{"entity": "researcher", "timestamp": "2026-08-17T08:24:32.364Z", "family": "Majda", "given": "Mateusz", "initials": "M", "orcid": "0000-0003-3405-2901", "affiliations": ["Ume\u00e5 Plant Science Centre (UPSC), Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences (SLU), 90183, Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/582d7b364d4d4442a7f470e52ed031bc.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/582d7b364d4d4442a7f470e52ed031bc"}}, "publications": [{"entity": "publication", "iuid": "e75a328b0c454c5db0f2f80fb863a92f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e75a328b0c454c5db0f2f80fb863a92f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e75a328b0c454c5db0f2f80fb863a92f"}}, "title": "HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella.", "authors": [{"family": "Dong", "given": "Yang", "initials": "Y", "orcid": "0000-0003-2117-538X", "researcher": {"href": "https://publications.scilifelab.se/researcher/2aec5d6e4f0046dfa7e101dc45bee6d7.json"}}, {"family": "Majda", "given": "Mateusz", "initials": "M", "orcid": "0000-0003-3405-2901", "researcher": {"href": "https://publications.scilifelab.se/researcher/582d7b364d4d4442a7f470e52ed031bc.json"}}, {"family": "\u0160imura", "given": "Jan", "initials": "J"}, {"family": "Horvath", "given": "Robert", "initials": "R"}, {"family": "Srivastava", "given": "Anjil K", "initials": "AK", "orcid": "0000-0001-9871-5781", "researcher": {"href": "https://publications.scilifelab.se/researcher/7f1e429f187d483e86336b2733592b2a.json"}}, {"family": "\u0141angowski", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Eldridge", "given": "Tilly", "initials": "T", "orcid": "0000-0003-1408-5001", "researcher": {"href": "https://publications.scilifelab.se/researcher/7feb9cd320e344e297bddc29826ccfd7.json"}}, {"family": "Stacey", "given": "Nicola", "initials": "N"}, {"family": "Slotte", "given": "Tanja", "initials": "T", "orcid": "0000-0001-6020-5102", "researcher": {"href": "https://publications.scilifelab.se/researcher/67c69ee78bae41478465a7e5fa63b946.json"}}, {"family": "Sadanandom", "given": "Ari", "initials": "A"}, {"family": "Ljung", "given": "Karin", "initials": "K"}, {"family": "Smith", "given": "Richard S", "initials": "RS"}, {"family": "\u00d8stergaard", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2020-10-05", "journal": {"title": "Curr. Biol.", "issn": "1879-0445", "volume": "30", "issue": "19", "pages": "3880-3888.e5", "issn-l": "0960-9822"}, "abstract": "Morphological variation is the basis of natural diversity and adaptation. For example, angiosperms (flowering plants) evolved during the Cretaceous period more than 100 mya and quickly colonized terrestrial habitats [1]. A major reason for their astonishing success was the formation of fruits, which exist in a myriad of different shapes and sizes [2]. Evolution of organ shape is fueled by variation in expression patterns of regulatory genes causing changes in anisotropic cell expansion and division patterns [3-5]. However, the molecular mechanisms that alter the polarity of growth to generate novel shapes are largely unknown. The heart-shaped fruits produced by members of the Capsella genus comprise an anatomical novelty, making it particularly well suited for studies on morphological diversification [6-8]. Here, we show that post-translational modification of regulatory proteins provides a critical step in organ-shape formation. Our data reveal that the SUMO protease, HEARTBREAK (HTB), from Capsella rubella controls the activity of the key regulator of fruit development, INDEHISCENT (CrIND in C. rubella), via de-SUMOylation. This post-translational modification initiates a transduction pathway required to ensure precisely localized auxin biosynthesis, thereby facilitating anisotropic cell expansion to ultimately form the heart-shaped Capsella fruit. Therefore, although variation in the expression of key regulatory genes is known to be a primary driver in morphological evolution, our work demonstrates how other processes-such as post-translational modification of one such regulator-affects organ morphology.", "doi": "10.1016/j.cub.2020.07.055", "pmid": "32795439", "labels": {"Swedish Metabolomics Centre": null}, "xrefs": [{"db": "pii", "key": "S0960-9822(20)31080-0"}, {"db": "pmc", "key": "PMC7544509"}], "notes": [], "created": "2020-12-11T11:56:12.239Z", "modified": "2025-10-17T13:03:16.627Z"}, {"entity": "publication", "iuid": "a758a54e14db475586eb19b410a7141a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a758a54e14db475586eb19b410a7141a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a758a54e14db475586eb19b410a7141a"}}, "title": "A role for the auxin precursor anthranilic acid in root gravitropism via regulation of PIN-FORMED protein polarity and relocalisation in Arabidopsis.", "authors": [{"family": "Doyle", "given": "Siamsa M", "initials": "SM", "orcid": "0000-0003-4889-3496", "researcher": {"href": "https://publications.scilifelab.se/researcher/4a82fafd2ab34ff2bac338ce451bb4bb.json"}}, {"family": "Rigal", "given": "Adeline", "initials": "A"}, {"family": "Grones", "given": "Peter", "initials": "P", "orcid": "0000-0003-4132-4151", "researcher": {"href": "https://publications.scilifelab.se/researcher/20417b1485074106b74042617b5e2e59.json"}}, {"family": "Karady", "given": "Michal", "initials": "M", "orcid": "0000-0002-5603-706X", "researcher": {"href": "https://publications.scilifelab.se/researcher/114911ccd31849e1a7584b5a52e9eb14.json"}}, {"family": "Barange", "given": "Deepak K", "initials": "DK", "orcid": "0000-0003-1279-1068", "researcher": {"href": "https://publications.scilifelab.se/researcher/d00627926367423093b7e1645ee55ad1.json"}}, {"family": "Majda", "given": "Mateusz", "initials": "M", "orcid": "0000-0003-3405-2901", "researcher": {"href": "https://publications.scilifelab.se/researcher/582d7b364d4d4442a7f470e52ed031bc.json"}}, {"family": "Pa\u0159\u00edzkov\u00e1", "given": "Barbora", "initials": "B", "orcid": "0000-0002-8125-2271", "researcher": {"href": "https://publications.scilifelab.se/researcher/c9dd3d0c062245a5b188e774955cd210.json"}}, {"family": "Karampelias", "given": "Michael", "initials": "M", "orcid": "0000-0002-2095-988X", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbd70d20b66b4fb4a8d1308b2f54e2a2.json"}}, {"family": "Zwiewka", "given": "Marta", "initials": "M"}, {"family": "P\u011bn\u010d\u00edk", "given": "Ale\u0161", "initials": "A"}, {"family": "Almqvist", "given": "Fredrik", "initials": "F"}, {"family": "Ljung", "given": "Karin", "initials": "K", "orcid": "0000-0003-2901-189X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f91b1e1f90c24559b915ebcd265804a4.json"}}, {"family": "Nov\u00e1k", "given": "Ond\u0159ej", "initials": "O", "orcid": "0000-0003-3452-0154", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c19165acb9a4ff79dd96af7fccdc5f8.json"}}, {"family": "Robert", "given": "St\u00e9phanie", "initials": "S", "orcid": "0000-0002-0013-3239", "researcher": {"href": "https://publications.scilifelab.se/researcher/74a96c43520f4c9c91e44be8a7d39e6c.json"}}], "type": "journal article", "published": "2019-08-00", "journal": {"title": "New Phytol.", "issn": "1469-8137", "issn-l": "0028-646X", "volume": "223", "issue": "3", "pages": "1420-1432"}, "abstract": "distribution of auxin within plant tissues is of great importance for developmental plasticity, including root gravitropic growth. Auxin flow is directed by the subcellular polar distribution and dynamic relocalisation of auxin transporters such as the PIN-FORMED (PIN) efflux carriers, which can be influenced by the main natural plant auxin indole-3-acetic acid (IAA). Anthranilic acid (AA) is an important early precursor of IAA and previously published studies with AA analogues have suggested that AA may also regulate PIN localisation. Using Arabidopsis thaliana as a model species, we studied an AA-deficient mutant displaying agravitropic root growth, treated seedlings with AA and AA analogues and transformed lines to over-produce AA while inhibiting its conversion to downstream IAA precursors. We showed that AA rescues root gravitropic growth in the AA-deficient mutant at concentrations that do not rescue IAA levels. Overproduction of AA affects root gravitropism without affecting IAA levels. Treatments with, or deficiency in, AA result in defects in PIN polarity and gravistimulus-induced PIN relocalisation in root cells. Our results revealed a previously unknown role for AA in the regulation of PIN subcellular localisation and dynamics involved in root gravitropism, which is independent of its better known role in IAA biosynthesis.", "doi": "10.1111/nph.15877", "pmid": "31038751", "labels": {"Swedish Metabolomics Centre": "Service", "Chemical Biology Consortium Sweden": "Service"}, "xrefs": [], "notes": [], "created": "2020-01-07T15:52:13.037Z", "modified": "2025-10-17T13:04:28.531Z"}]}