{"entity": "researcher", "timestamp": "2026-07-12T18:37:14.233Z", "family": "G\u00f6nd\u00f6r", "given": "Anita", "initials": "A", "orcid": "0000-0002-1523-4411", "affiliations": ["Department of Oncology and Pathology, Bioclinicum, Karolinska University Hospital, U2, Akademiska Str\u00e5ket 1, Karolinska Institutet, Stockholm, Sweden. anita.gondor@ki.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/611abc86936c400e91670eaee7a91fec.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/611abc86936c400e91670eaee7a91fec"}}, "publications": [{"entity": "publication", "iuid": "818045cf427e448a88ca0016ae161e99", "links": {"self": {"href": "https://publications.scilifelab.se/publication/818045cf427e448a88ca0016ae161e99.json"}, "display": {"href": "https://publications.scilifelab.se/publication/818045cf427e448a88ca0016ae161e99"}}, "title": "Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.", "authors": [{"family": "Chachoua", "given": "Ilyas", "initials": "I"}, {"family": "Tzelepis", "given": "Ilias", "initials": "I", "orcid": "0000-0001-5777-6334", "researcher": {"href": "https://publications.scilifelab.se/researcher/18d93209d4bd4173bebec63d50462fe5.json"}}, {"family": "Dai", "given": "Hao", "initials": "H"}, {"family": "Lim", "given": "Jia Pei", "initials": "JP"}, {"family": "Lewandowska-Ronnegren", "given": "Anna", "initials": "A"}, {"family": "Casagrande", "given": "Felipe Beccaria", "initials": "FB", "orcid": "0000-0003-1117-4754", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec52e8f2c91840858ed9c496481bc97b.json"}}, {"family": "Wu", "given": "Shuangyang", "initials": "S"}, {"family": "Vestlund", "given": "Johanna", "initials": "J", "orcid": "0000-0001-7158-905X", "researcher": {"href": "https://publications.scilifelab.se/researcher/1589ce6268784aa6b599b3fd07caeb9d.json"}}, {"family": "Mallet de Lima", "given": "Carolina Diettrich", "initials": "CD"}, {"family": "Bhartiya", "given": "Deeksha", "initials": "D"}, {"family": "Scholz", "given": "Barbara A", "initials": "BA"}, {"family": "Martino", "given": "Mirco", "initials": "M", "orcid": "0000-0002-0954-0359", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d73809cbf204985a5d90befd9f65766.json"}}, {"family": "Mehmood", "given": "Rashid", "initials": "R", "orcid": "0000-0002-3488-9413", "researcher": {"href": "https://publications.scilifelab.se/researcher/8e41df49c1e8470a9851829de9cf6a08.json"}}, {"family": "G\u00f6nd\u00f6r", "given": "Anita", "initials": "A", "orcid": "0000-0002-1523-4411", "researcher": {"href": "https://publications.scilifelab.se/researcher/611abc86936c400e91670eaee7a91fec.json"}}], "type": "journal article", "published": "2022-01-11", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "204"}, "abstract": "Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer-(OSE)-mediated gating of the active MYC to the nuclear pore in a poorly understood process. We show here that the principal tenet of the WNT-regulated MYC gating, facilitating nuclear export of the MYC mRNA, is regulated by a CTCF binding site (CTCFBS) within the OSE to confer growth advantage in HCT-116 cells. To achieve this, the CTCFBS directs the WNT-dependent trafficking of the OSE to the nuclear pore from intra-nucleoplasmic positions in a stepwise manner. Once the OSE reaches a peripheral position, which is triggered by a CTCFBS-mediated CCAT1 eRNA activation, its final stretch (\u22640.7 \u03bcm) to the nuclear pore requires the recruitment of AHCTF1, a key nucleoporin, to the CTCFBS. Thus, a WNT/\u00df-catenin-AHCTF1-CTCF-eRNA circuit enables the OSE to promote pathological cell growth by coordinating the trafficking of the active MYC gene within the 3D nuclear architecture.", "doi": "10.1038/s41467-021-27868-3", "pmid": "35017527", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-27868-3"}, {"db": "pmc", "key": "PMC8752836"}], "notes": [], "created": "2022-03-29T13:48:00.967Z", "modified": "2024-01-16T13:48:37.783Z"}]}