{"entity": "researcher", "timestamp": "2026-07-13T09:10:09.621Z", "family": "Larena", "given": "Maximilian", "initials": "M", "orcid": "0000-0002-8799-7645", "affiliations": ["Human Evolution, Department of Organismal Biology, Uppsala University, SE-752 36 Uppsala, Sweden; maximilian.larena@ebc.uu.se kurt.lambeck@anu.edu.au mattias.jakobsson@ebc.uu.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/5d580f1f3e584c809f5f22d7355f154f.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/5d580f1f3e584c809f5f22d7355f154f"}}, "publications": [{"entity": "publication", "iuid": "5c371c3254f24f45930def1fa3ba5c42", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5c371c3254f24f45930def1fa3ba5c42.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5c371c3254f24f45930def1fa3ba5c42"}}, "title": "Wide-scale geographical analysis of genetic ancestry in the South African Coloured population.", "authors": [{"family": "Lankheet", "given": "Imke", "initials": "I"}, {"family": "Hammar\u00e9n", "given": "Rickard", "initials": "R", "orcid": "0000-0001-9017-591X", "researcher": {"href": "https://publications.scilifelab.se/researcher/01a7b62a04c14b99bd73fb436006e4ff.json"}}, {"family": "Alva Caballero", "given": "Luc\u00eda Ximena", "initials": "LX"}, {"family": "Larena", "given": "Maximilian", "initials": "M", "orcid": "0000-0002-8799-7645", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d580f1f3e584c809f5f22d7355f154f.json"}}, {"family": "Malmstr\u00f6m", "given": "Helena", "initials": "H", "orcid": "0000-0002-6456-8055", "researcher": {"href": "https://publications.scilifelab.se/researcher/3b3397b2842142bea34c222f6683c0eb.json"}}, {"family": "Jolly", "given": "Cecile", "initials": "C"}, {"family": "Soodyall", "given": "Himla", "initials": "H"}, {"family": "de Jongh", "given": "Michael", "initials": "M"}, {"family": "Schlebusch", "given": "Carina", "initials": "C", "orcid": "0000-0002-8160-9621", "researcher": {"href": "https://publications.scilifelab.se/researcher/682f10853c1145649b8c76680605dd9b.json"}}], "type": "journal article", "published": "2025-07-22", "journal": {"title": "BMC Biol.", "issn": "1741-7007", "volume": "23", "issue": "1", "pages": "219", "issn-l": "1741-7007"}, "abstract": "The South African Coloured (SAC) population, a prominent admixed population in South Africa, reflects centuries of migration, admixture, and historical segregation. Descendants of local Khoe-San and Bantu-speaking populations, European settlers, and enslaved individuals from Africa and Asia, SAC individuals embody diverse ancestries. This study investigates the genetic makeup of SAC individuals, utilizing autosomal genotypes, mitochondrial DNA and Y-chromosome data. We analyse new genotype data for 125 SAC individuals from seven locations.\n\nOur analysis, based on a dataset comprising 356 SAC individuals from 22 geographic locations, revealed significant regional variations in ancestry. Khoe-San ancestry predominates in 14 locations, highlighting its lasting influence. Inland regions exhibit higher proportions of Khoe-San ancestry, eastern regions show more Bantu-speaker/West African ancestry, and western/coastal areas, particularly around Cape Town, display increased Asian ancestry. Additionally, sex-biased admixture ratios show male-biased admixture from East Africans and Europeans, and female-biased admixture from Khoe-San populations, which is supported by mitochondrial and Y-chromosome data.\n\nThe observed patterns of significant regional variation in ancestry reflect historical migrations and settlement patterns. This research underscores the importance of studying the SAC population to understand South Africa's historical migrations, providing insights into the complex genetic heritage of South Africans.", "doi": "10.1186/s12915-025-02317-5", "pmid": "40696318", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12281806"}, {"db": "pii", "key": "10.1186/s12915-025-02317-5"}], "notes": [], "created": "2025-08-19T13:34:50.043Z", "modified": "2025-11-14T11:08:46.149Z"}, {"entity": "publication", "iuid": "a2b369b29d704e429e7d6fc25ebcdee7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a2b369b29d704e429e7d6fc25ebcdee7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a2b369b29d704e429e7d6fc25ebcdee7"}}, "title": "Genetic Origins of the Kiritimati Population from Central-Eastern Micronesia.", "authors": [{"family": "Larena", "given": "Maximilian", "initials": "M", "orcid": "0000-0002-8799-7645", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d580f1f3e584c809f5f22d7355f154f.json"}}, {"family": "Chowdhury", "given": "Afifa Enam", "initials": "AE", "orcid": "0009-0000-8509-0276", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d3db9785b2f47fd93c5d4a23d8b2ced.json"}}, {"family": "Kels", "given": "Ma Junaliah Tuazon", "initials": "MJT", "orcid": "0000-0002-8730-1062", "researcher": {"href": "https://publications.scilifelab.se/researcher/083b0316d97f4be3a43126d01f9a173e.json"}}, {"family": "T\u00e4tte", "given": "Kai", "initials": "K", "orcid": "0000-0002-4753-8954", "researcher": {"href": "https://publications.scilifelab.se/researcher/d44e6836c0144dac85f38f1054520e44.json"}}, {"family": "Metspalu", "given": "Mait", "initials": "M", "orcid": "0000-0003-3099-9161", "researcher": {"href": "https://publications.scilifelab.se/researcher/0557a5b67af948ee8e47473a8ee621d7.json"}}, {"family": "Schlebusch", "given": "Carina M", "initials": "CM", "orcid": "0000-0002-8160-9621", "researcher": {"href": "https://publications.scilifelab.se/researcher/682f10853c1145649b8c76680605dd9b.json"}}, {"family": "Garcia-Bertrand", "given": "Ralph", "initials": "R", "orcid": "0000-0003-3011-9822", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e0cd4c1175c444c912c1a6db7f44665.json"}}, {"family": "Herrera", "given": "Rene J", "initials": "RJ", "orcid": "0000-0002-5119-4381", "researcher": {"href": "https://publications.scilifelab.se/researcher/8cd8305c817e4adabe92faeebb02fe6e.json"}}], "type": "journal article", "published": "2025-03-06", "journal": {"title": "Genome Biol Evol", "issn": "1759-6653", "volume": "17", "issue": "3", "issn-l": "1759-6653"}, "abstract": "The migration of Austronesian-speaking populations through Oceania has intrigued researchers for decades. The Kiribati islands, situated along the boundaries of Micronesia and Polynesia, provide a crucial link in this migration. We analyzed the genome-wide data of the Kiritimati population of Kiribati to uncover their genetic origins and connections with other Oceanian groups. Our study reveals that the Kiritimati population primarily exhibits Remote Oceanian-related ancestry associated with ancient Lapita and present-day Polynesian populations. In addition, our identity-by-descent analysis identifies populations from the coastal southern Philippines as their closest relatives in Island Southeast Asia. The genetic links between Kiritimati, ancient Lapita, and modern Polynesians underscore the shared ancestry and continuous gene flow across these regions. This genetic continuity and ongoing links are supported by linguistic and cultural evidence, illustrating a complex history of migration and admixture in Oceania.", "doi": "10.1093/gbe/evaf046", "pmid": "40065639", "labels": {"NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11937891"}, {"db": "pii", "key": "8069057"}], "notes": [], "created": "2025-09-08T07:15:27.954Z", "modified": "2025-11-14T11:07:53.391Z"}, {"entity": "publication", "iuid": "886b1418f40b4c32b01fd338e3302530", "links": {"self": {"href": "https://publications.scilifelab.se/publication/886b1418f40b4c32b01fd338e3302530.json"}, "display": {"href": "https://publications.scilifelab.se/publication/886b1418f40b4c32b01fd338e3302530"}}, "title": "Multiple migrations to the Philippines during the last 50,000 years.", "authors": [{"family": "Larena", "given": "Maximilian", "initials": "M", "orcid": "0000-0002-8799-7645", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d580f1f3e584c809f5f22d7355f154f.json"}}, {"family": "Sanchez-Quinto", "given": "Federico", "initials": "F", "orcid": "0000-0002-0201-6204", "researcher": {"href": "https://publications.scilifelab.se/researcher/c554aeb35ee04ee1ac43c5291a8d7f3c.json"}}, {"family": "Sj\u00f6din", "given": "Per", "initials": "P"}, {"family": "McKenna", "given": "James", "initials": "J"}, {"family": "Ebeo", "given": "Carlo", "initials": "C"}, {"family": "Reyes", "given": "Rebecca", "initials": "R"}, {"family": "Casel", "given": "Ophelia", "initials": "O"}, {"family": "Huang", "given": "Jin-Yuan", "initials": "JY"}, {"family": "Hagada", "given": "Kim Pullupul", "initials": "KP", "orcid": "0000-0002-1272-4132", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a2728ede8ca453c8e8c2fe8a98344bd.json"}}, {"family": "Guilay", "given": "Dennis", "initials": "D"}, {"family": "Reyes", "given": "Jennelyn", "initials": "J", "orcid": "0000-0002-9879-582X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3c1a796da8c44d178de38fab6109c132.json"}}, {"family": "Allian", "given": "Fatima Pir", "initials": "FP"}, {"family": "Mori", "given": "Virgilio", "initials": "V"}, {"family": "Azarcon", "given": "Lahaina Sue", "initials": "LS"}, {"family": "Manera", "given": "Alma", "initials": "A"}, {"family": "Terando", "given": "Celito", "initials": "C", "orcid": "0000-0002-4939-1802", "researcher": {"href": "https://publications.scilifelab.se/researcher/351d926e87094101bfba53fe7322680a.json"}}, {"family": "Jamero", "given": "Lucio", "initials": "L"}, {"family": "Sireg", "given": "Gauden", "initials": "G"}, {"family": "Manginsay-Tremedal", "given": "Renefe", "initials": "R"}, {"family": "Labos", "given": "Maria Shiela", "initials": "MS"}, {"family": "Vilar", "given": "Richard Dian", "initials": "RD"}, {"family": "Latiph", "given": "Acram", "initials": "A"}, {"family": "Saway", "given": "Rodelio Linsahay", "initials": "RL", "orcid": "0000-0003-2445-048X", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c910747bc3f41369eaa95eafcb2f381.json"}}, {"family": "Marte", "given": "Erwin", "initials": "E"}, {"family": "Magbanua", "given": "Pablito", "initials": "P"}, {"family": "Morales", "given": "Amor", "initials": "A"}, {"family": "Java", "given": "Ismael", "initials": "I"}, {"family": "Reveche", "given": "Rudy", "initials": "R"}, {"family": "Barrios", "given": "Becky", "initials": "B"}, {"family": "Burton", "given": "Erlinda", "initials": "E"}, {"family": "Salon", "given": "Jesus Christopher", "initials": "JC"}, {"family": "Kels", "given": "Ma Junaliah Tuazon", "initials": "MJT"}, {"family": "Albano", "given": "Adrian", "initials": "A"}, {"family": "Cruz-Angeles", "given": "Rose Beatrix", "initials": "RB", "orcid": "0000-0003-3828-4929", "researcher": {"href": "https://publications.scilifelab.se/researcher/b6ac99916cbb41e2990452c0446e88f5.json"}}, {"family": "Molanida", "given": "Edison", "initials": "E"}, {"family": "Graneh\u00e4ll", "given": "Lena", "initials": "L", "orcid": "0000-0001-9970-4080", "researcher": {"href": "https://publications.scilifelab.se/researcher/1900cb5164304c70ab0f5aa19cf10564.json"}}, {"family": "Vicente", "given": "M\u00e1rio", "initials": "M", "orcid": "0000-0002-9122-4530", "researcher": {"href": "https://publications.scilifelab.se/researcher/603244b141da49dfa9ff3a8d17f42b70.json"}}, {"family": "Edlund", "given": "Hanna", "initials": "H"}, {"family": "Loo", "given": "Jun-Hun", "initials": "JH"}, {"family": "Trejaut", "given": "Jean", "initials": "J", "orcid": "0000-0002-4245-0814", "researcher": {"href": "https://publications.scilifelab.se/researcher/57eab8fc843743929a82453430b422dc.json"}}, {"family": "Ho", "given": "Simon Y W", "initials": "SYW", "orcid": "0000-0002-0361-2307", "researcher": {"href": "https://publications.scilifelab.se/researcher/00d59fd0713e440b8ddb35f58c53f19c.json"}}, {"family": "Reid", "given": "Lawrence", "initials": "L"}, {"family": "Malmstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Schlebusch", "given": "Carina", "initials": "C", "orcid": "0000-0002-8160-9621", "researcher": {"href": "https://publications.scilifelab.se/researcher/682f10853c1145649b8c76680605dd9b.json"}}, {"family": "Lambeck", "given": "Kurt", "initials": "K"}, {"family": "Endicott", "given": "Phillip", "initials": "P", "orcid": "0000-0003-2452-8507", "researcher": {"href": "https://publications.scilifelab.se/researcher/de01eeca292648eaaf16fe9480923187.json"}}, {"family": "Jakobsson", "given": "Mattias", "initials": "M", "orcid": "0000-0001-7840-7853", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a4abe0fcb20492d9ec849c9fbf58a71.json"}}], "type": "historical article", "published": "2021-03-30", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "13", "issn-l": "0027-8424"}, "abstract": "Island Southeast Asia has recently produced several surprises regarding human history, but the region's complex demography remains poorly understood. Here, we report \u223c2.3 million genotypes from 1,028 individuals representing 115 indigenous Philippine populations and genome-sequence data from two \u223c8,000-y-old individuals from Liangdao in the Taiwan Strait. We show that the Philippine islands were populated by at least five waves of human migration: initially by Northern and Southern Negritos (distantly related to Australian and Papuan groups), followed by Manobo, Sama, Papuan, and Cordilleran-related populations. The ancestors of Cordillerans diverged from indigenous peoples of Taiwan at least \u223c8,000 y ago, prior to the arrival of paddy field rice agriculture in the Philippines \u223c2,500 y ago, where some of their descendants remain to be the least admixed East Asian groups carrying an ancestry shared by all Austronesian-speaking populations. These observations contradict an exclusive \"out-of-Taiwan\" model of farming-language-people dispersal within the last four millennia for the Philippines and Island Southeast Asia. Sama-related ethnic groups of southwestern Philippines additionally experienced some minimal South Asian gene flow starting \u223c1,000 y ago. Lastly, only a few lowlanders, accounting for <1% of all individuals, presented a low level of West Eurasian admixture, indicating a limited genetic legacy of Spanish colonization in the Philippines. Altogether, our findings reveal a multilayered history of the Philippines, which served as a crucial gateway for the movement of people that ultimately changed the genetic landscape of the Asia-Pacific region.", "doi": "10.1073/pnas.2026132118", "pmid": "33753512", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "2026132118"}, {"db": "pmc", "key": "PMC8020671"}], "notes": [], "created": "2021-12-10T11:33:51.314Z", "modified": "2024-01-16T13:48:40.354Z"}]}