{"entity": "researcher", "timestamp": "2026-04-16T18:10:10.363Z", "family": "Millen", "given": "Aletta M E", "initials": "AME", "orcid": "0000-0002-4831-7336", "affiliations": ["Wits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.", "School of Physiology, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2191, South Africa."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/51536887abb14df8895c213d86b0bf97.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/51536887abb14df8895c213d86b0bf97"}}, "publications": [{"entity": "publication", "iuid": "110ee03e5bac4f8c871a72dc21df4996", "links": {"self": {"href": "https://publications.scilifelab.se/publication/110ee03e5bac4f8c871a72dc21df4996.json"}, "display": {"href": "https://publications.scilifelab.se/publication/110ee03e5bac4f8c871a72dc21df4996"}}, "title": "Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model.", "authors": [{"family": "Millen", "given": "Aletta M E", "initials": "AME", "orcid": "0000-0002-4831-7336", "researcher": {"href": "https://publications.scilifelab.se/researcher/51536887abb14df8895c213d86b0bf97.json"}}, {"family": "Maluleke", "given": "Tshiamo T", "initials": "TT", "orcid": "0000-0002-7233-3555", "researcher": {"href": "https://publications.scilifelab.se/researcher/23f22398576f434a95aa463e27bf377e.json"}}, {"family": "Pienaar", "given": "Leandrie", "initials": "L"}, {"family": "Sallie", "given": "Farhanah N", "initials": "FN", "orcid": "0000-0002-8201-921X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f7bb9e03ca474a64b171b735c37a3875.json"}}, {"family": "Veerappan", "given": "Radhini", "initials": "R"}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications.scilifelab.se/researcher/64f6381de42949db8d30b56b526f3e26.json"}}, {"family": "Baijnath", "given": "Sooraj", "initials": "S", "orcid": "0000-0001-7860-1779", "researcher": {"href": "https://publications.scilifelab.se/researcher/a918cd14121f40bf88ad33082921e5c2.json"}}], "type": "journal article", "published": "2024-07-10", "journal": {"title": "Biology (Basel)", "issn": "2079-7737", "volume": "13", "issue": "7", "issn-l": null}, "abstract": "The effects of collagen-induced arthritis (CIA), a model of systemic inflammation, on brain regional molecular markers associated with neurological disorders are uncertain.\n\nThis study investigated the brain regional molecular changes in markers associated with inflammation and neuronal dysfunction in a CIA model.\n\nFourteen male Sprague Dawley rats were divided into control (n = 5) or CIA (n = 9) groups. 10 weeks after CIA induction, brain tissue was collected. Brain regional mRNA expression of inflammatory markers (IL-1\u03b2 and IL-6), apoptotic markers (BAX and Bcl2) and neurotrophic factors (BDNF, CREB and TrkB) was determined. Monoamine distribution and abundance in different brain regions were determine by mass spectrometry imaging (MSI).\n\nNeuroinflammation was confirmed in the CIA group by increased IL-\u03b2 mRNA expression, concurrent with an increased BAX/Bcl2 ratio. The mRNA expression of CREB was increased in the midbrain and hippocampus while BDNF was increased and TrkB was decreased across all brain regions in CIA compared to control animals. Serotonin was decreased in the midbrain and hippocampus while dopamine was decreased in the striatum of CIA rats, compared to controls.\n\nCIA resulted in neuroinflammation concurrent with an apoptotic state and aberrant expression of neurotrophic factors and monoamines in the brain, suggestive of neurodegeneration.", "doi": "10.3390/biology13070516", "pmid": "39056709", "labels": {"Spatial Mass Spectrometry": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11273993"}, {"db": "pii", "key": "biology13070516"}], "notes": [], "created": "2024-11-20T10:43:04.193Z", "modified": "2024-11-20T10:43:04.716Z"}]}