{"entity": "researcher", "timestamp": "2026-07-20T13:32:47.495Z", "family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "affiliations": ["Department of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2"}}, "publications": [{"entity": "publication", "iuid": "26b2d2e481ee4340b58cb2399170e18c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/26b2d2e481ee4340b58cb2399170e18c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/26b2d2e481ee4340b58cb2399170e18c"}}, "title": "Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Ruan", "given": "Xixin", "initials": "X", "orcid": "0000-0002-4937-9168", "researcher": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}}, {"family": "Li", "given": "Yuying", "initials": "Y", "orcid": "0000-0002-3231-7542", "researcher": {"href": "https://publications.scilifelab.se/researcher/019bd04ea79a42eda01be14c54af5090.json"}}, {"family": "Abramowitz", "given": "Sarah A", "initials": "SA"}, {"family": "Wang", "given": "Lijuan", "initials": "L", "orcid": "0000-0002-9797-0753", "researcher": {"href": "https://publications.scilifelab.se/researcher/97af8fc0299a4c25aa4f31841007a8f8.json"}}, {"family": "Jiang", "given": "Fangyuan", "initials": "F"}, {"family": "Xiong", "given": "Ying", "initials": "Y", "orcid": "0000-0001-7644-014X", "researcher": {"href": "https://publications.scilifelab.se/researcher/72484ccb61b140ca946294b68042c330.json"}}, {"family": "Levin", "given": "Michael G", "initials": "MG", "orcid": "0000-0002-9937-9932", "researcher": {"href": "https://publications.scilifelab.se/researcher/d165b2fd025f41fab9959e82610492a3.json"}}, {"family": "Voight", "given": "Benjamin F", "initials": "BF", "orcid": "0000-0002-6205-9994", "researcher": {"href": "https://publications.scilifelab.se/researcher/d3d9e9de96ee4983ba97efc14eb3d79b.json"}}, {"family": "Gill", "given": "Dipender", "initials": "D", "orcid": "0000-0001-7312-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca049660534b4f18ab8a16da46ffca52.json"}}, {"family": "Burgess", "given": "Stephen", "initials": "S", "orcid": "0000-0001-5365-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fd2dcaf4dbb4e4c91c2af460b8fa98f.json"}}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A", "orcid": "0000-0001-9594-4140", "researcher": {"href": "https://publications.scilifelab.se/researcher/f699e3a40b424acd9461ca03f288d6bc.json"}}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Li", "given": "Xue", "initials": "X", "orcid": "0000-0001-6880-2577", "researcher": {"href": "https://publications.scilifelab.se/researcher/360d5c60409d415f8c6957d9e3373cd0.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications.scilifelab.se/researcher/b878210396ae46eba9f04f78be5ff564.json"}}, {"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}], "type": "journal article", "published": "2025-07-11", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "6426", "issn-l": "2041-1723"}, "abstract": "Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 168,007 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian randomization identified modifiable risk factors and circulating proteins, informing disease prevention and drug development. Integrating genomic data from this cross-population genome-wide meta-analysis with proteomic profiling significantly enhanced AF risk prediction. This study advances our understanding of the genetic etiology of AF while also enhancing risk prediction, prevention strategies, and therapeutic development.", "doi": "10.1038/s41467-025-61720-2", "pmid": "40645996", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12254421"}, {"db": "pii", "key": "10.1038/s41467-025-61720-2"}], "notes": [], "created": "2025-11-28T10:45:39.870Z", "modified": "2025-11-28T10:45:40.305Z"}, {"entity": "publication", "iuid": "95cbfa77bb344c08bf41cb612bea42f1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/95cbfa77bb344c08bf41cb612bea42f1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/95cbfa77bb344c08bf41cb612bea42f1"}}, "title": "Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Ruan", "given": "Xixian", "initials": "X", "orcid": "0000-0002-4937-9168", "researcher": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}}, {"family": "Li", "given": "Xue", "initials": "X", "orcid": "0000-0001-6880-2577", "researcher": {"href": "https://publications.scilifelab.se/researcher/360d5c60409d415f8c6957d9e3373cd0.json"}}, {"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}], "type": "journal article", "published": "2025-03-03", "journal": {"title": "JNCI Cancer Spectr", "issn": "2515-5091", "volume": "9", "issue": "2", "issn-l": null}, "abstract": "The causes of bladder cancer are not completely understood. Our objective was to identify blood proteins and modifiable causal risk factors for bladder cancer by combining genome-wide association study (GWAS) and Mendelian randomization (MR) analyses.\n\nWe first performed a GWAS meta-analysis of 6984 bladder cancer case patients and 708 432 control individuals from 3 European databases. Next, we conducted 2-sample MR and colocalization analyses using data from the present GWAS and published GWAS meta-analyses on plasma proteins and modifiable factors.\n\nGenome-wide association study meta-analysis uncovered 17 bladder cancer susceptibility loci, of which 3 loci were novel. Genes were enriched in pathways related to the metabolic and catabolic processes of xenobiotics and cellular detoxification. Proteome-wide MR analysis based on cis-acting genetic variants revealed that higher plasma levels of glutathione S-transferases were strongly associated with a reduced risk of bladder cancer. There is strong evidence of colocalization between GSTM1 and bladder cancer. Finally, multivariable MR analyses of suspected risk factors for bladder cancer revealed independent causal associations between smoking and adiposity, particularly abdominal obesity, and risk of bladder cancer.\n\nFindings from this large-scale GWAS and multivariable MR analyses highlight the key role of detoxification processes, particularly glutathione S-transferase 1, as well as smoking and abdominal obesity in bladder cancer etiology.", "doi": "10.1093/jncics/pkaf014", "pmid": "39898788", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11950924"}, {"db": "pii", "key": "7997273"}], "notes": [], "created": "2025-11-28T10:49:53.296Z", "modified": "2025-11-28T10:49:53.391Z"}, {"entity": "publication", "iuid": "e6431c56a9a44473a9004b296677bac7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e6431c56a9a44473a9004b296677bac7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e6431c56a9a44473a9004b296677bac7"}}, "title": "Association between alcohol consumption and peripheral artery disease: two de novo prospective cohorts and a systematic review with meta-analysis.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Wu", "given": "Jing", "initials": "J"}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Sun", "given": "Yuhao", "initials": "Y", "orcid": "0000-0001-6987-3721", "researcher": {"href": "https://publications.scilifelab.se/researcher/aabdcfb442cd4ac7931e27767753bec3.json"}}, {"family": "Burgess", "given": "Stephen", "initials": "S", "orcid": "0000-0001-5365-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fd2dcaf4dbb4e4c91c2af460b8fa98f.json"}}, {"family": "Li", "given": "Xue", "initials": "X"}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "systematic review", "published": "2025-01-27", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": "32", "issue": "2", "pages": "149-155", "issn-l": "2047-4873"}, "abstract": "The association between alcohol consumption and risk of peripheral artery disease (PAD) is inconclusive. We conducted this study to examine the association between alcohol consumption and PAD risk in two de novo cohort studies and a meta-analysis of observational studies.\n\nA systematic review was conducted to identify studies on alcohol consumption in relation to PAD risk. We further used data from two cohorts of 70 116 Swedish and 405 406 British adults and performed a meta-analysis of results from previously published studies and current cohort studies. There was a U-shaped association between alcohol consumption and incident PAD risk in the Swedish and British cohorts. The meta-analysis of results of these two cohorts and previously published studies found that compared with non- or never-drinkers, the relative risk of PAD was 0.83 [95% confidence interval (CI) 0.77-0.89], 0.81 (95% CI 0.74-0.90), and 0.94 (95% CI 0.83-1.07) for light, moderate, and high-to-heavy alcohol drinkers, respectively. The nonlinear meta-analysis revealed a possibly U-shaped association between alcohol consumption and PAD risk (P nonlinearity <0.001). The risk of PAD was observed to be the lowest for 2 drinks/week and to be pronounced for \u226510 drinks/week. All these associations persisted in a sensitivity meta-analysis including cohort and other types of observational studies.\n\nAlcohol intake \u22642 drinks/week was associated with a reduced risk of PAD, and the risk of PAD became pronounced with intake \u226510 drinkers/week.", "doi": "10.1093/eurjpc/zwae142", "pmid": "38626304", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "mid", "key": "EMS197946"}, {"db": "pmc", "key": "PMC7616826"}, {"db": "pii", "key": "7646796"}], "notes": [], "created": "2025-02-28T14:17:20.622Z", "modified": "2025-02-28T14:17:20.701Z"}, {"entity": "publication", "iuid": "63fb6249957b4cf4a51c2d9024f273e8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/63fb6249957b4cf4a51c2d9024f273e8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/63fb6249957b4cf4a51c2d9024f273e8"}}, "title": "Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Titova", "given": "Olga E", "initials": "OE"}, {"family": "Zhang", "given": "Ke", "initials": "K"}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Li", "given": "Xue", "initials": "X"}, {"family": "Klarin", "given": "Derek", "initials": "D"}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A"}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications.scilifelab.se/researcher/b878210396ae46eba9f04f78be5ff564.json"}}, {"family": "VA Million Veteran Program", "given": "", "initials": ""}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Eur Heart J Open", "issn": "2752-4191", "volume": "3", "issue": "3", "pages": "oead056", "issn-l": null}, "abstract": "We conducted observational and Mendelian randomization (MR) analyses to explore the associations between blood proteins and risk of peripheral artery disease (PAD).\n\nThe observational cohort analyses included data on 257 proteins estimated in fasting blood samples from 12 136 Swedish adults aged 55-94 years who were followed up for incident PAD via the Swedish Patient Register. Mendelian randomization analyses were undertaken using cis-genetic variants strongly associated with the proteins as instrumental variables and genetic association summary statistic data for PAD from the FinnGen study (11 924 cases and 288 638 controls) and the Million Veteran Program (31 307 cases and 211 753 controls). The observational analysis, including 86 individuals diagnosed with incident PAD during a median follow-up of 6.6-year, identified 13 proteins [trefoil factor two, matrix metalloproteinase-12 (MMP-12), growth differentiation factor 15, V-set and immunoglobulin domain-containing protein two, N-terminal prohormone brain natriuretic peptide, renin, natriuretic peptides B, phosphoprotein associated with glycosphingolipid-enriched microdomains one, C-C motif chemokine 15, P-selectin, urokinase plasminogen activator surface receptor, angiopoietin-2, and C-type lectin domain family five member A] associated with the risk of PAD after multiple testing correction. Mendelian randomization analysis found associations of T-cell surface glycoprotein CD4, MMP-12, secretoglobin family 3A member 2, and ADM with PAD risk. The observational and MR associations for T-cell surface glycoprotein CD4 and MMP-12 were in opposite directions.\n\nThis study identified many circulating proteins in relation to the development of incident PAD. Future studies are needed to verify our findings and assess the predictive and therapeutic values of these proteins in PAD.", "doi": "10.1093/ehjopen/oead056", "pmid": "37323297", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10267302"}, {"db": "pii", "key": "oead056"}], "notes": [], "created": "2023-11-29T19:27:22.228Z", "modified": "2023-11-29T19:27:22.418Z"}]}