{"entity": "researcher", "timestamp": "2026-07-11T14:24:26.511Z", "family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "affiliations": ["Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8"}}, "publications": [{"entity": "publication", "iuid": "78b0c63fefe94913bcd52fec8d95d8db", "links": {"self": {"href": "https://publications.scilifelab.se/publication/78b0c63fefe94913bcd52fec8d95d8db.json"}, "display": {"href": "https://publications.scilifelab.se/publication/78b0c63fefe94913bcd52fec8d95d8db"}}, "title": "A randomized controlled cross-over trial of differences in acute effects on serum metabolites from isocaloric meals based on red meat, fatty fish, or soy protein.", "authors": [{"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}, {"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}], "type": "journal article", "published": "2025-05-26", "journal": {"title": "Eur J Nutr", "issn": "1436-6207", "volume": "64", "issue": "5", "pages": "187", "issn-l": null}, "abstract": "Reducing red meat intake in the Western diet is beneficial for health and the environment. However, red meat is nutrient-rich, so understanding the impact of substituting it with other protein sources such as fish or plant-based proteins is essential, especially for vulnerable groups like the elderly and those with chronic diseases. The purpose of this study was to study the postprandial response in serum metabolites in women with Rheumatoid Arthritis (RA) after intake of red meat, fatty fish, and soy protein.\n\nWomen with RA (n = 24) consumed isocaloric meals that included burgers made from either red meat, fatty fish, or soy protein in a crossover design. Blood samples were taken in fasting state before the meal (0 h) and at intervals up to 5 h after eating. Nuclear Magnetic Resonance (NMR) analysis quantified serum metabolites, and multivariate models and univariate statistics were applied to compare postprandial metabolite changes across protein sources.\n\nPostprandial metabolite patterns varied significantly by protein type. The fatty fish meal led to a faster and higher increase in metabolites, including creatinine, isoleucine, valine, and trimethylamine N-oxide, compared to red meat. Unidentified lipids also differed. However, metabolite patterns after soy protein were similar to those after red meat.\n\nThis postprandial crossover trial found that intake of fatty fish lead to a quicker and more pronounced increase in key blood concentrations of metabolites compared to red meat. However, metabolite profiles in serum based on NMR-analysis were similar after intake of soy protein compared to red meat.\n\nThe PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).", "doi": "10.1007/s00394-025-03710-0", "pmid": "40418340", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12106552"}, {"db": "pii", "key": "10.1007/s00394-025-03710-0"}, {"db": "ClinicalTrials.gov", "key": "NCT04247009"}], "notes": [], "created": "2025-11-27T08:05:28.633Z", "modified": "2025-11-27T08:05:28.716Z"}, {"entity": "publication", "iuid": "b41a066fba2b43eebb34302ff802267c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b41a066fba2b43eebb34302ff802267c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b41a066fba2b43eebb34302ff802267c"}}, "title": "Inflammatory and lipemic response to red meat intake in women with and without Rheumatoid Arthritis: a single meal study within a randomized controlled trial", "authors": [{"family": "S\u00e4llstr\u00f6m", "given": "Torsten", "initials": "T", "orcid": "0009-0001-4818-2531", "researcher": {"href": "https://publications.scilifelab.se/researcher/29042005e6f9498f81cef90894434bcf.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}, {"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}], "type": "journal-article", "published": "2025-04-11", "journal": {"title": "BMC Nutr", "issn": "2055-0928", "volume": "11", "issue": "1", "issn-l": null}, "abstract": null, "doi": "10.1186/s40795-025-01055-9", "pmid": null, "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [], "notes": [], "created": "2025-11-27T08:05:15.808Z", "modified": "2025-11-27T08:05:15.982Z"}, {"entity": "publication", "iuid": "fbd027dd45474789badb397607a262ed", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fbd027dd45474789badb397607a262ed.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fbd027dd45474789badb397607a262ed"}}, "title": "A randomized controlled cross-over trial investigating the acute inflammatory and metabolic response after meals based on red meat, fatty fish, or soy protein: the postprandial inflammation in rheumatoid arthritis (PIRA) trial.", "authors": [{"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}], "type": "journal article", "published": "2024-10-00", "journal": {"title": "Eur J Nutr", "issn": "1436-6207", "volume": "63", "issue": "7", "pages": "2631-2642", "issn-l": null}, "abstract": "Rheumatoid Arthritis (RA) has a point prevalence of around 20 million people worldwide. Patients with RA often believe that food intake affects disease activity, and that intake of red meat aggravate symptoms. The main objective of the Postprandial Inflammation in Rheumatoid Arthritis (PIRA) trial was to assess whether postprandial inflammation and serum lipid profile are affected differently by a meal including red meat, fatty fish, or a soy protein (vegan) meal.\n\nUsing a randomized controlled crossover design, 25 patients were assigned to eat isocaloric hamburger meals consisting of red meat (60% beef, 40% pork), fatty fish (salmon), or soy protein for breakfast. Blood samples were taken before meals and at intervals up to 5 h postprandial. The analysis included the inflammation marker interleukin 6 (IL-6) and serum lipids.\n\nNo significant differences in postprandial IL-6 or triglyceride concentrations were found between meals. However, the area under the curve of very low density lipoprotein (VLDL) particle counts, as well as VLDL-4-bound cholesterol, triglycerides, and phospholipids, was higher after the fatty fish compared to both red meat and soy protein.\n\nPostprandial inflammation assessed by IL-6 did not indicate any acute negative effects of red meat intake compared to fatty fish- or soy protein in patients with RA. The fatty fish meal resulted in a higher number of VLDL-particles and more lipids in the form of small VLDL particles compared to the other protein sources.", "doi": "10.1007/s00394-024-03451-6", "pmid": "38935139", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11490451"}, {"db": "pii", "key": "10.1007/s00394-024-03451-6"}], "notes": [], "created": "2024-11-28T14:39:02.189Z", "modified": "2025-10-17T13:03:52.709Z"}, {"entity": "publication", "iuid": "105f960199ea414c8b533eded245b31c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/105f960199ea414c8b533eded245b31c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/105f960199ea414c8b533eded245b31c"}}, "title": "Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.", "authors": [{"family": "Aoun", "given": "Mike", "initials": "M", "orcid": "0000-0002-7814-3787", "researcher": {"href": "https://publications.scilifelab.se/researcher/3e342417528f4a92a8e84558359b6bfa.json"}}, {"family": "Coelho", "given": "Ana", "initials": "A", "orcid": "0000-0001-7783-9750", "researcher": {"href": "https://publications.scilifelab.se/researcher/163d8babd72b406d94647b4cfd9d7e5b.json"}}, {"family": "Kr\u00e4mer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-2288-2361", "researcher": {"href": "https://publications.scilifelab.se/researcher/50b1230e5acf4ad89344e8d1ae404ef2.json"}}, {"family": "Saxena", "given": "Amit", "initials": "A", "orcid": "0000-0002-1185-8649", "researcher": {"href": "https://publications.scilifelab.se/researcher/d230e0159adc4d7dbd1c3e7ded94dcec.json"}}, {"family": "Sabatier", "given": "Pierre", "initials": "P", "orcid": "0000-0002-2734-1791", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a75556311084e2b827ab1f646d7a16c.json"}}, {"family": "Beusch", "given": "Christian Michel", "initials": "CM", "orcid": "0000-0001-9100-8283", "researcher": {"href": "https://publications.scilifelab.se/researcher/278e50b11a3c4ef69b6e2708f99b5f3e.json"}}, {"family": "L\u00f6nnblom", "given": "Erik", "initials": "E", "orcid": "0000-0002-1311-2541", "researcher": {"href": "https://publications.scilifelab.se/researcher/0f5683b51d554ff482bd76c0ded3aaa2.json"}}, {"family": "Geng", "given": "Manman", "initials": "M", "orcid": "0009-0003-7502-4699", "researcher": {"href": "https://publications.scilifelab.se/researcher/0370014234f54ad08bba271bc19f2703.json"}}, {"family": "Do", "given": "Nhu-Nguyen", "initials": "NN", "orcid": "0000-0001-6483-8062", "researcher": {"href": "https://publications.scilifelab.se/researcher/0de1bfd7cdc945378b2eb973237345bc.json"}}, {"family": "Xu", "given": "Zhongwei", "initials": "Z", "orcid": "0000-0001-5178-3437", "researcher": {"href": "https://publications.scilifelab.se/researcher/f056000b3af842bda8cdd411da7d44ad.json"}}, {"family": "Zhang", "given": "Jingdian", "initials": "J", "orcid": "0000-0002-5685-8386", "researcher": {"href": "https://publications.scilifelab.se/researcher/e208f3fec0f34151a5916ff260e2ace7.json"}}, {"family": "He", "given": "Yibo", "initials": "Y", "orcid": "0000-0003-0659-2150", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e734ee308394c35ba53ef6ed344cfa7.json"}}, {"family": "Romero Castillo", "given": "Laura", "initials": "L", "orcid": "0000-0002-0271-212X", "researcher": {"href": "https://publications.scilifelab.se/researcher/432706cab4ec46258698725df3b02f6c.json"}}, {"family": "Abolhassani", "given": "Hassan", "initials": "H", "orcid": "0000-0002-4838-0407", "researcher": {"href": "https://publications.scilifelab.se/researcher/20370042ca1045c3bcaac67821a93df2.json"}}, {"family": "Xu", "given": "Bingze", "initials": "B", "orcid": "0000-0002-5341-1722", "researcher": {"href": "https://publications.scilifelab.se/researcher/d262ebec52004d1f8bc77d43cafe0cc7.json"}}, {"family": "Viljanen", "given": "Johan", "initials": "J", "orcid": "0009-0003-7291-4178", "researcher": {"href": "https://publications.scilifelab.se/researcher/2519e15fb9c74494a72cfcea38c304ca.json"}}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications.scilifelab.se/researcher/a069374613a7403b818ce7ca400f3627.json"}}, {"family": "Fernandez Lahore", "given": "Gonzalo", "initials": "G", "orcid": "0000-0002-4291-0251", "researcher": {"href": "https://publications.scilifelab.se/researcher/520747ac45e94b0fb8f0fb08b849eecc.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Kastbom", "given": "Alf", "initials": "A", "orcid": "0000-0001-7187-1477", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9b6d835959e4613995904bf3a01733c.json"}}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe4dd47b8ca1436e8a26fdea33f5e7f6.json"}}, {"family": "Kihlberg", "given": "Jan", "initials": "J", "orcid": "0000-0002-4205-6040", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9805d4f39cc48f79a6e6ba076917021.json"}}, {"family": "Zubarev", "given": "Roman A", "initials": "RA", "orcid": "0000-0001-9839-2089", "researcher": {"href": "https://publications.scilifelab.se/researcher/e971b9cdec2b4411934f9c5d535da8b4.json"}}, {"family": "Burkhardt", "given": "Harald", "initials": "H", "orcid": "0000-0002-6261-3131", "researcher": {"href": "https://publications.scilifelab.se/researcher/89e31cfcedb24f4ba63420e8ac7903a6.json"}}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications.scilifelab.se/researcher/49e60d22dd1a4dd1a4ca5a50d9fc4fc7.json"}}], "type": "journal article", "published": "2023-11-06", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "220", "issue": "11", "issn-l": "0022-1007"}, "abstract": "B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural autoreactive B cells (C1-B) specific for a defined triple-helical epitope on collagen type-II (COL2), constituting a sizeable fraction of the physiological B cell repertoire in mice, rats, and humans. Adoptive transfer of C1-B suppressed arthritis independently of IL10, separating them from IL10-secreting regulatory B cells. Single-cell sequencing revealed an antigen processing and presentation signature, including induced expression of CD72 and CCR7 as surface markers. C1-B presented COL2 to T cells and induced the expansion of regulatory T cells in a contact-dependent manner. CD72 blockade impeded this effect suggesting a new downstream suppressor mechanism that regulates antigen-specific T cell tolerization. Thus, our results indicate that autoreactive antigen-specific na\u00efve B cells tolerize infiltrating T cells against self-antigens to impede the development of tissue-specific autoimmune inflammation.", "doi": "10.1084/jem.20230101", "pmid": "37695523", "labels": {"Bioinformatics Support and Infrastructure": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10494526"}, {"db": "pii", "key": "276247"}], "notes": [], "created": "2023-11-16T12:01:57.118Z", "modified": "2024-01-16T13:48:31.724Z"}, {"entity": "publication", "iuid": "3e14d69f3011432a9f05cd68d3f08da2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e14d69f3011432a9f05cd68d3f08da2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e14d69f3011432a9f05cd68d3f08da2"}}, "title": "Exploring the differences in serum metabolite profiles after intake of red meat in women with rheumatoid arthritis and a matched control group.", "authors": [{"family": "Lindqvist", "given": "Helen M", "initials": "HM", "orcid": "0000-0002-2627-0434", "researcher": {"href": "https://publications.scilifelab.se/researcher/d98498df02eb40fb8de3016da37d6f8a.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Hulander", "given": "Erik", "initials": "E", "orcid": "0000-0003-3416-2748", "researcher": {"href": "https://publications.scilifelab.se/researcher/910a2dc80a8a4f449d2a3bf8e4d2f046.json"}}, {"family": "B\u00e4rebring", "given": "Linnea", "initials": "L", "orcid": "0000-0002-1612-1697", "researcher": {"href": "https://publications.scilifelab.se/researcher/b9d45c7e27274cab907ffd3bc92ccfaf.json"}}, {"family": "Winkvist", "given": "Anna", "initials": "A", "orcid": "0000-0001-9122-7240", "researcher": {"href": "https://publications.scilifelab.se/researcher/e34ca937891145e190390ae9418d2243.json"}}], "type": "journal article", "published": "2023-10-09", "journal": {"title": "Eur J Nutr", "issn": "1436-6207", "issn-l": null}, "abstract": "Studies have suggested that women with RA tend to avoid red meat more often than women without RA, based on their perception that it exacerbates their symptoms. Therefore, the aim of this study is to investigate and compare the postprandial metabolic response following the consumption of a red meat meal in patients with RA and a matched control group.\n\nParticipants were challenged with a meal with red meat and blood samples were collected before and at 0.5, 1, 2, 3 and 5 h after the meal. Serum metabolites were quantified by Nuclear Magnetic Resonance (NMR) analysis. Orthogonal Projections to Latent Structures with Discriminant Analysis (OPLS-DA) was used to evaluate separation by metabolites due to diagnosis of RA or not and to identify changes in metabolites related to RA. Incremental area under the curve was calculated for univariate comparisons for 23 metabolites.\n\nThe matched groups, including 22 women with RA and 22 women without RA, did not differ significantly in age, body mass index, diet quality or reported physical activity. OPLS-DA models had a limited quality indicating that there were no differences in metabolite patterns between the groups. However, phenylalanine was significantly higher in concentration in women with RA compared to controls in both fasting and postprandial samples.\n\nTo conclude, this well-controlled postprandial intervention study found a significantly higher concentration of phenylalanine in both fasting and postprandial samples of women with RA compared to matched women without RA. These findings warrant further investigation in larger studies.\n\nThe PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).", "doi": "10.1007/s00394-023-03257-y", "pmid": "37814020", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pii", "key": "10.1007/s00394-023-03257-y"}, {"db": "ClinicalTrials.gov", "key": "NCT04247009"}], "notes": [], "created": "2023-12-04T09:27:52.694Z", "modified": "2025-10-17T13:03:53.471Z"}, {"entity": "publication", "iuid": "143d8fa5b14d4da59b547cdab40f00ee", "links": {"self": {"href": "https://publications.scilifelab.se/publication/143d8fa5b14d4da59b547cdab40f00ee.json"}, "display": {"href": "https://publications.scilifelab.se/publication/143d8fa5b14d4da59b547cdab40f00ee"}}, "title": "Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.", "authors": [{"family": "Li", "given": "Taotao", "initials": "T", "orcid": "0000-0001-6775-9976", "researcher": {"href": "https://publications.scilifelab.se/researcher/2f265876c30443b8a8ef616d7029e64a.json"}}, {"family": "Ge", "given": "Changrong", "initials": "C"}, {"family": "Kr\u00e4mer", "given": "Alexander", "initials": "A"}, {"family": "Sareila", "given": "Outi", "initials": "O", "orcid": "0000-0001-5644-8216", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf109dc5ef0c4ad4ac2bd28770555e09.json"}}, {"family": "Leu Agelii", "given": "Monica", "initials": "M", "orcid": "0000-0003-4013-7549", "researcher": {"href": "https://publications.scilifelab.se/researcher/521b91a3f436415e96585996f64b85b1.json"}}, {"family": "Johansson", "given": "Linda", "initials": "L", "orcid": "0000-0001-7071-4699", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b9129e8ce7846e5b35b50f1ff4493e2.json"}}, {"family": "Forslind", "given": "Kristina", "initials": "K"}, {"family": "L\u00f6nnblom", "given": "Erik", "initials": "E", "orcid": "0000-0002-1311-2541", "researcher": {"href": "https://publications.scilifelab.se/researcher/0f5683b51d554ff482bd76c0ded3aaa2.json"}}, {"family": "Yang", "given": "Min", "initials": "M"}, {"family": "Xu", "given": "Bingze", "initials": "B", "orcid": "0000-0002-5341-1722", "researcher": {"href": "https://publications.scilifelab.se/researcher/d262ebec52004d1f8bc77d43cafe0cc7.json"}}, {"family": "Li", "given": "Qixing", "initials": "Q"}, {"family": "Cheng", "given": "Lei", "initials": "L"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Fernandez", "given": "Gonzalo", "initials": "G"}, {"family": "Kastbom", "given": "Alf", "initials": "A", "orcid": "0000-0001-7187-1477", "researcher": {"href": "https://publications.scilifelab.se/researcher/f9b6d835959e4613995904bf3a01733c.json"}}, {"family": "Rantap\u00e4\u00e4-Dahlqvist", "given": "Solbritt", "initials": "S", "orcid": "0000-0001-8259-3863", "researcher": {"href": "https://publications.scilifelab.se/researcher/dfca4bfdcf3946fda64397d3b7debc59.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications.scilifelab.se/researcher/49e60d22dd1a4dd1a4ca5a50d9fc4fc7.json"}}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "Ann. Rheum. Dis.", "issn": "1468-2060", "volume": "82", "issue": "6", "pages": "799-808", "issn-l": "0003-4967"}, "abstract": "To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA).\n\nIgG response towards a library of GPI peptides in patients with early RA, pre-symptomatic individuals and population controls, as well as in mice, were tested by bead-based multiplex immunoassays and ELISA. Monoclonal IgG were generated, and the binding specificity and affinity were determined by ELISA, gel size exclusion chromatography, surface plasma resonance and X-ray crystallography. Arthritogenicity was investigated by passive transfer experiments. Antigen-specific B cells were identified by peptide tetramer staining.\n\nPeptide GPI293-307 was the dominant B cell epitope in K/BxN and GPI-immunised mice. We could detect B cells and low levels of IgM antibodies binding the GPI293-307 epitopes, and high affinity anti-GPI293-307 IgG antibodies already 7 days after GPI immunisation, immediately before arthritis onset. Transfer of anti-GPI293-307 IgG antibodies induced arthritis in mice. Moreover, anti-GPI293-307 IgG antibodies were more frequent in individuals prior to RA onset (19%) than in controls (7.5%). GPI293-307-specific antibodies were associated with radiographic joint damage. Crystal structures of the Fab-peptide complex revealed that this epitope is not exposed in native GPI but requires conformational change of the protein in inflamed joint for effective recognition by anti-GPI293-307 antibodies.\n\nWe have identified the major pathogenic B cell epitope of the RA-associated autoantigen GPI, at position 293-307, exposed only on structurally modified GPI on the cartilage surface. B cells to this neo-epitope escape tolerance and could potentially play a role in the pathogenesis of RA.", "doi": "10.1136/ard-2022-223633", "pmid": "36858822", "labels": {"Bioinformatics Long-term Support WABI": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "ard-2022-223633"}], "notes": [], "created": "2023-11-23T13:32:53.288Z", "modified": "2023-11-23T13:32:53.448Z"}, {"entity": "publication", "iuid": "c387fb518b4a4cbfa7a96172dc66cda2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c387fb518b4a4cbfa7a96172dc66cda2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c387fb518b4a4cbfa7a96172dc66cda2"}}, "title": "Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells.", "authors": [{"family": "Camponeschi", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-6472-2438", "researcher": {"href": "https://publications.scilifelab.se/researcher/ccbaffafd6a24f4abed1e402219fa472.json"}}, {"family": "Kl\u00e4sener", "given": "Kathrin", "initials": "K", "orcid": "0000-0002-5969-2553", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a46292d2b6d4a46897e5b2fdcbaea25.json"}}, {"family": "Sundell", "given": "Timothy", "initials": "T", "orcid": "0000-0001-6244-1790", "researcher": {"href": "https://publications.scilifelab.se/researcher/b856449e4da74c9b913751835d0fdc50.json"}}, {"family": "Lundqvist", "given": "Christina", "initials": "C", "orcid": "0000-0002-2256-4072", "researcher": {"href": "https://publications.scilifelab.se/researcher/10b339e6cc1f48f3a5f736201038ee59.json"}}, {"family": "Manna", "given": "Paul T", "initials": "PT", "orcid": "0000-0002-2260-2075", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad6605820c294d408293b5a3cc6fdcdc.json"}}, {"family": "Ayoubzadeh", "given": "Negar", "initials": "N", "orcid": "0000-0002-9562-1947", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a5abf127036470a8e62917ece7cfc1b.json"}}, {"family": "Sundqvist", "given": "Martina", "initials": "M", "orcid": "0000-0002-0859-0792", "researcher": {"href": "https://publications.scilifelab.se/researcher/24e6273caf214eab9f4c7c4c8f20a186.json"}}, {"family": "Thorarinsdottir", "given": "Katrin", "initials": "K", "orcid": "0000-0003-2708-1990", "researcher": {"href": "https://publications.scilifelab.se/researcher/dcabbfe494e84a948ef32d94b13fd795.json"}}, {"family": "Gatto", "given": "Mariele", "initials": "M", "orcid": "0000-0003-4012-1248", "researcher": {"href": "https://publications.scilifelab.se/researcher/89af57d620344ca58a1e20c889075002.json"}}, {"family": "Visentini", "given": "Marcella", "initials": "M", "orcid": "0000-0002-4053-6091", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5f4c67ea260466f870cce36476ebf0b.json"}}, {"family": "\u00d6nnheim", "given": "Karin", "initials": "K", "orcid": "0000-0001-5415-6842", "researcher": {"href": "https://publications.scilifelab.se/researcher/e91d446634074987a47b6d0451f33010.json"}}, {"family": "Aranburu", "given": "Alaitz", "initials": "A", "orcid": "0000-0002-7024-7733", "researcher": {"href": "https://publications.scilifelab.se/researcher/41cd21f636e340af93fb3bb0544b158b.json"}}, {"family": "Forsman", "given": "Huamei", "initials": "H", "orcid": "0000-0002-8781-284X", "researcher": {"href": "https://publications.scilifelab.se/researcher/d47631a564bc43f8b37f31adc1aaa043.json"}}, {"family": "Ekwall", "given": "Olov", "initials": "O", "orcid": "0000-0002-4506-9955", "researcher": {"href": "https://publications.scilifelab.se/researcher/2d7af11d7d30410d8fe5f3b5fbd0ba1d.json"}}, {"family": "Fogelstrand", "given": "Linda", "initials": "L", "orcid": "0000-0003-3698-8519", "researcher": {"href": "https://publications.scilifelab.se/researcher/f39ff709aa0646b8ad5e520780a0ad49.json"}}, {"family": "Gjertsson", "given": "Inger", "initials": "I", "orcid": "0000-0002-9301-4844", "researcher": {"href": "https://publications.scilifelab.se/researcher/56e95592e89f43cba8eb30bd32da1cc8.json"}}, {"family": "Reth", "given": "Michael", "initials": "M", "orcid": "0000-0002-1025-7198", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9c45a119af24ccdb30c04ceff46ceaf.json"}}, {"family": "M\u00e5rtensson", "given": "Inga-Lill", "initials": "IL", "orcid": "0000-0003-3415-0560", "researcher": {"href": "https://publications.scilifelab.se/researcher/c4f5cf8b693a4915b71a58e700768d6f.json"}}], "type": "journal article", "published": "2022-09-05", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "219", "issue": "9", "issn-l": "0022-1007"}, "abstract": "CD38 is a multifunctional protein expressed on the surface of B cells in healthy individuals but also in B cell malignancies. Previous studies have suggested a connection between CD38 and components of the IgM class B cell antigen receptor (IgM-BCR) and its coreceptor complex. Here, we provide evidence that CD38 is closely associated with CD19 in resting B cells and with the IgM-BCR upon engagement. We show that targeting CD38 with an antibody, or removing this molecule with CRISPR/Cas9, inhibits the association of CD19 with the IgM-BCR, impairing BCR signaling in normal and malignant B cells. Together, our data suggest that CD38 is a new member of the BCR coreceptor complex, where it exerts a modulatory effect on B cell activation upon antigen recognition by regulating CD19. Our study also reveals a new mechanism where \u03b1-CD38 antibodies could be a valuable option in therapeutic approaches to B cell malignancies driven by aberrant BCR signaling.", "doi": "10.1084/jem.20220201", "pmid": "35819358", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9280193"}, {"db": "pii", "key": "213348"}], "notes": [], "created": "2023-03-07T14:34:14.812Z", "modified": "2024-01-16T13:46:28.455Z"}]}