{"entity": "researcher", "timestamp": "2026-08-08T15:28:20.364Z", "family": "Lilley", "given": "Kathryn S", "initials": "KS", "orcid": "0000-0003-0594-6543", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/77b4e7e18a88455199308070d6da7ea3.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/77b4e7e18a88455199308070d6da7ea3"}}, "publications": [{"entity": "publication", "iuid": "a8fbcd4a221c4de2a1151348bd4c9304", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a8fbcd4a221c4de2a1151348bd4c9304.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a8fbcd4a221c4de2a1151348bd4c9304"}}, "title": "Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer.", "authors": [{"family": "Kauko", "given": "Otto", "initials": "O", "orcid": "0000-0001-8948-9452", "researcher": {"href": "https://publications.scilifelab.se/researcher/c5390cad42a0409f8b66f56ab23ca232.json"}}, {"family": "Turunen", "given": "Mikko", "initials": "M"}, {"family": "Pihlajamaa", "given": "P\u00e4ivi", "initials": "P", "orcid": "0000-0001-9725-6907", "researcher": {"href": "https://publications.scilifelab.se/researcher/1171591a6a724f50a631d34948c6f14a.json"}}, {"family": "H\u00e4kkinen", "given": "Antti", "initials": "A", "orcid": "0000-0002-8081-1588", "researcher": {"href": "https://publications.scilifelab.se/researcher/b00bca666f344d4980a97bbdba20361e.json"}}, {"family": "Queiroz", "given": "Rayner M L", "initials": "RML"}, {"family": "P\u00e4\u00e4kk\u00f6nen", "given": "Mirva", "initials": "M"}, {"family": "Ventel\u00e4", "given": "Sami", "initials": "S"}, {"family": "Gaetani", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-5610-0797", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b58e5cef5224fdcbdcd626fb798b169.json"}}, {"family": "Lundstr\u00f6m", "given": "Susanna L", "initials": "SL", "orcid": "0000-0003-2363-4287", "researcher": {"href": "https://publications.scilifelab.se/researcher/916e190e150e465c9e6afc11911bae04.json"}}, {"family": "Murgia", "given": "Antonio", "initials": "A"}, {"family": "Sahu", "given": "Biswajyoti", "initials": "B", "orcid": "0000-0001-6576-5440", "researcher": {"href": "https://publications.scilifelab.se/researcher/283b12ad225d4fb2b4e38b7f10c026d4.json"}}, {"family": "Routila", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5385-7065", "researcher": {"href": "https://publications.scilifelab.se/researcher/71ee18226e6e4a42ae83b7106ca8b343.json"}}, {"family": "Wei", "given": "Gong-Hong", "initials": "G"}, {"family": "Irjala", "given": "Heikki", "initials": "H", "orcid": "0000-0003-3054-4677", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf759b807e9640aab8fcadbad0c60662.json"}}, {"family": "Griffin", "given": "Julian L", "initials": "JL", "orcid": "0000-0003-1336-7744", "researcher": {"href": "https://publications.scilifelab.se/researcher/98e91146412f4bd2a0bed9331efee8d2.json"}}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS", "orcid": "0000-0003-0594-6543", "researcher": {"href": "https://publications.scilifelab.se/researcher/77b4e7e18a88455199308070d6da7ea3.json"}}, {"family": "Kivioja", "given": "Teemu", "initials": "T", "orcid": "0000-0002-7732-2177", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c318f57c5ce4f4bb747e19514caa907.json"}}, {"family": "Hautaniemi", "given": "Sampsa", "initials": "S", "orcid": "0000-0002-7749-2694", "researcher": {"href": "https://publications.scilifelab.se/researcher/a29cabf8ec5e4f78b9d14984a60c3e84.json"}}, {"family": "Taipale", "given": "Jussi", "initials": "J", "orcid": "0000-0003-4204-0951", "researcher": {"href": "https://publications.scilifelab.se/researcher/43111333f8a84b2cbbceb64d4e1e3bc5.json"}}], "type": "journal article", "published": "2025-08-22", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "11", "issue": "34", "pages": "eadt1798"}, "abstract": "Mutations in numerous genes contribute to human cancer, with different oncogenic lesions prevalent in different cancer types. However, the malignant phenotype is simple, characterized by unrestricted cell growth, invasion, and often metastasis. One possible hypothesis explaining this dichotomy is that cancer genes regulate common targets, which then function as master regulators of essential cancer phenotypes. To identify mechanisms that drive the most fundamental feature shared by all tumors-unrestricted cell proliferation-we used a multiomic approach, which identified translation and ribosome biogenesis as common targets of major oncogenic pathways across cancer types. Proteomic analysis of tumors and functional studies of cell cultures established nucleolar and coiled-body phosphoprotein 1 as a key node, whose convergent regulation, both transcriptionally and posttranslationally, is critical for tumor cell proliferation. Our results indicate that lineage-specific oncogenic pathways regulate the same set of targets for growth control, revealing key downstream nodes that could be targeted for therapy or chemoprevention.", "doi": "10.1126/sciadv.adt1798", "pmid": "40834066", "labels": {"Chemical Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC13155486"}], "notes": [], "created": "2025-11-25T16:41:01.046Z", "modified": "2026-05-25T19:26:02.282Z"}, {"entity": "publication", "iuid": "ccd54446c7604b2d944e433c3fc245ab", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ccd54446c7604b2d944e433c3fc245ab.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ccd54446c7604b2d944e433c3fc245ab"}}, "title": "Subcellular proteomics.", "authors": [{"family": "Christopher", "given": "Josie A", "initials": "JA"}, {"family": "Stadler", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-6781-1938", "researcher": {"href": "https://publications.scilifelab.se/researcher/2db3b27c7d7143cbacc8c1dd8ac90a31.json"}}, {"family": "Martin", "given": "Claire E", "initials": "CE", "orcid": "0000-0001-8346-414X", "researcher": {"href": "https://publications.scilifelab.se/researcher/283b9e3574454cd6892ab5bc964f7353.json"}}, {"family": "Morgenstern", "given": "Marcel", "initials": "M", "orcid": "0000-0001-6880-4839", "researcher": {"href": "https://publications.scilifelab.se/researcher/8da72791863f463cad99442103d83338.json"}}, {"family": "Pan", "given": "Yanbo", "initials": "Y", "orcid": "0000-0001-9442-7782", "researcher": {"href": "https://publications.scilifelab.se/researcher/00403ea0d7bd4218a6b9ba507fa2fa26.json"}}, {"family": "Betsinger", "given": "Cora N", "initials": "CN", "orcid": "0000-0001-9263-3873", "researcher": {"href": "https://publications.scilifelab.se/researcher/90fe36ad250546f7af5422c53e1aff77.json"}}, {"family": "Rattray", "given": "David G", "initials": "DG", "orcid": "0000-0002-2444-0663", "researcher": {"href": "https://publications.scilifelab.se/researcher/090cec60bc574c29809b7124d80b6170.json"}}, {"family": "Mahdessian", "given": "Diana", "initials": "D", "orcid": "0000-0003-0750-1070", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc22f13eb21a4c75a6e7cad7686bcc8a.json"}}, {"family": "Gingras", "given": "Anne-Claude", "initials": "A", "orcid": "0000-0002-6090-4437", "researcher": {"href": "https://publications.scilifelab.se/researcher/21315bcb23a144069b3568d7afd0b00b.json"}}, {"family": "Warscheid", "given": "Bettina", "initials": "B", "orcid": "0000-0001-5096-1975", "researcher": {"href": "https://publications.scilifelab.se/researcher/24f95112121a4e0c88c746703712017c.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications.scilifelab.se/researcher/8406a97bac744a59b1bc951978994581.json"}}, {"family": "Cristea", "given": "Ileana M", "initials": "IM"}, {"family": "Foster", "given": "Leonard J", "initials": "LJ", "orcid": "0000-0001-8551-4817", "researcher": {"href": "https://publications.scilifelab.se/researcher/84bc1af03ee243ca91c3f230ce711154.json"}}, {"family": "Emili", "given": "Andrew", "initials": "A", "orcid": "0000-0001-8995-246X", "researcher": {"href": "https://publications.scilifelab.se/researcher/337c75cec31e4051b979e7217d823999.json"}}, {"family": "Lilley", "given": "Kathryn S", "initials": "KS", "orcid": "0000-0003-0594-6543", "researcher": {"href": "https://publications.scilifelab.se/researcher/77b4e7e18a88455199308070d6da7ea3.json"}}], "type": "journal article", "published": "2021-04-29", "journal": {"title": "Nat Rev Methods Primers", "issn": "2662-8449", "issn-l": null, "volume": "1", "issue": "1", "pages": null}, "abstract": "The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins localize to these niches to fulfil their function, enabling discreet biological processes to occur in synchrony. Dynamic movement of proteins between niches is essential for cellular processes such as signalling, growth, proliferation, motility and programmed cell death, and mutations causing aberrant protein localization are associated with a wide range of diseases. Determining the location of proteins in different cell states and cell types and how proteins relocalize following perturbation is important for understanding their functions, related cellular processes and pathologies associated with their mislocalization. In this Primer, we cover the major spatial proteomics methods for determining the location, distribution and abundance of proteins within subcellular structures. These technologies include fluorescent imaging, protein proximity labelling, organelle purification and cell-wide biochemical fractionation. We describe their workflows, data outputs and applications in exploring different cell biological scenarios, and discuss their main limitations. Finally, we describe emerging technologies and identify areas that require technological innovation to allow better characterization of the spatial proteome.", "doi": "10.1038/s43586-021-00029-y", "pmid": "34549195", "labels": {"Spatial Proteomics": "Technology development"}, "xrefs": [{"db": "pmc", "key": "PMC8451152"}, {"db": "mid", "key": "NIHMS1715590"}], "notes": [], "created": "2021-05-04T13:33:02.777Z", "modified": "2023-06-19T11:25:03.018Z"}]}