{"entity": "researcher", "timestamp": "2026-08-15T06:30:55.779Z", "family": "Cotugno", "given": "Nicola", "initials": "N", "orcid": "0000-0002-7748-1581", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/56dc2dd7b83d4fbd9d20a008f89604da.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/56dc2dd7b83d4fbd9d20a008f89604da"}}, "publications": [{"entity": "publication", "iuid": "8e454ae8c8a04cc2874f7a2f09a423f9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8e454ae8c8a04cc2874f7a2f09a423f9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8e454ae8c8a04cc2874f7a2f09a423f9"}}, "title": "Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology.", "authors": [{"family": "Cotugno", "given": "Nicola", "initials": "N", "orcid": "0000-0002-7748-1581", "researcher": {"href": "https://publications.scilifelab.se/researcher/56dc2dd7b83d4fbd9d20a008f89604da.json"}}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications.scilifelab.se/researcher/7f80953fcc4f42fabfc21a70d6a39aba.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications.scilifelab.se/researcher/27e5b15541cb4305aacfbcdc76e8070c.json"}}, {"family": "Bonfante", "given": "Francesco", "initials": "F"}, {"family": "Petrara", "given": "Maria Raffaella", "initials": "MR"}, {"family": "Pighi", "given": "Chiara", "initials": "C"}, {"family": "Cifaldi", "given": "Loredana", "initials": "L"}, {"family": "Zangari", "given": "Paola", "initials": "P"}, {"family": "Bernardi", "given": "Stefania", "initials": "S"}, {"family": "Cursi", "given": "Laura", "initials": "L"}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Manno", "given": "Emma Concetta", "initials": "EC"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1c02699a9564c09bff0a28036089857.json"}}, {"family": "Linardos", "given": "Giulia", "initials": "G"}, {"family": "Piccioni", "given": "Livia", "initials": "L"}, {"family": "Barbieri", "given": "Maria Antonietta", "initials": "MA"}, {"family": "Perrotta", "given": "Daniela", "initials": "D"}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Don\u00e0", "given": "Daniele", "initials": "D"}, {"family": "Giaquinto", "given": "Carlo", "initials": "C"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Concato", "given": "Carlo", "initials": "C"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "De Rossi", "given": "Anita", "initials": "A", "orcid": "0000-0001-6435-7509", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ae101a8104840a09a3c965b2ad6d862.json"}}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications.scilifelab.se/researcher/275341cd978547cfa2aaf179cbd74011.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Pediatr Allergy Immunol", "issn": "1399-3038", "issn-l": "0905-6157", "volume": "32", "issue": "8", "pages": "1833-1842"}, "abstract": "Although SARS-CoV-2 immunizations have started in most countries, children are not currently included in the vaccination programs; thus, it remains crucial to define their anti-SARS-CoV-2 immune response in order to minimize the risk for other epidemic waves. This study sought to provide a description of the virology ad anti-SARS-CoV-2 immunity in children with distinct symptomatology.\n\nBetween March and July 2020, we recruited 15 SARS-CoV-2 asymptomatic (AS) and 51 symptomatic (SY) children, stratified according to WHO clinical classification. We measured SARS-CoV-2 viral load using ddPCR and qPCR in longitudinally collected nasopharyngeal swab samples. To define anti-SARS-CoV-2 antibodies, we measured neutralization activity and total IgG load (DiaSorin). We also evaluated antigen-specific B and CD8+T cells, using a labeled S1+S2 protein and ICAM expression, respectively. Plasma protein profiling was performed with Olink.\n\nVirological profiling showed that AS patients had lower viral load at diagnosis (p = .004) and faster virus clearance (p = .0002) compared with SY patients. Anti-SARS-CoV-2 humoral and cellular response did not appear to be associated with the presence of symptoms. AS and SY patients showed similar titers of SARS-CoV-2 IgG, levels of neutralizing activity, and frequency of Ag-specific B and CD8+ T cells, whereas pro-inflammatory plasma protein profile was found to be associated with symptomatology.\n\nWe demonstrated the development of anti-SARS-CoV-2 humoral and cellular response with any regard to symptomatology, suggesting the ability of both SY and AS patients to contribute toward herd immunity. The virological profiling of AS patients suggested that they have lower virus load associated with faster virus clearance.", "doi": "10.1111/pai.13585", "pmid": "34174102", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8420243"}], "notes": [], "created": "2022-07-11T08:29:44.391Z", "modified": "2023-06-19T11:10:16.918Z"}, {"entity": "publication", "iuid": "7b76865fb2364e6fa8946090ea425154", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7b76865fb2364e6fa8946090ea425154.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7b76865fb2364e6fa8946090ea425154"}}, "title": "The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.", "authors": [{"family": "Consiglio", "given": "Camila Rosat", "initials": "CR", "orcid": "0000-0002-8901-2328", "researcher": {"href": "https://publications.scilifelab.se/researcher/7df7044aa718438ca370ed90cdd9c282.json"}}, {"family": "Cotugno", "given": "Nicola", "initials": "N", "orcid": "0000-0002-7748-1581", "researcher": {"href": "https://publications.scilifelab.se/researcher/56dc2dd7b83d4fbd9d20a008f89604da.json"}}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Amodio", "given": "Donato", "initials": "D", "orcid": "0000-0003-4550-3018", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1c02699a9564c09bff0a28036089857.json"}}, {"family": "Rodriguez", "given": "Lucie", "initials": "L", "orcid": "0000-0002-3692-9060", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f9c2cfec48e4c4d8e9bc528a02d489b.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Zicari", "given": "Sonia", "initials": "S", "orcid": "0000-0003-1240-8057", "researcher": {"href": "https://publications.scilifelab.se/researcher/6721817c6fa143d69be06d7bcc960579.json"}}, {"family": "Ruggiero", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-1041-7489", "researcher": {"href": "https://publications.scilifelab.se/researcher/7f80953fcc4f42fabfc21a70d6a39aba.json"}}, {"family": "Pascucci", "given": "Giuseppe Rubens", "initials": "GR", "orcid": "0000-0002-5978-1193", "researcher": {"href": "https://publications.scilifelab.se/researcher/27e5b15541cb4305aacfbcdc76e8070c.json"}}, {"family": "Santilli", "given": "Veronica", "initials": "V"}, {"family": "Campbell", "given": "Tessa", "initials": "T"}, {"family": "Bryceson", "given": "Yenan", "initials": "Y"}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Marchesi", "given": "Alessandra", "initials": "A"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications.scilifelab.se/researcher/92e81aa6b0cf4ff0a18b14098bf0fcc1.json"}}, {"family": "Campana", "given": "Andrea", "initials": "A"}, {"family": "Villani", "given": "Alberto", "initials": "A", "orcid": "0000-0002-9120-0424", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d74ddfe5709426783a3b9c753cacad3.json"}}, {"family": "Rossi", "given": "Paolo", "initials": "P"}, {"family": "CACTUS Study Team", "given": "", "initials": ""}, {"family": "Landegren", "given": "Nils", "initials": "N"}, {"family": "Palma", "given": "Paolo", "initials": "P", "orcid": "0000-0002-3066-4719", "researcher": {"href": "https://publications.scilifelab.se/researcher/275341cd978547cfa2aaf179cbd74011.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}], "type": "journal article", "published": "2020-11-12", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "183", "issue": "4", "pages": "968-981.e7"}, "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.", "doi": "10.1016/j.cell.2020.09.016", "pmid": "32966765", "labels": {"Autoimmunity and Serology Profiling": "Service", "Affinity Proteomics Stockholm": "Service", "Cellular Immunomonitoring": "Technology development", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0092-8674(20)31157-0"}, {"db": "pmc", "key": "PMC7474869"}], "notes": [], "created": "2020-09-07T21:59:50.131Z", "modified": "2024-01-16T13:48:41.355Z"}]}