{"entity": "researcher", "timestamp": "2026-08-07T18:46:48.150Z", "family": "Spetz", "given": "Anna-Lena", "initials": "AL", "orcid": "0000-0003-3964-9512", "affiliations": ["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, 10691, Sweden. anna-lena.spetz@su.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/70270e32d48d486799cc9dd61e36a4f1.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/70270e32d48d486799cc9dd61e36a4f1"}}, "publications": [{"entity": "publication", "iuid": "aa033e622fbc43ffb6090c29ba97d1a8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aa033e622fbc43ffb6090c29ba97d1a8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aa033e622fbc43ffb6090c29ba97d1a8"}}, "title": "The viral protein corona directs viral pathogenesis and amyloid aggregation.", "authors": [{"family": "Ezzat", "given": "Kariem", "initials": "K", "orcid": "0000-0003-4186-0675", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f2f1d3d8a5d467c8fc3b95388e4c606.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f15f303cb2044cfa81719700137e3603.json"}}, {"family": "P\u00e5lsson", "given": "Sandra", "initials": "S"}, {"family": "Roberts", "given": "Thomas C", "initials": "TC"}, {"family": "J\u00e4rver", "given": "Peter", "initials": "P"}, {"family": "Dondalska", "given": "Aleksandra", "initials": "A"}, {"family": "Bestas", "given": "Burcu", "initials": "B"}, {"family": "Sobkowiak", "given": "Michal J", "initials": "MJ"}, {"family": "Lev\u00e4nen", "given": "Bettina", "initials": "B"}, {"family": "Sk\u00f6ld", "given": "Magnus", "initials": "M"}, {"family": "Thompson", "given": "Elizabeth A", "initials": "EA"}, {"family": "Saher", "given": "Osama", "initials": "O"}, {"family": "Kari", "given": "Otto K", "initials": "OK"}, {"family": "Lajunen", "given": "Tatu", "initials": "T", "orcid": "0000-0001-6234-9193", "researcher": {"href": "https://publications.scilifelab.se/researcher/55d9cb27b0734ca496514762ed1627f0.json"}}, {"family": "Sverremark Ekstr\u00f6m", "given": "Eva", "initials": "E", "orcid": "0000-0001-6271-8681", "researcher": {"href": "https://publications.scilifelab.se/researcher/d7519ea4bf1f43dcab124c3d62b489db.json"}}, {"family": "Nilsson", "given": "Caroline", "initials": "C"}, {"family": "Ishchenko", "given": "Yevheniia", "initials": "Y"}, {"family": "Malm", "given": "Tarja", "initials": "T"}, {"family": "Wood", "given": "Matthew J A", "initials": "MJA"}, {"family": "Power", "given": "Ultan F", "initials": "UF", "orcid": "0000-0003-3246-3774", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0d135555da74520a0d4b7733cd6ddd7.json"}}, {"family": "Masich", "given": "Sergej", "initials": "S"}, {"family": "Lind\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/7468c415a46645a3a4c3d28badcff954.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications.scilifelab.se/researcher/8406a97bac744a59b1bc951978994581.json"}}, {"family": "Spetz", "given": "Anna-Lena", "initials": "AL", "orcid": "0000-0003-3964-9512", "researcher": {"href": "https://publications.scilifelab.se/researcher/70270e32d48d486799cc9dd61e36a4f1.json"}}, {"family": "El Andaloussi", "given": "Samir", "initials": "S"}], "type": "journal article", "published": "2019-05-27", "journal": {"volume": "10", "issn": "2041-1723", "issue": "1", "pages": "2331", "title": "Nat Commun", "issn-l": "2041-1723"}, "abstract": "Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid \u03b2-peptide (A\u03b242), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.", "doi": "10.1038/s41467-019-10192-2", "pmid": "31133680", "labels": {"Global Proteomics and Proteogenomics": "Technology development", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-019-10192-2"}, {"db": "pmc", "key": "PMC6536551"}], "notes": [], "created": "2020-01-07T12:31:23.818Z", "modified": "2024-01-16T13:48:44.332Z"}, {"entity": "publication", "iuid": "6c018d7fe577404c9ce7c148a8d5ecd4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6c018d7fe577404c9ce7c148a8d5ecd4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6c018d7fe577404c9ce7c148a8d5ecd4"}}, "title": "Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis.", "authors": [{"family": "J\u00e4rver", "given": "Peter", "initials": "P", "orcid": "0000-0001-9643-5874", "researcher": {"href": "https://publications.scilifelab.se/researcher/7645ffd2a3f7458b805892f41fd1e124.json"}}, {"family": "Dondalska", "given": "Aleksandra", "initials": "A"}, {"family": "Poux", "given": "Candice", "initials": "C"}, {"family": "Sandberg", "given": "AnnSofi", "initials": "A"}, {"family": "Bergenstr\u00e5hle", "given": "Joseph", "initials": "J"}, {"family": "Sk\u00f6ld", "given": "Annette E", "initials": "AE"}, {"family": "Dereuddre-Bosquet", "given": "Nathalie", "initials": "N"}, {"family": "Martinon", "given": "Fr\u00e9deric", "initials": "F"}, {"family": "P\u00e5lsson", "given": "Sandra", "initials": "S"}, {"family": "Zaghloul", "given": "Eman", "initials": "E"}, {"family": "Brodin", "given": "David", "initials": "D"}, {"family": "Sander", "given": "Birgitta", "initials": "B"}, {"family": "Lennox", "given": "Kim A", "initials": "KA"}, {"family": "Behlke", "given": "Mark A", "initials": "MA"}, {"family": "El-Andaloussi", "given": "Samir", "initials": "S"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications.scilifelab.se/researcher/8406a97bac744a59b1bc951978994581.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications.scilifelab.se/researcher/4a4e6ca0f29b4ead8569e2729481c3e0.json"}}, {"family": "LeGrand", "given": "Roger", "initials": "R"}, {"family": "Spetz", "given": "Anna-Lena", "initials": "AL", "orcid": "0000-0003-3964-9512", "researcher": {"href": "https://publications.scilifelab.se/researcher/70270e32d48d486799cc9dd61e36a4f1.json"}}], "type": "journal article", "published": "2018-10-26", "journal": {"volume": "8", "issn": "2045-2322", "issue": "1", "pages": "15841", "title": "Sci Rep", "issn-l": "2045-2322"}, "abstract": "Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that single-stranded oligonucleotides (ssON) inhibit endocytic pathways used by cargo destined for TLR3/4/7 signaling endosomes. Both ssDNA and ssRNA conferred the endocytic inhibition, it was concentration dependent, and required a certain ssON length. The ssON-mediated inhibition modulated signaling downstream of TLRs that localized within the affected endosomal pathway. We further show that injection of ssON dampens dsRNA-mediated inflammatory responses in the skin of non-human primates. These studies reveal a regulatory role for extracellular ssON in the endocytic uptake of TLR ligands and provide a mechanistic explanation of their immunomodulation. The identified ssON-mediated interference of endocytosis (SOMIE) is a regulatory process that temporarily dampens TLR3/4/7 signaling, thereby averting excessive immune responses.", "doi": "10.1038/s41598-018-33960-4", "pmid": "30367171", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "Global Proteomics and Proteogenomics": "Collaborative"}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-018-33960-4"}, {"db": "pmc", "key": "PMC6203749"}], "notes": [], "created": "2019-01-04T14:04:14.911Z", "modified": "2021-07-08T11:26:36.978Z"}]}