{"entity": "researcher", "timestamp": "2026-07-20T12:16:57.364Z", "family": "Alvarado-Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673"}}, "publications": [{"entity": "publication", "iuid": "d0227fdc5b3843deb2096267d97646b6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d0227fdc5b3843deb2096267d97646b6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d0227fdc5b3843deb2096267d97646b6"}}, "title": "Targeting TUBG1 in RB1\u2010negative tumors", "authors": [{"family": "Lindstr\u00f6m", "given": "Lisa", "initials": "L", "orcid": "0009-0008-4510-4635", "researcher": {"href": "https://publications.scilifelab.se/researcher/1091020b47274bfcb2f03a329057d7ae.json"}}, {"family": "Zhou", "given": "Jingkai", "initials": "J", "orcid": "0000-0002-9867-3486", "researcher": {"href": "https://publications.scilifelab.se/researcher/5dc6dcbd404c47eca422a2167085492e.json"}}, {"family": "Villoutreix", "given": "Bruno O", "initials": "BO", "orcid": "0000-0002-6456-7730", "researcher": {"href": "https://publications.scilifelab.se/researcher/faac02c89da248e4b2b393614365c304.json"}}, {"family": "Malycheva", "given": "Darina", "initials": "D"}, {"family": "Otrocka", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-2139-8236", "researcher": {"href": "https://publications.scilifelab.se/researcher/f60f84f70b744033b0c94b6d24e1c405.json"}}, {"family": "Gustavsson", "given": "Anna\u2010Lena", "initials": "A", "orcid": "0000-0003-4332-2336", "researcher": {"href": "https://publications.scilifelab.se/researcher/6b014ef7ea0d461b8e2ddb87506b1252.json"}}, {"family": "Lundb\u00e4ck", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8145-7808", "researcher": {"href": "https://publications.scilifelab.se/researcher/e13df787cb884549bcf333aba4e6f010.json"}}, {"family": "Bliman", "given": "David", "initials": "D", "orcid": "0000-0003-0487-8366", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e29451fca1644f3a6fd2bd4bbff9594.json"}}, {"family": "Shameem", "given": "Muhammad Anwar", "initials": "MA", "orcid": "0000-0001-6173-3417", "researcher": {"href": "https://publications.scilifelab.se/researcher/7c7fb16605874dfe93c1343f6ab32e67.json"}}, {"family": "Straw", "given": "Megan", "initials": "M"}, {"family": "Riesbeck", "given": "Kristian", "initials": "K", "orcid": "0000-0001-6274-6965", "researcher": {"href": "https://publications.scilifelab.se/researcher/d757ccad30b043748c8fe48a7308210c.json"}}, {"family": "Olsson", "given": "Roger", "initials": "R", "orcid": "0000-0002-7107-3472", "researcher": {"href": "https://publications.scilifelab.se/researcher/f3e5a72515bf44e98f43d4690c6e577e.json"}}, {"family": "Alvarado\u2010Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "researcher": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673.json"}}], "type": "journal-article", "published": "2025-03-15", "journal": {"title": "The FASEB Journal", "issn": "0892-6638", "volume": "39", "issue": "5", "issn-l": "0892-6638"}, "abstract": null, "doi": "10.1096/fj.202403180rr", "pmid": null, "labels": {"Chemical Biology Consortium Sweden": "Collaborative"}, "xrefs": [], "notes": [], "created": "2025-04-23T10:27:30.624Z", "modified": "2025-10-17T13:04:26.785Z"}, {"entity": "publication", "iuid": "588c74de2d17433bb685094ea5947079", "links": {"self": {"href": "https://publications.scilifelab.se/publication/588c74de2d17433bb685094ea5947079.json"}, "display": {"href": "https://publications.scilifelab.se/publication/588c74de2d17433bb685094ea5947079"}}, "title": "The \u03b3-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells.", "authors": [{"family": "Corvaisier", "given": "Matthieu", "initials": "M"}, {"family": "Zhou", "given": "Jingkai", "initials": "J"}, {"family": "Malycheva", "given": "Darina", "initials": "D"}, {"family": "Cornella", "given": "Nicola", "initials": "N"}, {"family": "Chioureas", "given": "Dimitrios", "initials": "D"}, {"family": "Gustafsson", "given": "Nina M S", "initials": "NMS", "orcid": "0000-0001-6401-0548", "researcher": {"href": "https://publications.scilifelab.se/researcher/4484176c6d67435d9564a5fb65319e24.json"}}, {"family": "Rossell\u00f3", "given": "Catalina Ana", "initials": "CA", "orcid": "0000-0002-8977-607X", "researcher": {"href": "https://publications.scilifelab.se/researcher/e30f3fde2ced4d9aad8810029b7fc68e.json"}}, {"family": "Ayora", "given": "Silvia", "initials": "S", "orcid": "0000-0003-3121-1786", "researcher": {"href": "https://publications.scilifelab.se/researcher/40a4fa4ad7b244faa96b5b9460fea933.json"}}, {"family": "Li", "given": "Tongbin", "initials": "T"}, {"family": "Ekstr\u00f6m-Holka", "given": "Kristina", "initials": "K"}, {"family": "Jirstr\u00f6m", "given": "Karin", "initials": "K"}, {"family": "Lindstr\u00f6m", "given": "Lisa", "initials": "L"}, {"family": "Alvarado-Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "researcher": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673.json"}}], "type": "journal article", "published": "2021-06-22", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "4", "issue": "1", "pages": "767", "issn-l": "2399-3642"}, "abstract": "Changes in the location of \u03b3-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of \u03b3-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the \u03b3-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels of \u03b3-tubulin reduce the nuclear pool of PCNA. In addition, the \u03b3-tubulin C terminus encodes a PCNA-interacting peptide (PIP) motif, and a \u03b3-tubulin-PIP-mutant affects the nuclear accumulation of PCNA. In a cell-free system, PCNA and \u03b3-tubulin formed a complex. In tumors, there is a significant positive correlation between TUBG1 and PCNA expression. Thus, we report a novel mechanism that constitutes the basis for tumor growth by which the \u03b3-tubulin meshwork maintains indefinite proliferation by acting as an opportune scaffold for the transport of PCNA from the cytosol to the chromatin.", "doi": "10.1038/s42003-021-02280-1", "pmid": "34158617", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s42003-021-02280-1"}, {"db": "pmc", "key": "PMC8219688"}], "notes": [], "created": "2021-11-03T15:39:48.182Z", "modified": "2021-11-10T12:23:58.806Z"}, {"entity": "publication", "iuid": "c3dcf2e9bf1d4382866d6a7c7b6018f7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c3dcf2e9bf1d4382866d6a7c7b6018f7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c3dcf2e9bf1d4382866d6a7c7b6018f7"}}, "title": "The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization.", "authors": [{"family": "Lindstr\u00f6m", "given": "Lisa", "initials": "L"}, {"family": "Li", "given": "Tongbin", "initials": "T"}, {"family": "Malycheva", "given": "Darina", "initials": "D"}, {"family": "Kancharla", "given": "Arun", "initials": "A"}, {"family": "Nilsson", "given": "Hel\u00e9n", "initials": "H"}, {"family": "Vishnu", "given": "Neelanjan", "initials": "N"}, {"family": "Mulder", "given": "Hindrik", "initials": "H"}, {"family": "Johansson", "given": "Martin", "initials": "M"}, {"family": "Rossell\u00f3", "given": "Catalina Ana", "initials": "CA"}, {"family": "Alvarado-Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "researcher": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673.json"}}], "type": "journal article", "published": "2018-05-03", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "1", "issue": "1", "pages": "37", "issn-l": "2399-3642"}, "abstract": "In the cell, \u03b3-tubulin establishes a cellular network of threads named the \u03b3-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that \u03b3-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that \u03b3-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of \u03b3-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of \u03b3-tubulin DNA-binding domain enhanced the association of \u03b3-tubulin with mitochondria. Our results demonstrate that \u03b3-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that \u03b3-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.", "doi": "10.1038/s42003-018-0037-3", "pmid": "30271923", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service", "National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s42003-018-0037-3"}, {"db": "pmc", "key": "PMC6123723"}], "notes": [], "created": "2020-01-23T16:26:11.434Z", "modified": "2021-11-03T15:41:13.583Z"}, {"entity": "publication", "iuid": "f52e06e45f5441fd85c12a288c5606c4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f52e06e45f5441fd85c12a288c5606c4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f52e06e45f5441fd85c12a288c5606c4"}}, "title": "RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer.", "authors": [{"family": "Ehl\u00e9n", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Nodin", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Rexhepaj", "given": "Elton", "initials": "E"}, {"family": "Br\u00e4ndstedt", "given": "Jenny", "initials": "J"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications.scilifelab.se/researcher/ff81da3cb0cf4262873b993a1b06798c.json"}}, {"family": "Alvarado-Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "researcher": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673.json"}}, {"family": "Pont\u00e9n", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0703-3940", "researcher": {"href": "https://publications.scilifelab.se/researcher/a8b56979a6c74891aa277fb28848b6ce.json"}}, {"family": "Brennan", "given": "Donal J", "initials": "DJ"}, {"family": "Jirstr\u00f6m", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2011-08-00", "journal": {"volume": "4", "issn": "1936-5233", "issue": "4", "pages": "212-221", "title": "Transl Oncol", "issn-l": null}, "abstract": "The RNA-binding motif protein 3 (RBM3) was initially discovered as a putative cancer biomarker based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). We previously reported an association between high expression of RBM3 and prolonged survival in breast and epithelial ovarian cancer (EOC). Because the function of RBM3 has not been fully elucidated, the aim of this study was to use gene set enrichment analysis to identify the underlying biologic processes associated with RBM3 expression in a previously analyzed EOC cohort (cohort 1, n = 267). This revealed an association between RBM3 expression and several cellular processes involved in the maintenance of DNA integrity. RBM3-regulated genes were subsequently screened in the HPA to select for putative prognostic markers, and candidate proteins were analyzed in the ovarian cancer cell line A2780, whereby an up-regulation of Chk1, Chk2, and MCM3 was demonstrated in siRBM3-treated cells compared to controls. The prognostic value of these markers was assessed at the messenger RNA level in cohort 1 and the protein level in an independent EOC cohort (cohort 2, n = 154). High expression levels of Chk1, Chk2, and MCM3 were associated with a significantly shorter survival in both cohorts, and phosphorylated Chk2 was an adverse prognostic marker in cohort 2. These results uncover a putative role for RBM3 in DNA damage response, which might, in part, explain its cisplatin-sensitizing properties and good prognostic value in EOC. Furthermore, it is demonstrated that Chk1, Chk2, and MCM3 are poor prognostic markers in EOC.", "doi": "10.1593/tlo.11106", "pmid": "21804916", "labels": {"Tissue Profiling": null}, "xrefs": [{"db": "pmc", "key": "PMC3140008"}], "notes": [], "created": "2017-05-04T14:55:49.446Z", "modified": "2021-06-22T12:17:19.596Z"}]}