{"entity": "researcher", "timestamp": "2026-08-15T21:47:01.988Z", "family": "Bostr\u00f6m", "given": "Adrian Desai E", "initials": "ADE", "orcid": "0000-0001-8604-9638", "affiliations": ["Department of Clinical Sciences/Psychiatry, Ume\u00e5 University, Ume\u00e5, Sweden. adrian.desai.bostrom@ki.se.", "Department of Women's and Children's Health/Neuropediatrics, Karolinska Institutet, Stockholm, Sweden. adrian.desai.bostrom@ki.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/5ace74b9a4894d82a16e7ff445bbcea6.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/5ace74b9a4894d82a16e7ff445bbcea6"}}, "publications": [{"entity": "publication", "iuid": "eec4c83790864c44b1c29201e9e0559a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/eec4c83790864c44b1c29201e9e0559a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/eec4c83790864c44b1c29201e9e0559a"}}, "title": "Accelerated epigenetic aging in women with emotionally unstable personality disorder and a history of suicide attempts.", "authors": [{"family": "Bostr\u00f6m", "given": "Adrian Desai E", "initials": "ADE", "orcid": "0000-0001-8604-9638", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ace74b9a4894d82a16e7ff445bbcea6.json"}}, {"family": "Andersson", "given": "Peter", "initials": "P"}, {"family": "Jamshidi", "given": "Esmail", "initials": "E"}, {"family": "Wilczek", "given": "Alexander", "initials": "A"}, {"family": "Nilsonne", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M"}, {"family": "\u00c5sberg", "given": "Marie", "initials": "M"}, {"family": "Jokinen", "given": "Jussi", "initials": "J"}], "type": "journal article", "published": "2023-02-22", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "13", "issue": "1", "pages": "66", "issn-l": "2158-3188"}, "abstract": "Emotional unstable personality disorder (EUPD; previously borderline personality disorder, BPD) is associated with excess natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. Previous studies demonstrated that GrimAge - a state-of-the-art epigenetic age (EA) estimator - strongly predicts mortality risk and physiological dysregulation. Herein, we utilize the GrimAge algorithm to investigate whether women with EUPD and a history of recent suicide attempts exhibit EA acceleration (EAA) in comparison to healthy controls. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from 97 EUPD patients and 32 healthy controls. The control group was significantly older (p < 0.0001) and reported lesser exposure to violent behavior in both youth and adulthood (p < 0.0001). Groups were otherwise comparable regarding gender, BMI, or tobacco usage (p > 0.05). EA estimator DNAmGrimAge exceeded chronological age by 8.8 and 2.3 years in the EUPD and control group, respectively. Similarly, EAA marker AgeAccelGrim was substantially higher in EUPD subjects when compared to controls, in both univariate and multivariate analyzes (p < 0.00001). Tobacco usage conferred substantial within-group effects on the EA-chronological age difference, i.e., 10.74 years (SD = 4.19) compared to 6.00 years (SD = 3.10) in the non-user EUPD group (p < 0.00001). Notably, past alcohol and substance abuse, use of psychotropic medications, global assessment of functioning, self-reported exposure to violent behavior in youth and adulthood, later completed suicide (N = 8) and age at first suicide attempt did not predict EAA in the EUPD group (p > 0.05). These results underscore the importance of addressing medical health conditions along with low-cost preventative interventions aimed at improving somatic health outcomes in EUPD, such as efforts to support cessation of tobacco use. The independency of GrimAge to other EA algorithms in this group of severely impaired EUPD patients, suggest it may have unique characteristics to evaluate risk of adverse health outcomes in context of psychiatric disorders.", "doi": "10.1038/s41398-023-02369-7", "pmid": "36813766", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "NGI SNP genotyping": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-023-02369-7"}, {"db": "pmc", "key": "PMC9946998"}], "notes": [], "created": "2023-02-24T13:14:04.756Z", "modified": "2023-02-24T13:14:04.784Z"}, {"entity": "publication", "iuid": "af20ba6362a54f1bb72479cd4ba927c2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/af20ba6362a54f1bb72479cd4ba927c2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/af20ba6362a54f1bb72479cd4ba927c2"}}, "title": "Accelerated epigenetic aging in suicide attempters uninfluenced by high intent-to-die and choice of lethal methods.", "authors": [{"family": "Jokinen", "given": "Jussi", "initials": "J"}, {"family": "Andersson", "given": "Peter", "initials": "P"}, {"family": "Chatzittofis", "given": "Andreas", "initials": "A", "orcid": "0000-0002-6635-9564", "researcher": {"href": "https://publications.scilifelab.se/researcher/35583d0beb824e068ffd9c015d46309d.json"}}, {"family": "Savard", "given": "Josephine", "initials": "J", "orcid": "0000-0002-0140-4109", "researcher": {"href": "https://publications.scilifelab.se/researcher/19be5afe66ea42d5a2d5cb1695ff0da6.json"}}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M"}, {"family": "\u00c5sberg", "given": "Marie", "initials": "M"}, {"family": "Bostr\u00f6m", "given": "Adrian Desai E", "initials": "ADE", "orcid": "0000-0001-8604-9638", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ace74b9a4894d82a16e7ff445bbcea6.json"}}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "12", "issue": "1", "pages": "224", "issn-l": "2158-3188"}, "abstract": "Suicide attempts (SA) are associated with excess non-suicidal mortality, putatively mediated in part by premature cellular senescence. Epigenetic age (EA) estimators of biological age have been previously demonstrated to strongly predict physiological dysregulation and mortality risk. Herein, we investigate if violent SA with high intent-to-die is predictive of epigenetics-derived estimates of biological aging. The genome-wide methylation pattern was measured using the Illumina Infinium Methylation EPIC BeadChip in whole blood of 88 suicide attempters. Subjects were stratified into two groups based on the putative risk of later committed suicide (low- [n = 58] and high-risk [n = 30]) in dependency of SA method (violent or non-violent) and/or intent-to-die (high/low). Estimators of intrinsic and extrinsic EA acceleration, one marker optimized to predict physiological dysregulation (DNAmPhenoAge/AgeAccelPheno) and one optimized to predict lifespan (DNAmGrimAge/AgeAccelGrim) were investigated for associations to severity of SA, by univariate and multivariate analyses. The study was adequately powered to detect differences of 2.2 years in AgeAccelGrim in relation to SA severity. Baseline DNAmGrimAge exceeded chronological age by 7.3 years on average across all samples, conferring a mean 24.6% increase in relation to actual age. No individual EA acceleration marker was differentiated by suicidal risk group (p > 0.1). Thus, SA per se but not severity of SA is related to EA, implicating that excess non-suicidal mortality in SA is unrelated to risk of committed suicide. Preventative healthcare efforts aimed at curtailing excess mortality after SA may benefit from acting equally powerful to recognize somatic comorbidities irrespective of the severity inherent in the act itself.", "doi": "10.1038/s41398-022-01998-8", "pmid": "35654772", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "NGI SNP genotyping": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-022-01998-8"}], "notes": [], "created": "2022-06-14T13:16:27.182Z", "modified": "2022-06-14T13:16:27.377Z"}]}