{"entity": "researcher", "timestamp": "2026-07-17T08:23:36.249Z", "family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "affiliations": ["Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a"}}, "publications": [{"entity": "publication", "iuid": "26b2d2e481ee4340b58cb2399170e18c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/26b2d2e481ee4340b58cb2399170e18c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/26b2d2e481ee4340b58cb2399170e18c"}}, "title": "Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Ruan", "given": "Xixin", "initials": "X", "orcid": "0000-0002-4937-9168", "researcher": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}}, {"family": "Li", "given": "Yuying", "initials": "Y", "orcid": "0000-0002-3231-7542", "researcher": {"href": "https://publications.scilifelab.se/researcher/019bd04ea79a42eda01be14c54af5090.json"}}, {"family": "Abramowitz", "given": "Sarah A", "initials": "SA"}, {"family": "Wang", "given": "Lijuan", "initials": "L", "orcid": "0000-0002-9797-0753", "researcher": {"href": "https://publications.scilifelab.se/researcher/97af8fc0299a4c25aa4f31841007a8f8.json"}}, {"family": "Jiang", "given": "Fangyuan", "initials": "F"}, {"family": "Xiong", "given": "Ying", "initials": "Y", "orcid": "0000-0001-7644-014X", "researcher": {"href": "https://publications.scilifelab.se/researcher/72484ccb61b140ca946294b68042c330.json"}}, {"family": "Levin", "given": "Michael G", "initials": "MG", "orcid": "0000-0002-9937-9932", "researcher": {"href": "https://publications.scilifelab.se/researcher/d165b2fd025f41fab9959e82610492a3.json"}}, {"family": "Voight", "given": "Benjamin F", "initials": "BF", "orcid": "0000-0002-6205-9994", "researcher": {"href": "https://publications.scilifelab.se/researcher/d3d9e9de96ee4983ba97efc14eb3d79b.json"}}, {"family": "Gill", "given": "Dipender", "initials": "D", "orcid": "0000-0001-7312-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca049660534b4f18ab8a16da46ffca52.json"}}, {"family": "Burgess", "given": "Stephen", "initials": "S", "orcid": "0000-0001-5365-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fd2dcaf4dbb4e4c91c2af460b8fa98f.json"}}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A", "orcid": "0000-0001-9594-4140", "researcher": {"href": "https://publications.scilifelab.se/researcher/f699e3a40b424acd9461ca03f288d6bc.json"}}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Li", "given": "Xue", "initials": "X", "orcid": "0000-0001-6880-2577", "researcher": {"href": "https://publications.scilifelab.se/researcher/360d5c60409d415f8c6957d9e3373cd0.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications.scilifelab.se/researcher/b878210396ae46eba9f04f78be5ff564.json"}}, {"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}], "type": "journal article", "published": "2025-07-11", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "6426", "issn-l": "2041-1723"}, "abstract": "Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 168,007 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian randomization identified modifiable risk factors and circulating proteins, informing disease prevention and drug development. Integrating genomic data from this cross-population genome-wide meta-analysis with proteomic profiling significantly enhanced AF risk prediction. This study advances our understanding of the genetic etiology of AF while also enhancing risk prediction, prevention strategies, and therapeutic development.", "doi": "10.1038/s41467-025-61720-2", "pmid": "40645996", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12254421"}, {"db": "pii", "key": "10.1038/s41467-025-61720-2"}], "notes": [], "created": "2025-11-28T10:45:39.870Z", "modified": "2025-11-28T10:45:40.305Z"}, {"entity": "publication", "iuid": "95cbfa77bb344c08bf41cb612bea42f1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/95cbfa77bb344c08bf41cb612bea42f1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/95cbfa77bb344c08bf41cb612bea42f1"}}, "title": "Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Ruan", "given": "Xixian", "initials": "X", "orcid": "0000-0002-4937-9168", "researcher": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}}, {"family": "Li", "given": "Xue", "initials": "X", "orcid": "0000-0001-6880-2577", "researcher": {"href": "https://publications.scilifelab.se/researcher/360d5c60409d415f8c6957d9e3373cd0.json"}}, {"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}], "type": "journal article", "published": "2025-03-03", "journal": {"title": "JNCI Cancer Spectr", "issn": "2515-5091", "volume": "9", "issue": "2", "issn-l": null}, "abstract": "The causes of bladder cancer are not completely understood. Our objective was to identify blood proteins and modifiable causal risk factors for bladder cancer by combining genome-wide association study (GWAS) and Mendelian randomization (MR) analyses.\n\nWe first performed a GWAS meta-analysis of 6984 bladder cancer case patients and 708 432 control individuals from 3 European databases. Next, we conducted 2-sample MR and colocalization analyses using data from the present GWAS and published GWAS meta-analyses on plasma proteins and modifiable factors.\n\nGenome-wide association study meta-analysis uncovered 17 bladder cancer susceptibility loci, of which 3 loci were novel. Genes were enriched in pathways related to the metabolic and catabolic processes of xenobiotics and cellular detoxification. Proteome-wide MR analysis based on cis-acting genetic variants revealed that higher plasma levels of glutathione S-transferases were strongly associated with a reduced risk of bladder cancer. There is strong evidence of colocalization between GSTM1 and bladder cancer. Finally, multivariable MR analyses of suspected risk factors for bladder cancer revealed independent causal associations between smoking and adiposity, particularly abdominal obesity, and risk of bladder cancer.\n\nFindings from this large-scale GWAS and multivariable MR analyses highlight the key role of detoxification processes, particularly glutathione S-transferase 1, as well as smoking and abdominal obesity in bladder cancer etiology.", "doi": "10.1093/jncics/pkaf014", "pmid": "39898788", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11950924"}, {"db": "pii", "key": "7997273"}], "notes": [], "created": "2025-11-28T10:49:53.296Z", "modified": "2025-11-28T10:49:53.391Z"}, {"entity": "publication", "iuid": "e6431c56a9a44473a9004b296677bac7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e6431c56a9a44473a9004b296677bac7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e6431c56a9a44473a9004b296677bac7"}}, "title": "Association between alcohol consumption and peripheral artery disease: two de novo prospective cohorts and a systematic review with meta-analysis.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Wu", "given": "Jing", "initials": "J"}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Sun", "given": "Yuhao", "initials": "Y", "orcid": "0000-0001-6987-3721", "researcher": {"href": "https://publications.scilifelab.se/researcher/aabdcfb442cd4ac7931e27767753bec3.json"}}, {"family": "Burgess", "given": "Stephen", "initials": "S", "orcid": "0000-0001-5365-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fd2dcaf4dbb4e4c91c2af460b8fa98f.json"}}, {"family": "Li", "given": "Xue", "initials": "X"}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "systematic review", "published": "2025-01-27", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "volume": "32", "issue": "2", "pages": "149-155", "issn-l": "2047-4873"}, "abstract": "The association between alcohol consumption and risk of peripheral artery disease (PAD) is inconclusive. We conducted this study to examine the association between alcohol consumption and PAD risk in two de novo cohort studies and a meta-analysis of observational studies.\n\nA systematic review was conducted to identify studies on alcohol consumption in relation to PAD risk. We further used data from two cohorts of 70 116 Swedish and 405 406 British adults and performed a meta-analysis of results from previously published studies and current cohort studies. There was a U-shaped association between alcohol consumption and incident PAD risk in the Swedish and British cohorts. The meta-analysis of results of these two cohorts and previously published studies found that compared with non- or never-drinkers, the relative risk of PAD was 0.83 [95% confidence interval (CI) 0.77-0.89], 0.81 (95% CI 0.74-0.90), and 0.94 (95% CI 0.83-1.07) for light, moderate, and high-to-heavy alcohol drinkers, respectively. The nonlinear meta-analysis revealed a possibly U-shaped association between alcohol consumption and PAD risk (P nonlinearity <0.001). The risk of PAD was observed to be the lowest for 2 drinks/week and to be pronounced for \u226510 drinks/week. All these associations persisted in a sensitivity meta-analysis including cohort and other types of observational studies.\n\nAlcohol intake \u22642 drinks/week was associated with a reduced risk of PAD, and the risk of PAD became pronounced with intake \u226510 drinkers/week.", "doi": "10.1093/eurjpc/zwae142", "pmid": "38626304", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "mid", "key": "EMS197946"}, {"db": "pmc", "key": "PMC7616826"}, {"db": "pii", "key": "7646796"}], "notes": [], "created": "2025-02-28T14:17:20.622Z", "modified": "2025-02-28T14:17:20.701Z"}, {"entity": "publication", "iuid": "7d7056994fca4f8b9c3760e5ebabf144", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7d7056994fca4f8b9c3760e5ebabf144.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7d7056994fca4f8b9c3760e5ebabf144"}}, "title": "Plasma proteome and incident myocardial infarction: sex-specific differences.", "authors": [{"family": "Titova", "given": "Olga E", "initials": "OE", "orcid": "0000-0003-2747-1606", "researcher": {"href": "https://publications.scilifelab.se/researcher/cefa36fe86504ecab7fcc4a30869a038.json"}}, {"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Byberg", "given": "Liisa", "initials": "L", "orcid": "0000-0002-4421-6466", "researcher": {"href": "https://publications.scilifelab.se/researcher/b3b127d82f1a4c35bb73f32658c924ee.json"}}, {"family": "Baron", "given": "John A", "initials": "JA", "orcid": "0000-0003-3461-1056", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b36e84f1e4d496d815b4f2d2fc46953.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications.scilifelab.se/researcher/4c517dacca7c4ec58a3e03b59ffb4044.json"}}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K", "orcid": "0000-0003-2815-1217", "researcher": {"href": "https://publications.scilifelab.se/researcher/eff63868e95240f695d47e871e31947f.json"}}, {"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}], "type": "journal article", "published": "2024-11-14", "journal": {"title": "Eur. Heart J.", "issn": "1522-9645", "volume": "45", "issue": "43", "pages": "4647-4657", "issn-l": "0195-668X"}, "abstract": "Few population-based cohort studies, including both men and women, have explored circulating proteins associated with incident myocardial infarction (MI). This study investigated the relationships between circulating cardiometabolic-related proteins and MI risk using cohort-based and Mendelian randomization (MR) analyses and explored potential sex-specific differences.\n\nThe discovery cohort included 11 751 Swedish adults (55-93 years). Data on 259 proteins assessed with Olink proximity extension assays, biochemical, and questionnaire-based information were used. Participants were followed up for incident MI and death over 8 years through linkage to Swedish registers. Replication analyses were conducted on the UK Biobank sample (n = 51 613). In MR analyses, index cis-genetic variants strongly related to the proteins were used as instrumental variables. Genetic association summary statistic data for MI were obtained from the CARDIoGRAMplusC4D consortium and FinnGen.\n\nForty-five proteins were associated with incident MI in discovery and replication samples following adjustment for potential confounders and multiple testing. In the secondary analysis, 13 of the protein associations were sex-specific, with most associations identified among women. In MR analysis, genetically predicted higher levels of renin, follistatin, and retinoic acid receptor responder protein 2 were linked to an increased risk of MI. Tissue factor pathway inhibitor, tumor necrosis factor receptors 1 and 2, placenta growth factor had an inverse association with MI.\n\nThis study identified both new and confirmed previously established associations between circulating proteins and incident MI and, for the first time, suggested sex-specific patterns in multiple protein-MI associations.", "doi": "10.1093/eurheartj/ehae658", "pmid": "39397782", "labels": {"Bioinformatics Support for Computational Resources": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11560279"}, {"db": "pii", "key": "7821005"}], "notes": [], "created": "2025-02-28T14:17:15.433Z", "modified": "2025-11-25T19:20:36.405Z"}, {"entity": "publication", "iuid": "f8bce6d98b1b42439dca998634a7341e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f8bce6d98b1b42439dca998634a7341e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f8bce6d98b1b42439dca998634a7341e"}}, "title": "Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Li", "given": "Xue", "initials": "X"}, {"family": "Liu", "given": "Qianwen", "initials": "Q"}, {"family": "Wang", "given": "Zhe", "initials": "Z"}, {"family": "Jiang", "given": "Xia", "initials": "X", "orcid": "0000-0001-5878-8986", "researcher": {"href": "https://publications.scilifelab.se/researcher/a2fe031ca68a40bd9e64be9265bebb29.json"}}, {"family": "Burgess", "given": "Stephen", "initials": "S", "orcid": "0000-0001-5365-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fd2dcaf4dbb4e4c91c2af460b8fa98f.json"}}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "journal article", "published": "2023-07-03", "journal": {"title": "J Endocr Soc", "issn": "2472-1972", "volume": "7", "issue": "8", "pages": "bvad090", "issn-l": null}, "abstract": "The causality and pathways of the associations between physical activity and inactivity and the risk of type 2 diabetes remain inconclusive.\n\nWe conducted an updated mendelian randomization (MR) study to explore the associations of moderate-to-vigorous physical activity (MVPA) and leisure screen time (LST) with type 2 diabetes mellitus (T2DM).\n\nGenetic variants strongly associated with MVPA or LST with low linkage disequilibrium were selected as instrumental variables from a genome-wide meta-analysis including more than 600 000 individuals. Summary-level data on T2DM were obtained from the DIAbetes Genetics Replication And Meta-analysis consortium including 898 130 individuals. Data on possible intermediates (adiposity indicators, lean mass, glycemic traits, and inflammatory biomarkers) were extracted from large-scale genome-wide association studies (n = 21 758-681 275). Univariable and multivariable MR analyses were performed to estimate the total and direct effects of MVPA and LST on T2DM. Methylation MR analysis was performed for MVPA in relation to diabetes.\n\nThe odds ratio of T2DM was 0.70 (95% CI, 0.55-0.88; P = .002) per unit increase in the log-odds ratio of having MVPA and 1.45 (95% CI, 1.30-1.62; P = 7.62 \u00d7 10-11) per SD increase in genetically predicted LST. These associations attenuated in multivariable MR analyses adjusted for genetically predicted waist-to-hip ratio, body mass index, lean mass, and circulating C-reactive protein. The association between genetically predicted MVPA and T2DM attenuated after adjusting for genetically predicted fasting insulin levels. Two physical activity-related methylation biomarkers (cg17332422 in ADAMTS2 and cg09531019) were associated with the risk of T2DM (P < .05).\n\nThe study suggests causal associations of MVPA and LST with T2DM that appear to be mediated by obesity, lean mass, and chronic low-grade inflammation.", "doi": "10.1210/jendso/bvad090", "pmid": "37415875", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10321115"}, {"db": "pii", "key": "bvad090"}], "notes": [], "created": "2023-11-29T19:27:16.765Z", "modified": "2023-11-29T19:27:16.864Z"}, {"entity": "publication", "iuid": "42b5d2e030ac40ada385f5aa642da4af", "links": {"self": {"href": "https://publications.scilifelab.se/publication/42b5d2e030ac40ada385f5aa642da4af.json"}, "display": {"href": "https://publications.scilifelab.se/publication/42b5d2e030ac40ada385f5aa642da4af"}}, "title": "Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Titova", "given": "Olga E", "initials": "OE"}, {"family": "Zhang", "given": "Ke", "initials": "K"}, {"family": "Gou", "given": "Wanglong", "initials": "W"}, {"family": "Schillemans", "given": "Tessa", "initials": "T"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P"}, {"family": "Chen", "given": "Jie", "initials": "J"}, {"family": "Li", "given": "Xue", "initials": "X"}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A"}, {"family": "Bruzelius", "given": "Maria", "initials": "M"}, {"family": "Klarin", "given": "Derek", "initials": "D"}, {"family": "Damrauer", "given": "Scott M", "initials": "SM"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "meta-analysis", "published": "2023-05-00", "journal": {"title": "Br. J. Haematol.", "issn": "1365-2141", "volume": "201", "issue": "4", "pages": "783-792", "issn-l": "0007-1048"}, "abstract": "We conducted cohort and Mendelian randomisation (MR) analyses to examine the associations of circulating proteins with risk of venous thromboembolism (VTE) to provide evidence basis for disease prevention and drug development. Cohort analysis was performed in 11 803 participants without baseline VTE. Cox regression was used to estimate the associations between 257 proteins and VTE risk. A machine-learning model was constructed to compare the importance of identified proteins and traditional risk factors. Genetic association data on VTE were obtained from a genome-wide meta-analysis (26 066 cases and 624 053 controls) and FinnGen (14 454 cases and 294 700 controls). The cohort analysis, including 353 incident VTE cases diagnosed during a 6.6-year follow-up, identified 21 proteins associated with VTE risk after false discovery rate correction. The machine-learning model indicated that body mass index and von Willebrand factor (vWF) made the same as well as most of the contributions to the overall model prediction. MR analysis found that genetically predicted levels of vWF, SERPINE1 (plasminogen activator inhibitor 1, known as PAI-1), EPHB4 (ephrin type-B receptor 4), TYRO3 (tyrosine-protein kinase receptor TYRO3), TNFRSF11A (tumour necrosis factor receptor superfamily member 11A), and BOC (brother of CDO) were causally associated with VTE risk.", "doi": "10.1111/bjh.18679", "pmid": "36734038", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-29T19:16:46.566Z", "modified": "2023-11-29T19:16:46.605Z"}, {"entity": "publication", "iuid": "63fb6249957b4cf4a51c2d9024f273e8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/63fb6249957b4cf4a51c2d9024f273e8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/63fb6249957b4cf4a51c2d9024f273e8"}}, "title": "Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Titova", "given": "Olga E", "initials": "OE"}, {"family": "Zhang", "given": "Ke", "initials": "K"}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Li", "given": "Xue", "initials": "X"}, {"family": "Klarin", "given": "Derek", "initials": "D"}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A"}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications.scilifelab.se/researcher/b878210396ae46eba9f04f78be5ff564.json"}}, {"family": "VA Million Veteran Program", "given": "", "initials": ""}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Eur Heart J Open", "issn": "2752-4191", "volume": "3", "issue": "3", "pages": "oead056", "issn-l": null}, "abstract": "We conducted observational and Mendelian randomization (MR) analyses to explore the associations between blood proteins and risk of peripheral artery disease (PAD).\n\nThe observational cohort analyses included data on 257 proteins estimated in fasting blood samples from 12 136 Swedish adults aged 55-94 years who were followed up for incident PAD via the Swedish Patient Register. Mendelian randomization analyses were undertaken using cis-genetic variants strongly associated with the proteins as instrumental variables and genetic association summary statistic data for PAD from the FinnGen study (11 924 cases and 288 638 controls) and the Million Veteran Program (31 307 cases and 211 753 controls). The observational analysis, including 86 individuals diagnosed with incident PAD during a median follow-up of 6.6-year, identified 13 proteins [trefoil factor two, matrix metalloproteinase-12 (MMP-12), growth differentiation factor 15, V-set and immunoglobulin domain-containing protein two, N-terminal prohormone brain natriuretic peptide, renin, natriuretic peptides B, phosphoprotein associated with glycosphingolipid-enriched microdomains one, C-C motif chemokine 15, P-selectin, urokinase plasminogen activator surface receptor, angiopoietin-2, and C-type lectin domain family five member A] associated with the risk of PAD after multiple testing correction. Mendelian randomization analysis found associations of T-cell surface glycoprotein CD4, MMP-12, secretoglobin family 3A member 2, and ADM with PAD risk. The observational and MR associations for T-cell surface glycoprotein CD4 and MMP-12 were in opposite directions.\n\nThis study identified many circulating proteins in relation to the development of incident PAD. Future studies are needed to verify our findings and assess the predictive and therapeutic values of these proteins in PAD.", "doi": "10.1093/ehjopen/oead056", "pmid": "37323297", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10267302"}, {"db": "pii", "key": "oead056"}], "notes": [], "created": "2023-11-29T19:27:22.228Z", "modified": "2023-11-29T19:27:22.418Z"}]}