{"entity": "researcher", "timestamp": "2026-07-17T17:43:49.861Z", "family": "Maurya", "given": "Devendra Kumar", "initials": "DK", "orcid": "0000-0001-6052-4314", "affiliations": ["Department of Molecular Biology, Ume\u00e5 University, Ume\u00e5, SE901 87, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/7538f712473945629fe5371a5ff4fc73.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/7538f712473945629fe5371a5ff4fc73"}}, "publications": [{"entity": "publication", "iuid": "1a8578beca9d4f599daedc3b45656e0e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1a8578beca9d4f599daedc3b45656e0e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1a8578beca9d4f599daedc3b45656e0e"}}, "title": "A multivesicular body-like organelle mediates stimulus-regulated trafficking of olfactory ciliary transduction proteins.", "authors": [{"family": "Maurya", "given": "Devendra Kumar", "initials": "DK", "orcid": "0000-0001-6052-4314", "researcher": {"href": "https://publications.scilifelab.se/researcher/7538f712473945629fe5371a5ff4fc73.json"}}, {"family": "Berghard", "given": "Anna", "initials": "A", "orcid": "0000-0001-8367-9589", "researcher": {"href": "https://publications.scilifelab.se/researcher/234eeb58a90642e7827db9c9d61abc18.json"}}, {"family": "Bohm", "given": "Staffan", "initials": "S", "orcid": "0000-0001-9950-7597", "researcher": {"href": "https://publications.scilifelab.se/researcher/c97bf7c882f6472a904f283c67929ae8.json"}}], "type": "journal article", "published": "2022-11-12", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "6889", "issn-l": "2041-1723"}, "abstract": "Stimulus transduction in cilia of olfactory sensory neurons is mediated by odorant receptors, G\u03b1olf, adenylate cyclase-3, cyclic nucleotide-gated and chloride ion channels. Mechanisms regulating trafficking and localization of these proteins in the dendrite are unknown. By lectin/immunofluorescence staining and in vivo correlative light-electron microscopy (CLEM), we identify a retinitis pigmentosa-2 (RP2), ESCRT-0 and synaptophysin-containing multivesicular organelle that is not part of generic recycling/degradative/exosome pathways. The organelle's intraluminal vesicles contain the olfactory transduction proteins except for Golf subunits G\u03b313 and G\u03b21. Instead, G\u03b21 colocalizes with RP2 on the organelle's outer membrane. The organelle accumulates in response to stimulus deprivation, while odor stimuli or adenylate cyclase activation cause outer membrane disintegration, release of intraluminal vesicles, and RP2/G\u03b21 translocation to the base of olfactory cilia. Together, these findings reveal the existence of a dendritic organelle that mediates both stimulus-regulated storage of olfactory ciliary transduction proteins and membrane-delimited sorting important for G protein heterotrimerization.", "doi": "10.1038/s41467-022-34604-y", "pmid": "36371422", "labels": {"Integrated Microscopy Technologies Ume\u00e5": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9653401"}, {"db": "pii", "key": "10.1038/s41467-022-34604-y"}], "notes": [], "created": "2022-12-05T17:14:23.375Z", "modified": "2022-12-05T17:14:23.472Z"}]}