c37b37c72b653e20c28.json"}}], "type": "journal article", "published": "2024-01-31", "journal": {"title": "Proc. Biol. Sci.", "issn": "1471-2954", "volume": "291", "issue": "2015", "pages": "20232382", "issn-l": "0962-8452"}, "abstract": "Recombination is a central evolutionary process that reshuffles combinations of alleles along chromosomes, and consequently is expected to influence the efficacy of direct selection via Hill-Robertson interference. Additionally, the indirect effects of selection on neutral genetic diversity are expected to show a negative relationship with recombination rate, as background selection and genetic hitchhiking are stronger when recombination rate is low. However, owing to the limited availability of recombination rate estimates across divergent species, the impact of evolutionary changes in recombination rate on genomic signatures of selection remains largely unexplored. To address this question, we estimate recombination rate in two Ficedula flycatcher species, the taiga flycatcher (Ficedula albicilla) and collared flycatcher (Ficedula albicollis). We show that recombination rate is strongly correlated with signatures of indirect selection, and that evolutionary changes in recombination rate between species have observable impacts on this relationship. Conversely, signatures of direct selection on coding sequences show little to no relationship with recombination rate, even when restricted to genes where recombination rate is conserved between species. Thus, using measures of indirect and direct selection that bridge micro- and macro-evolutionary timescales, we demonstrate that the role of recombination rate and its dynamics varies for different signatures of selection.", "doi": "10.1098/rspb.2023.2382", "pmid": "38228173", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10791521"}], "notes": [], "created": "2024-11-25T10:26:12.315Z", "modified": "2025-02-28T14:19:32.393Z"}, {"entity": "publication", "iuid": "c076418d68764ae2a155af8f6a65e145", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c076418d68764ae2a155af8f6a65e145.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c076418d68764ae2a155af8f6a65e145"}}, "title": "The genomic basis of hybrid male sterility in <i>Ficedula<\/i> flycatchers", "authors": [{"family": "Segami", "given": "J Carolina", "initials": "JC", "orcid": "0000-0002-9885-1537", "researcher": {"href": "https://publications.scilifelab.se/researcher/df8671d266d944f6830a3aa995dd85b1.json"}}, {"family": "Mugal", "given": "Carina F", "initials": "CF", "orcid": "0000-0003-4220-4928", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b82f77594994c37b37c72b653e20c28.json"}}, {"family": "Cunha", "given": "Catarina", "initials": "C", "orcid": "0000-0001-9038-2337", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9611df9603145b792ffb1601e388e61.json"}}, {"family": "Bergin", "given": "Claudia", "initials": "C", "orcid": "0000-0001-7960-1789", "researcher": {"href": "https://publications.scilifelab.se/researcher/fdd58ab07d964bcfb865ce67f7826816.json"}}, {"family": "Schmitz", "given": "Monika", "initials": "M"}, {"family": "Semon", "given": "Marie", "initials": "M", "orcid": "0000-0003-3479-7524", "researcher": {"href": "https://publications.scilifelab.se/researcher/5080c342bcd849e5bd77f5910c62c65a.json"}}, {"family": "Qvarnstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0002-1178-4053", "researcher": {"href": "https://publications.scilifelab.se/researcher/143f35c30ac14357b6eb615a05cad060.json"}}], "type": "posted-content", "published": "2022-09-19", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.09.19.508503", "pmid": null, "labels": {"Microbial Single Cell Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2022-11-29T15:02:36.373Z", "modified": "2025-12-18T19:59:41.272Z"}, {"entity": "publication", "iuid": "963affe5f83c476580407cca1d72abcd", "links": {"self": {"href": "https://publications.scilifelab.se/publication/963affe5f83c476580407cca1d72abcd.json"}, "display": {"href": "https://publications.scilifelab.se/publication/963affe5f83c476580407cca1d72abcd"}}, "title": "Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals", "authors": [{"family": "Segami", "given": "J Carolina", "initials": "JC", "orcid": "0000-0002-9885-1537", "researcher": {"href": "https://publications.scilifelab.se/researcher/df8671d266d944f6830a3aa995dd85b1.json"}}, {"family": "Semon", "given": "Marie", "initials": "M", "orcid": "0000-0003-3479-7524", "researcher": {"href": "https://publications.scilifelab.se/researcher/5080c342bcd849e5bd77f5910c62c65a.json"}}, {"family": "Cunha", "given": "Catarina", "initials": "C", "orcid": "0000-0001-9038-2337", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9611df9603145b792ffb1601e388e61.json"}}, {"family": "Bergin", "given": "Claudia", "initials": "C", "orcid": "0000-0001-7960-1789", "researcher": {"href": "https://publications.scilifelab.se/researcher/fdd58ab07d964bcfb865ce67f7826816.json"}}, {"family": "Mugal", "given": "Carina F", "initials": "CF", "orcid": "0000-0003-4220-4928", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b82f77594994c37b37c72b653e20c28.json"}}, {"family": "Qvarnstr\u00f6m", "given": "Anna", "initials": "A", "orcid": "0000-0002-1178-4053", "researcher": {"href": "https://publications.scilifelab.se/researcher/143f35c30ac14357b6eb615a05cad060.json"}}], "type": "posted-content", "published": "2022-01-23", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.01.22.477241", "pmid": null, "labels": {"Microbial Single Cell Genomics": "Technology development"}, "xrefs": [], "notes": [], "created": "2022-11-29T13:59:48.493Z", "modified": "2025-12-18T20:02:53.534Z"}, {"entity": "publication", "iuid": "144f11f34c2647769832d1490ea233c6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/144f11f34c2647769832d1490ea233c6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/144f11f34c2647769832d1490ea233c6"}}, "title": "Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids.", "authors": [{"family": "Mugal", "given": "Carina F", "initials": "CF", "orcid": "0000-0003-4220-4928", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b82f77594994c37b37c72b653e20c28.json"}}, {"family": "Wang", "given": "Mi", "initials": "M"}, {"family": "Backstr\u00f6m", "given": "Niclas", "initials": "N"}, {"family": "Wheatcroft", "given": "David", "initials": "D"}, {"family": "\u00c5lund", "given": "Murielle", "initials": "M"}, {"family": "S\u00e9mon", "given": "Marie", "initials": "M"}, {"family": "McFarlane", "given": "S Eryn", "initials": "SE"}, {"family": "Dutoit", "given": "Ludovic", "initials": "L"}, {"family": "Qvarnstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Ellegren", "given": "Hans", "initials": "H", "orcid": "0000-0002-5035-1736", "researcher": {"href": "https://publications.scilifelab.se/researcher/819e68cc7125446baec6165aabd2d19c.json"}}], "type": "journal article", "published": "2020-12-00", "journal": {"title": "Genome Res.", "issn": "1549-5469", "volume": "30", "issue": "12", "pages": "1727-1739", "issn-l": "1088-9051"}, "abstract": "Changes in interacting cis- and trans-regulatory elements are important candidates for Dobzhansky-Muller hybrid incompatibilities and may contribute to hybrid dysfunction by giving rise to misexpression in hybrids. To gain insight into the molecular mechanisms and determinants of gene expression evolution in natural populations, we analyzed the transcriptome from multiple tissues of two recently diverged Ficedula flycatcher species and their naturally occurring F1 hybrids. Differential gene expression analysis revealed that the extent of differentiation between species and the set of differentially expressed genes varied across tissues. Common to all tissues, a higher proportion of Z-linked genes than autosomal genes showed differential expression, providing evidence for a fast-Z effect. We further found clear signatures of hybrid misexpression in brain, heart, kidney, and liver. However, while testis showed the highest divergence of gene expression among tissues, it showed no clear signature of misexpression in F1 hybrids, even though these hybrids were found to be sterile. It is therefore unlikely that incompatibilities between cis-trans regulatory changes explain the observed sterility. Instead, we found evidence that cis-regulatory changes play a significant role in the evolution of gene expression in testis, which illustrates the tissue-specific nature of cis-regulatory evolution bypassing constraints associated with pleiotropic effects of genes.", "doi": "10.1101/gr.254508.119", "pmid": "33144405", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "gr.254508.119"}, {"db": "pmc", "key": "PMC7706733"}], "notes": [], "created": "2020-12-08T23:45:03.587Z", "modified": "2024-01-16T13:48:41.199Z"}]}