{"entity": "researcher", "timestamp": "2026-08-15T06:44:40.746Z", "family": "Hasselgren", "given": "Malin", "initials": "M", "orcid": "0000-0002-4875-4413", "affiliations": ["Department of Zoology, Stockholm University, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/7e7f1368a98040f4a683c3d082483079.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/7e7f1368a98040f4a683c3d082483079"}}, "publications": [{"entity": "publication", "iuid": "22942ea7e4604351ab779e9dac5bcad1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/22942ea7e4604351ab779e9dac5bcad1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/22942ea7e4604351ab779e9dac5bcad1"}}, "title": "That's So Last Season: Unraveling the Genomic Consequences of Fur Farming in Arctic Foxes (Vulpes lagopus).", "authors": [{"family": "Cockerill", "given": "Christopher A", "initials": "CA", "orcid": "0000-0001-9776-3183", "researcher": {"href": "https://publications.scilifelab.se/researcher/43a0788d687045f7b0257996a55327b0.json"}}, {"family": "Chac\u00f3n-Duque", "given": "J Camilo", "initials": "JC"}, {"family": "Bergfeldt", "given": "Nora", "initials": "N"}, {"family": "von Seth", "given": "Johanna", "initials": "J"}, {"family": "Bj\u00f6rklund", "given": "Gabriella", "initials": "G"}, {"family": "Hasselgren", "given": "Malin", "initials": "M", "orcid": "0000-0002-4875-4413", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e7f1368a98040f4a683c3d082483079.json"}}, {"family": "Wall\u00e9n", "given": "Johan", "initials": "J"}, {"family": "Angerbj\u00f6rn", "given": "Anders", "initials": "A"}, {"family": "Fuglei", "given": "Eva", "initials": "E"}, {"family": "Unnsteinsdottir", "given": "Ester Rut", "initials": "ER"}, {"family": "White", "given": "Paula", "initials": "P"}, {"family": "Samelius", "given": "Gustaf", "initials": "G"}, {"family": "Alisauskas", "given": "Ray", "initials": "R"}, {"family": "Berteaux", "given": "Dominique", "initials": "D"}, {"family": "Flagstad", "given": "\u00d8ystein", "initials": "\u00d8"}, {"family": "Landa", "given": "Arild", "initials": "A"}, {"family": "Eide", "given": "Nina E", "initials": "NE"}, {"family": "Olsen", "given": "Remi-Andr\u00e9", "initials": "R"}, {"family": "Bunikis", "given": "Ignas", "initials": "I"}, {"family": "P\u00e1lsson", "given": "Sn\u00e6bj\u00f6rn", "initials": "S", "orcid": "0000-0002-4297-3500", "researcher": {"href": "https://publications.scilifelab.se/researcher/44a3d48564f04b5ea53d14f19bb623cc.json"}}, {"family": "Magn\u00fasson", "given": "Kristinn P\u00e9tur", "initials": "KP"}, {"family": "Dal\u00e9n", "given": "Love", "initials": "L"}, {"family": "Nor\u00e9n", "given": "Karin", "initials": "K", "orcid": "0000-0002-9707-5206", "researcher": {"href": "https://publications.scilifelab.se/researcher/40450a7e8cda45ba8292b9a677b3fb29.json"}}], "type": "journal article", "published": "2025-11-13", "journal": {"title": "Mol. Ecol.", "issn": "1365-294X", "issn-l": "0962-1083", "volume": null, "issue": null, "pages": "e70166"}, "abstract": "Humans have relied on animal fur for centuries, yet fur farming only began recently during the mid-19th Century. Little is known about this incipient domestication or the genomic processes involved. Domestication may involve founder effects, population bottlenecks and low population size, which, when combined with intense artificial selection, lead to inbreeding, a limited gene pool and reduced fitness. The arctic fox (Vulpes lagopus) has been farmed intensively since the early 1900s and has been artificially selected for economic phenotypes. We investigated the origin of these lineages and the genomic consequences of intensive farming by comparing the genomes of farmed and wild arctic foxes from across their range. Our research indicates recent inbreeding through long Runs of Homozygosity and reduced genomic variation in farmed foxes relative to their respective wild populations. We identified a coastal ecotype origin for all Fennoscandian farmed arctic foxes, aligning them phylogenetically with the wild Icelandic population, a geographically isolated and phenotypically distinct coastal lineage. The depleted genome-wide heterozygosity and increased recent inbreeding in farmed fox lineages is consistent with a heavy consequence of domestication, shedding light on the demographic history and genomic consequences of human manipulation. We highlight the need for increased genomic investigations into fur farm populations to understand the incipient domestication process and uncover the cost of intense farming. The genomic consequences of domestication must be considered in the management of fur farms, with actionable steps needed to prevent descendants of escaped farmed foxes from polluting the gene pool in the wild through introgression.", "doi": "10.1111/mec.70166", "pmid": "41229383", "labels": {"NGI Uppsala (Uppsala Genome Center)": "Collaborative", "National Genomics Infrastructure": "Service", "NGI Long read": "Collaborative", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service", "NGI Other": "Service"}, "xrefs": [], "notes": [], "created": "2025-11-16T14:58:28.536Z", "modified": "2025-11-19T07:43:38.634Z"}, {"entity": "publication", "iuid": "9efe05ebc70c4c4693210baba690ef94", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9efe05ebc70c4c4693210baba690ef94.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9efe05ebc70c4c4693210baba690ef94"}}, "title": "Genomic and fitness consequences of inbreeding in an endangered carnivore.", "authors": [{"family": "Hasselgren", "given": "Malin", "initials": "M", "orcid": "0000-0002-4875-4413", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e7f1368a98040f4a683c3d082483079.json"}}, {"family": "Dussex", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-9179-8593", "researcher": {"href": "https://publications.scilifelab.se/researcher/a8ce91163131424a99f8815c2cb96953.json"}}, {"family": "von Seth", "given": "Johanna", "initials": "J", "orcid": "0000-0002-1324-7489", "researcher": {"href": "https://publications.scilifelab.se/researcher/caeaa61758c4474ebd104ec232041341.json"}}, {"family": "Angerbj\u00f6rn", "given": "Anders", "initials": "A"}, {"family": "Olsen", "given": "Remi-Andr\u00e9", "initials": "RA"}, {"family": "Dal\u00e9n", "given": "Love", "initials": "L", "orcid": "0000-0001-8270-7613", "researcher": {"href": "https://publications.scilifelab.se/researcher/48ecf726779249ac9d12f4f7a1cc62bf.json"}}, {"family": "Nor\u00e9n", "given": "Karin", "initials": "K", "orcid": "0000-0002-9707-5206", "researcher": {"href": "https://publications.scilifelab.se/researcher/40450a7e8cda45ba8292b9a677b3fb29.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Mol. Ecol.", "issn": "1365-294X", "volume": "30", "issue": "12", "pages": "2790-2799", "issn-l": "0962-1083"}, "abstract": "Reduced fitness through genetic drift and inbreeding is a major threat to small and isolated populations. Although previous studies have generally used genetically verified pedigrees to document effects of inbreeding and gene flow, these often fail to capture the whole inbreeding history of the species. By assembling a draft arctic fox (Vulpes lagopus) genome and resequencing complete genomes of 23 additional foxes born before and after a well-documented immigration event in Scandinavia, we here look into the genomic consequences of inbreeding and genetic rescue. We found a difference in genome-wide diversity, with 18% higher heterozygosity and 81% lower FROH in immigrant F1 compared to native individuals. However, more distant descendants of immigrants (F2, F3) did not show the same pattern. We also found that foxes with lower inbreeding had higher probability to survive their first year of life. Our results demonstrate the important link between genetic variation and fitness as well as the transient nature of genetic rescue. Moreover, our results have implications in conservation biology as they demonstrate that inbreeding depression can effectively be detected in the wild by a genomic approach.", "doi": "10.1111/mec.15943", "pmid": "33955096", "labels": {"NGI Stockholm (Genomics Production)": null, "NGI Stockholm (Genomics Applications)": null, "National Genomics Infrastructure": null, "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "Dryad", "key": "10.5061/dryad.gmsbcc2mn"}], "notes": [], "created": "2021-06-09T12:16:53.553Z", "modified": "2024-01-16T13:48:39.611Z"}]}