{"entity": "researcher", "timestamp": "2026-03-05T08:25:52.038Z", "family": "Mu", "given": "Yabing", "initials": "Y", "orcid": "0000-0003-3193-1425", "affiliations": ["Department of Medical Bioscience, Ume\u00e5 University, Ume\u00e5, Sweden. yabing.mu@umu.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/626d44f4c6d7498ea7e2690e9f7008d5.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/626d44f4c6d7498ea7e2690e9f7008d5"}}, "publications": [{"entity": "publication", "iuid": "4a95cb368b7e43af872e0dd1190cd040", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4a95cb368b7e43af872e0dd1190cd040.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4a95cb368b7e43af872e0dd1190cd040"}}, "title": "The T\u03b2RI promotes migration and metastasis through thrombospondin 1 and ITGAV in prostate cancer cells.", "authors": [{"family": "Mu", "given": "Yabing", "initials": "Y", "orcid": "0000-0003-3193-1425", "researcher": {"href": "https://publications.scilifelab.se/researcher/626d44f4c6d7498ea7e2690e9f7008d5.json"}}, {"family": "Wallenius", "given": "Anders", "initials": "A"}, {"family": "Zang", "given": "Guangxiang", "initials": "G"}, {"family": "Zhu", "given": "Shaochun", "initials": "S", "orcid": "0000-0001-9945-6718", "researcher": {"href": "https://publications.scilifelab.se/researcher/50c472868ea0437bb9a5a1b0a574bc39.json"}}, {"family": "Rudolfsson", "given": "Stina", "initials": "S"}, {"family": "Aripaka", "given": "Karthik", "initials": "K", "orcid": "0000-0001-5071-6187", "researcher": {"href": "https://publications.scilifelab.se/researcher/2622fdbe964f4f99810cdc20c67a9fe0.json"}}, {"family": "Bergh", "given": "Anders", "initials": "A", "orcid": "0000-0001-5163-5821", "researcher": {"href": "https://publications.scilifelab.se/researcher/ba7945f3e27f4628ba29c7003b3bdf36.json"}}, {"family": "Mateus", "given": "Andr\u00e9", "initials": "A"}, {"family": "Landstr\u00f6m", "given": "Mar\u00e9ne", "initials": "M", "orcid": "0000-0001-6737-7230", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2f02fcfb1c1497d81a6f343bc0e6928.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "Oncogene", "issn": "1476-5594", "issn-l": "0950-9232", "volume": "43", "issue": "45", "pages": "3321-3334"}, "abstract": "TGF\u03b2 potently modifies the extracellular matrix (ECM), which is thought to favor tumor cell invasion. However, the mechanism whereby the cancer cells employ the ECM proteins to facilitate their motility is largely unknown. In this study we used RNA-seq and proteomic analysis to examine the proteins secreted by castration-resistant prostate cancer (CRPC) cells upon TGF\u03b2 treatment and found that thrombospondin 1 (THBS1) was observed to be one of the predominant proteins. The CRISPR Cas9, or siRNA techniques was used to downregulate TGF\u03b2 type I receptor (T\u03b2RI) to interfere with TGF\u03b2 signaling in various cancer cells in vitro. The interaction of ECM proteins with the T\u03b2RI in the migratory prostate cancer cells in response to TGF\u03b21 was demonstrated by several different techniques to reveal that THBS1 mediates cell migration by interacting with integrin subunit alpha V (ITGAV) and T\u03b2RI. Deletion of T\u03b2RI or THBS1 in cancer cells prevented their migration and invasion. THBS1 belongs to a group of tumorigenic ECM proteins induced via TGF\u03b2 signaling in CRPC cells, and high expression of THBS1 in human prostate cancer tissues correlated with the degree of malignancy. TGF\u03b2-induced production of THBS1 through T\u03b2RI facilitates the invasion and metastasis of CRPC cells as shown in vivo xenograft animal experiments.", "doi": "10.1038/s41388-024-03165-3", "pmid": "39304722", "labels": {"NGI Uppsala (Uppsala Genome Center)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support and Infrastructure": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41388-024-03165-3"}], "notes": [], "created": "2024-11-05T07:21:43.281Z", "modified": "2024-11-15T09:56:41.242Z"}]}