{"entity": "researcher", "timestamp": "2026-07-20T15:49:29.800Z", "family": "Hauser", "given": "Janosch", "initials": "J", "orcid": "0000-0003-3601-0342", "affiliations": ["KTH Royal Institute of Technology, Micro and Nanosystems, 10044 Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/72c09040563d4a9fa1e935f0aa3c0b59.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/72c09040563d4a9fa1e935f0aa3c0b59"}}, "publications": [{"entity": "publication", "iuid": "df28b62c4ade41b4bd9c61f3dd69c57b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/df28b62c4ade41b4bd9c61f3dd69c57b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/df28b62c4ade41b4bd9c61f3dd69c57b"}}, "title": "Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories.", "authors": [{"family": "Hauser", "given": "Janosch", "initials": "J", "orcid": "0000-0003-3601-0342", "researcher": {"href": "https://publications.scilifelab.se/researcher/72c09040563d4a9fa1e935f0aa3c0b59.json"}}, {"family": "Dale", "given": "Matilda", "initials": "M"}, {"family": "Beck", "given": "Olof", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications.scilifelab.se/researcher/aba5822711b246b397fffacb7ae403b3.json"}}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-9552-4234", "researcher": {"href": "https://publications.scilifelab.se/researcher/446ac390fcad4ced98cd8d7c89e1d4da.json"}}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Roxhed", "given": "Niclas", "initials": "N", "orcid": "0000-0002-7147-6730", "researcher": {"href": "https://publications.scilifelab.se/researcher/3739210caaf14a28898849f20bf6ece5.json"}}], "type": "journal article", "published": "2022-12-22", "journal": {"title": "Anal. Chem.", "issn": "1520-6882", "issn-l": "0003-2700"}, "abstract": "Patient-centric sampling strategies, where the patient performs self-sampling and ships the sample to a centralized laboratory for readout, are on the verge of widespread adaptation. However, the key to a successful patient-centric workflow is user-friendliness, with few noncritical user interactions, and simple, ideally biohazard-free shipment. Here, we present a capillary-driven microfluidic device designed to perform the critical biomarker capturing step of a multiplexed immunoassay at the time of sample collection. On-chip sample drying enables biohazard-free shipment and allows us to make use of advanced analytics of specialized laboratories that offer the needed analytical sensitivity, reliability, and affordability. Using C-Reactive Protein, MCP1, S100B, IGFBP1, and IL6 as model blood biomarkers, we demonstrate the multiplexing capability and applicability of the device to a patient-centric workflow. The presented quantification of a biomarker panel opens up new possibilities for e-doctor and e-health applications.", "doi": "10.1021/acs.analchem.2c04318", "pmid": "36548393", "labels": {"Affinity Proteomics Stockholm": "Technology development"}, "xrefs": [], "notes": [], "created": "2022-12-23T11:24:53.381Z", "modified": "2022-12-23T11:24:53.434Z"}]}