{"entity": "researcher", "timestamp": "2026-10-02T02:52:08.160Z", "family": "Saarinen", "given": "Marcus", "initials": "M", "orcid": "0000-0001-9019-8396", "affiliations": ["Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.", "Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/51d5a0b93eba44ff8df36b8948d48532.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/51d5a0b93eba44ff8df36b8948d48532"}}, "publications": [{"entity": "publication", "iuid": "3e6fc79de2f546eb89f4767000de0ec4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e6fc79de2f546eb89f4767000de0ec4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e6fc79de2f546eb89f4767000de0ec4"}}, "title": "Systematic identification of p11 as a signaling modulator across the GPCRome.", "authors": [{"family": "Saarinen", "given": "Marcus", "initials": "M", "orcid": "0000-0001-9019-8396", "researcher": {"href": "https://publications.scilifelab.se/researcher/51d5a0b93eba44ff8df36b8948d48532.json"}}, {"family": "Kotliar", "given": "Ilana B", "initials": "IB", "orcid": "0000-0001-9533-4828", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddf97aaf7767453a9a165e6198fda679.json"}}, {"family": "H\u00f6ffkes", "given": "Inga", "initials": "I"}, {"family": "Branzell", "given": "Niclas", "initials": "N", "orcid": "0009-0009-3472-6903", "researcher": {"href": "https://publications.scilifelab.se/researcher/4bde4ad10f0146379233871ea29ea918.json"}}, {"family": "Bowin", "given": "Carl-Fredrik", "initials": "CF", "orcid": "0000-0001-9090-9493", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1d268a249b84fc99fbc924eee151311.json"}}, {"family": "Dahl", "given": "Leo", "initials": "L", "orcid": "0000-0003-1492-3052", "researcher": {"href": "https://publications.scilifelab.se/researcher/d4df506f315c4289935b935a503efd56.json"}}, {"family": "Da Silva", "given": "Elisa", "initials": "E", "orcid": "0009-0006-0105-2402", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c3b2d4d4fef4b52b4b15095a5e83de6.json"}}, {"family": "Glaros", "given": "Vassilis", "initials": "V"}, {"family": "Abney", "given": "Alonso", "initials": "A", "orcid": "0000-0002-0164-8314", "researcher": {"href": "https://publications.scilifelab.se/researcher/a409d1eb8ac84a9699649def4e91cf00.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications.scilifelab.se/researcher/50dffce4f4444dd8b5ff8f9294146a0b.json"}}, {"family": "Kreslavsky", "given": "Taras", "initials": "T", "orcid": "0000-0002-6672-1914", "researcher": {"href": "https://publications.scilifelab.se/researcher/94bb90e31ed1447a9835a1adae1c8daa.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications.scilifelab.se/researcher/aba5822711b246b397fffacb7ae403b3.json"}}, {"family": "Sakmar", "given": "Thomas P", "initials": "TP", "orcid": "0000-0002-2836-8953", "researcher": {"href": "https://publications.scilifelab.se/researcher/1130157044664f8b994b94e3b199cc30.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications.scilifelab.se/researcher/5199496295334771ba3c5621a83a6f43.json"}}], "type": "journal article", "published": "2026-10-02", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "12", "issue": "40", "pages": "eaeg6567", "issn-l": "2375-2548"}, "abstract": "The microprotein p11 (S100A10) is a ubiquitously expressed molecular scaffold that is known to be required for behavioral responses to certain antidepressants, presumably through its effect on G protein-coupled receptor (GPCR)-mediated signaling. Here, we demonstrate that p11 recruitment to GPCRs is promoted by an active receptor conformation. Furthermore, by mapping the GPCR-p11 interactome using a multiplexed suspension bead array (SBA) of 211 receptors, we identified more than two dozen high-confidence physical interactors across diverse GPCR signaling families. We define the functional significance of these interactions by focusing on a novel SBA screening hit, the protease-activated receptor 2 (PAR2). Transcriptomic fingerprinting and signaling assays in p11-knockout cells reveal that p11 acts as an amplifier of endogenous PAR2 signaling. PAR2 and p11 are specifically coexpressed in vivo in a subset of sensory neurons, and p11-deficient mice exhibit a blunted PAR2-mediated inflammatory response. Our results establish p11 as a widespread, activity-dependent modulator of GPCR-mediated signaling outcomes across diverse physiological processes.", "doi": "10.1126/sciadv.aeg6567", "pmid": "42814836", "labels": {"CRISPR Functional Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC13626081"}], "notes": [], "created": "2026-10-01T17:33:21.076Z", "modified": "2026-10-01T17:33:22.082Z"}]}