{"entity": "researcher", "timestamp": "2026-07-18T18:46:03.843Z", "family": "Iyegbe", "given": "Conrad", "initials": "C", "orcid": "0000-0003-4908-5183", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/4cd641fce5e543aea0ccd02982d92db0.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/4cd641fce5e543aea0ccd02982d92db0"}}, "publications": [{"entity": "publication", "iuid": "905503ab005d4de1b7710f488a80b3af", "links": {"self": {"href": "https://publications.scilifelab.se/publication/905503ab005d4de1b7710f488a80b3af.json"}, "display": {"href": "https://publications.scilifelab.se/publication/905503ab005d4de1b7710f488a80b3af"}}, "title": "Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.", "authors": [{"family": "Strom", "given": "Nora I", "initials": "NI", "orcid": "0000-0002-5261-8852", "researcher": {"href": "https://publications.scilifelab.se/researcher/bcd18b76d8d948dfb5529a2be294ecab.json"}}, {"family": "Burton", "given": "Christie L", "initials": "CL", "orcid": "0000-0002-8955-6528", "researcher": {"href": "https://publications.scilifelab.se/researcher/4607f407ac9d4213a81b4a77b4cce4ad.json"}}, {"family": "Iyegbe", "given": "Conrad", "initials": "C", "orcid": "0000-0003-4908-5183", "researcher": {"href": "https://publications.scilifelab.se/researcher/4cd641fce5e543aea0ccd02982d92db0.json"}}, {"family": "Silzer", "given": "Talisa", "initials": "T", "orcid": "0000-0002-8894-0368", "researcher": {"href": "https://publications.scilifelab.se/researcher/bab53669fd09412bb6cea8e9ba045a07.json"}}, {"family": "Antonyan", "given": "Lilit", "initials": "L", "orcid": "0000-0002-6138-3725", "researcher": {"href": "https://publications.scilifelab.se/researcher/7514916d8c1845c5b05ecda57a1e6178.json"}}, {"family": "Pool", "given": "Ren\u00e9", "initials": "R", "orcid": "0000-0001-5579-0933", "researcher": {"href": "https://publications.scilifelab.se/researcher/fc33e91c50654a6a88a44db4b6755f73.json"}}, {"family": "Lemire", "given": "Mathieu", "initials": "M", "orcid": "0000-0001-6222-9028", "researcher": {"href": "https://publications.scilifelab.se/researcher/40eb65594aa6465487bd22280813868a.json"}}, {"family": "Crowley", "given": "James J", "initials": "JJ", "orcid": "0000-0001-9051-1557", "researcher": {"href": "https://publications.scilifelab.se/researcher/14ecad66262b47dcadebcc8c7e759024.json"}}, {"family": "Hottenga", "given": "Jouke-Jan", "initials": "JJ", "orcid": "0000-0002-5668-2368", "researcher": {"href": "https://publications.scilifelab.se/researcher/75553b594b1f4255833de730f7f7d170.json"}}, {"family": "Ivanov", "given": "Volen Z", "initials": "VZ", "orcid": "0000-0001-6349-0500", "researcher": {"href": "https://publications.scilifelab.se/researcher/aedb00517ebb4620b67d7ca53fbc6207.json"}}, {"family": "Larsson", "given": "Henrik", "initials": "H", "orcid": "0000-0002-6851-3297", "researcher": {"href": "https://publications.scilifelab.se/researcher/21f2cca2f6b74c5393c0fc33bcf15ee6.json"}}, {"family": "Lichtenstein", "given": "Paul", "initials": "P", "orcid": "0000-0003-3037-5287", "researcher": {"href": "https://publications.scilifelab.se/researcher/4db67c51837b4cdfa18cacbc3fca1173.json"}}, {"family": "Magnusson", "given": "Patrik", "initials": "P", "orcid": "0000-0002-7315-7899", "researcher": {"href": "https://publications.scilifelab.se/researcher/b277b6387de142bbab91fad82d9eff09.json"}}, {"family": "R\u00fcck", "given": "Christian", "initials": "C", "orcid": "0000-0002-8742-0168", "researcher": {"href": "https://publications.scilifelab.se/researcher/496a782babf3403ba32f805f360d246f.json"}}, {"family": "Schachar", "given": "Russell", "initials": "R", "orcid": "0000-0002-2015-4395", "researcher": {"href": "https://publications.scilifelab.se/researcher/b38a298da97e4917951701907b4e9c3f.json"}}, {"family": "Wu", "given": "Hei Man", "initials": "HM", "orcid": "0000-0003-1559-7586", "researcher": {"href": "https://publications.scilifelab.se/researcher/1578fafcb32642609d408fcff09cd91e.json"}}, {"family": "Cath", "given": "Danielle", "initials": "D"}, {"family": "Crosbie", "given": "Jennifer", "initials": "J", "orcid": "0000-0002-8710-3322", "researcher": {"href": "https://publications.scilifelab.se/researcher/c600d1e64efa49738c960f7fb8f8f7b0.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D", "orcid": "0000-0002-4545-0924", "researcher": {"href": "https://publications.scilifelab.se/researcher/9954431e50b749aeb6957835ae1632f3.json"}}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI", "orcid": "0000-0002-7099-7972", "researcher": {"href": "https://publications.scilifelab.se/researcher/4b66ab2525fd4a468e7a4ad14c955cb4.json"}}, {"family": "Mattheisen", "given": "Manuel", "initials": "M", "orcid": "0000-0002-8442-493X", "researcher": {"href": "https://publications.scilifelab.se/researcher/c38fef539c2c4cebb81eff917aa3d4ef.json"}}, {"family": "Meier", "given": "Sandra M", "initials": "SM", "orcid": "0000-0002-3287-5894", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c232f699657481ea911bbb5ed11ea1b.json"}}, {"family": "Smit", "given": "Dirk J A", "initials": "DJA", "orcid": "0000-0001-8301-8860", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe64f7980537495aba79c0eca978e95d.json"}}, {"family": "Arnold", "given": "Paul D", "initials": "PD", "orcid": "0000-0003-2496-4624", "researcher": {"href": "https://publications.scilifelab.se/researcher/c21fa35b3bf246ab8a96866510fc069b.json"}}], "type": "journal article", "published": "2024-09-00", "journal": {"title": "Mol. Psychiatry", "issn": "1476-5578", "volume": "29", "issue": "9", "pages": "2714-2723", "issn-l": "1359-4184"}, "abstract": "While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13-38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported OCS to date (N = 33,943 with complete phenotypic and genome-wide data), combining the results from seven large-scale population-based cohorts from Sweden, the Netherlands, England, and Canada (including six twin cohorts and one cohort of unrelated individuals). We found no genome-wide significant associations at the single-nucleotide polymorphism (SNP) or gene-level, but a polygenic risk score (PRS) based on the OCD GWAS previously published by the Psychiatric Genetics Consortium (PGC-OCD) was significantly associated with OCS (Pfixed = 3.06 \u00d7 10-5). Also, one curated gene set (Mootha Gluconeogenesis) reached Bonferroni-corrected significance (Ngenes = 28, Beta = 0.79, SE = 0.16, Pbon = 0.008). Expression of genes in this set is high at sites of insulin mediated glucose disposal. Dysregulated insulin signaling in the etiology of OCS has been suggested by a previous study describing a genetic overlap of OCS with insulin signaling-related traits in children and adolescents. We report a SNP heritability of 4.1% (P = 0.0044) in the meta-analyzed GWAS, and heritability estimates based on the twin cohorts of 33-43%. Genetic correlation analysis showed that OCS were most strongly associated with OCD (rG = 0.72, p = 0.0007) among all tested psychiatric disorders (N = 11). Of all 97 tested phenotypes, 24 showed a significant genetic correlation with OCS, and 66 traits showed concordant directions of effect with OCS and OCD. OCS have a significant polygenic contribution and share genetic risk with diagnosed OCD, supporting the hypothesis that OCD represents the extreme end of widely distributed OCS in the population.", "doi": "10.1038/s41380-024-02489-6", "pmid": "38548983", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11420085"}, {"db": "pii", "key": "10.1038/s41380-024-02489-6"}], "notes": [], "created": "2024-11-25T10:15:18.944Z", "modified": "2025-02-28T14:14:02.221Z"}]}