{"entity": "researcher", "timestamp": "2026-08-09T13:22:42.458Z", "family": "Uni\u00f3n Caballero", "given": "Andrea", "initials": "A", "orcid": "0000-0001-5500-9019", "affiliations": ["Biomarkers and Nutrimetabolomics Laboratory, Department de Nutrici\u00f3, Ci\u00e8ncies de l'Alimentaci\u00f3 i Gastronomia, Institut de Recerca en Nutrici\u00f3 i Seguretat Aliment\u00e0ria (INSA-UB), Facultat de Farm\u00e0cia i Ci\u00e8ncies de l'Alimentaci\u00f3, Universitat de Barcelona, Barcelona 08028, Spain.", "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid 28029, Spain."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/4ef06c4ba2cd471c97c402af62b34385.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/4ef06c4ba2cd471c97c402af62b34385"}}, "publications": [{"entity": "publication", "iuid": "36d41f27cba2473e9498ad1733f0a1ad", "links": {"self": {"href": "https://publications.scilifelab.se/publication/36d41f27cba2473e9498ad1733f0a1ad.json"}, "display": {"href": "https://publications.scilifelab.se/publication/36d41f27cba2473e9498ad1733f0a1ad"}}, "title": "Metabolite Biomarkers Linking a High-Fiber Rye Intervention with Cardiometabolic Risk Factors: The RyeWeight Study.", "authors": [{"family": "Uni\u00f3n Caballero", "given": "Andrea", "initials": "A", "orcid": "0000-0001-5500-9019", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ef06c4ba2cd471c97c402af62b34385.json"}}, {"family": "Mero\u00f1o", "given": "Tom\u00e1s", "initials": "T", "orcid": "0000-0002-2673-3494", "researcher": {"href": "https://publications.scilifelab.se/researcher/76a887d04cc84fe394befeee1c5e6cc1.json"}}, {"family": "\u00c5berg", "given": "Sebastian", "initials": "S"}, {"family": "Nordin", "given": "Elise", "initials": "E"}, {"family": "Dicksved", "given": "Johan", "initials": "J"}, {"family": "S\u00e1nchez-Pla", "given": "Alex", "initials": "A"}, {"family": "Cubedo", "given": "Marta", "initials": "M"}, {"family": "Carmona-Pontaque", "given": "Francisco", "initials": "F"}, {"family": "Iversen", "given": "Kia No\u0337hr", "initials": "KN"}, {"family": "Mart\u00ednez-Hu\u00e9lamo", "given": "Miriam", "initials": "M"}, {"family": "Guadall", "given": "Anna", "initials": "A"}, {"family": "Landberg", "given": "Rikard", "initials": "R"}, {"family": "Andr\u00e9s-Lacueva", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8494-4978", "researcher": {"href": "https://publications.scilifelab.se/researcher/5374c25bdb4845ddaf5afc498ff68222.json"}}], "type": "journal article", "published": "2025-09-03", "journal": {"title": "J. Agric. Food Chem.", "issn": "1520-5118", "volume": "73", "issue": "35", "pages": "21869-21879", "issn-l": "0021-8561"}, "abstract": "Wholegrain rye, considered one of the cereals with the highest content of dietary fiber and bioactive compounds, has been linked with reduced risk of cardiometabolic diseases. Thus, biomarkers reflecting its intake and/or the metabolic effect after consumption are essential to better elucidate its health effects. Our aim was to identify plasma metabolite biomarkers associated with a high-fiber rye intervention and to assess the associations between these metabolites, gut microbiota composition, and cardiometabolic risk factors in a 12-week randomized controlled trial comparing a hypocaloric diet with high-fiber rye (n = 108) or refined wheat (n = 99) in participants with obesity. Rye intervention increased plasma concentrations of benzoxazinoids (DIBOA-S) and phenylacetamides (2-HPA-S and 2-HHPA-S), gut microbial metabolites (indolepropionic acid, 2-aminophenol, enterolactone sulfate, and enterolactone glucuronide), betainized compounds (pipecolic-betaine), phenolic acids (2,6-DHBA and gallic acid-4-sulfate), and diverse endogenous metabolites. Microbiota composition changes were increased Eubacterium xylanophilum and Agathobacter and decreased Ruminococcus torques and Romboutsia. Moreover, the intervention effect was mostly captured by changes in metabolites and gut microbiota compared to clinical variables. Gallic acid-4-sulfate and phenylacetamides were associated with reductions in weight, fat mass, BMI, or fasting insulin levels even after adjusting for plasma alkylresorcinols, used as markers for rye intake compliance. Altogether, these metabolites may constitute biomarkers of wholegrain rye cardiometabolic effects.", "doi": "10.1021/acs.jafc.5c01415", "pmid": "40838659", "labels": {"Chalmers Mass Spectrometry Infrastructure": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC12412176"}], "notes": [], "created": "2025-12-01T05:42:35.304Z", "modified": "2025-12-01T05:42:35.625Z"}]}