{"entity": "researcher", "timestamp": "2026-10-05T21:00:11.493Z", "family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "affiliations": ["Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, 171 77 Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/54d696167bca4a389807143f84baeafe.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/54d696167bca4a389807143f84baeafe"}}, "publications": [{"entity": "publication", "iuid": "1c5a6133d47f4a73ae56d921da61b6df", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1c5a6133d47f4a73ae56d921da61b6df.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1c5a6133d47f4a73ae56d921da61b6df"}}, "title": "Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes", "authors": [{"family": "Venetz-Arenas", "given": "Natalia", "initials": "N"}, {"family": "Schulte", "given": "Tim", "initials": "T"}, {"family": "M\u00fcller", "given": "Sandra", "initials": "S"}, {"family": "Wallden", "given": "Karin", "initials": "K"}, {"family": "Fischer", "given": "Stefanie", "initials": "S"}, {"family": "Resink", "given": "Tom", "initials": "T"}, {"family": "Kadri", "given": "Nadir", "initials": "N", "orcid": "0000-0003-2623-4094", "researcher": {"href": "https://publications.scilifelab.se/researcher/70724b181f324c7aac42468a177dcff4.json"}}, {"family": "Paladino", "given": "Maria", "initials": "M"}, {"family": "Pina", "given": "Nicole", "initials": "N"}, {"family": "Radom", "given": "Filip", "initials": "F"}, {"family": "Villemagne", "given": "Denis", "initials": "D"}, {"family": "Bruckmaier", "given": "Sandra", "initials": "S"}, {"family": "Cornelius", "given": "Andreas", "initials": "A"}, {"family": "Hospodarsch", "given": "Tanja", "initials": "T"}, {"family": "Alici", "given": "Evren", "initials": "E", "orcid": "0000-0001-5307-6648", "researcher": {"href": "https://publications.scilifelab.se/researcher/94af705a738741dd928e90fe403b9475.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications.scilifelab.se/researcher/54d696167bca4a389807143f84baeafe.json"}}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications.scilifelab.se/researcher/3bdd56cf648f4411945163135f9a7140.json"}}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications.scilifelab.se/researcher/f639c1a9dca647c0b583ce74ab398f02.json"}}, {"family": "Carroni", "given": "Marta", "initials": "M", "orcid": "0000-0002-7697-6427", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7f1bc1767024368abcb11a83184994a.json"}}, {"family": "Levitsky", "given": "Victor", "initials": "V"}, {"family": "Sandalova", "given": "Tatyana", "initials": "T", "orcid": "0000-0002-7694-6420", "researcher": {"href": "https://publications.scilifelab.se/researcher/8adca17a49fc47b696cb2b2795f83e6f.json"}}, {"family": "Walser", "given": "Marcel", "initials": "M"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications.scilifelab.se/researcher/39682601d1a24f5ba1d103bf74c9acbd.json"}}], "type": "journal-article", "published": "2025-12-00", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "28", "issue": "12", "pages": "113926", "issn-l": "2589-0042"}, "abstract": null, "doi": "10.1016/j.isci.2025.113926", "pmid": null, "labels": {"Cryo-EM": "Collaborative"}, "xrefs": [], "notes": [], "created": "2025-11-23T22:19:59.150Z", "modified": "2025-12-21T19:10:20.517Z"}, {"entity": "publication", "iuid": "9322d91734fa4ade8db29e7f933c0ac0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9322d91734fa4ade8db29e7f933c0ac0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9322d91734fa4ade8db29e7f933c0ac0"}}, "title": "The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications.scilifelab.se/researcher/54d696167bca4a389807143f84baeafe.json"}}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4a3a0f566a342db89c54b87a50d5e5b.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Rao Muvva", "given": "Jagadeeswara", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications.scilifelab.se/researcher/3bdd56cf648f4411945163135f9a7140.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications.scilifelab.se/researcher/8391879473274bc1b14b3f8fea7f9fc9.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "J Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e3185cf86534a96983b39dd93df454a.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "pages": "e13195", "issn-l": "0300-9475"}, "abstract": "The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS-CoV-2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined na\u00efve patient-groups as they presented with moderate and severe COVID-19 disease. The present Resource Article describes how the Karolinska KI/K COVID-19 Immune Atlas allow scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS-CoV-2 infection in an online setting.", "doi": "10.1111/sji.13195", "pmid": "35652743", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9287045"}], "notes": [], "created": "2022-11-16T17:15:26.201Z", "modified": "2022-11-16T17:15:26.261Z"}, {"entity": "publication", "iuid": "6ba3a0a503434b1d9709bdead1716425", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6ba3a0a503434b1d9709bdead1716425.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6ba3a0a503434b1d9709bdead1716425"}}, "title": "Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.", "authors": [{"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e879a6ef8ff45bea049986707480e99.json"}}, {"family": "Scharenberg", "given": "Marlena", "initials": "M", "orcid": "0000-0002-7659-7216", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ef22a304bdc429a81d7acf143f6295f.json"}}, {"family": "Mold", "given": "Jeff E", "initials": "JE", "orcid": "0000-0003-2195-2978", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ba167f912244d879746ed60a3c19568.json"}}, {"family": "H\u00e5rd", "given": "Joanna", "initials": "J", "orcid": "0000-0003-4575-5629", "researcher": {"href": "https://publications.scilifelab.se/researcher/3c209a378be54ae699e7157892c3a709.json"}}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E", "orcid": "0000-0001-6045-108X", "researcher": {"href": "https://publications.scilifelab.se/researcher/726903b084194aeb885b4cb42a8d33db.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Nguyen", "given": "Son", "initials": "S"}, {"family": "Wilson", "given": "Jennifer N", "initials": "JN"}, {"family": "Al-Ameri", "given": "Mamdoh", "initials": "M"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications.scilifelab.se/researcher/54d696167bca4a389807143f84baeafe.json"}}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications.scilifelab.se/researcher/b87ccad53d354bdd80af490dc8a0c019.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}], "type": "journal article", "published": "2021-03-16", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "11", "pages": "e2016580118", "issn-l": "0027-8424"}, "abstract": "Human adaptive-like \"memory\" CD56dimCD16+ natural killer (NK) cells in peripheral blood from cytomegalovirus-seropositive individuals have been extensively investigated in recent years and are currently explored as a treatment strategy for hematological cancers. However, treatment of solid tumors remains limited due to insufficient NK cell tumor infiltration, and it is unknown whether large expansions of adaptive-like NK cells that are equipped for tissue residency and tumor homing exist in peripheral tissues. Here, we show that human lung and blood contains adaptive-like CD56brightCD16- NK cells with hallmarks of tissue residency, including expression of CD49a. Expansions of adaptive-like lung tissue-resident NK (trNK) cells were found to be present independently of adaptive-like CD56dimCD16+ NK cells and to be hyperresponsive toward target cells. Together, our data demonstrate that phenotypically, functionally, and developmentally distinct subsets of adaptive-like NK cells exist in human lung and blood. Given their tissue-related character and hyperresponsiveness, human lung adaptive-like trNK cells might represent a suitable alternative for therapies targeting solid tumors.", "doi": "10.1073/pnas.2016580118", "pmid": "33836578", "labels": {"NGI Stockholm (Genomics Production)": null, "NGI Stockholm (Genomics Applications)": null, "National Genomics Infrastructure": null}, "xrefs": [{"db": "pii", "key": "2016580118"}, {"db": "pmc", "key": "PMC7980282"}], "notes": [], "created": "2021-06-09T12:16:15.739Z", "modified": "2021-11-10T12:26:18.872Z"}]}