{"entity": "researcher", "timestamp": "2026-07-20T00:50:51.624Z", "family": "Tedder", "given": "Andrew", "initials": "A", "orcid": "0000-0002-7378-4673", "affiliations": ["Department of Ecology, Environment and Plant Sciences, Science for Life Laboratory, Stockholm University, SE-106 91, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/8a29b3c1160f46bf8b21e331268eb4b1.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/8a29b3c1160f46bf8b21e331268eb4b1"}}, "publications": [{"entity": "publication", "iuid": "ddf03b5f1f1c47209a97f015b429d9c4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ddf03b5f1f1c47209a97f015b429d9c4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ddf03b5f1f1c47209a97f015b429d9c4"}}, "title": "On the origin of the widespread self-compatible allotetraploid Capsella bursa-pastoris (Brassicaceae).", "authors": [{"family": "Bachmann", "given": "J\u00f6rg A", "initials": "JA", "orcid": "0000-0002-7212-813X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dadd1300e85443d8ee98a2d58d08a4b.json"}}, {"family": "Tedder", "given": "Andrew", "initials": "A", "orcid": "0000-0002-7378-4673", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a29b3c1160f46bf8b21e331268eb4b1.json"}}, {"family": "Fracassetti", "given": "Marco", "initials": "M", "orcid": "0000-0002-2962-2669", "researcher": {"href": "https://publications.scilifelab.se/researcher/695213cdd1a645cbbf10d44122237b18.json"}}, {"family": "Steige", "given": "Kim A", "initials": "KA"}, {"family": "Lafon-Placette", "given": "Cl\u00e9ment", "initials": "C"}, {"family": "K\u00f6hler", "given": "Claudia", "initials": "C", "orcid": "0000-0002-2619-4857", "researcher": {"href": "https://publications.scilifelab.se/researcher/accd3f9307614c8ab67154dd5e50cdac.json"}}, {"family": "Slotte", "given": "Tanja", "initials": "T"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Heredity (Edinb)", "issn": "1365-2540", "issn-l": "0018-067X", "volume": "127", "issue": "1", "pages": "124-134"}, "abstract": "Polyploidy, or whole-genome duplication, is a common speciation mechanism in plants. An important barrier to polyploid establishment is a lack of compatible mates. Because self-compatibility alleviates this problem, it has long been hypothesized that there should be an association between polyploidy and self-compatibility (SC), but empirical support for this prediction is mixed. Here, we investigate whether the molecular makeup of the Brassicaceae self-incompatibility (SI) system, and specifically dominance relationships among S-haplotypes mediated by small RNAs, could facilitate loss of SI in allopolyploid crucifers. We focus on the allotetraploid species Capsella bursa-pastoris, which formed ~300 kya by hybridization and whole-genome duplication involving progenitors from the lineages of Capsella orientalis and Capsella grandiflora. We conduct targeted long-read sequencing to assemble and analyze eight full-length S-locus haplotypes, representing both homeologous subgenomes of C. bursa-pastoris. We further analyze small RNA (sRNA) sequencing data from flower buds to identify candidate dominance modifiers. We find that C. orientalis-derived S-haplotypes of C. bursa-pastoris harbor truncated versions of the male SI specificity gene SCR and express a conserved sRNA-based candidate dominance modifier with a target in the C. grandiflora-derived S-haplotype. These results suggest that pollen-level dominance may have facilitated loss of SI in C. bursa-pastoris. Finally, we demonstrate that spontaneous somatic tetraploidization after a wide cross between C. orientalis and C. grandiflora can result in production of self-compatible tetraploid offspring. We discuss the implications of this finding on the mode of formation of this widespread weed.", "doi": "10.1038/s41437-021-00434-9", "pmid": "33875831", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41437-021-00434-9"}, {"db": "pmc", "key": "PMC8249383"}], "notes": [], "created": "2021-09-02T09:52:09.038Z", "modified": "2024-01-16T13:48:39.247Z"}, {"entity": "publication", "iuid": "e0e653f6b4f54d8584da0f7e3225d6ab", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e0e653f6b4f54d8584da0f7e3225d6ab.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e0e653f6b4f54d8584da0f7e3225d6ab"}}, "title": "Genetic basis and timing of a major mating system shift in Capsella.", "authors": [{"family": "Bachmann", "given": "J\u00f6rg A", "initials": "JA"}, {"family": "Tedder", "given": "Andrew", "initials": "A", "orcid": "0000-0002-7378-4673", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a29b3c1160f46bf8b21e331268eb4b1.json"}}, {"family": "Laenen", "given": "Benjamin", "initials": "B"}, {"family": "Fracassetti", "given": "Marco", "initials": "M", "orcid": "0000-0002-2962-2669", "researcher": {"href": "https://publications.scilifelab.se/researcher/695213cdd1a645cbbf10d44122237b18.json"}}, {"family": "D\u00e9samor\u00e9", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0003-1922-3557", "researcher": {"href": "https://publications.scilifelab.se/researcher/e117d822871c4a38960b526e3d0dcd0a.json"}}, {"family": "Lafon-Placette", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0001-6634-8104", "researcher": {"href": "https://publications.scilifelab.se/researcher/63262f71f9c54f438d6f08380d799d96.json"}}, {"family": "Steige", "given": "Kim A", "initials": "KA"}, {"family": "Callot", "given": "Caroline", "initials": "C"}, {"family": "Marande", "given": "William", "initials": "W"}, {"family": "Neuffer", "given": "Barbara", "initials": "B"}, {"family": "Berg\u00e8s", "given": "H\u00e9l\u00e8ne", "initials": "H", "orcid": "0000-0002-5492-1062", "researcher": {"href": "https://publications.scilifelab.se/researcher/728be2338bd2407980d11b8850d85d9c.json"}}, {"family": "K\u00f6hler", "given": "Claudia", "initials": "C", "orcid": "0000-0002-2619-4857", "researcher": {"href": "https://publications.scilifelab.se/researcher/accd3f9307614c8ab67154dd5e50cdac.json"}}, {"family": "Castric", "given": "Vincent", "initials": "V", "orcid": "0000-0002-4461-4915", "researcher": {"href": "https://publications.scilifelab.se/researcher/f891128567d64aaba03bdd9f4bc5d458.json"}}, {"family": "Slotte", "given": "Tanja", "initials": "T", "orcid": "0000-0001-6020-5102", "researcher": {"href": "https://publications.scilifelab.se/researcher/67c69ee78bae41478465a7e5fa63b946.json"}}], "type": "journal article", "published": "2019-10-00", "journal": {"volume": "224", "issn": "1469-8137", "issue": "1", "pages": "505-517", "title": "New Phytol.", "issn-l": "0028-646X"}, "abstract": "A crucial step in the transition from outcrossing to self-fertilization is the loss of genetic self-incompatibility (SI). In the Brassicaceae, SI involves the interaction of female and male specificity components, encoded by the genes SRK and SCR at the self-incompatibility locus (S-locus). Theory predicts that S-linked mutations, and especially dominant mutations in SCR, are likely to contribute to loss of SI. However, few studies have investigated the contribution of dominant mutations to loss of SI in wild plant species. Here, we investigate the genetic basis of loss of SI in the self-fertilizing crucifer species Capsella orientalis, by combining genetic mapping, long-read sequencing of complete S-haplotypes, gene expression analyses and controlled crosses. We show that loss of SI in C. orientalis occurred < 2.6 Mya and maps as a dominant trait to the S-locus. We identify a fixed frameshift deletion in the male specificity gene SCR and confirm loss of male SI specificity. We further identify an S-linked small RNA that is predicted to cause dominance of self-compatibility. Our results agree with predictions on the contribution of dominant S-linked mutations to loss of SI, and thus provide new insights into the molecular basis of mating system transitions.", "doi": "10.1111/nph.16035", "pmid": "31254395", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "GENBANK", "key": "PRJEB32122"}, {"db": "GENBANK", "key": "KJ772374.1"}], "notes": [], "created": "2019-12-03T10:47:11.816Z", "modified": "2024-01-16T13:48:43.769Z"}]}