{"entity": "researcher", "timestamp": "2026-08-15T07:24:25.632Z", "family": "Sopova", "given": "Elena", "initials": "E", "orcid": "0000-0001-7561-331X", "affiliations": ["Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/49eae62ecbbf45848dc5d2808d363010.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/49eae62ecbbf45848dc5d2808d363010"}}, "publications": [{"entity": "publication", "iuid": "4f5ab34ce2334c658b9c8fb041665f50", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4f5ab34ce2334c658b9c8fb041665f50.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4f5ab34ce2334c658b9c8fb041665f50"}}, "title": "Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.", "authors": [{"family": "Filograna", "given": "Roberta", "initials": "R", "orcid": "0000-0002-6581-9426", "researcher": {"href": "https://publications.scilifelab.se/researcher/7d215cffe2dc48a18d051a2229c8ce9f.json"}}, {"family": "Lee", "given": "Seungmin", "initials": "S", "orcid": "0000-0002-0903-0973", "researcher": {"href": "https://publications.scilifelab.se/researcher/175203731b3048bc8763ab5155e6b84f.json"}}, {"family": "Tiklov\u00e1", "given": "Katar\u00edna", "initials": "K"}, {"family": "Mennuni", "given": "Mara", "initials": "M", "orcid": "0000-0001-6199-6233", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d3b8d76aacd4f47ae62d0de66e9222a.json"}}, {"family": "Jonsson", "given": "Viktor", "initials": "V", "orcid": "0000-0002-1445-5220", "researcher": {"href": "https://publications.scilifelab.se/researcher/a1ed4977f0c243ad847c4ec0ab24fd88.json"}}, {"family": "Ringn\u00e9r", "given": "Markus", "initials": "M"}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Sopova", "given": "Elena", "initials": "E", "orcid": "0000-0001-7561-331X", "researcher": {"href": "https://publications.scilifelab.se/researcher/49eae62ecbbf45848dc5d2808d363010.json"}}, {"family": "Shupliakov", "given": "Oleg", "initials": "O", "orcid": "0000-0001-5352-6848", "researcher": {"href": "https://publications.scilifelab.se/researcher/136d6cd739f04017accb6198a9626a38.json"}}, {"family": "Koolmeister", "given": "Camilla", "initials": "C", "orcid": "0000-0002-4052-3442", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a59865b375744c7adeeaed402a2e0b5.json"}}, {"family": "Olson", "given": "Lars", "initials": "L", "orcid": "0000-0001-7378-7420", "researcher": {"href": "https://publications.scilifelab.se/researcher/80e5c20645b94c0b94f2405e7ae3e8e2.json"}}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Larsson", "given": "Nils-G\u00f6ran", "initials": "NG", "orcid": "0000-0001-5100-996X", "researcher": {"href": "https://publications.scilifelab.se/researcher/1dc68aa2893a4ab8845fc32d8d6bc59a.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "PLoS Genet.", "issn": "1553-7404", "volume": "17", "issue": "9", "pages": "e1009822", "issn-l": "1553-7390"}, "abstract": "Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial damage over time and mitochondrial defects have been frequently reported in Parkinson's disease (PD) patients. However, the causal contribution of adult-onset mitochondrial dysfunction to PD remains uncertain. Here, we developed a mouse model lacking Mitofusin 2 (MFN2), a key regulator of mitochondrial network homeostasis, in adult midbrain DA neurons. The knockout mice develop severe and progressive DA neuron-specific mitochondrial dysfunction resulting in neurodegeneration and parkinsonism. To gain further insights into pathophysiological events, we performed transcriptomic analyses of isolated DA neurons and found that mitochondrial dysfunction triggers an early onset immune response, which precedes mitochondrial swelling, mtDNA depletion, respiratory chain deficiency and cell death. Our experiments show that the immune response is an early pathological event when mitochondrial dysfunction is induced in adult midbrain DA neurons and that neuronal death may be promoted non-cell autonomously by the cross-talk and activation of surrounding glial cells.", "doi": "10.1371/journal.pgen.1009822", "pmid": "34570766", "labels": {"Bioinformatics Long-term Support WABI": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC8496783"}, {"db": "pii", "key": "PGENETICS-D-21-00764"}], "notes": [], "created": "2023-03-03T21:44:47.290Z", "modified": "2023-03-03T21:44:47.441Z"}, {"entity": "publication", "iuid": "dbf4b623cec545a3bbfbdfe959dc2337", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dbf4b623cec545a3bbfbdfe959dc2337.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dbf4b623cec545a3bbfbdfe959dc2337"}}, "title": "A latent lineage potential in resident neural stem cells enables spinal cord repair.", "authors": [{"family": "Llorens-Bobadilla", "given": "Enric", "initials": "E", "orcid": "0000-0002-7891-1272", "researcher": {"href": "https://publications.scilifelab.se/researcher/3144601c466246cfa70acbe8c7ee00ee.json"}}, {"family": "Chell", "given": "James M", "initials": "JM", "orcid": "0000-0003-3019-4750", "researcher": {"href": "https://publications.scilifelab.se/researcher/5f42dee5363240b7ad5db1ec421d9932.json"}}, {"family": "Le Merre", "given": "Pierre", "initials": "P", "orcid": "0000-0003-4205-7411", "researcher": {"href": "https://publications.scilifelab.se/researcher/ba592e9aa93b433cb85ff11a786b0a71.json"}}, {"family": "Wu", "given": "Yicheng", "initials": "Y"}, {"family": "Zamboni", "given": "Margherita", "initials": "M", "orcid": "0000-0003-0664-4707", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f196173b40b4819a5fcd11bf76a4e6e.json"}}, {"family": "Bergenstr\u00e5hle", "given": "Joseph", "initials": "J"}, {"family": "Stenudd", "given": "Moa", "initials": "M"}, {"family": "Sopova", "given": "Elena", "initials": "E", "orcid": "0000-0001-7561-331X", "researcher": {"href": "https://publications.scilifelab.se/researcher/49eae62ecbbf45848dc5d2808d363010.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications.scilifelab.se/researcher/4a4e6ca0f29b4ead8569e2729481c3e0.json"}}, {"family": "Shupliakov", "given": "Oleg", "initials": "O", "orcid": "0000-0001-5352-6848", "researcher": {"href": "https://publications.scilifelab.se/researcher/136d6cd739f04017accb6198a9626a38.json"}}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications.scilifelab.se/researcher/88931dd9e39c48e2820b89080c3945ad.json"}}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J", "orcid": "0000-0001-5819-458X", "researcher": {"href": "https://publications.scilifelab.se/researcher/23064ee2ac9b4c2fb1eb94e61f92148e.json"}}], "type": "journal article", "published": "2020-10-02", "journal": {"title": "Science", "issn": "1095-9203", "issn-l": "0036-8075", "volume": "370", "issue": "6512", "pages": "eabb8795"}, "abstract": "Injuries to the central nervous system (CNS) are inefficiently repaired. Resident neural stem cells manifest a limited contribution to cell replacement. We have uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the injured mouse spinal cord. Integrating multimodal single-cell analysis, we found that neural stem cells are in a permissive chromatin state that enables the unfolding of a normally latent gene expression program for oligodendrogenesis after injury. Ectopic expression of the transcription factor OLIG2 unveiled abundant stem cell-derived oligodendrogenesis, which followed the natural progression of oligodendrocyte differentiation, contributed to axon remyelination, and stimulated functional recovery of axon conduction. Recruitment of resident stem cells may thus serve as an alternative to cell transplantation after CNS injury.", "doi": "10.1126/science.abb8795", "pmid": "33004487", "labels": {"Eukaryotic Single Cell Genomics (ESCG)": "Service", "Integrated Microscopy Technologies Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "370/6512/eabb8795"}], "notes": [], "created": "2020-10-05T10:44:49.529Z", "modified": "2021-11-10T12:46:38.225Z"}]}