{"entity": "researcher", "timestamp": "2026-08-07T10:34:43.301Z", "family": "Burkhardt", "given": "Harald", "initials": "H", "orcid": "0000-0002-6261-3131", "affiliations": ["Fraunhofer Institute for Translational Medicine and Pharmacology, and Fraunhofer Cluster of Excellence for Immune-Mediated Diseases , Frankfurt am Main, Germany.", "Division of Rheumatology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/89e31cfcedb24f4ba63420e8ac7903a6.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/89e31cfcedb24f4ba63420e8ac7903a6"}}, "publications": [{"entity": "publication", "iuid": "105f960199ea414c8b533eded245b31c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/105f960199ea414c8b533eded245b31c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/105f960199ea414c8b533eded245b31c"}}, "title": "Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.", "authors": [{"family": "Aoun", "given": "Mike", "initials": "M", "orcid": "0000-0002-7814-3787", "researcher": {"href": "https://publications.scilifelab.se/researcher/3e342417528f4a92a8e84558359b6bfa.json"}}, {"family": "Coelho", "given": "Ana", "initials": "A", "orcid": "0000-0001-7783-9750", "researcher": {"href": "https://publications.scilifelab.se/researcher/163d8babd72b406d94647b4cfd9d7e5b.json"}}, {"family": "Kr\u00e4mer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2288-2361", "researcher": {"href": "https://publications.scilifelab.se/researcher/50b1230e5acf4ad89344e8d1ae404ef2.json"}}, {"family": "Saxena", "given": "Amit", "initials": "A", "orcid": "0000-0002-1185-8649", "researcher": {"href": "https://publications.scilifelab.se/researcher/d230e0159adc4d7dbd1c3e7ded94dcec.json"}}, {"family": "Sabatier", "given": "Pierre", "initials": "P", "orcid": "0000-0002-2734-1791", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a75556311084e2b827ab1f646d7a16c.json"}}, {"family": "Beusch", "given": "Christian Michel", "initials": "CM", "orcid": "0000-0001-9100-8283", "researcher": {"href": "https://publications.scilifelab.se/researcher/278e50b11a3c4ef69b6e2708f99b5f3e.json"}}, {"family": "L\u00f6nnblom", "given": "Erik", "initials": "E", "orcid": "0000-0002-1311-2541", "researcher": {"href": "https://publications.scilifelab.se/researcher/0f5683b51d554ff482bd76c0ded3aaa2.json"}}, {"family": "Geng", "given": "Manman", "initials": "M", "orcid": "0009-0003-7502-4699", "researcher": {"href": "https://publications.scilifelab.se/researcher/0370014234f54ad08bba271bc19f2703.json"}}, {"family": "Do", "given": "Nhu-Nguyen", "initials": "NN", "orcid": "0000-0001-6483-8062", "researcher": {"href": "https://publications.scilifelab.se/researcher/0de1bfd7cdc945378b2eb973237345bc.json"}}, {"family": "Xu", "given": "Zhongwei", "initials": "Z", "orcid": "0000-0001-5178-3437", "researcher": {"href": "https://publications.scilifelab.se/researcher/f056000b3af842bda8cdd411da7d44ad.json"}}, {"family": "Zhang", "given": "Jingdian", "initials": "J", "orcid": "0000-0002-5685-8386", "researcher": {"href": "https://publications.scilifelab.se/researcher/e208f3fec0f34151a5916ff260e2ace7.json"}}, {"family": "He", "given": "Yibo", "initials": "Y", "orcid": "0000-0003-0659-2150", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e734ee308394c35ba53ef6ed344cfa7.json"}}, {"family": "Romero Castillo", "given": "Laura", "initials": "L", "orcid": "0000-0002-0271-212X", "researcher": {"href": "https://publications.scilifelab.se/researcher/432706cab4ec46258698725df3b02f6c.json"}}, {"family": "Abolhassani", "given": "Hassan", "initials": "H", "orcid": "0000-0002-4838-0407", "researcher": {"href": "https://publications.scilifelab.se/researcher/20370042ca1045c3bcaac67821a93df2.json"}}, {"family": "Xu", "given": "Bingze", "initials": "B", "orcid": "0000-0002-5341-1722", "researcher": {"href": "https://publications.scilifelab.se/researcher/d262ebec52004d1f8bc77d43cafe0cc7.json"}}, {"family": "Viljanen", "given": "Johan", "initials": "J", "orcid": "0009-0003-7291-4178", "researcher": {"href": "https://publications.scilifelab.se/researcher/2519e15fb9c74494a72cfcea38c304ca.json"}}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications.scilifelab.se/researcher/a069374613a7403b818ce7ca400f3627.json"}}, {"family": "Fernandez Lahore", "given": "Gonzalo", "initials": "G", "orcid": "0000-0002-4291-0251", "researcher": {"href": "https://publications.scilifelab.se/researcher/520747ac45e94b0fb8f0fb08b849eecc.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Kastbom", "given": "Alf", "initials": "A", "orcid": "0000-0001-7187-1477", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9b6d835959e4613995904bf3a01733c.json"}}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe4dd47b8ca1436e8a26fdea33f5e7f6.json"}}, {"family": "Kihlberg", "given": "Jan", "initials": "J", "orcid": "0000-0002-4205-6040", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9805d4f39cc48f79a6e6ba076917021.json"}}, {"family": "Zubarev", "given": "Roman A", "initials": "RA", "orcid": "0000-0001-9839-2089", "researcher": {"href": "https://publications.scilifelab.se/researcher/e971b9cdec2b4411934f9c5d535da8b4.json"}}, {"family": "Burkhardt", "given": "Harald", "initials": "H", "orcid": "0000-0002-6261-3131", "researcher": {"href": "https://publications.scilifelab.se/researcher/89e31cfcedb24f4ba63420e8ac7903a6.json"}}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications.scilifelab.se/researcher/49e60d22dd1a4dd1a4ca5a50d9fc4fc7.json"}}], "type": "journal article", "published": "2023-11-06", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "220", "issue": "11", "issn-l": "0022-1007"}, "abstract": "B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural autoreactive B cells (C1-B) specific for a defined triple-helical epitope on collagen type-II (COL2), constituting a sizeable fraction of the physiological B cell repertoire in mice, rats, and humans. Adoptive transfer of C1-B suppressed arthritis independently of IL10, separating them from IL10-secreting regulatory B cells. Single-cell sequencing revealed an antigen processing and presentation signature, including induced expression of CD72 and CCR7 as surface markers. C1-B presented COL2 to T cells and induced the expansion of regulatory T cells in a contact-dependent manner. CD72 blockade impeded this effect suggesting a new downstream suppressor mechanism that regulates antigen-specific T cell tolerization. Thus, our results indicate that autoreactive antigen-specific na\u00efve B cells tolerize infiltrating T cells against self-antigens to impede the development of tissue-specific autoimmune inflammation.", "doi": "10.1084/jem.20230101", "pmid": "37695523", "labels": {"Bioinformatics Support and Infrastructure": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10494526"}, {"db": "pii", "key": "276247"}], "notes": [], "created": "2023-11-16T12:01:57.118Z", "modified": "2024-01-16T13:48:31.724Z"}]}