{"entity": "researcher", "timestamp": "2026-08-16T19:32:51.107Z", "family": "Tislevoll", "given": "Benedicte Sjo", "initials": "BS", "orcid": "0000-0003-4962-997X", "affiliations": ["Centre for Cancer Biomarkers (CCBIO), Department of Clinical Science, University of Bergen, Bergen, Norway."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/6874ed44ded94d709e1d11fc62af6b43.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/6874ed44ded94d709e1d11fc62af6b43"}}, "publications": [{"entity": "publication", "iuid": "477434a47b94448f836521f7892ec2be", "links": {"self": {"href": "https://publications.scilifelab.se/publication/477434a47b94448f836521f7892ec2be.json"}, "display": {"href": "https://publications.scilifelab.se/publication/477434a47b94448f836521f7892ec2be"}}, "title": "Early response evaluation by single cell signaling profiling in acute myeloid leukemia.", "authors": [{"family": "Tislevoll", "given": "Benedicte Sjo", "initials": "BS", "orcid": "0000-0003-4962-997X", "researcher": {"href": "https://publications.scilifelab.se/researcher/6874ed44ded94d709e1d11fc62af6b43.json"}}, {"family": "Helles\u00f8y", "given": "Monica", "initials": "M", "orcid": "0000-0002-0115-7427", "researcher": {"href": "https://publications.scilifelab.se/researcher/a2df980a59134a4e82c3ac5e0edfecc9.json"}}, {"family": "Fagerholt", "given": "Oda Helen Eck", "initials": "OHE", "orcid": "0000-0002-5712-8860", "researcher": {"href": "https://publications.scilifelab.se/researcher/38167da5fcd94d14856785c8dd3319e9.json"}}, {"family": "Gullaksen", "given": "Stein-Erik", "initials": "SE"}, {"family": "Srivastava", "given": "Aashish", "initials": "A", "orcid": "0000-0003-0532-3979", "researcher": {"href": "https://publications.scilifelab.se/researcher/a69d8575b0dd4fc99fe8e6a601706a90.json"}}, {"family": "Birkeland", "given": "Even", "initials": "E"}, {"family": "Kleftogiannis", "given": "Dimitrios", "initials": "D", "orcid": "0000-0003-1086-821X", "researcher": {"href": "https://publications.scilifelab.se/researcher/88b8cce357b54b3cb0d22e5dd995d8d0.json"}}, {"family": "Ayuda-Dur\u00e1n", "given": "Pilar", "initials": "P", "orcid": "0000-0002-9799-3680", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c39b575f5e1485b98e6271d56da8751.json"}}, {"family": "Piechaczyk", "given": "Laure", "initials": "L"}, {"family": "Tadele", "given": "Dagim Shiferaw", "initials": "DS", "orcid": "0000-0001-8319-678X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b2524c8c8754beda75c6118d372b56e.json"}}, {"family": "Skavland", "given": "J\u00f8rn", "initials": "J"}, {"family": "Baliakas", "given": "Panagotis", "initials": "P", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications.scilifelab.se/researcher/17370bd509dc4b1081af5aed9e5117c7.json"}}, {"family": "Hovland", "given": "Randi", "initials": "R", "orcid": "0000-0001-8543-2213", "researcher": {"href": "https://publications.scilifelab.se/researcher/a0ea76c7a8a349b9b4c367f294d455f5.json"}}, {"family": "Andresen", "given": "Vibeke", "initials": "V", "orcid": "0000-0002-2368-2978", "researcher": {"href": "https://publications.scilifelab.se/researcher/43af3d6b0a4a432796443809e2facaaf.json"}}, {"family": "Seternes", "given": "Ole Morten", "initials": "OM", "orcid": "0000-0001-8537-3612", "researcher": {"href": "https://publications.scilifelab.se/researcher/843d4ab66cf04591aa1ec42503ebd6bf.json"}}, {"family": "Tvedt", "given": "Tor Henrik Anderson", "initials": "THA"}, {"family": "Aghaeepour", "given": "Nima", "initials": "N", "orcid": "0000-0002-6117-8764", "researcher": {"href": "https://publications.scilifelab.se/researcher/a61941f98d9e43e289e94dc59ff9dfcc.json"}}, {"family": "Gavasso", "given": "Sonia", "initials": "S"}, {"family": "Porkka", "given": "Kimmo", "initials": "K", "orcid": "0000-0003-4112-5902", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f4ebafb55b34613af79c4d16a3eb75c.json"}}, {"family": "Jonassen", "given": "Inge", "initials": "I", "orcid": "0000-0003-4110-0748", "researcher": {"href": "https://publications.scilifelab.se/researcher/c609d886fc37469196e4bb639a0a89bb.json"}}, {"family": "Fl\u00f8isand", "given": "Yngvar", "initials": "Y", "orcid": "0000-0001-7267-1944", "researcher": {"href": "https://publications.scilifelab.se/researcher/f221b95eed9649618358528c075e4da2.json"}}, {"family": "Enserink", "given": "Jorrit", "initials": "J", "orcid": "0000-0002-2394-5387", "researcher": {"href": "https://publications.scilifelab.se/researcher/b0f0fc1c8ab142d39502e5b3df86b1bc.json"}}, {"family": "Blaser", "given": "Nello", "initials": "N", "orcid": "0000-0001-9489-1657", "researcher": {"href": "https://publications.scilifelab.se/researcher/22c9faae544a4d188acd34946ead8647.json"}}, {"family": "Gjertsen", "given": "Bj\u00f8rn Tore", "initials": "BT", "orcid": "0000-0001-9358-9704", "researcher": {"href": "https://publications.scilifelab.se/researcher/96c4d4aadc5f4ffb85df2176935b77db.json"}}], "type": "journal article", "published": "2023-01-07", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "115", "issn-l": "2041-1723"}, "abstract": "Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy is a significant predictor of patient 5-year overall survival in this cohort. Validation by RNA sequencing shows induction of MAPK target gene expression in patients with high phospho-ERK1/2 24 h post-chemotherapy, while proteomics confirm an increase of the p38 prime target MAPK activated protein kinase 2 (MAPKAPK2). In this study, we demonstrate that mass cytometry can be a valuable tool for early response evaluation in AML and elucidate the potential of functional signaling analyses in precision oncology diagnostics.", "doi": "10.1038/s41467-022-35624-4", "pmid": "36611026", "labels": {"Clinical Genomics Uppsala": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9825407"}, {"db": "pii", "key": "10.1038/s41467-022-35624-4"}], "notes": [], "created": "2023-11-29T08:27:28.554Z", "modified": "2023-11-29T08:27:29.154Z"}]}