{"entity": "researcher", "timestamp": "2026-07-19T06:17:44.602Z", "family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d"}}, "publications": [{"entity": "publication", "iuid": "7cdd71fc9b3a4e96bbece5625ab29d9e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7cdd71fc9b3a4e96bbece5625ab29d9e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7cdd71fc9b3a4e96bbece5625ab29d9e"}}, "title": "Selection against domestication alleles in introduced rabbit populations.", "authors": [{"family": "Andrade", "given": "Pedro", "initials": "P", "orcid": "0000-0003-2540-2471", "researcher": {"href": "https://publications.scilifelab.se/researcher/beb2336f18d94c57bbf9089dd6d06ccf.json"}}, {"family": "Alves", "given": "Joel M", "initials": "JM", "orcid": "0000-0001-6138-9134", "researcher": {"href": "https://publications.scilifelab.se/researcher/118178b7f76e4b5ba3ec39914aee7b57.json"}}, {"family": "Pereira", "given": "Paulo", "initials": "P", "orcid": "0000-0001-9519-7691", "researcher": {"href": "https://publications.scilifelab.se/researcher/c8913fec8d89466480fa55e47e47e2ce.json"}}, {"family": "Rubin", "given": "Carl-Johan", "initials": "CJ", "orcid": "0000-0001-8238-5052", "researcher": {"href": "https://publications.scilifelab.se/researcher/0bd98ada4083444e8336ef3ec53df488.json"}}, {"family": "Silva", "given": "Eug\u00e9nio", "initials": "E", "orcid": "0000-0002-9680-3494", "researcher": {"href": "https://publications.scilifelab.se/researcher/099c8fd4d8324c5f8e39f8798d680e29.json"}}, {"family": "Sprehn", "given": "C Grace", "initials": "CG", "orcid": "0000-0002-4164-4246", "researcher": {"href": "https://publications.scilifelab.se/researcher/b51f6d45361e4aa187fc74870a38ac3f.json"}}, {"family": "Enbody", "given": "Erik", "initials": "E", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Afonso", "given": "Sandra", "initials": "S", "orcid": "0000-0001-7212-991X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ced62caf88e446c796ad9b022517442c.json"}}, {"family": "Faria", "given": "Rui", "initials": "R"}, {"family": "Zhang", "given": "Yexin", "initials": "Y", "orcid": "0000-0001-8253-4951", "researcher": {"href": "https://publications.scilifelab.se/researcher/b5f20139428b4ebf93a8c478dd969264.json"}}, {"family": "Bonino", "given": "Never", "initials": "N"}, {"family": "Duckworth", "given": "Janine A", "initials": "JA"}, {"family": "Garreau", "given": "Herv\u00e9", "initials": "H", "orcid": "0000-0001-6195-1457", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9687c1ad7c04774aadaeb3f22abb034.json"}}, {"family": "Letnic", "given": "Mike", "initials": "M"}, {"family": "Strive", "given": "Tanja", "initials": "T", "orcid": "0000-0003-2971-8406", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0155b46301d490d974c8045f43ba4f6.json"}}, {"family": "Thulin", "given": "Carl-Gustaf", "initials": "CG", "orcid": "0000-0001-6543-748X", "researcher": {"href": "https://publications.scilifelab.se/researcher/b71a9794d2f94bdea1793abe41790d69.json"}}, {"family": "Queney", "given": "Guillaume", "initials": "G"}, {"family": "Villafuerte", "given": "Rafael", "initials": "R"}, {"family": "Jiggins", "given": "Francis M", "initials": "FM", "orcid": "0000-0001-7470-8157", "researcher": {"href": "https://publications.scilifelab.se/researcher/f3992869d5e249968d550b75307fdc4a.json"}}, {"family": "Ferrand", "given": "Nuno", "initials": "N"}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}, {"family": "Carneiro", "given": "Miguel", "initials": "M", "orcid": "0000-0001-9882-7775", "researcher": {"href": "https://publications.scilifelab.se/researcher/b1d62d41fce4469b878ea399d2d0abbf.json"}}], "type": "journal article", "published": "2024-08-00", "journal": {"title": "Nat Ecol Evol", "issn": "2397-334X", "volume": "8", "issue": "8", "pages": "1543-1555", "issn-l": "2397-334X"}, "abstract": "Humans have moved domestic animals around the globe for thousands of years. These have occasionally established feral populations in nature, often with devastating ecological consequences. To understand how natural selection shapes re-adaptation into the wild, we investigated one of the most successful colonizers in history, the European rabbit. By sequencing the genomes of 297 rabbits across three continents, we show that introduced populations exhibit a mixed wild-domestic ancestry. We show that alleles that increased in frequency during domestication were preferentially selected against in novel natural environments. Interestingly, causative mutations for common domestication traits sometimes segregate at considerable frequencies if associated with less drastic phenotypes (for example, coat colour dilution), whereas mutations that are probably strongly maladaptive in nature are absent. Whereas natural selection largely targeted different genomic regions in each introduced population, some of the strongest signals of parallelism overlap genes associated with neuronal or brain function. This limited parallelism is probably explained by extensive standing genetic variation resulting from domestication together with the complex mixed ancestry of introduced populations. Our findings shed light on the selective and molecular mechanisms that enable domestic animals to re-adapt to the wild and provide important insights for the mitigation and management of invasive populations.", "doi": "10.1038/s41559-024-02443-3", "pmid": "38907020", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "NGI Short read": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41559-024-02443-3"}], "notes": [], "created": "2024-11-12T10:54:12.925Z", "modified": "2024-11-25T10:19:02.495Z"}, {"entity": "publication", "iuid": "57d336fde81e4a409b232134a6c24a50", "links": {"self": {"href": "https://publications.scilifelab.se/publication/57d336fde81e4a409b232134a6c24a50.json"}, "display": {"href": "https://publications.scilifelab.se/publication/57d336fde81e4a409b232134a6c24a50"}}, "title": "Low mutation load in a supergene underpinning alternative male mating strategies in ruff (Calidris pugnax).", "authors": [{"family": "Hill", "given": "Jason", "initials": "J", "orcid": "0000-0002-0151-8931", "researcher": {"href": "https://publications.scilifelab.se/researcher/a2cb6f3cce5f4919959e18074d51256d.json"}}, {"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Bi", "given": "Huijuan", "initials": "H"}, {"family": "Lamichhaney", "given": "Sangeet", "initials": "S"}, {"family": "Lei", "given": "Weipan", "initials": "W"}, {"family": "Chen", "given": "Juexin", "initials": "J"}, {"family": "Wei", "given": "Chentao", "initials": "C"}, {"family": "Liu", "given": "Yang", "initials": "Y", "orcid": "0000-0003-4580-5518", "researcher": {"href": "https://publications.scilifelab.se/researcher/abd2de623f33467b89b1cf800db4b3f5.json"}}, {"family": "Schwochow", "given": "Doreen", "initials": "D"}, {"family": "Younis", "given": "Shady", "initials": "S"}, {"family": "Widemo", "given": "Fredrik", "initials": "F"}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}], "type": "journal article", "published": "2023-10-06", "journal": {"title": "Mol. Biol. Evol.", "issn": "1537-1719", "issn-l": "0737-4038", "volume": "40", "issue": "12", "pages": "msad224"}, "abstract": "A paradox in evolutionary biology is how supergenes can maintain high fitness despite reduced effective population size, the suppression of recombination, and the expected accumulation of mutational load. The ruff supergene involves two rare inversion haplotypes (Satellite and Faeder). These are recessive lethals but with dominant effects on male mating strategies, plumage, and body size. Sequence divergence to the wild-type (Independent) haplotype indicates that the inversion could be as old as 4 million years. Here we have constructed a highly contiguous genome assembly of the inversion region for both the Independent and Satellite haplotypes. Based on the new data we estimate that the recombination event(s) creating the Satellite haplotype occurred only about 70,000 years ago. Contrary to expectations for supergenes, we find no substantial expansion of repeats and only a modest mutation load on the Satellite and Faeder haplotypes despite high sequence divergence to the non-inverted haplotype (1.46%). The essential centromere protein N gene CENPN is disrupted by the inversion, and is as well conserved on the inversion haplotypes as on the noninversion haplotype. These results suggest that the inversion may be much younger than previously thought. The low mutation load, despite recessive lethality, may be explained by the introgression of the inversion from a now extinct lineage.", "doi": "10.1093/molbev/msad224", "pmid": "37804117", "labels": {"NGI Long read": "Service", "National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "7296052"}], "notes": [], "created": "2023-10-10T08:45:20.886Z", "modified": "2024-01-16T13:48:31.996Z"}, {"entity": "publication", "iuid": "0e6c5f5e44e3406b9d3f38f57c040da5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0e6c5f5e44e3406b9d3f38f57c040da5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0e6c5f5e44e3406b9d3f38f57c040da5"}}, "title": "Community-wide genome sequencing reveals 30 years of Darwin's finch evolution.", "authors": [{"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Sendell-Price", "given": "Ashley T", "initials": "AT"}, {"family": "Sprehn", "given": "C Grace", "initials": "CG", "orcid": "0000-0002-4164-4246", "researcher": {"href": "https://publications.scilifelab.se/researcher/b51f6d45361e4aa187fc74870a38ac3f.json"}}, {"family": "Rubin", "given": "Carl-Johan", "initials": "C"}, {"family": "Visscher", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-2143-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/dcdb41d4720b436494304f74e33206ae.json"}}, {"family": "Grant", "given": "B Rosemary", "initials": "BR"}, {"family": "Grant", "given": "Peter R", "initials": "PR", "orcid": "0000-0002-7347-5758", "researcher": {"href": "https://publications.scilifelab.se/researcher/18a184c706054257a130b2ae0694d858.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}], "type": "journal article", "published": "2023-09-29", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "381", "issue": "6665", "pages": "eadf6218"}, "abstract": "A fundamental goal in evolutionary biology is to understand the genetic architecture of adaptive traits. Using whole-genome data of 3955 of Darwin's finches on the Gal\u00e1pagos Island of Daphne Major, we identified six loci of large effect that explain 45% of the variation in the highly heritable beak size of Geospiza fortis, a key ecological trait. The major locus is a supergene comprising four genes. Abrupt changes in allele frequencies at the loci accompanied a strong change in beak size caused by natural selection during a drought. A gradual change in Geospiza scandens occurred across 30 years as a result of introgressive hybridization with G. fortis. This study shows how a few loci with large effect on a fitness-related trait contribute to the genetic potential for rapid adaptive radiation.", "doi": "10.1126/science.adf6218", "pmid": "37769091", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2023-10-12T11:14:44.927Z", "modified": "2024-01-16T13:48:32.043Z"}, {"entity": "publication", "iuid": "63ad8a91be7b4bf59b292f2cb6a2cd03", "links": {"self": {"href": "https://publications.scilifelab.se/publication/63ad8a91be7b4bf59b292f2cb6a2cd03.json"}, "display": {"href": "https://publications.scilifelab.se/publication/63ad8a91be7b4bf59b292f2cb6a2cd03"}}, "title": "Systematics of the avian family Alaudidae using multilocus and genomic data", "authors": [{"family": "Alstr\u00f6m", "given": "Per", "initials": "P"}, {"family": "Mohammadi", "given": "Zeinolabedin", "initials": "Z"}, {"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Irestedt", "given": "Martin", "initials": "M"}, {"family": "Engelbrecht", "given": "Derek", "initials": "D", "orcid": "0000-0001-8732-1306", "researcher": {"href": "https://publications.scilifelab.se/researcher/62394875d9d94a039baeb826adc016eb.json"}}, {"family": "Crochet", "given": "Pierre Andr\u00e9", "initials": "PA"}, {"family": "Guillaumet", "given": "Alban", "initials": "A", "orcid": "0000-0002-1021-7807", "researcher": {"href": "https://publications.scilifelab.se/researcher/0786878a7c914d61a2fd602e3f659389.json"}}, {"family": "Rancilhac", "given": "Lo\u00efs", "initials": "L", "orcid": "0000-0002-9859-1448", "researcher": {"href": "https://publications.scilifelab.se/researcher/c3a53ef0421c4c0990fbf9ef20f6bd3b.json"}}, {"family": "Tieleman", "given": "B Irene", "initials": "BI", "orcid": "0000-0003-4334-4359", "researcher": {"href": "https://publications.scilifelab.se/researcher/4f700e14122e4ceabd566ab5f9534cd1.json"}}, {"family": "Olsson", "given": "Urban", "initials": "U"}, {"family": "Donald", "given": "Paul F", "initials": "PF"}, {"family": "Stervander", "given": "Martin", "initials": "M", "orcid": "0000-0002-6139-7828", "researcher": {"href": "https://publications.scilifelab.se/researcher/03619f15ff3d4cb2a1d30cf7fc82607c.json"}}], "type": "journal-article", "published": "2023-00-00", "journal": {"title": "Avian Research", "issn": "2053-7166", "volume": "14", "pages": "100095", "issn-l": null}, "abstract": null, "doi": "10.1016/j.avrs.2023.100095", "pmid": null, "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-25T10:11:56.410Z", "modified": "2024-11-25T10:11:56.668Z"}, {"entity": "publication", "iuid": "7f08b122459149d9ac2a582fcc398431", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7f08b122459149d9ac2a582fcc398431.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7f08b122459149d9ac2a582fcc398431"}}, "title": "Rapid adaptive radiation of Darwin's finches depends on ancestral genetic modules.", "authors": [{"family": "Rubin", "given": "Carl-Johan", "initials": "CJ", "orcid": "0000-0001-8238-5052", "researcher": {"href": "https://publications.scilifelab.se/researcher/0bd98ada4083444e8336ef3ec53df488.json"}}, {"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Dobreva", "given": "Mariya P", "initials": "MP", "orcid": "0000-0002-7152-1044", "researcher": {"href": "https://publications.scilifelab.se/researcher/b7264631debb4687be22a07e768c4a07.json"}}, {"family": "Abzhanov", "given": "Arhat", "initials": "A"}, {"family": "Davis", "given": "Brian W", "initials": "BW", "orcid": "0000-0002-6121-135X", "researcher": {"href": "https://publications.scilifelab.se/researcher/63981f53ab2e4dc09a4a2a62ae0b7a84.json"}}, {"family": "Lamichhaney", "given": "Sangeet", "initials": "S", "orcid": "0000-0003-4826-0349", "researcher": {"href": "https://publications.scilifelab.se/researcher/602a2f371eae45e4b9d8f9748f285ef4.json"}}, {"family": "Pettersson", "given": "Mats", "initials": "M", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications.scilifelab.se/researcher/27011c7fbb8a44dda536a4fc876675b0.json"}}, {"family": "Sendell-Price", "given": "Ashley T", "initials": "AT"}, {"family": "Sprehn", "given": "C Grace", "initials": "CG"}, {"family": "Valle", "given": "Carlos A", "initials": "CA", "orcid": "0000-0002-5523-634X", "researcher": {"href": "https://publications.scilifelab.se/researcher/69b5e00396c5482786b9eeeea2316cfb.json"}}, {"family": "Vasco", "given": "Karla", "initials": "K", "orcid": "0000-0002-4617-5864", "researcher": {"href": "https://publications.scilifelab.se/researcher/e080c032415840ca864356927ac7fda9.json"}}, {"family": "Wallerman", "given": "Ola", "initials": "O"}, {"family": "Grant", "given": "B Rosemary", "initials": "BR"}, {"family": "Grant", "given": "Peter R", "initials": "PR", "orcid": "0000-0002-7347-5758", "researcher": {"href": "https://publications.scilifelab.se/researcher/18a184c706054257a130b2ae0694d858.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}], "type": "journal article", "published": "2022-07-08", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "27", "pages": "eabm5982", "issn-l": "2375-2548"}, "abstract": "Recent adaptive radiations are models for investigating mechanisms contributing to the evolution of biodiversity. An unresolved question is the relative importance of new mutations, ancestral variants, and introgressive hybridization for phenotypic evolution and speciation. Here, we address this issue using Darwin's finches and investigate the genomic architecture underlying their phenotypic diversity. Admixture mapping for beak and body size in the small, medium, and large ground finches revealed 28 loci showing strong genetic differentiation. These loci represent ancestral haplotype blocks with origins predating speciation events during the Darwin's finch radiation. Genes expressed in the developing beak are overrepresented in these genomic regions. Ancestral haplotypes constitute genetic modules for selection and act as key determinants of the unusual phenotypic diversity of Darwin's finches. Such ancestral haplotype blocks can be critical for how species adapt to environmental variability and change.", "doi": "10.1126/sciadv.abm5982", "pmid": "35857449", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9269886"}], "notes": [], "created": "2022-11-09T15:47:58.882Z", "modified": "2024-01-16T13:48:35.858Z"}, {"entity": "publication", "iuid": "1ca0729f557a4cd3b8cb790b4a9d5961", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1ca0729f557a4cd3b8cb790b4a9d5961.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1ca0729f557a4cd3b8cb790b4a9d5961"}}, "title": "Asymmetric introgression reveals the genetic architecture of a plumage trait.", "authors": [{"family": "Semenov", "given": "Georgy A", "initials": "GA", "orcid": "0000-0002-7218-7885", "researcher": {"href": "https://publications.scilifelab.se/researcher/79bb787f3be449299a263dcab28021b9.json"}}, {"family": "Linck", "given": "Ethan", "initials": "E"}, {"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Harris", "given": "Rebecca B", "initials": "RB"}, {"family": "Khaydarov", "given": "David R", "initials": "DR"}, {"family": "Alstr\u00f6m", "given": "Per", "initials": "P", "orcid": "0000-0001-7182-2763", "researcher": {"href": "https://publications.scilifelab.se/researcher/f426ea7151c546939b707d5ed71e7d04.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}, {"family": "Taylor", "given": "Scott A", "initials": "SA", "orcid": "0000-0001-9580-9125", "researcher": {"href": "https://publications.scilifelab.se/researcher/36c6baa1b23242e0bfd586d7e42c0cb9.json"}}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1019", "issn-l": "2041-1723"}, "abstract": "Genome-wide variation in introgression rates across hybrid zones offers a powerful opportunity for studying population differentiation. One poorly understood pattern of introgression is the geographic displacement of a trait implicated in lineage divergence from genome-wide population boundaries. While difficult to interpret, this pattern can facilitate the dissection of trait genetic architecture because traits become uncoupled from their ancestral genomic background. We studied an example of trait displacement generated by the introgression of head plumage coloration from personata to alba subspecies of the white wagtail. A previous study of their hybrid zone in Siberia revealed that the geographic transition in this sexual signal that mediates assortative mating was offset from other traits and genetic markers. Here we show that head plumage is associated with two small genetic regions. Despite having a simple genetic architecture, head plumage inheritance is consistent with partial dominance and epistasis, which could contribute to its asymmetric introgression.", "doi": "10.1038/s41467-021-21340-y", "pmid": "33589637", "labels": {"NGI Stockholm (Genomics Production)": null, "NGI Stockholm (Genomics Applications)": null, "National Genomics Infrastructure": null, "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21340-y"}, {"db": "pmc", "key": "PMC7884433"}, {"db": "Dryad", "key": "10.5061/dryad.dv41ns1wv"}], "notes": [], "created": "2021-06-09T12:16:14.581Z", "modified": "2024-01-16T13:48:40.705Z"}, {"entity": "publication", "iuid": "1f5e1b21a6a5486793d238251900e16e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1f5e1b21a6a5486793d238251900e16e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1f5e1b21a6a5486793d238251900e16e"}}, "title": "Ecological adaptation in European eels is based on phenotypic plasticity.", "authors": [{"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Pettersson", "given": "Mats E", "initials": "ME", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications.scilifelab.se/researcher/27011c7fbb8a44dda536a4fc876675b0.json"}}, {"family": "Sprehn", "given": "C Grace", "initials": "CG"}, {"family": "Palm", "given": "Stefan", "initials": "S", "orcid": "0000-0002-9890-8265", "researcher": {"href": "https://publications.scilifelab.se/researcher/0ebffe35bae646eb8a15163b0cb0820f.json"}}, {"family": "Wickstr\u00f6m", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0001-6335-8833", "researcher": {"href": "https://publications.scilifelab.se/researcher/0ce9d80227974a21be858a2925338f93.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}], "type": "journal article", "published": "2021-01-26", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "4", "pages": "e2022620118", "issn-l": "0027-8424"}, "abstract": "The relative role of genetic adaptation and phenotypic plasticity is of fundamental importance in evolutionary ecology [M. J. West-Eberhard, Proc. Natl. Acad. Sci. U.S.A. 102 (suppl. 1), 6543-6549 (2005)]. European eels have a complex life cycle, including transitions between life stages across ecological conditions in the Sargasso Sea, where spawning occurs, and those in brackish and freshwater bodies from northern Europe to northern Africa. Whether continental eel populations consist of locally adapted and genetically distinct populations or comprise a single panmictic population has received conflicting support. Here we use whole-genome sequencing and show that European eels belong to one panmictic population. A complete lack of geographical genetic differentiation is demonstrated. We postulate that this is possible because the most critical life stages-spawning and embryonic development-take place under near-identical conditions in the Sargasso Sea. We further show that within-generation selection, which has recently been proposed as a mechanism for genetic adaptation in eels, can only marginally change allele frequencies between cohorts of eels from different geographic regions. Our results strongly indicate plasticity as the predominant mechanism for how eels respond to diverse environmental conditions during postlarval stages, ultimately solving a long-standing question for a classically enigmatic species.", "doi": "10.1073/pnas.2022620118", "pmid": "33479174", "labels": {"NGI Stockholm (Genomics Production)": null, "NGI Stockholm (Genomics Applications)": null, "National Genomics Infrastructure": null, "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "2022620118"}, {"db": "pmc", "key": "PMC7848574"}], "notes": [], "created": "2021-06-09T12:16:45.953Z", "modified": "2024-01-16T13:48:40.922Z"}, {"entity": "publication", "iuid": "0e0f91643ac84e9e82be060080efcbe8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0e0f91643ac84e9e82be060080efcbe8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0e0f91643ac84e9e82be060080efcbe8"}}, "title": "Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding.", "authors": [{"family": "Gustafsson", "given": "Robert", "initials": "R", "orcid": "0000-0002-4854-5531", "researcher": {"href": "https://publications.scilifelab.se/researcher/16dd7e73adad4f85972d1d546bfa6d2a.json"}}, {"family": "Eckhard", "given": "Ulrich", "initials": "U", "orcid": "0000-0001-5863-4514", "researcher": {"href": "https://publications.scilifelab.se/researcher/78dae054a57d43c89852aac77a2ad6da.json"}}, {"family": "Ye", "given": "Weihua", "initials": "W"}, {"family": "Enbody", "given": "Erik D", "initials": "ED", "orcid": "0000-0003-1349-628X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a4df51b279746539cae2fa83c37456d.json"}}, {"family": "Pettersson", "given": "Mats", "initials": "M"}, {"family": "Jemth", "given": "Per", "initials": "P"}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd3343c12f994b1fabcae23027d3a76d.json"}}, {"family": "Selmer", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-12-03", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "10", "issue": "12", "issn-l": null}, "abstract": "Phosphoglucomutase 5 (PGM5) in humans is known as a structural muscle protein without enzymatic activity, but detailed understanding of its function is lacking. PGM5 belongs to the alpha-D-phosphohexomutase family and is closely related to the enzymatically active metabolic enzyme PGM1. In the Atlantic herring, Clupea harengus, PGM5 is one of the genes strongly associated with ecological adaptation to the brackish Baltic Sea. We here present the first crystal structures of PGM5, from the Atlantic and Baltic herring, differing by a single substitution Ala330Val. The structure of PGM5 is overall highly similar to structures of PGM1. The structure of the Baltic herring PGM5 in complex with the substrate glucose-1-phosphate shows conserved substrate binding and active site compared to human PGM1, but both PGM5 variants lack phosphoglucomutase activity under the tested conditions. Structure comparison and sequence analysis of PGM5 and PGM1 from fish and mammals suggest that the lacking enzymatic activity of PGM5 is related to differences in active-site loops that are important for flipping of the reaction intermediate. The Ala330Val substitution does not alter structure or biophysical properties of PGM5 but, due to its surface-exposed location, could affect interactions with protein-binding partners.", "doi": "10.3390/biom10121631", "pmid": "33287293", "labels": {"Protein Science Facility (PSF)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC7761743"}, {"db": "pii", "key": "biom10121631"}], "notes": [], "created": "2024-04-03T14:12:52.445Z", "modified": "2024-04-03T14:12:52.932Z"}]}