{"entity": "researcher", "timestamp": "2026-08-10T14:09:19.399Z", "family": "Rauschmeier", "given": "Ren\u00e9", "initials": "R", "orcid": "0000-0002-1073-4046", "affiliations": ["Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/79f8968c617e4d5db26486c2c467b76c.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/79f8968c617e4d5db26486c2c467b76c"}}, "publications": [{"entity": "publication", "iuid": "3725797cb1794d6a9449232d6e451b75", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3725797cb1794d6a9449232d6e451b75.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3725797cb1794d6a9449232d6e451b75"}}, "title": "Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.", "authors": [{"family": "Rauschmeier", "given": "Ren\u00e9", "initials": "R", "orcid": "0000-0002-1073-4046", "researcher": {"href": "https://publications.scilifelab.se/researcher/79f8968c617e4d5db26486c2c467b76c.json"}}, {"family": "Reinhardt", "given": "Annika", "initials": "A", "orcid": "0000-0002-7468-9985", "researcher": {"href": "https://publications.scilifelab.se/researcher/8f556d6e77814aa4808f373cfcb01639.json"}}, {"family": "Gustafsson", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-4997-6795", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc6de7e7552d4d4c9a8bee9e992d3e6b.json"}}, {"family": "Glaros", "given": "Vassilis", "initials": "V", "orcid": "0000-0001-6211-9515", "researcher": {"href": "https://publications.scilifelab.se/researcher/52e51bdbb2d2472582cc6387dc381746.json"}}, {"family": "Artemov", "given": "Artem V", "initials": "AV", "orcid": "0000-0002-0056-4549", "researcher": {"href": "https://publications.scilifelab.se/researcher/96355d3e9b394fb790d4f8785dec6d68.json"}}, {"family": "Dunst", "given": "Josefine", "initials": "J", "orcid": "0000-0003-0061-0901", "researcher": {"href": "https://publications.scilifelab.se/researcher/968039236aae4f19b97c4cdac9d5d3d7.json"}}, {"family": "Taneja", "given": "Reshma", "initials": "R", "orcid": "0000-0001-6214-6177", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d94af8d9565471d978e934e90544144.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}, {"family": "M\u00e5nsson", "given": "Robert", "initials": "R", "orcid": "0000-0003-0738-0328", "researcher": {"href": "https://publications.scilifelab.se/researcher/eafa5ad22891454298bf31a94d77175f.json"}}, {"family": "Busslinger", "given": "Meinrad", "initials": "M", "orcid": "0000-0002-9111-9351", "researcher": {"href": "https://publications.scilifelab.se/researcher/363a1d70b8a34b55a0d0e57eb7d60550.json"}}, {"family": "Kreslavsky", "given": "Taras", "initials": "T", "orcid": "0000-0002-6672-1914", "researcher": {"href": "https://publications.scilifelab.se/researcher/94bb90e31ed1447a9835a1adae1c8daa.json"}}], "type": "journal article", "published": "2022-02-07", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "219", "issue": "2", "issn-l": "0022-1007"}, "abstract": "The generation of high-affinity antibodies against pathogens and vaccines requires the germinal center (GC) reaction, which relies on a complex interplay between specialized effector B and CD4 T lymphocytes, the GC B cells and T follicular helper (TFH) cells. Intriguingly, several positive key regulators of the GC reaction are common for both cell types. Here, we report that the transcription factor Bhlhe40 is a crucial cell-intrinsic negative regulator affecting both the B and T cell sides of the GC reaction. In activated CD4 T cells, Bhlhe40 was required to restrain proliferation, thus limiting the number of TFH cells. In B cells, Bhlhe40 executed its function in the first days after immunization by selectively restricting the generation of the earliest GC B cells but not of early memory B cells or plasmablasts. Bhlhe40-deficient mice with progressing age succumbed to a B cell lymphoma characterized by the accumulation of monoclonal GC B-like cells and polyclonal TFH cells in various tissues.", "doi": "10.1084/jem.20211406", "pmid": "34919144", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "212923"}, {"db": "pmc", "key": "PMC8689665"}], "notes": [], "created": "2022-11-09T15:55:32.305Z", "modified": "2024-01-16T13:48:37.533Z"}]}