{"entity": "researcher", "timestamp": "2026-07-20T15:40:30.013Z", "family": "Giglio", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1349-9336", "affiliations": ["Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.", "Department of Oncology, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/5bde1c5f1cfd42df988ca7353a800ecb.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/5bde1c5f1cfd42df988ca7353a800ecb"}}, "publications": [{"entity": "publication", "iuid": "d174e3174b0a40048a8077f2f8ee7d24", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d174e3174b0a40048a8077f2f8ee7d24.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d174e3174b0a40048a8077f2f8ee7d24"}}, "title": "Changes in the Proteome in the Development of Chronic Human Papillomavirus Infection-A Prospective Study in HIV Positive and HIV Negative Rwandan Women.", "authors": [{"family": "Bienvenu", "given": "Emile", "initials": "E"}, {"family": "Mukanyangezi", "given": "Marie Francoise", "initials": "MF"}, {"family": "Rulisa", "given": "Stephen", "initials": "S"}, {"family": "Martner", "given": "Anna", "initials": "A", "orcid": "0000-0002-6598-5221", "researcher": {"href": "https://publications.scilifelab.se/researcher/7cd028aac9124c4098a9bbc033affe6e.json"}}, {"family": "Hass\u00e9us", "given": "Bengt", "initials": "B"}, {"family": "Vorontsov", "given": "Egor", "initials": "E"}, {"family": "Tobin", "given": "Gunnar", "initials": "G"}, {"family": "Giglio", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1349-9336", "researcher": {"href": "https://publications.scilifelab.se/researcher/5bde1c5f1cfd42df988ca7353a800ecb.json"}}], "type": "journal article", "published": "2021-11-28", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "13", "issue": "23", "issn-l": "2072-6694"}, "abstract": "Effects on the proteome when a high risk (HR)-HPV infection occurs, when it is cleared and when it becomes chronic were investigated. Moreover, biomarker panels that could identify cervical risk lesions were assessed.\n\nCytology, HPV screening and proteomics were performed on cervical samples from Rwandan HIV+ and HIV- women at baseline, at 9 months, at 18 months and at 24 months. Biological pathways were identified using the String database.\n\nThe most significantly affected pathway when an incident HR-HPV infection occurred was neutrophil degranulation, and vesicle-mediated transport was the most significantly affected pathway when an HR-HPV infection was cleared; protein insertion into membrane in chronic HR-HPV lesions and in lesions where HR-HPVs were cleared were compared; and cellular catabolic process in high-grade lesions was compared to that in negative lesions. A four-biomarker panel (EIF1; BLOC1S5; LIMCH1; SGTA) was identified, which was able to distinguish chronic HR-HPV lesions from cleared HR-HPV/negative lesions (sensitivity 100% and specificity 91%). Another four-biomarker panel (ERH; IGKV2-30; TMEM97; DNAJA4) was identified, which was able to distinguish high-grade lesions from low-grade/negative lesions (sensitivity 100% and specificity 81%).\n\nWe have identified the biological pathways triggered in HR-HPV infection, when HR-HPV becomes chronic and when cervical risk lesions develop. Moreover, we have identified potential biomarkers that may help to identify women with cervical risk lesions.", "doi": "10.3390/cancers13235983", "pmid": "34885095", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8656715"}, {"db": "pii", "key": "cancers13235983"}], "notes": [], "created": "2023-03-07T14:36:26.067Z", "modified": "2024-01-16T13:46:29.788Z"}]}